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Conserved domains on  [gi|442618950|ref|NP_001262544|]
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flyers-cup, isoform F [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-428 3.56e-43

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 162.03  E-value: 3.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  98 LTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISpKIEN 177
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT-DLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 178 LQSLTVLTLHDNalvelpPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 257
Cdd:COG4886   95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 258 NNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEG 337
Cdd:COG4886  169 NQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 338 NEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVE 417
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                        330
                 ....*....|.
gi 442618950 418 GNPIKTIRRDI 428
Cdd:COG4886  327 LLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
629-778 1.64e-16

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 629 VVDFARNQLSTLPNGLQHMKDLvTELVLSNNVIGYVPQFISQFTRISFLNLSNNLLNDLPTEFGVLNTLRELNIANNRFP 708
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTNL-KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 709 CIPNCVYELQGLEILIASENHIKMLNVSgLQNMRRLSTLDLRNNDIETVPpILGNLTNITHLELVGNPFR 778
Cdd:COG4886  196 DLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-428 3.56e-43

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 162.03  E-value: 3.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  98 LTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISpKIEN 177
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT-DLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 178 LQSLTVLTLHDNalvelpPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 257
Cdd:COG4886   95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 258 NNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEG 337
Cdd:COG4886  169 NQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 338 NEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVE 417
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                        330
                 ....*....|.
gi 442618950 418 GNPIKTIRRDI 428
Cdd:COG4886  327 LLLLKGLLVTL 337
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 158-419 1.26e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.98  E-value: 1.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-------------------- 215
Cdd:PLN00113 238 LNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 216 -----QLPRAMYSLPELRHLNISYNEFV-ELNPDISDLHMLEFLDGGHNNIQS-LPGGIGFLVRLTALLLPYNHIK-ELP 287
Cdd:PLN00113 318 nnftgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIP 397

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 288 PDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGNEAL 341
Cdd:PLN00113 398 KSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqmlslarnkffgGLPDSFGSKRL 477

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 342 NELHASNN-FIKIIPKAMcSNLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISLQVEG 418
Cdd:PLN00113 478 ENLDLSRNqFSGAVPRKL-GSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556


                 .
gi 442618950 419 N 419
Cdd:PLN00113 557 N 557
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
629-778 1.64e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 629 VVDFARNQLSTLPNGLQHMKDLvTELVLSNNVIGYVPQFISQFTRISFLNLSNNLLNDLPTEFGVLNTLRELNIANNRFP 708
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTNL-KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 709 CIPNCVYELQGLEILIASENHIKMLNVSgLQNMRRLSTLDLRNNDIETVPpILGNLTNITHLELVGNPFR 778
Cdd:COG4886  196 DLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 272-426 5.61e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 5.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 272 RLTALLLPYNHIKELPpDLVNMRSLQKIDLMHNDLTSLpEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFI 351
Cdd:cd21340    3 RITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 352 KII----------------------------PKAMCSNLPHLKILDLRDNKITELpDELCLLRNLNRLDVSNNTIS---V 400
Cdd:cd21340   81 SVVeglenltnleelhienqrlppgekltfdPRSLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleE 159

                        170       180
                 ....*....|....*....|....*.
gi 442618950 401 LPVTLSSLAHLISLQVEGNPIKTIRR 426
Cdd:cd21340  160 LLDLLSSWPSLRELDLTGNPVCKKPK 185
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 694-781 1.80e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 694 LNTLRELNIANNRFP-----CI-PNCVYELQG-LEILIASENHIKmlNVSGLQNMRRLSTLDLRNN---DIETVPPILGN 763
Cdd:cd21340   89 LTNLEELHIENQRLPpgeklTFdPRSLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNqisDLEELLDLLSS 166

                         90
                 ....*....|....*....
gi 442618950 764 LTNITHLELVGNPF-RQPR 781
Cdd:cd21340  167 WPSLRELDLTGNPVcKKPK 185
LRR_8 pfam13855
Leucine rich repeat;
158-214 6.77e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442618950  158 LNNLDLSSNTLTHISPKI-ENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKL 214
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
718-777 7.39e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618950  718 QGLEILIASENHIKMLNVSGLQNMRRLSTLDLRNNDIETVPPI-LGNLTNITHLELVGNPF 777
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
602-802 1.21e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.38  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 602 RTLAVNLEELTSVPDQVfqiarDEGVHVVDFARNQLSTLPnglQHMKDLVTELVLSNNVIGYVPQfisqftrisflnlsn 681
Cdd:PRK15370 265 QSLDLFHNKISCLPENL-----PEELRYLSVYDNSIRTLP---AHLPSGITHLNVQSNSLTALPE--------------- 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 682 nllndlptefgvlntlrelniannrfpCIPncvyelQGLEILIASENHIKMLNVS---GLQNmrrlstLDLRNNDI---- 754
Cdd:PRK15370 322 ---------------------------TLP------PGLKTLEAGENALTSLPASlppELQV------LDVSKNQItvlp 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 442618950 755 ETVPPILGNLtNITHLELVGNPFRQPRHQILMKGTDAIMSYLRDRIPT 802
Cdd:PRK15370 363 ETLPPTITTL-DVSRNALTNLPENLPAALQIMQASRNNLVRLPESLPH 409
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-428 3.56e-43

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 162.03  E-value: 3.56e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  98 LTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNTLTHISpKIEN 177
Cdd:COG4886   16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLT-DLGD 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 178 LQSLTVLTLHDNalvelpPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 257
Cdd:COG4886   95 LTNLTELDLSGN------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSN 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 258 NNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILELPEFEG 337
Cdd:COG4886  169 NQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGN 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 338 NEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISVLPVTLSSLAHLISLQVE 417
Cdd:COG4886  249 LTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326

                        330
                 ....*....|.
gi 442618950 418 GNPIKTIRRDI 428
Cdd:COG4886  327 LLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
88-414 1.02e-38

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 149.31  E-value: 1.02e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  88 ERSTHEDDQVLTQELWKLARKSGTLNLSNKALARVPKRLYDINEADADSKAVNLEQLTIKEEDAWWNQVPLNNLDLSSNT 167
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQ 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 168 LTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDL 247
Cdd:COG4886  125 LTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPEPLGNL 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 248 HMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELpPDLVNMRSLQKIDLMHNDLTSLPEDMGlLRKLDCLYLQHN 327
Cdd:COG4886  205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL-PELGNLTNLEELDLSNNQLTDLPPLAN-LTNLKTLDLSNN 282

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 328 DI-------LELPEFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNNTISV 400
Cdd:COG4886  283 QLtdlklkeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                        330
                 ....*....|....
gi 442618950 401 LPVTLSSLAHLISL 414
Cdd:COG4886  363 LTLLLTLGLLGLLE 376
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
158-424 3.67e-28

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 118.11  E-value: 3.67e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEF 237
Cdd:COG4886    6 LSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 238 VELNPDISDLHMLEFLDGGHNNiqslpgGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLR 317
Cdd:COG4886   86 LLGLTDLGDLTNLTELDLSGNE------ELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 318 KLDCLYLQHNDILELP-EFEGNEALNELHASNNFIKIIPKAMcSNLPHLKILDLRDNKITELPDELCLLRNLNRLDVSNN 396
Cdd:COG4886  160 NLKSLDLSNNQLTDLPeELGNLTNLKELDLSNNQITDLPEPL-GNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNN 238

                        250       260
                 ....*....|....*....|....*...
gi 442618950 397 TISVLPVtLSSLAHLISLQVEGNPIKTI 424
Cdd:COG4886  239 QLTDLPE-LGNLTNLEELDLSNNQLTDL 265
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 158-419 1.26e-17

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 87.98  E-value: 1.26e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-------------------- 215
Cdd:PLN00113 238 LNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPSIFSLQKLISLDLSDNSLSgeipelviqlqnleilhlfs 317

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 216 -----QLPRAMYSLPELRHLNISYNEFV-ELNPDISDLHMLEFLDGGHNNIQS-LPGGIGFLVRLTALLLPYNHIK-ELP 287
Cdd:PLN00113 318 nnftgKIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTGeIPEGLCSSGNLFKLILFSNSLEgEIP 397

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 288 PDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGNEAL 341
Cdd:PLN00113 398 KSLGACRSLRRVRLQDNSFSgELPSEFTKLPLVYFLDISNNNLQgrinsrkwdmpslqmlslarnkffgGLPDSFGSKRL 477

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 342 NELHASNN-FIKIIPKAMcSNLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISLQVEG 418
Cdd:PLN00113 478 ENLDLSRNqFSGAVPRKL-GSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556


                 .
gi 442618950 419 N 419
Cdd:PLN00113 557 N 557
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
629-778 1.64e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 1.64e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 629 VVDFARNQLSTLPNGLQHMKDLvTELVLSNNVIGYVPQFISQFTRISFLNLSNNLLNDLPTEFGVLNTLRELNIANNRFP 708
Cdd:COG4886  117 SLDLSGNQLTDLPEELANLTNL-KELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQIT 195

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 709 CIPNCVYELQGLEILIASENHIKMLNVSgLQNMRRLSTLDLRNNDIETVPpILGNLTNITHLELVGNPFR 778
Cdd:COG4886  196 DLPEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
230-431 1.93e-16

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.29  E-value: 1.93e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 230 LNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNdltsl 309
Cdd:COG4886   32 LLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN----- 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 310 pEDMGLLRKLDCLYLQHNDILELP-EFEGNEALNELHASNNFIKIIPKAMcSNLPHLKILDLRDNKITELPDELCLLRNL 388
Cdd:COG4886  107 -EELSNLTNLESLDLSGNQLTDLPeELANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPEELGNLTNL 184

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 442618950 389 NRLDVSNNTISVLPVTLSSLAHLISLQVEGNPIKTIRRDILQC 431
Cdd:COG4886  185 KELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPEPLANL 227
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
641-778 5.44e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 5.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 641 PNGLQHMKDLvTELVLSNNVIGYVPQFISQFTRISFLNLSNNLLNDLPTEFGVLNTLRELNIANNRFPCIPNCVYELQGL 720
Cdd:COG4886  106 NEELSNLTNL-ESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNL 184

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442618950 721 EILIASENHIKMLNVSgLQNMRRLSTLDLRNNDIETVPPILGNLTNITHLELVGNPFR 778
Cdd:COG4886  185 KELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLT 241
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
158-355 1.04e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.90  E-value: 1.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLTHISPKIENLQSLTVLTLHDNALVELPpEIGKLEKLVRLNVSHNKLSQLPrAMYSLPELRHLNISYNEF 237
Cdd:COG4886  207 LEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLP-ELGNLTNLEELDLSNNQLTDLP-PLANLTNLKTLDLSNNQL 284

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 238 VELNPD-ISDLHMLEFLDGGHNNIQSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLL 316
Cdd:COG4886  285 TDLKLKeLELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 442618950 317 RKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIP 355
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLL 403
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 158-421 4.02e-14

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 76.43  E-value: 4.02e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-------------------------ELPPEIGKLEKLVRLNVSH 211
Cdd:PLN00113 166 LKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgqiprelgqmkslkwiylgynnlsgEIPYEIGGLTSLNHLDLVY 245

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 212 NKLS-------------------------QLPRAMYSLPELRHLNISYN----EFVELnpdISDLHMLEFLDGGHNNIQ- 261
Cdd:PLN00113 246 NNLTgpipsslgnlknlqylflyqnklsgPIPPSIFSLQKLISLDLSDNslsgEIPEL---VIQLQNLEILHLFSNNFTg 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 262 SLPGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-------------------------SLPEDMGL 315
Cdd:PLN00113 323 KIPVALTSLPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgeipeglcssgnlfklilfsnslegEIPKSLGA 402

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 316 LRKLDCLYLQHNDIL-ELP-EFEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKIT-ELPDeLCLLRNLNRLD 392
Cdd:PLN00113 403 CRSLRRVRLQDNSFSgELPsEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPD-SFGSKRLENLD 481

                        330       340       350
                 ....*....|....*....|....*....|
gi 442618950 393 VSNNTIS-VLPVTLSSLAHLISLQVEGNPI 421
Cdd:PLN00113 482 LSRNQFSgAVPRKLGSLSELMQLKLSENKL 511
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 193-414 3.19e-13

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 73.73  E-value: 3.19e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 193 ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLP-ELRHLNISYNEFV-----------------------ELNPDISDL 247
Cdd:PLN00113  84 KISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSsSLRYLNLSNNNFTgsiprgsipnletldlsnnmlsgEIPNDIGSF 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 248 HMLEFLD-GGHNNIQSLPGGIGFLVRLTALLLPYNH-IKELPPDLVNMRSLQKI------------------------DL 301
Cdd:PLN00113 164 SSLKVLDlGGNVLVGKIPNSLTNLTSLEFLTLASNQlVGQIPRELGQMKSLKWIylgynnlsgeipyeiggltslnhlDL 243

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 302 MHNDLT-SLPEDMGLLRKLDCLYLQHNDIL-------------------------ELPEFEGN-EALNELHA-SNNFIKI 353
Cdd:PLN00113 244 VYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgpippsifslqklisldlsdnslsgEIPELVIQlQNLEILHLfSNNFTGK 323

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442618950 354 IPKAMCSnLPHLKILDLRDNKIT-ELPDELCLLRNLNRLDVSNNTIS-VLPVTLSSLAHLISL 414
Cdd:PLN00113 324 IPVALTS-LPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKL 385
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 272-426 5.61e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 5.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 272 RLTALLLPYNHIKELPpDLVNMRSLQKIDLMHNDLTSLpEDMGLLRKLDCLYLQHNDILELPEFEGNEALNELHASNNFI 351
Cdd:cd21340    3 RITHLYLNDKNITKID-NLSLCKNLKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 352 KII----------------------------PKAMCSNLPHLKILDLRDNKITELpDELCLLRNLNRLDVSNNTIS---V 400
Cdd:cd21340   81 SVVeglenltnleelhienqrlppgekltfdPRSLAALSNSLRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISdleE 159

                        170       180
                 ....*....|....*....|....*.
gi 442618950 401 LPVTLSSLAHLISLQVEGNPIKTIRR 426
Cdd:cd21340  160 LLDLLSSWPSLRELDLTGNPVCKKPK 185
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 115-349 1.30e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.80  E-value: 1.30e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 115 SNKALARVPKRLYDINEADADSKAVNleQLTIKEEDAWWNQVPLNNLDLSSNTL-THISPKIENLQSLTVLTLHDNALV- 192
Cdd:PLN00113 341 SNKFSGEIPKNLGKHNNLTVLDLSTN--NLTGEIPEGLCSSGNLFKLILFSNSLeGEIPKSLGACRSLRRVRLQDNSFSg 418

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 193 ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQ-SLPGGIGFL 270
Cdd:PLN00113 419 ELPSEFTKLPLVYFLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSgAVPRKLGSL 498

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 271 VRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-SLP---EDMGLLRKLDclyLQHNDIL-ELPEFEGN-EALNE 343
Cdd:PLN00113 499 SELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPasfSEMPVLSQLD---LSQNQLSgEIPKNLGNvESLVQ 575


                 ....*.
gi 442618950 344 LHASNN 349
Cdd:PLN00113 576 VNISHN 581
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
592-777 5.28e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 5.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 592 PRWVYKLRHTRTLAVNLEELTSVPDQVFQIardEGVHVVDFARNQLSTLPNGLQHMKDLvTELVLSNNVIGYVPQFISQF 671
Cdd:COG4886  129 PEELANLTNLKELDLSNNQLTDLPEPLGNL---TNLKSLDLSNNQLTDLPEELGNLTNL-KELDLSNNQITDLPEPLGNL 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 672 TRISFLNLSNNLLNDLPTEFGVLNTLRELNIANNRFPCIPNcvyelqgleiliasenhikmlnvsgLQNMRRLSTLDLRN 751
Cdd:COG4886  205 TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPE-------------------------LGNLTNLEELDLSN 259

                        170       180
                 ....*....|....*....|....*.
gi 442618950 752 NDIETVPPiLGNLTNITHLELVGNPF 777
Cdd:COG4886  260 NQLTDLPP-LANLTNLKTLDLSNNQL 284
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
182-405 6.65e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 69.34  E-value: 6.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 182 TVLTLHDNALVELPPEIGklEKLVRLNVSHNKLSQLPRAMYSlpELRHLNISYNEFVELNPDISDlhMLEFLDGGHNNIQ 261
Cdd:PRK15370 181 TELRLKILGLTTIPACIP--EQITTLILDNNELKSLPENLQG--NIKTLYANSNQLTSIPATLPD--TIQEMELSINRIT 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 262 SLPGGIGflVRLTALLLPYNHIKELPPDLVNmrSLQKIDLMHNDLTSLPEDmgLLRKLDCLYLQHNDILELPEfEGNEAL 341
Cdd:PRK15370 255 ELPERLP--SALQSLDLFHNKISCLPENLPE--ELRYLSVYDNSIRTLPAH--LPSGITHLNVQSNSLTALPE-TLPPGL 327

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442618950 342 NELHASNNFIKIIPKAMCsnlPHLKILDLRDNKITELPDelCLLRNLNRLDVSNNTISVLPVTL 405
Cdd:PRK15370 328 KTLEAGENALTSLPASLP---PELQVLDVSKNQITVLPE--TLPPTITTLDVSRNALTNLPENL 386
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 155-310 1.31e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 68.34  E-value: 1.31e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 155 QVPLNN-LDLSSNTLT-HISPKIENLQSLTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQ-LPRAMYSLPELRHLN 231
Cdd:PLN00113 426 KLPLVYfLDISNNNLQgRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGaVPRKLGSLSELMQLK 505

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 232 ISYNEFVELNPD-ISDLHMLEFLDGGHNNIQ-SLPGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDL-T 307
Cdd:PLN00113 506 LSENKLSGEIPDeLSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhG 585


                 ...
gi 442618950 308 SLP 310
Cdd:PLN00113 586 SLP 588
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
650-777 1.85e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.88  E-value: 1.85e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 650 LVTELVLSNNVIGYVPQFISQFTRISFLNLSNNLLNDLPTEFGVLNTLRELNIANNRFPCIPNCVYELQGLEILIASENH 729
Cdd:COG4886   68 LLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQ 147

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442618950 730 IKMLNvSGLQNMRRLSTLDLRNNDIETVPPILGNLTNITHLELVGNPF 777
Cdd:COG4886  148 LTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQI 194
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 158-707 2.42e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 67.57  E-value: 2.42e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLPELRHLNISY 234
Cdd:PLN00113 142 LETLDLSNNMLSgEIPNDIGSFSSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVgQIPRELGQMKSLKWIYLGY 221

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 235 NEfvelnpdisdlhmlefLDGGhnniqsLPGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-SLPED 312
Cdd:PLN00113 222 NN----------------LSGE------IPYEIGGLTSLNHLDLVYNNLTgPIPSSLGNLKNLQYLFLYQNKLSgPIPPS 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 313 MGLLRKLDCLYLQHNDIL-ELPEFEGN-EALNELHA-SNNFIKIIPKAMCSnLPHLKILDLRDNKIT-ELPDELCLLRNL 388
Cdd:PLN00113 280 IFSLQKLISLDLSDNSLSgEIPELVIQlQNLEILHLfSNNFTGKIPVALTS-LPRLQVLQLWSNKFSgEIPKNLGKHNNL 358

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 389 NRLDVSNNTIS-VLPVTLSSLAHLISLQVEGNPIKTirrdilqcgttRILKTLhdravakakeegggvddastSAGISVT 467
Cdd:PLN00113 359 TVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEG-----------EIPKSL--------------------GACRSLR 407

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 468 RLRggqMDDGDIPGNFPDSFHHQQQQNGFQCPcsypcqqqqmqqqfcvyeplrncqeyDRQTQGRIYEPENYQQQHQNGS 547
Cdd:PLN00113 408 RVR---LQDNSFSGELPSEFTKLPLVYFLDIS--------------------------NNNLQGRINSRKWDMPSLQMLS 458

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 548 L-RSLFVQQqqqrmeypYPGYFMYQQQQQQQFSYEQdpssRSAVHPRwvyKLRhtrtlavNLEELTSVpdqvfqiardeg 626
Cdd:PLN00113 459 LaRNKFFGG--------LPDSFGSKRLENLDLSRNQ----FSGAVPR---KLG-------SLSELMQL------------ 504

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 627 vhvvDFARNQLS-TLPNGLQHMKDLVTELVLSNNVIGYVPQFISQFTRISFLNLSNNLLN-DLPTEFGVLNTLRELNIAN 704
Cdd:PLN00113 505 ----KLSENKLSgEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISH 580


                 ...
gi 442618950 705 NRF 707
Cdd:PLN00113 581 NHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 158-270 5.75e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.86  E-value: 5.75e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLTHISP-KIENLQSLTVLTLHDNALV-ELPPEIGKLEKLVRLNVSHNKLS-QLPRAMYSLPELRHLNISY 234
Cdd:PLN00113 477 LENLDLSRNQFSGAVPrKLGSLSELMQLKLSENKLSgEIPDELSSCKKLVSLDLSHNQLSgQIPASFSEMPVLSQLDLSQ 556

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 442618950 235 NEFV-ELNPDISDLHMLEFLDGGHNNIQ-SLPGGIGFL 270
Cdd:PLN00113 557 NQLSgEIPKNLGNVESLVQVNISHNHLHgSLPSTGAFL 594
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 168-379 8.24e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.72  E-value: 8.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 168 LTHIS------PKIENL---QSLTVLTLHDNALVELPPeIGKLEKLVRLNVSHNKLSQLPRaMYSLPELRHLNISYNEFV 238
Cdd:cd21340    4 ITHLYlndkniTKIDNLslcKNLKVLYLYDNKITKIEN-LEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRIS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 239 ELNpDISDLHMLEFLdggHNNIQSLPGGIGFLVR---LTALLlpynhikelppdlvnmRSLQKIDLMHNDLTSLpEDMGL 315
Cdd:cd21340   82 VVE-GLENLTNLEEL---HIENQRLPPGEKLTFDprsLAALS----------------NSLRVLNISGNNIDSL-EPLAP 140

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442618950 316 LRKLDCLYLQHNDILELPEFEGnealnelhasnnfikiipkaMCSNLPHLKILDLRDNKITELP 379
Cdd:cd21340  141 LRNLEQLDASNNQISDLEELLD--------------------LLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 158-310 1.17e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 1.17e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLTHIsPKIENLQSLTVLTLHDNALVELPPeIGKLEKLVRLNVSHNKLSQL-------------------- 217
Cdd:cd21340   26 LKVLYLYDNKITKI-ENLEFLTNLTHLYLQNNQIEKIEN-LENLVNLKKLYLGGNRISVVeglenltnleelhienqrlp 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 218 --------PRAMYSL-PELRHLNISYNEFVELNPdISDLHMLEFLDGGHNNIQSlpggigflvrltalllpynhIKELPP 288
Cdd:cd21340  104 pgekltfdPRSLAALsNSLRVLNISGNNIDSLEP-LAPLRNLEQLDASNNQISD--------------------LEELLD 162

                        170       180
                 ....*....|....*....|..
gi 442618950 289 DLVNMRSLQKIDLMHNDLTSLP 310
Cdd:cd21340  163 LLSSWPSLRELDLTGNPVCKKP 184
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 694-781 1.80e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.48  E-value: 1.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 694 LNTLRELNIANNRFP-----CI-PNCVYELQG-LEILIASENHIKmlNVSGLQNMRRLSTLDLRNN---DIETVPPILGN 763
Cdd:cd21340   89 LTNLEELHIENQRLPpgeklTFdPRSLAALSNsLRVLNISGNNID--SLEPLAPLRNLEQLDASNNqisDLEELLDLLSS 166

                         90
                 ....*....|....*....
gi 442618950 764 LTNITHLELVGNPF-RQPR 781
Cdd:cd21340  167 WPSLRELDLTGNPVcKKPK 185
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
181-421 2.48e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 54.40  E-value: 2.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 181 LTVLTLHDNALVELP---PEIGKLEklvrlnVSHNKLSQLPRAMyslPELRHLNISYNEFVELNPDISDLHMLEFLDGGH 257
Cdd:PRK15387 224 ITTLVIPDNNLTSLPalpPELRTLE------VSGNQLTSLPVLP---PGLLELSIFSNPLTHLPALPSGLCKLWIFGNQL 294

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 258 NNIQSLPGGI-------GFLVRLTAL------LLPYNHIKELPPDLVNmrSLQKIDLMHNDLTSLPEdmgLLRKLDCLYL 324
Cdd:PRK15387 295 TSLPVLPPGLqelsvsdNQLASLPALpselckLWAYNNQLTSLPTLPS--GLQELSVSDNQLASLPT---LPSELYKLWA 369

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 325 QHNDILELPEFEgnEALNELHASNNFIKIIPKamcsnLP-HLKILDLRDNKITELPdelCLLRNLNRLDVSNNTISVLPV 403
Cdd:PRK15387 370 YNNRLTSLPALP--SGLKELIVSGNRLTSLPV-----LPsELKELMVSGNRLTSLP---MLPSGLLSLSVYRNQLTRLPE 439

                        250
                 ....*....|....*...
gi 442618950 404 TLSSLAHLISLQVEGNPI 421
Cdd:PRK15387 440 SLIHLSSETTVNLEGNPL 457
LRR_8 pfam13855
Leucine rich repeat;
158-214 6.77e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 6.77e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 442618950  158 LNNLDLSSNTLTHISPKI-ENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKL 214
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
317-375 1.56e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.98  E-value: 1.56e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618950  317 RKLDCLYLQHNDILELPE--FEGNEALNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKI 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
272-411 3.32e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.85  E-value: 3.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 272 RLTALLLPYNHIKELPPDL-VNMRSLQkidLMHNDLTSLPEDmgLLRKLDCLYLQHNDILELPEFegnealnelhasnnf 350
Cdd:PRK15370 200 QITTLILDNNELKSLPENLqGNIKTLY---ANSNQLTSIPAT--LPDTIQEMELSINRITELPER--------------- 259

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442618950 351 ikiIPKAmcsnlphLKILDLRDNKITELPDelCLLRNLNRLDVSNNTISVLPVTL-SSLAHL 411
Cdd:PRK15370 260 ---LPSA-------LQSLDLFHNKISCLPE--NLPEELRYLSVYDNSIRTLPAHLpSGITHL 309
LRR_8 pfam13855
Leucine rich repeat;
203-260 3.45e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 3.45e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  203 KLVRLNVSHNKLSQL-PRAMYSLPELRHLNISYNEFVELNPD-ISDLHMLEFLDGGHNNI 260
Cdd:pfam13855   2 NLRSLDLSNNRLTSLdDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
272-329 2.56e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.56e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  272 RLTALLLPYNHIKELPPD-LVNMRSLQKIDLMHNDLTSL-PEDMGLLRKLDCLYLQHNDI 329
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGaFKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
635-779 3.02e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 3.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 635 NQLSTLPNGLQHMKDLVTELVLSNNVIGYVPQFISQFTRISFLNLSNNLLNDLPTEFGVLNTLRELNIANNRFPCIPNCV 714
Cdd:COG4886   13 LLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDL 92

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442618950 715 YELQGLEILIASENhikmlnvSGLQNMRRLSTLDLRNNDIETVPPILGNLTNITHLELVGNPFRQ 779
Cdd:COG4886   93 GDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTD 150
LRR_8 pfam13855
Leucine rich repeat;
718-777 7.39e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.36  E-value: 7.39e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618950  718 QGLEILIASENHIKMLNVSGLQNMRRLSTLDLRNNDIETVPPI-LGNLTNITHLELVGNPF 777
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
158-331 1.02e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 45.92  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 158 LNNLDLSSNTLTHIsPKI-----------ENLQSLTV-------LTLHDNALVELPPEIGKLEKLVRLNvshNKLSQLPr 219
Cdd:PRK15387 264 LLELSIFSNPLTHL-PALpsglcklwifgNQLTSLPVlppglqeLSVSDNQLASLPALPSELCKLWAYN---NQLTSLP- 338

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 220 amySLPE-LRHLNISYNEFVELNPDISDLHMLEFLDGGHNNIQSLPGGIGFLV----RLTALLLPYNHIKELPPDLVNMR 294
Cdd:PRK15387 339 ---TLPSgLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIvsgnRLTSLPVLPSELKELMVSGNRLT 415

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 442618950 295 SLQ-------KIDLMHNDLTSLPEDMGLLRKLDCLYLQHNDILE 331
Cdd:PRK15387 416 SLPmlpsgllSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSE 459
LRR_8 pfam13855
Leucine rich repeat;
225-283 1.95e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.95e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618950  225 PELRHLNISYNEFVELNPDI-SDLHMLEFLDGGHNNIQSL-PGGIGFLVRLTALLLPYNHI 283
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 158-225 2.76e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 2.76e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442618950 158 LNNLDLSSNTLT-HISPKIENLQSLTVLTLHDNALVELPPE-IGKLEKLVRLNVSHNKLS-QLPRAMYSLP 225
Cdd:PLN03150 444 LQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNGSIPEsLGQLTSLRILNLNGNSLSgRVPAALGGRL 514
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
111-317 5.10e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 5.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 111 TLNLSNKALARVPKRLydineadadSKAVNLEQLtikeeDAWWNQVP----------LNNLDLSSNTLTHIsPKIENLQS 180
Cdd:COG4886  209 ELDLSGNQLTDLPEPL---------ANLTNLETL-----DLSNNQLTdlpelgnltnLEELDLSNNQLTDL-PPLANLTN 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 181 LTVLTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLDGGHNNI 260
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 442618950 261 QSLPGGIGFLVRLTALLLPYNHIKELPPDLVNMRSLQKIDLMHNDLTSLPEDMGLLR 317
Cdd:COG4886  354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
PLN03150 PLN03150
hypothetical protein; Provisional
 252-327 6.43e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.27  E-value: 6.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 252 FLDGGHNNIQSL----PGGIGFLVRLTALLLPYNHIK-ELPPDLVNMRSLQKIDLMHNDLT-SLPEDMGLLRKLDCLYLQ 325
Cdd:PLN03150 419 FIDGLGLDNQGLrgfiPNDISKLRHLQSINLSGNSIRgNIPPSLGSITSLEVLDLSYNSFNgSIPESLGQLTSLRILNLN 498


                 ..
gi 442618950 326 HN 327
Cdd:PLN03150 499 GN 500
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 202-345 8.00e-04

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 43.32  E-value: 8.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  202 EKLVRLNVSHNKLSQLPRAMYSLPELRHLNISYNEFVELNPDISDLHMLEFLD-GGHNNIQSLPGGIGFLVRLTALLLPY 280
Cdd:PLN03210  611 ENLVKLQMQGSKLEKLWDGVHSLTGLRNIDLRGSKNLKEIPDLSMATNLETLKlSDCSSLVELPSSIQYLNKLEDLDMSR 690

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442618950  281 NHIKELPPDLVNMRSLQKIDLMH-NDLTSLPEdmgLLRKLDCLYLQHNDILELPEFEGNEALNELH 345
Cdd:PLN03210  691 CENLEILPTGINLKSLYRLNLSGcSRLKSFPD---ISTNISWLDLDETAIEEFPSNLRLENLDELI 753
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
602-802 1.21e-03

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 42.38  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 602 RTLAVNLEELTSVPDQVfqiarDEGVHVVDFARNQLSTLPnglQHMKDLVTELVLSNNVIGYVPQfisqftrisflnlsn 681
Cdd:PRK15370 265 QSLDLFHNKISCLPENL-----PEELRYLSVYDNSIRTLP---AHLPSGITHLNVQSNSLTALPE--------------- 321

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 682 nllndlptefgvlntlrelniannrfpCIPncvyelQGLEILIASENHIKMLNVS---GLQNmrrlstLDLRNNDI---- 754
Cdd:PRK15370 322 ---------------------------TLP------PGLKTLEAGENALTSLPASlppELQV------LDVSKNQItvlp 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 442618950 755 ETVPPILGNLtNITHLELVGNPFRQPRHQILMKGTDAIMSYLRDRIPT 802
Cdd:PRK15370 363 ETLPPTITTL-DVSRNALTNLPENLPAALQIMQASRNNLVRLPESLPH 409
LRR_8 pfam13855
Leucine rich repeat;
341-421 1.27e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  341 LNELHASNNFIKIIPKAMCSNLPHLKILDLRDNKITELPdelcllrnlnrldvsnntisvlPVTLSSLAHLISLQVEGNP 420
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLS----------------------PGAFSGLPSLRYLDLSGNR 60


                  .
gi 442618950  421 I 421
Cdd:pfam13855  61 L 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 155-377 1.66e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.19  E-value: 1.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 155 QVPLNNLDLSSNTLTHISPKIENLQSLTV--LTLHDNALVELPPEIGKLEKLVRLNVSHNKLSQLPRAMYSLPE------ 226
Cdd:cd00116    2 QLSLKGELLKTERATELLPKLLCLQVLRLegNTLGEEAAKALASALRPQPSLKELCLSLNETGRIPRGLQSLLQgltkgc 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 227 -LRHLNISYNEFVELNPD-ISDLHMLEFLDGGHNNIQSLPGGIGFLVrLTALllpynhiKELPPDLvnmrslQKIDLMHN 304
Cdd:cd00116   82 gLQELDLSDNALGPDGCGvLESLLRSSSLQELKLNNNGLGDRGLRLL-AKGL-------KDLPPAL------EKLVLGRN 147

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442618950 305 DLTS-----LPEDMGLLRKLDCLYLQHNDILElpefEGNEALNELHASNnfikiipkamcsnlPHLKILDLRDNKITE 377
Cdd:cd00116  148 RLEGasceaLAKALRANRDLKELNLANNGIGD----AGIRALAEGLKAN--------------CNLEVLDLNNNGLTD 207
LRR_8 pfam13855
Leucine rich repeat;
257-306 3.26e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 3.26e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 442618950  257 HNNIQSLPGGIGF-LVRLTALLLPYNHIKELPPD-LVNMRSLQKIDLMHNDL 306
Cdd:pfam13855  10 NNRLTSLDDGAFKgLSNLKVLDLSNNLLTTLSPGaFSGLPSLRYLDLSGNRL 61
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 111-362 4.38e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 40.63  E-value: 4.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  111 TLNLSNKALARVPKRLYDINeadadskAVNLEQLTIKEEDAWWNQVPLNNLdlssntLTHISPkienlqSLTVLTLHDN- 189
Cdd:PLN03210  729 WLDLDETAIEEFPSNLRLEN-------LDELILCEMKSEKLWERVQPLTPL------MTMLSP------SLTRLFLSDIp 789

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  190 ALVELPPEIGKLEKLVRLNVSHNK-LSQLPRAMySLPELRHLNISYNEFVELNPDISdlhmlefldgghNNIQSlpggig 268
Cdd:PLN03210  790 SLVELPSSIQNLHKLEHLEIENCInLETLPTGI-NLESLESLDLSGCSRLRTFPDIS------------TNISD------ 850

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950  269 flvrltaLLLPYNHIKELPPDLVNMRSLQKIDLMH-NDLTSLPEDMGLLRKLDclYLQHNDILELPEFEGNEALNEL-HA 346
Cdd:PLN03210  851 -------LNLSRTGIEEVPWWIEKFSNLSFLDMNGcNNLQRVSLNISKLKHLE--TVDFSDCGALTEASWNGSPSEVaMA 921

                         250
                  ....*....|....*.
gi 442618950  347 SNNFIKIIPKAMCSNL 362
Cdd:PLN03210  922 TDNIHSKLPSTVCINF 937
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 341-380 6.69e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.30  E-value: 6.69e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 442618950  341 LNELHASNNFIKIIPkaMCSNLPHLKILDLRDN-KITELPD 380
Cdd:pfam12799   3 LEVLDLSNNQITDIP--PLAKLPNLETLDLSGNnKITDLSD 41
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 595-780 7.09e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 7.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 595 VYKLRHTRTLAVNLEELT-SVPDQVFQIArdEGVHVVDFARNQLS-TLPNGlqHMKDLVTeLVLSNNVI-GYVPQFISQF 671
Cdd:PLN00113  89 IFRLPYIQTINLSNNQLSgPIPDDIFTTS--SSLRYLNLSNNNFTgSIPRG--SIPNLET-LDLSNNMLsGEIPNDIGSF 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442618950 672 TRISFLNLSNNLLN-DLPTEFGVLNTLRELNIANNRFPC-IPNCVYELQGLEILIASENhikmlNVSG-----LQNMRRL 744
Cdd:PLN00113 164 SSLKVLDLGGNVLVgKIPNSLTNLTSLEFLTLASNQLVGqIPRELGQMKSLKWIYLGYN-----NLSGeipyeIGGLTSL 238

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 442618950 745 STLDL-RNNDIETVPPILGNLTNITHLELVGNPFRQP 780
Cdd:PLN00113 239 NHLDLvYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGP 275
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 316-378 9.26e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 9.26e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442618950 316 LRKLDCLYLQHNDILELPEFEGNEALNELHASNNFIKIIPKamCSNLPHLKILDLRDNKITEL 378
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKI 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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