WHAMM and JMY related, isoform C [Drosophila melanogaster]
Protein Classification
WH2 domain-containing protein( domain architecture ID 10490927)
WH2 (WASP-Homology 2, or Wiskott-Aldrich homology 2) domain-containing protein similar to Mus musculus espin isoform 6
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| WH2 | pfam02205 | WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ... |
442-464 | 2.17e-04 | ||
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin. : Pssm-ID: 460490 Cd Length: 28 Bit Score: 38.25 E-value: 2.17e-04
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| WH2 | pfam02205 | WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ... |
442-464 | 2.17e-04 | ||
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin. Pssm-ID: 460490 Cd Length: 28 Bit Score: 38.25 E-value: 2.17e-04
|
||||||
| WH2 | smart00246 | Wiskott Aldrich syndrome homology region 2; Wiskott Aldrich syndrome homology region 2 / ... |
445-462 | 4.38e-04 | ||
Wiskott Aldrich syndrome homology region 2; Wiskott Aldrich syndrome homology region 2 / actin-binding motif Pssm-ID: 128542 Cd Length: 18 Bit Score: 37.56 E-value: 4.38e-04
|
||||||
| WH2 | cd21762 | Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins; This ... |
442-462 | 1.35e-03 | ||
Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins; This family contains the Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) as well as thymosin-beta (Tbeta; also called beta-thymosin or betaT) domains that are small, widespread intrinsically disordered actin-binding peptides displaying significant sequence variability and different regulations of actin self-assembly in motile and morphogenetic processes. These WH2/betaT peptides are identified by a central consensus actin-binding motif LKKT/V flanked by variable N-terminal and C-terminal extensions; the betaT shares a more extended and conserved C-terminal half than WH2. These single or repeated domains are found in actin-binding proteins (ABPs) such as the hematopoietic-specific protein WASP, its ubiquitously expressed ortholog neural-WASP (N-WASP), WASP-interacting protein (WAS/WASL-interacting protein family members 1 and 2), and WASP-family verprolin homologous protein (WAVE/SCAR) isoforms: WAVE1, WAVE2, and WAVE3. Also included are the WH2 domains found in inverted formin FH2 domain-containing protein (INF2), Cordon bleu (Cobl) protein, vasodilator-stimulated phosphoprotein (VASP) homology protein and actobindin (found in amoebae). These ABPs are commonly multidomain proteins that contain signaling domains and structurally conserved actin-binding motifs, the most important being the WH2 domain motif through which they bind actin in order to direct the location, rate, and timing for actin assembly in the cell into different structures, such as filopodia, lamellipodia, stress fibers, and focal adhesions. The WH2 domain motif is one of the most abundant actin-binding motifs in Wiskott-Aldrich syndrome proteins (WASPs) where they activate Arp2/3-dependent actin nucleation and branching in response to signals mediated by Rho-family GTPases. The thymosin beta (Tbeta) domains in metazoans act in cells as major actin-sequestering peptides; their complex with monomeric ATP-actin (G-ATP-actin) cannot polymerize at either filament (F-actin) end. Pssm-ID: 409196 Cd Length: 22 Bit Score: 36.03 E-value: 1.35e-03
|
||||||
| Name | Accession | Description | Interval | E-value | ||
| WH2 | pfam02205 | WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in ... |
442-464 | 2.17e-04 | ||
WH2 motif; The WH2 motif (for Wiskott Aldrich syndrome homology region 2) has been shown in WASP and Scar1 (mammalian homolog) to be the region that interacts with actin. Pssm-ID: 460490 Cd Length: 28 Bit Score: 38.25 E-value: 2.17e-04
|
||||||
| WH2 | smart00246 | Wiskott Aldrich syndrome homology region 2; Wiskott Aldrich syndrome homology region 2 / ... |
445-462 | 4.38e-04 | ||
Wiskott Aldrich syndrome homology region 2; Wiskott Aldrich syndrome homology region 2 / actin-binding motif Pssm-ID: 128542 Cd Length: 18 Bit Score: 37.56 E-value: 4.38e-04
|
||||||
| WH2 | cd21762 | Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins; This ... |
442-462 | 1.35e-03 | ||
Wiskott-Aldrich Syndrome Homology (WASP) region 2 (WH2 motif), and similar proteins; This family contains the Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) as well as thymosin-beta (Tbeta; also called beta-thymosin or betaT) domains that are small, widespread intrinsically disordered actin-binding peptides displaying significant sequence variability and different regulations of actin self-assembly in motile and morphogenetic processes. These WH2/betaT peptides are identified by a central consensus actin-binding motif LKKT/V flanked by variable N-terminal and C-terminal extensions; the betaT shares a more extended and conserved C-terminal half than WH2. These single or repeated domains are found in actin-binding proteins (ABPs) such as the hematopoietic-specific protein WASP, its ubiquitously expressed ortholog neural-WASP (N-WASP), WASP-interacting protein (WAS/WASL-interacting protein family members 1 and 2), and WASP-family verprolin homologous protein (WAVE/SCAR) isoforms: WAVE1, WAVE2, and WAVE3. Also included are the WH2 domains found in inverted formin FH2 domain-containing protein (INF2), Cordon bleu (Cobl) protein, vasodilator-stimulated phosphoprotein (VASP) homology protein and actobindin (found in amoebae). These ABPs are commonly multidomain proteins that contain signaling domains and structurally conserved actin-binding motifs, the most important being the WH2 domain motif through which they bind actin in order to direct the location, rate, and timing for actin assembly in the cell into different structures, such as filopodia, lamellipodia, stress fibers, and focal adhesions. The WH2 domain motif is one of the most abundant actin-binding motifs in Wiskott-Aldrich syndrome proteins (WASPs) where they activate Arp2/3-dependent actin nucleation and branching in response to signals mediated by Rho-family GTPases. The thymosin beta (Tbeta) domains in metazoans act in cells as major actin-sequestering peptides; their complex with monomeric ATP-actin (G-ATP-actin) cannot polymerize at either filament (F-actin) end. Pssm-ID: 409196 Cd Length: 22 Bit Score: 36.03 E-value: 1.35e-03
|
||||||
| WH2_WAVE | cd22057 | Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome ... |
444-465 | 2.49e-03 | ||
Wiskott Aldrich syndrome homology region 2 (WH2 motif) found in Wiskott-Aldrich Syndrome Protein Family members 1 (WASP1 or WAVE1), 2 (WASP2 or WAVE2) and 3 (WASP3 or WAVE3); This family contains the Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 (WH2) found in three Wiskott-Aldrich syndrome protein (WASP) family verprolin homologous protein (SCAR/WAVE) isoforms: WAVE1, WAVE2, and WAVE3. Members of this family activate actin related protein (Arp)2/3-dependent actin nucleation and branching in response to signals mediated by Rho-family GTPases. The domain structure of these proteins varies, reflecting different modes of regulation; however, they all share a common C-terminal WH2 region which constitutes the smallest fragment necessary for Arp2/3 activation. These proteins interact with actin via their WH2 domain. Pssm-ID: 409200 Cd Length: 28 Bit Score: 35.53 E-value: 2.49e-03
|
||||||
| Blast search parameters | ||||
|
