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Conserved domains on  [gi|442633260|ref|NP_001262026|]
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uncharacterized protein Dmel_CG18223, isoform C [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc super family cl21584
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 60-95 4.96e-08

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


The actual alignment was detected with superfamily member smart00020:

Pssm-ID: 473915  Cd Length: 229  Bit Score: 48.44  E-value: 4.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 442633260    60 YVVSIRSRRPHklfgdnHFCGGVIISRTYILTSAHC 95
Cdd:smart00020  15 WQVSLQYGGGR------HFCGGSLISPRWVLTAAHC 44
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 60-95 4.96e-08

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 48.44  E-value: 4.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 442633260    60 YVVSIRSRRPHklfgdnHFCGGVIISRTYILTSAHC 95
Cdd:smart00020  15 WQVSLQYGGGR------HFCGGSLISPRWVLTAAHC 44
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 60-95 1.08e-07

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 47.27  E-value: 1.08e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 442633260  60 YVVSIRSRRPHklfgdnHFCGGVIISRTYILTSAHC 95
Cdd:cd00190   14 WQVSLQYTGGR------HFCGGSLISPRWVLTAAHC 43
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 75-95 1.38e-06

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 44.64  E-value: 1.38e-06
                         10        20
                 ....*....|....*....|.
gi 442633260  75 DNHFCGGVIISRTYILTSAHC 95
Cdd:COG5640   55 SGQFCGGTLIAPRWVLTAAHC 75
Trypsin pfam00089
Trypsin;
60-95 1.40e-05

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 41.66  E-value: 1.40e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442633260   60 YVVSIRSRRPHklfgdnHFCGGVIISRTYILTSAHC 95
Cdd:pfam00089  14 WQVSLQLSSGK------HFCGGSLISENWVLTAAHC 43
 
Name Accession Description Interval E-value
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 60-95 4.96e-08

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 48.44  E-value: 4.96e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 442633260    60 YVVSIRSRRPHklfgdnHFCGGVIISRTYILTSAHC 95
Cdd:smart00020  15 WQVSLQYGGGR------HFCGGSLISPRWVLTAAHC 44
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 60-95 1.08e-07

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 47.27  E-value: 1.08e-07
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 442633260  60 YVVSIRSRRPHklfgdnHFCGGVIISRTYILTSAHC 95
Cdd:cd00190   14 WQVSLQYTGGR------HFCGGSLISPRWVLTAAHC 43
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 75-95 1.38e-06

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 44.64  E-value: 1.38e-06
                         10        20
                 ....*....|....*....|.
gi 442633260  75 DNHFCGGVIISRTYILTSAHC 95
Cdd:COG5640   55 SGQFCGGTLIAPRWVLTAAHC 75
Trypsin pfam00089
Trypsin;
60-95 1.40e-05

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 41.66  E-value: 1.40e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 442633260   60 YVVSIRSRRPHklfgdnHFCGGVIISRTYILTSAHC 95
Cdd:pfam00089  14 WQVSLQLSSGK------HFCGGSLISENWVLTAAHC 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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