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Conserved domains on  [gi|442633430|ref|NP_001262061|]
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uncharacterized protein Dmel_CG8765, isoform C [Drosophila melanogaster]

Protein Classification

Myb/SANT-like transcription factor( domain architecture ID 10651957)

Myb/SANT-like transcription factor with an N-terminal MADF domain, which resembles the 3 alpha-helix bundle of the DNA-binding Myb domains

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
316-403 1.10e-27

subfamily of SANT domain;


:

Pssm-ID: 214738  Cd Length: 89  Bit Score: 106.67  E-value: 1.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430   316 ELITLIQQEDMIYNYGNENYRNAKLKMEVWEEIARKLKKSVKQCRLKWKALRDQYAREHKRLRTLMHID-ATSRWKHYNS 394
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNGKSGGgKKSKWEYFDR 80


                   ....*....
gi 442633430   395 LSFLQKYIQ 403
Cdd:smart00595  81 LSFLRPVIR 89
MADF smart00595
subfamily of SANT domain;
42-123 5.13e-27

subfamily of SANT domain;


:

Pssm-ID: 214738  Cd Length: 89  Bit Score: 104.75  E-value: 5.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430    42 LISLVSQEQSLYNPKHPHYRSTKIKDEKWLEIGSNVGWSDVQCKSKWKAMRDQYCRELKRAKAC----SKAVKWKYFKEL 117
Cdd:smart00595   2 LIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNGksggGKKSKWEYFDRL 81


                   ....*.
gi 442633430   118 DFLRPY 123
Cdd:smart00595  82 SFLRPV 87
 
Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
316-403 1.10e-27

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 106.67  E-value: 1.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430   316 ELITLIQQEDMIYNYGNENYRNAKLKMEVWEEIARKLKKSVKQCRLKWKALRDQYAREHKRLRTLMHID-ATSRWKHYNS 394
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNGKSGGgKKSKWEYFDR 80


                   ....*....
gi 442633430   395 LSFLQKYIQ 403
Cdd:smart00595  81 LSFLRPVIR 89
MADF smart00595
subfamily of SANT domain;
42-123 5.13e-27

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 104.75  E-value: 5.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430    42 LISLVSQEQSLYNPKHPHYRSTKIKDEKWLEIGSNVGWSDVQCKSKWKAMRDQYCRELKRAKAC----SKAVKWKYFKEL 117
Cdd:smart00595   2 LIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNGksggGKKSKWEYFDRL 81


                   ....*.
gi 442633430   118 DFLRPY 123
Cdd:smart00595  82 SFLRPV 87
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 317-398 1.90e-26

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 103.14  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430  317 LITLIQQEDMIYNYGNENYRNAKLKMEVWEEIARKLK--KSVKQCRLKWKALRDQYAREHKRLRTLMHIDATSRWKHYNS 394
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGsdVPVEDCKKRWKNLRDQYRRELRRKRTNSGELYKSRWYYYEE 80


                  ....
gi 442633430  395 LSFL 398
Cdd:pfam10545  81 LSFL 84
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 42-120 2.46e-19

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 82.72  E-value: 2.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430   42 LISLVSQEQSLYNPKHPHYRSTKIKDEKWLEIGSNVGW--SDVQCKSKWKAMRDQYCRELKRAKACSKAVK---WKYFKE 116
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSdvPVEDCKKRWKNLRDQYRRELRRKRTNSGELYksrWYYYEE 80


                  ....
gi 442633430  117 LDFL 120
Cdd:pfam10545  81 LSFL 84
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 335-372 1.51e-05

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 43.04  E-value: 1.51e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 442633430 335 YRNAKLKMEVWEEIARKLKK-----SVKQCRLKWKALRDQYAR 372
Cdd:cd12203   22 FQETKSKKALWEEIAAKMRElgynrSAKQCKEKWENLNKYYKK 64
 
Name Accession Description Interval E-value
MADF smart00595
subfamily of SANT domain;
316-403 1.10e-27

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 106.67  E-value: 1.10e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430   316 ELITLIQQEDMIYNYGNENYRNAKLKMEVWEEIARKLKKSVKQCRLKWKALRDQYAREHKRLRTLMHID-ATSRWKHYNS 394
Cdd:smart00595   1 RLIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNGKSGGgKKSKWEYFDR 80


                   ....*....
gi 442633430   395 LSFLQKYIQ 403
Cdd:smart00595  81 LSFLRPVIR 89
MADF smart00595
subfamily of SANT domain;
42-123 5.13e-27

subfamily of SANT domain;


Pssm-ID: 214738  Cd Length: 89  Bit Score: 104.75  E-value: 5.13e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430    42 LISLVSQEQSLYNPKHPHYRSTKIKDEKWLEIGSNVGWSDVQCKSKWKAMRDQYCRELKRAKAC----SKAVKWKYFKEL 117
Cdd:smart00595   2 LIELVRERPCLWDRRHPDYRNKEEKRKAWEEIAEELGLSVEECKKRWKNLRDRYRRELKRLQNGksggGKKSKWEYFDRL 81


                   ....*.
gi 442633430   118 DFLRPY 123
Cdd:smart00595  82 SFLRPV 87
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 317-398 1.90e-26

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 103.14  E-value: 1.90e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430  317 LITLIQQEDMIYNYGNENYRNAKLKMEVWEEIARKLK--KSVKQCRLKWKALRDQYAREHKRLRTLMHIDATSRWKHYNS 394
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGsdVPVEDCKKRWKNLRDQYRRELRRKRTNSGELYKSRWYYYEE 80


                  ....
gi 442633430  395 LSFL 398
Cdd:pfam10545  81 LSFL 84
MADF_DNA_bdg pfam10545
Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 ...
 42-120 2.46e-19

Alcohol dehydrogenase transcription factor Myb/SANT-like; The myb/SANT-like domain in Adf-1 (MADF) is an approximately 80-amino-acid module that directs sequence specific DNA binding to a site consisting of multiple tri-nucleotide repeats. The MADF domain is found in one or more copies in eukaryotic and viral proteins and is often associated with the BESS domain. It is likely that the MADF domain is more closely related to the myb/SANT domain than it is to other HTH domains.


Pssm-ID: 463144  Cd Length: 84  Bit Score: 82.72  E-value: 2.46e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430   42 LISLVSQEQSLYNPKHPHYRSTKIKDEKWLEIGSNVGW--SDVQCKSKWKAMRDQYCRELKRAKACSKAVK---WKYFKE 116
Cdd:pfam10545   1 LIELVREHPCLWDRSHPDYRNRDARERAWEEIAEELGSdvPVEDCKKRWKNLRDQYRRELRRKRTNSGELYksrWYYYEE 80


                  ....
gi 442633430  117 LDFL 120
Cdd:pfam10545  81 LSFL 84
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 314-393 3.00e-10

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 56.89  E-value: 3.00e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430  314 EKELITLIQqEDMIYNYGNENYRNAKlkmeVWEEIARKL-----KKSVKQCRLKWKALRDQYAREHKRLRtlmhiDATSR 388
Cdd:pfam13837   9 TLALIEIWG-ERLELRFQESKKRNKK----LWEEIAEKMaelgyNRSPEQCKEKWENLKKKYRKEKEGNN-----GSGSS 78


                  ....*
gi 442633430  389 WKHYN 393
Cdd:pfam13837  79 WPFFE 83
GT1 cd12203
GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription ...
 335-372 1.51e-05

GT1, myb-like, SANT family; GT-1, a myb-like protein, is one of the GT trihelix transcription factors. GT-1 binds the GT cis-element of rbcS-3A, a light-induced gene, as a dimer. Arabidopsis GT-1 is a trans-activator and acts in the stabilization of components of the transcription pre-initiation complex comprised of TFIIA-TBP-TATA. The isolated GT-1 DNA-binding domain is sufficient to bind DNA. This region closely resembles the myb domain, but with longer helices. It has been proposed that GT-1 may respond to light signals via calcium-dependent phosphorylation to create a light-modulated molecular switch. These proteins are members of the SANT/myb group. SANT is named after 'SWI3, ADA2, N-CoR and TFIIIB', several factors that share this domain. The SANT domain resembles the 3 alpha-helix bundle of the DNA-binding Myb domains and is found in a diverse set of proteins.


Pssm-ID: 213402  Cd Length: 66  Bit Score: 43.04  E-value: 1.51e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 442633430 335 YRNAKLKMEVWEEIARKLKK-----SVKQCRLKWKALRDQYAR 372
Cdd:cd12203   22 FQETKSKKALWEEIAAKMRElgynrSAKQCKEKWENLNKYYKK 64
SANT cd00167
'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric ...
 314-366 4.15e-03

'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is also found in regulatory transcriptional repressor complexes where it also binds DNA.


Pssm-ID: 238096 [Multi-domain]  Cd Length: 45  Bit Score: 35.63  E-value: 4.15e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 442633430 314 EKELITLIQQedmiynYGNENyrnaklkmevWEEIARKL-KKSVKQCRLKWKAL 366
Cdd:cd00167    7 DELLLEAVKK------YGKNN----------WEKIAKELpGRTPKQCRERWRNL 44
Myb_DNA-bind_4 pfam13837
Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb ...
 31-116 4.97e-03

Myb/SANT-like DNA-binding domain; This presumed domain appears to be related to other Myb/SANT-like DNA binding domains. In particular pfam10545 seems most related. This family is greatly expanded in plants and appears in several proteins annotated as transposon proteins.


Pssm-ID: 463994  Cd Length: 84  Bit Score: 36.48  E-value: 4.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442633430   31 ENVVSIPKELILISLVSQEQSLynpkhpHYR-STKIKDEKWLEI-------GSNVgwSDVQCKSKWKAMRDQYCRELKRA 102
Cdd:pfam13837   1 RNKWTEEETLALIEIWGERLEL------RFQeSKKRNKKLWEEIaekmaelGYNR--SPEQCKEKWENLKKKYRKEKEGN 72

                          90
                  ....*....|....
gi 442633430  103 KacSKAVKWKYFKE 116
Cdd:pfam13837  73 N--GSGSSWPFFEE 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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