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Conserved domains on  [gi|442632197|ref|NP_001261815|]
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meiotic central spindle, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 20-95 2.84e-12

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


:

Pssm-ID: 462262  Cd Length: 75  Bit Score: 62.09  E-value: 2.84e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442632197   20 NCRACAEHSSILVDLFSKEISDPPIWEMLNSILPeICRVKRDEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQL 95
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDSEKTLAEILEDCTG-IELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 284-362 2.76e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 53.18  E-value: 2.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 284 GERPFKCPL--CPKAYTHGPTLKSHM-HTHDEEKGHKCPQCDKT--FYTRgnlrahiqrhtgERPYKCPDCPQTFAKNSG 358
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQKLHENPSPEKMniFSAK------------DKPYRCEVCDKRYKNLNG 413


                 ....
gi 442632197 359 LKLH 362
Cdd:COG5189  414 LKYH 417
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-474 3.18e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 287 PFKCPLCPKAYTHGPTLKSHM----HTHDEEKGHKCP--QCDKTFYTRGNLRAHIQRHTGERPYKCPDCPqtfaknsGLK 360
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsvnHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLN-------SSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 361 LHSRLHKEERPfkcelcgkGFVQNQHLITHLRVHNGDRQFkcpdCDKSFFEKSNMMKHQRTH--SGIKPFKCEECGQAFS 438
Cdd:COG5048  362 KFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNS----CIRNFKRDSNLSLHIITHlsFRPYNCKNPPCSKSFN 429

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 442632197 439 HNHHLKSHLRIHTGEKPYKCDQCGKgFSANQSLMKH 474
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-571 2.15e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 383 QNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGI-KPFKCEECGQAFSHNHHLKSHLR--IHTGE--KPYK 457
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFS 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 458 CD--QCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPD-EPKTLHQCPH--CDVRFALKKT 532
Cdd:COG5048  324 CPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDlKNDKKSETLSnsCIRNFKRDSN 403

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 442632197 533 LDKHITSHKIRPHPCPQCPegfFSQKSLKKHLRLHNLKK 571
Cdd:COG5048  404 LSLHIITHLSFRPYNCKNP---PCSKSFNRHYNLIPHKK 439
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 20-95 2.84e-12

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 62.09  E-value: 2.84e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442632197   20 NCRACAEHSSILVDLFSKEISDPPIWEMLNSILPeICRVKRDEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQL 95
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDSEKTLAEILEDCTG-IELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 284-362 2.76e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 53.18  E-value: 2.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 284 GERPFKCPL--CPKAYTHGPTLKSHM-HTHDEEKGHKCPQCDKT--FYTRgnlrahiqrhtgERPYKCPDCPQTFAKNSG 358
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQKLHENPSPEKMniFSAK------------DKPYRCEVCDKRYKNLNG 413


                 ....
gi 442632197 359 LKLH 362
Cdd:COG5189  414 LKYH 417
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 21-94 3.56e-07

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 47.90  E-value: 3.56e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442632197    21 CRACAEHSSILVDLFSkEISDPPIWEMLNSILPeICRVKRDEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQ 94
Cdd:smart00868   2 CRLCLSESENLVSIFD-ESSEASLAEKIEECTG-IEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-474 3.18e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 287 PFKCPLCPKAYTHGPTLKSHM----HTHDEEKGHKCP--QCDKTFYTRGNLRAHIQRHTGERPYKCPDCPqtfaknsGLK 360
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsvnHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLN-------SSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 361 LHSRLHKEERPfkcelcgkGFVQNQHLITHLRVHNGDRQFkcpdCDKSFFEKSNMMKHQRTH--SGIKPFKCEECGQAFS 438
Cdd:COG5048  362 KFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNS----CIRNFKRDSNLSLHIITHlsFRPYNCKNPPCSKSFN 429

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 442632197 439 HNHHLKSHLRIHTGEKPYKCDQCGKgFSANQSLMKH 474
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-466 4.54e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.54e-05
                          10        20
                  ....*....|....*....|....*
gi 442632197  442 HLKSHLRIHTGEKPYKCDQCGKGFS 466
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-571 2.15e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 383 QNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGI-KPFKCEECGQAFSHNHHLKSHLR--IHTGE--KPYK 457
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFS 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 458 CD--QCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPD-EPKTLHQCPH--CDVRFALKKT 532
Cdd:COG5048  324 CPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDlKNDKKSETLSnsCIRNFKRDSN 403

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 442632197 533 LDKHITSHKIRPHPCPQCPegfFSQKSLKKHLRLHNLKK 571
Cdd:COG5048  404 LSLHIITHLSFRPYNCKNP---PCSKSFNRHYNLIPHKK 439
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-355 2.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 442632197  330 NLRAHIQRHTGERPYKCPDCPQTFAK 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
zf-AD pfam07776
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 20-95 2.84e-12

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 462262  Cd Length: 75  Bit Score: 62.09  E-value: 2.84e-12
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442632197   20 NCRACAEHSSILVDLFSKEISDPPIWEMLNSILPeICRVKRDEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQL 95
Cdd:pfam07776   1 VCRLCLDESDELIPIFDPSDSEKTLAEILEDCTG-IELDPNDLLPKQICERCLSKLQEFYSFRERCLESQELLQEL 75
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 284-362 2.76e-07

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 53.18  E-value: 2.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 284 GERPFKCPL--CPKAYTHGPTLKSHM-HTHDEEKGHKCPQCDKT--FYTRgnlrahiqrhtgERPYKCPDCPQTFAKNSG 358
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMlHGHQNQKLHENPSPEKMniFSAK------------DKPYRCEVCDKRYKNLNG 413


                 ....
gi 442632197 359 LKLH 362
Cdd:COG5189  414 LKYH 417
zf-AD smart00868
Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical ...
 21-94 3.56e-07

Zinc-finger associated domain (zf-AD); The zf-AD domain, also known as ZAD, forms an atypical treble-cleft-like zinc co-ordinating fold. The zf-AD domain is thought to be involved in mediating dimer formation, but does not bind to DNA.


Pssm-ID: 214871  Cd Length: 73  Bit Score: 47.90  E-value: 3.56e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442632197    21 CRACAEHSSILVDLFSkEISDPPIWEMLNSILPeICRVKRDEMPQKICPTCLVAAQNAFHFRHKCEQSFQFFSQ 94
Cdd:smart00868   2 CRLCLSESENLVSIFD-ESSEASLAEKIEECTG-IEIEPDDGLPKVICGDCLEKLESFHKFRERCRESDELLRE 73
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
287-474 3.18e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 3.18e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 287 PFKCPLCPKAYTHGPTLKSHM----HTHDEEKGHKCP--QCDKTFYTRGNLRAHIQRHTGERPYKCPDCPqtfaknsGLK 360
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLrsvnHSGESLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEKLLN-------SSS 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 361 LHSRLHKEERPfkcelcgkGFVQNQHLITHLRVHNGDRQFkcpdCDKSFFEKSNMMKHQRTH--SGIKPFKCEECGQAFS 438
Cdd:COG5048  362 KFSPLLNNEPP--------QSLQQYKDLKNDKKSETLSNS----CIRNFKRDSNLSLHIITHlsFRPYNCKNPPCSKSFN 429

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 442632197 439 HNHHLKSHLRIHTGEKPYKCDQCGKgFSANQSLMKH 474
Cdd:COG5048  430 RHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
442-466 4.54e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 4.54e-05
                          10        20
                  ....*....|....*....|....*
gi 442632197  442 HLKSHLRIHTGEKPYKCDQCGKGFS 466
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
227-393 8.13e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 8.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 227 SLLCTECGVSYSTQKALARHVAKHKEQGDTQKPHLCDF--CGRGFRTNAQLTTHRRRHTGERPFKCPLCPKAYTHGP--- 301
Cdd:COG5048  289 PIKSKQCNISFSRSSPLTRHLRSVNHSGESLKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPlln 368

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 302 --TLKSHMHTHDEEKGHK----CPQCDKTFYTRGNLRAHIQRHTGERP--YKCPDCPQTFAKNSGLKLHSRLHKEERPFK 373
Cdd:COG5048  369 nePPQSLQQYKDLKNDKKsetlSNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        170       180
                 ....*....|....*....|
gi 442632197 374 CELCGKgFVQNQHLITHLRV 393
Cdd:COG5048  449 CSILKS-FRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
383-571 2.15e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.15e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 383 QNQHLITHLRVHNGDRQFKCPDCDKSFFEKSNMMKHQRTHSGI-KPFKCEECGQAFSHNHHLKSHLR--IHTGE--KPYK 457
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFS 323

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 458 CD--QCGKGFSANQSLMKHTLWHVDNNDRPFKCSQCPKAYDTQQSLRGHEKTHKNPD-EPKTLHQCPH--CDVRFALKKT 532
Cdd:COG5048  324 CPysLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNEPPQSLQQYKDlKNDKKSETLSnsCIRNFKRDSN 403

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 442632197 533 LDKHITSHKIRPHPCPQCPegfFSQKSLKKHLRLHNLKK 571
Cdd:COG5048  404 LSLHIITHLSFRPYNCKNP---PCSKSFNRHYNLIPHKK 439
zf-H2C2_2 pfam13465
Zinc-finger double domain;
414-439 1.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.33e-03
                          10        20
                  ....*....|....*....|....*.
gi 442632197  414 NMMKHQRTHSGIKPFKCEECGQAFSH 439
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
330-355 2.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 442632197  330 NLRAHIQRHTGERPYKCPDCPQTFAK 355
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-299 2.42e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.42e-03
                          10        20
                  ....*....|....*....|....*
gi 442632197  275 LTTHRRRHTGERPFKCPLCPKAYTH 299
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 400-422 4.38e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.38e-03
                          10        20
                  ....*....|....*....|...
gi 442632197  400 FKCPDCDKSFFEKSNMMKHQRTH 422
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 428-450 4.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.88e-03
                          10        20
                  ....*....|....*....|...
gi 442632197  428 FKCEECGQAFSHNHHLKSHLRIH 450
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
426-568 6.08e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 39.29  E-value: 6.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442632197 426 KPFKCEECGQAFSHNHHLKSHLRIHTGEKPYKC--DQCGKGFSANQSLMKHTLWHvdNNDRPFKCSQCPKAYDTQQSLRG 503
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTH--HNNPSDLNSKSLPLSNSKASSSS 109

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442632197 504 HEKTHKNPDEPKTLHQCPHCDVRFalKKTLDKHITSHKIRPHPCPQCPEGFFSQK-SLKKHLRLHN 568
Cdd:COG5048  110 LSSSSSNSNDNNLLSSHSLPPSSR--DPQLPDLLSISNLRNNPLPGNNSSSVNTPqSNSLHPPLPA 173
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 316-338 7.52e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 7.52e-03
                          10        20
                  ....*....|....*....|...
gi 442632197  316 HKCPQCDKTFYTRGNLRAHIQRH 338
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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