NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|442617778|ref|NP_001262323|]
View 

uncharacterized protein Dmel_CG15177, isoform B [Drosophila melanogaster]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-177 1.13e-09

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 52.64  E-value: 1.13e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442617778  112 ERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHEGD-DEDELIELRAKFDVDKDGVISFEDYSSVVS 177
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPlSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-177 1.13e-09

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 52.64  E-value: 1.13e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442617778  112 ERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHEGD-DEDELIELRAKFDVDKDGVISFEDYSSVVS 177
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPlSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 116-171 7.27e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 42.15  E-value: 7.27e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442617778 116 KFAFEVYDTKNTGVIDREQVGVACEKFFhEGDDEDELIELRAKFDVDKDGVISFED 171
Cdd:cd00051    3 REAFRLFDKDGDGTISADELKAALKSLG-EGLSEEEIDEMIREVDKDGDGKIDFEE 57
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
94-178 2.75e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.78  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617778  94 VSPRAWVDLFELYTTEDLERRMKFAFEVYDTKNTGVIDREQVGVACEKFfheGDDEDELIELRAKFDVDKDGVISFEDYS 173
Cdd:COG5126   50 ISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTAL---GVSEEEADELFARLDTDGDGKISFEEFV 126


                 ....*
gi 442617778 174 SVVSQ 178
Cdd:COG5126  127 AAVRD 131
PTZ00183 PTZ00183
centrin; Provisional
 108-178 3.84e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 36.59  E-value: 3.84e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442617778 108 TEDLERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHEGDDEdELIELRAKFDVDKDGVISFEDYSSVVSQ 178
Cdd:PTZ00183  12 TEDQKKEIREAFDLFDTDGSGTIDPKELKVAMRSLGFEPKKE-EIKQMIADVDKDGSGKIDFEEFLDIMTK 81
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-177 1.13e-09

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 52.64  E-value: 1.13e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442617778  112 ERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHEGD-DEDELIELRAKFDVDKDGVISFEDYSSVVS 177
Cdd:pfam13499   1 EEKLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGEPlSDEEVEELFKEFDLDKDGRISFEEFLELYS 67
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 116-171 7.27e-06

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 42.15  E-value: 7.27e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442617778 116 KFAFEVYDTKNTGVIDREQVGVACEKFFhEGDDEDELIELRAKFDVDKDGVISFED 171
Cdd:cd00051    3 REAFRLFDKDGDGTISADELKAALKSLG-EGLSEEEIDEMIREVDKDGDGKIDFEE 57
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
94-178 2.75e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 39.78  E-value: 2.75e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617778  94 VSPRAWVDLFELYTTEDLERRMKFAFEVYDTKNTGVIDREQVGVACEKFfheGDDEDELIELRAKFDVDKDGVISFEDYS 173
Cdd:COG5126   50 ISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLLTAL---GVSEEEADELFARLDTDGDGKISFEEFV 126


                 ....*
gi 442617778 174 SVVSQ 178
Cdd:COG5126  127 AAVRD 131
PTZ00183 PTZ00183
centrin; Provisional
 108-178 3.84e-03

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 36.59  E-value: 3.84e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442617778 108 TEDLERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHEGDDEdELIELRAKFDVDKDGVISFEDYSSVVSQ 178
Cdd:PTZ00183  12 TEDQKKEIREAFDLFDTDGSGTIDPKELKVAMRSLGFEPKKE-EIKQMIADVDKDGSGKIDFEEFLDIMTK 81
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
112-190 9.60e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 35.15  E-value: 9.60e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617778 112 ERRMKFAFEVYDTKNTGVIDREQVGVACEKFFHegddedeliELRAKFDVDKDGVISFEDYSSVVSQQ--PVLVEFLGWL 189
Cdd:COG5126    4 RRKLDRRFDLLDADGDGVLERDDFEALFRRLWA---------TLFSEADTDGDGRISREEFVAGMESLfeATVEPFARAA 74


                 .
gi 442617778 190 F 190
Cdd:COG5126   75 F 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH