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Conserved domains on  [gi|442633811|ref|NP_001262133|]
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uncharacterized protein Dmel_CG12983, isoform F [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Casc1_N super family cl25546
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 17-152 5.34e-05

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


The actual alignment was detected with superfamily member pfam15927:

Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 42.35  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633811   17 ELLSEEEWMaRRNIYMQRLADLKTSV-AFIDDAVEEYKELQKQKLRNDKWNSYLACDGLPNPSRPAEIRKFIFQL----- 90
Cdd:pfam15927  24 ERREEEEEE-RLAAEQDRRAEELEELkHLLEERKEALEKLRAEAREEAEWERYMRCDGLPDPRDEQEINTFISLWreeee 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633811   91 ----NFMEQESCA----NEISWVLSVDecSVLSQAPDRCDRTRKIMEKSRPNVGQLYDETVQRILATIER 152
Cdd:pfam15927 103 edidEVMETCTLVleliEELEELLLDT--PPEELAEKYVEQYKEVILVLRELINKKIDEATAHLLRQADE 170
 
Name Accession Description Interval E-value
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 17-152 5.34e-05

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 42.35  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633811   17 ELLSEEEWMaRRNIYMQRLADLKTSV-AFIDDAVEEYKELQKQKLRNDKWNSYLACDGLPNPSRPAEIRKFIFQL----- 90
Cdd:pfam15927  24 ERREEEEEE-RLAAEQDRRAEELEELkHLLEERKEALEKLRAEAREEAEWERYMRCDGLPDPRDEQEINTFISLWreeee 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633811   91 ----NFMEQESCA----NEISWVLSVDecSVLSQAPDRCDRTRKIMEKSRPNVGQLYDETVQRILATIER 152
Cdd:pfam15927 103 edidEVMETCTLVleliEELEELLLDT--PPEELAEKYVEQYKEVILVLRELINKKIDEATAHLLRQADE 170
 
Name Accession Description Interval E-value
Casc1_N pfam15927
Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally ...
 17-152 5.34e-05

Cancer susceptibility candidate 1 N-terminus; This presumed domain is functionally uncharacterized. This domain family is found in eukaryotes, and is approximately 200 amino acids in length. The family is found in association with pfam12366. There are two completely conserved residues (N and W) that may be functionally important.


Pssm-ID: 464947 [Multi-domain]  Cd Length: 201  Bit Score: 42.35  E-value: 5.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633811   17 ELLSEEEWMaRRNIYMQRLADLKTSV-AFIDDAVEEYKELQKQKLRNDKWNSYLACDGLPNPSRPAEIRKFIFQL----- 90
Cdd:pfam15927  24 ERREEEEEE-RLAAEQDRRAEELEELkHLLEERKEALEKLRAEAREEAEWERYMRCDGLPDPRDEQEINTFISLWreeee 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633811   91 ----NFMEQESCA----NEISWVLSVDecSVLSQAPDRCDRTRKIMEKSRPNVGQLYDETVQRILATIER 152
Cdd:pfam15927 103 edidEVMETCTLVleliEELEELLLDT--PPEELAEKYVEQYKEVILVLRELINKKIDEATAHLLRQADE 170
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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