Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKEtNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRID 531
Cdd:cd20026    1 KPPYSYAQLIVQAISSAPDKQLTLSGIYAYITKNYPYYRTA-DKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 78

Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKEtNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRID 531
Cdd:cd20026    1 KPPYSYAQLIVQAISSAPDKQLTLSGIYAYITKNYPYYRTA-DKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 78

forkhead associated (FHA) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two-winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The Forkhead (FH) domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 151 SPPYGELRF-NQEVLPITdAVTVIGRNSSTSLVHFNVAENNLVSRKHFQVLYDVelRAFFVQCLSKNGIFVDDFLQRRNV 229
Cdd:cd22688    1 GAAIARLEGrEFEYLMRK-SRVVIGRNSSRGPVDVNMGHSSFISRKHLEIFYEG--GRFFLLCNGKNGIFVDGVFQRRGA 77

                         90       100
                 ....*....|....*....|...
gi 442631649 230 DPLRLPQRCYFRFPSTEIRIEFE 252
Cdd:cd22688   78 PPLQLPKTCVFRFPSTNIKIVFE 100

Transcription factor of the Forkhead/HNF3 family [Transcription];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 439 LFQTPSTASYNHNEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARS 518
Cdd:COG5025  323 STLSDLSADVNRTSKPAFSYANSITQAILSSPSGKMTLSEIYSWISSNLPYYR-HKPTAWQNSIRHNLSLNKSFEKVPRS 401

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 519 QDEPGKGSFWRIDPDSGAkliDHSYKKRRQRSSqgfrpPYGMPRSAPVSPSHMDNSRESSPL-QDIVLQS 587
Cdd:COG5025  402 ASQPGKGCFWKIDYSYIY---EKESKRNPRSPK-----KSPSAHSVHQKLSLHVNDLYQSPAtSDIASSS 463

Forkhead associated (FHA) domain, binds pSer, pThr, pTyr [Signal transduction mechanisms];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 161 QEVLPITDAVTVIGRNSSTSLvhfnVAENNLVSRKHFQVLYDVElrAFFVQCL-SKNGIFVDDflqRRNVDPLRLPQRCY 239
Cdd:COG1716   13 GRRFPLDGGPLTIGRAPDNDI----VLDDPTVSRRHARIRRDGG--GWVLEDLgSTNGTFVNG---QRVTEPAPLRDGDV 83

                         90
                 ....*....|...
gi 442631649 240 FRFPSTEIRIEFE 252
Cdd:COG1716   84 IRLGKTELRFRLS 96

Forkhead (FH) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both, positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKEtNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRID 531
Cdd:cd20026    1 KPPYSYAQLIVQAISSAPDKQLTLSGIYAYITKNYPYYRTA-DKGWQNSIRHNLSLNRYFIKVPRSQEEPGKGSFWRID 78

Forkhead domain;

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649  453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:pfam00250   1 KPPYSYAALIAMAILSSPEKKLTLSEIYEWISENFPYYR-TADKGWQNSIRHNLSLNKCFVKVPRPKDEPGKGSYWTIDP 79

                  ....*..
gi 442631649  533 DSGAKLI 539
Cdd:pfam00250  80 EYEEMFE 86

forkhead associated (FHA) domain found in the Forkhead box protein K (FOXK) subfamily; The FOXK subfamily includes two-winged helix transcription factors, FOXK1 and FOXK2. FOXK1, also called myocyte nuclear factor (MNF), acts as a transcriptional regulator that binds to the upstream enhancer region (CCAC box) of myoglobin genes. It positively regulates Wnt/beta-catenin signaling by translocating dishevelled (DVL) proteins into the nucleus. It also reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression. In addition, FOXK1 plays important roles in multiple human cancers. FOXK2, also called cellular transcription factor ILF-1 or interleukin enhancer-binding factor 1, is a transcriptional regulator that recognizes the core sequence 5'-TAAACA-3'. It binds to NFAT-like motifs (purine-rich) in the IL2 promoter. It also binds to the HIV-1 long terminal repeat. FOXK2 may be involved in both positive and negative regulation of important viral and cellular promoter elements. In addition, FOXK2 plays a critical role in suppressing tumorigenesis. The Forkhead (FH) domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. The FHA domain is a small phosphopeptide recognition module.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 151 SPPYGELRF-NQEVLPITdAVTVIGRNSSTSLVHFNVAENNLVSRKHFQVLYDVelRAFFVQCLSKNGIFVDDFLQRRNV 229
Cdd:cd22688    1 GAAIARLEGrEFEYLMRK-SRVVIGRNSSRGPVDVNMGHSSFISRKHLEIFYEG--GRFFLLCNGKNGIFVDGVFQRRGA 77

                         90       100
                 ....*....|....*....|...
gi 442631649 230 DPLRLPQRCYFRFPSTEIRIEFE 252
Cdd:cd22688   78 PPLQLPKTCVFRFPSTNIKIVFE 100

Forkhead (FH) domain found in Forkhead box (FOX) family of transcription factors and similar proteins; The FOX family comprises diverse tissue- and cell type-specific transcription factors with an evolutionary conserved "Forkhead (FH)" or "winged helix" DNA-binding domain. FH is named for the Drosophila fork head protein, a transcription factor which promotes terminal rather than segmental development. The structure of the FH domain contains 2 flexible loops or "wings" in the C-terminal region, hence the term winged helix. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'. They participate in a variety of cellular processes, such as cell cycle progression, proliferation, differentiation, migration, metabolism, and DNA damage response. Their expression can be regulated by multiple factors, and they can act as co-activators and/or transcriptional repressors. Fifty FOX-encoding genes in humans have been categorized into 19 subfamilies based on protein sequence homology (FOXA to FOXS).

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631649 454 PPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETnKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWR 529
Cdd:cd00059    1 PPYSYAALIALAILSSPDKRLTLSEIYKWIEDNFPYYRTAT-KGWKNSIRHNLSLNKCFVKVPREPSDPGKGSYWT 75

Forkhead (FH) domain found in Forkhead box protein J1 (FOXJ1) and similar proteins; FOXJ1, also called Forkhead-related protein FKHL13 or hepatocyte nuclear factor 3 Forkhead homolog 4 (HFH-4), acts as a transcription factor specifically required for the formation of motile cilia. It acts by activating transcription of genes that mediate assembly of motile cilia, such as CFAP157. FOXJ1 binds the DNA consensus sequences 5'-HWDTGTTTGTTTA-3' or 5'-KTTTGTTGTTKTW-3' (where H is not G, W is A or T, D is not C, and K is G or T). It activates the transcription of a variety of ciliary proteins in the developing brain and lung. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKeTNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20023    1 KPPYSYATLICMAMQASKKTKITLSAIYKWITDNFMYYRV-ADPTWQNSIRHNLSLNKCFIKVPRSKDEPGKGGFWRIDP 79

Forkhead (FH) domain found in the Forkhead box protein G (FOXG) subfamily; The FOXG subfamily includes a winged helix transcription factor FOXG1, which is also called brain factor 1 (BF-1), brain factor 2 (BF-2), Forkhead box protein G1A, Forkhead box protein G1B, Forkhead box protein G1C, Forkhead-related protein FKHL1, Forkhead-related protein FKHL2, or Forkhead-related protein FKHL3. FOXG1 acts as a transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon. It is repetitively used in the sequential events of telencephalic development to control multi-steps of brain circuit formation ranging from cell cycle control to neuronal differentiation in a clade- and species-specific manner. Individuals with mutations in FOXG1 harbor "FOXG1-related encephalopathy", characterized by two clinical phenotypes/syndromes including microcephaly, developmental delay, severe cognitive disabilities, early-onset dyskinesia and hyperkinetic movements, stereotypies, epilepsy, and cerebral malformation for those with deletions or intragenic mutations of FOXG1. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20021    1 KPPFSYNALIMMAIRQSPEKRLTLNGIYEFIMKNFPYYR-ENKQGWQNSIRHNLSLNKCFVKVPRHYDDPGKGNYWMLDP 79

Forkhead (FH) domain found in the Forkhead box protein E (FOXE) subfamily; The FOXE subfamily includes two winged helix transcription factors, FOXE1 (also known as FOXE2) and FOXE3. FOXE1, also called Forkhead-related protein FKHL15, HFKH4, HNF-3/fork head-like protein 5 (HFKL5), or thyroid transcription factor 2 (TTF-2), is a transcription factor that binds consensus sites on a variety of gene promoters and activate their transcription. FOXE3, also called Forkhead-related protein FKHL12 or Forkhead-related transcription factor 8 (FREAC-8), is a transcription factor that controls lens epithelial cell growth through regulation of proliferation, apoptosis, and the cell cycle. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20019    1 KPPYSYIALIAMAIANSPERKLTLGGIYKFIMERFPFYR-DNSKKWQNSIRHNLTLNDCFVKIPREPGRPGKGNYWTLDP 79

                         90
                 ....*....|....*
gi 442631649 533 DSGAKLIDHSYKKRR 547
Cdd:cd20019   80 AAEDMFDNGSFLRRR 94

Forkhead (FH) domain found in the Forkhead box protein I (FOXI) subfamily; The FOXI subfamily includes three human winged helix transcription factors, FOXI1-3, Xenopus laevis FoxI1c, and similar proteins. FOXI1 acts as a transcriptional activator required for the development of normal hearing, sense of balance, and kidney function. FOXI2 may act as a transcriptional activator that plays a possible role in controlling cellular identity. Loss of function mutations in the FOXI2 gene may contribute to ectodermal dysplasia. FOXI3 plays a critical role in the development of the inner ear and jaw. It is a regulator of ectodermal development. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631649 454 PPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKeTNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRID 531
Cdd:cd20025    1 PPYSYSALIAMAIQSAPEKKLTLSQIYQYVAENFPFYKR-SKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLD 77

Forkhead (FH) domain found in Drosophila melanogaster protein fork head (dFKH) and similar proteins; dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKgWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20041    1 KPPYSYISLITMAIQNSPNKMVTLSEIYQFIMDLFPFYRQNQQR-WQNSIRHSLSFNDCFVKVPRTPDKPGKGSFWTLHP 79

                         90
                 ....*....|....*..
gi 442631649 533 DSGAKLIDHSYKKRRQR 549
Cdd:cd20041   80 DSGNMFENGCYLRRQKR 96

Forkhead (FH) domain found in Forkhead box protein C1 (FOXC1) and similar proteins; FOXC1, also called Forkhead-related protein FKHL7, or Forkhead-related transcription factor 3 (FREAC-3), is a DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as the development of the eyes, bones, cardiovascular system, kidneys, and skin. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20044    6 KPPYSYIALITMAIQNAPDKKITLNGIYQFIMERFPFYR-DNKQGWQNSIRHNLSLNECFVKVPRDDKKPGKGSYWTLDP 84

                 ..
gi 442631649 533 DS 534
Cdd:cd20044   85 DS 86

Forkhead (FH) domain found in Forkhead box protein S1 (FOXS1); FOXS1, also called Forkhead-like 18 protein or Forkhead-related transcription factor 10 (FREAC-10), is a transcriptional repressor that suppresses transcription from the FASLG, FOXO3, and FOXO4 promoters. It may have a role in the organization of the testicular vasculature. It has also been implicated in energy turnover, motor function, and body weight. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20037    2 KPPYSYIALIAMAIQSSPGQRATLSGIYRYIMGRFAFYR-HNRPGWQNSIRHNLSLNECFVKVPRDDRKPGKGSYWTLDP 80

                         90
                 ....*....|....*..
gi 442631649 533 DSGAKLIDHSYKKRRQR 549
Cdd:cd20037   81 DCHDMFEHGSFLRRRRR 97

Forkhead (FH) domain found in the Forkhead box protein A (FOXA) subfamily; The FOXA subfamily includes three winged helix transcription factors, FOXA1 (also called hepatocyte nuclear factor 3-alpha or transcription factor 3A), FOXA2 (also called hepatocyte nuclear factor 3-beta or transcription factor 3B), and FOXA3 (also called hepatocyte nuclear factor 3-gamma or transcription factor 3G). FOXA1 is essential for epithelial lineage differentiation and has been found to be upregulated in numerous cancers. FOXA2 controls cell differentiation. It is a key transcriptional regulator that maintains airway mucus homeostasis and may also have an important role in bone metabolism. FOXA3 acts as an essential transcriptional regulator engaged in adipogenesis and energy metabolism. This subfamily also includes Xenopus tropicalis FOXA4, Drosophila melanogaster protein fork head (dFKH), and similar proteins. FOXA4 is only present in amphibians, where it is required for the correct regionalization and maintenance of the central nervous system. dFKH promotes terminal as opposed to segmental development. In the absence of dFKH, this developmental switch does not occur. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKgWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20015    1 KPPYSYISLITMAIQQSPSKMLTLSEIYQWIMDLFPYYRQNQQR-WQNSIRHSLSFNDCFVKVPRSPDKPGKGSYWTLHP 79

                         90
                 ....*....|....*..
gi 442631649 533 DSGAKLIDHSYKKRRQR 549
Cdd:cd20015   80 DSGNMFENGCYLRRQKR 96

Forkhead (FH) domain found in the Forkhead box protein B (FOXB) subfamily; The FOXB subfamily includes two winged helix transcription factors, FOXB1 (also called transcription factor FKH-5) and FOXB2 (also called transcription factor FKH-4). FOXB1 controls development of mammary glands and regions of the central nervous system (CNS) that regulate the milk-ejection reflex. It is essential for access of mammillothalamic axons to the thalamus. FOXB2 may act as a tumor suppressor; it has been found to inhibit the malignant characteristics of the pancreatic cancer cell line Panc-1 in vitro. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKgWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20016    1 KPPYSYISLTAMAIQSSPEKMLPLSDIYKFIMDRFPYYRKNTQR-WQNSLRHNLSFNDCFIKIPRRPDRPGKGSYWALHP 79

Forkhead (FH) domain found in Forkhead box protein J2 (FOXJ2) and similar proteins; FOXJ2, also called Fork head homologous X (FHX), plays an important role in tumorigenesis, progression, and metastasis of certain cancers. It acts as a transcriptional activator that can bind to two different type of DNA binding sites. It is specifically expressed in meiotic spermatocytes in adult mouse testes and appears to promote meiotic progression during spermatogenesis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKeTNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRID 531
Cdd:cd20051    2 KPPYSYATLITYAINSSPAKKMTLSEIYRWICDNFPYYRN-AGVGWKNSIRHNLSLNKCFRKVPRPRDDPGKGSYWMID 79

Forkhead (FH) domain found in Forkhead box protein I1 (FOXI1) and similar proteins; FOXI1 is also called Forkhead-related protein FKHL10, Forkhead-related transcription factor 6 (FREAC-6), Hepatocyte nuclear factor 3 Forkhead homolog 3 (HFH-3), or HNF-3/fork-head homolog 3. It is a master regulator of vacuolar H-ATPase proton pump subunits in the inner ear, kidney, and epididymis, and is required for the development of normal hearing, sense of balance, and kidney function. Its epididymal expression is required for male fertility. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKeTNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20053    4 RPPYSYSALIAMAIHGAPDKRLTLSQIYQYVADNFPFYNK-SKAGWQNSIRHNLSLNDCFKKVPRDEDDPGKGNYWTLDP 82

                         90
                 ....*....|....*..
gi 442631649 533 DSGAKLIDHSYKKRRQR 549
Cdd:cd20053   83 NCEKMFDNGNFRRKRKR 99

Forkhead (FH) domain found in Forkhead box protein D3 (FOXD3) and similar proteins; FOXD3, also called HNF3/FH transcription factor genesis, acts as a transcriptional repressor that binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It also acts as a transcriptional activator. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20047    2 KPPYSYIALITMAILQSPQKKLTLSGICEFISNRFPYYR-EKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDP 80

                         90
                 ....*....|....*..
gi 442631649 533 DSGAKLIDHSYKKRRQR 549
Cdd:cd20047   81 QSEDMFDNGSFLRRRKR 97

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2) and similar proteins; The FOXN2-like group includes two FOXN subfamily winged helix transcription factors, FOXN2 and FOXN3. FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN3, also called checkpoint suppressor 1, acts as a transcriptional repressor that may be involved in DNA damage-inducible cell cycle arrests (checkpoints). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARSQDEpGKGSFWRI 530
Cdd:cd20031    1 KPPYSFSCLIFMAIESSPEKALPVKDIYSWIEKHFPYYR-NAPSGWKNSIRHNLSLNKCFKKVEKEKNK-GKGSLWCV 76

Forkhead (FH) domain found in Forkhead box proteins FOXD1, FOXD2 and similar proteins; FOXD1, also called Forkhead-related protein FKHL8, or Forkhead-related transcription factor 4 (FREAC-4), is involved in transcriptional activation of Placental Growth Factor (PGF) and the complement component (C3) genes. It plays an important role in early embryonic development and organogenesis, and functions as an oncogene in several cancers. FOXD2, also called Forkhead-related protein FKHL17, or Forkhead-related transcription factor 9 (FREAC-9), is a probable transcription factor involved in embryogenesis and somatogenesis. It has been found that long noncoding RNA FOXD2 adjacent opposite strand RNA1 (lncRNA FOXD2-AS1) expression is upregulated in various human malignancies, including gastric, lung, bladder, colorectal, nasopharyngeal, esophageal, hepatocellular, thyroid and skin cancer. It is a promising candidate as a new biomarker and therapeutic target for cancer diagnosis/prognostication due to high tissue specificity and elevated efficiency. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRkETNKGWQNSIRHNLSLNRYFIKVARSQDEPGKGSFWRIDP 532
Cdd:cd20046    1 KPPYSYIALITMAILQSPKKRLTLSEICEFISNRFPYYR-EKFPAWQNSIRHNLSLNDCFVKIPREPGNPGKGNYWTLDP 79

                         90
                 ....*....|....*..
gi 442631649 533 DSGAKLIDHSYKKRRQR 549
Cdd:cd20046   80 ESADMFDNGSFLRRRKR 96

Forkhead (FH) domain found in the Forkhead box protein O (FOXO) subfamily; The FOXO subfamily includes several winged helix transcription factors: FOXO1, FOXO3, FOXO4 and FOXO6. FOXO transcription factors are involved in the regulation of longevity phenomenon via insulin and insulin-like growth factor signaling. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members. FOXO1, also called Forkhead box protein O1A or Forkhead in rhabdomyosarcoma (FKHR), is a transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. FOXO3, also called AF6q21 protein or Forkhead in rhabdomyosarcoma-like 1 (FKHRL1), is a transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. It recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis, and prognosis. The FH domain is a winged helix DNA-binding domain.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631649 457 SYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKET----NKGWQNSIRHNLSLNRYFIKVarSQDEPGKGSFWRID 531
Cdd:cd20032    4 SYADLITKAIESSPDKRLTLQQIYDWMVRNVPYFKDKGdsnsSAGWKNSIRHNLSLHSRFVRV--QNEGTGKSSWWTLN 80

Forkhead (FH) domain found in Forkhead box protein Q1 (FOXQ1) and similar proteins; FOXQ1, also called HNF-3/Forkhead-like protein 1 (HFH-1), or hepatocyte nuclear factor 3 Forkhead homolog 1, plays a role in hair follicle differentiation. It has also been reported to promote epithelial differentiation, inhibit smooth muscle differentiation, activate T cells and autoimmunity, and control mucin gene expression and granule content in stomach surface mucous cells. FOXQ1 is significantly associated with the pathogenesis of various tumor types including gastric, breast, colorectal, pancreatic, bladder and ovarian cancer, and glioma. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETnKGWQNSIRHNLSLNRYFIKVARSQDEP-GKGSFWRID 531
Cdd:cd20034    1 KPPYSYIALIAMAIRDSPSGRLTLAEINEYLMKKFPFFRGSY-TGWRNSVRHNLSLNDCFVKVLRDPSRPwGKDNYWTIN 79

Forkhead (FH) domain found in the Forkhead box protein M (FOXM) subfamily; The FOXM subfamily includes a winged helix transcription factor, FOXM1, which is also called Forkhead-related protein FKHL16, Hepatocyte nuclear factor 3 Forkhead homolog 11 (HFH-11), HNF-3/fork-head homolog 11, M-phase phosphoprotein 2, MPM-2 reactive phosphoprotein 2, transcription factor Trident, or Winged-helix factor from INS-1 cells. FOXM1 acts as a transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. It plays a role in the control of cell proliferation. It is also involved in DNA break repair, participating in the DNA damage checkpoint response. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKGWQNSIRHNLSLNRYFIkvaRSQDEPGKGSFWRIDP 532
Cdd:cd20029    1 RPPYSYMALIQFAINSTEDKRMTLKEIYTWIEDHFPYFKHTAKPGWKNSIRHNLSLHDIFV---RETSANGKGSFWTLRP 77

Forkhead (FH) domain found in the Forkhead box protein H (FOXH) subfamily; The FOXH subfamily includes a winged helix transcription factor, FOXH1, which is also called Forkhead activin signal transducer 1 (Fast-1), or Forkhead activin signal transducer 2 (Fast-2). FOXH1 acts as a transcriptional activator that recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. It is required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. FOXH1 forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETnKGWQNSIRHNLSLNRYFIKVARSQDEP-GKGSFWRID 531
Cdd:cd20022    1 KPPYSYLAMIALAIQNSPEKRLTLSEIIKALSTMFPFFKGEY-KGWKDSVRHNLSSNDCFVKVLKDPGKPqAKGNYWTVD 79

Forkhead (FH) domain found in Forkhead box protein N2 (FOXN2); FOXN2, also called human T-cell leukemia virus enhancer factor (HTLF), is a potential tumor suppressor that can facilitate replication fork reversal. It acts as a transcription factor that binds to the purine-rich region in human T-cell leukemia virus long terminal repeat (HTLV-I LTR). It may be a potential therapeutic and radiosensitization target for lung cancer. FOXN2 has also been found to be down-regulated in breast cancer, where it regulates migration, invasion, and epithelial-mesenchymal transition. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNkGWQNSIRHNLSLNRYFIKVARSQDEP-GKGSFWRID 531
Cdd:cd20058    2 KPPYSFSLLIYMAIEHSPNKCLPVKEIYSWILEHFPYFSTAPT-GWKNSVRHNLSLNKCFRKVERSHGKVnGKGSLWCVD 80

                 ..
gi 442631649 532 PD 533
Cdd:cd20058   81 PE 82

Forkhead (FH) domain found in Forkhead box protein O4 (FOXO4) and similar proteins; FOXO4, also called Fork head domain transcription factor AFX1, is a transcription factor involved in the regulation of the insulin signaling pathway. It binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 457 SYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKE----TNKGWQNSIRHNLSLNRYFIKVarSQDEPGKGSFWRIDP 532
Cdd:cd20062    8 SYAELISQAIESSPEKRLTLAQIYEWMVKSVPYFKDKgdsnSSAGWKNSIRHNLSLHSKFIKV--HNEATGKSSWWMLNP 85

                 .
gi 442631649 533 D 533
Cdd:cd20062   86 E 86

Forkhead (FH) domain found in Forkhead box protein O6 (FOXO6) and similar proteins; FOXO6 acts as a transcriptional activator that may play an important role on tumor invasion, metastasis and prognosis. The FH domain is a winged helix DNA-binding domain. All FOXOs bind to the consensus sequence 5'-GTAAACAA-3', known as the DAF-16 family member-binding element, which includes the core sequence 5'-(A/C)AA(C/T)A-3' recognized by all FOX family members.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 457 SYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKE----TNKGWQNSIRHNLSLNRYFIKVarsQDE-PGKGSFWRID 531
Cdd:cd20063    4 SYADLITKAIESSPDKRLTLSQIYDWMVRYVPYFKDKgdsnSSAGWKNSIRHNLSLHTRFIRV---QNEgTGKSSWWMLN 80

                 ....
gi 442631649 532 PDSG 535
Cdd:cd20063   81 PEGG 84

Forkhead (FH) domain found in Forkhead box protein P2 (FOXP2); FOXP2, also called CAG repeat protein 44, or Trinucleotide repeat-containing gene 10 protein, is a transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. It may also play a role in developing neural, gastrointestinal, and cardiovascular tissues. An arginine-to-histidine missense mutation (R553H) in the FOXP2 Forkhead domain has been linked to a severe speech and language disorder. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKgWQNSIRHNLSLNRYFIKVarsqdEPGKGSFWRIDp 532
Cdd:cd20065    2 RPPFTYATLIRQAIMESSDRQLTLNEIYSWFTRTFAYFRRNAAT-WKNAVRHNLSLHKCFVRV-----ENVKGAVWTVD- 74

                         90
                 ....*....|....*
gi 442631649 533 dsgakliDHSYKKRR 547
Cdd:cd20065   75 -------EVEYQKRR 82

Forkhead (FH) domain found in Forkhead box protein P1 (FOXP1); FOXP1, also called Mac-1-regulated Forkhead (MFH), is a transcription factor that is widely expressed and has a broad range of functions. It has been shown to have a role in cardiac, lung, and lymphocyte development. Deregulation of FOXP1 is an important contributor to the pathogenesis of diffuse large B-cell lymphoma (DLBCL), suggesting it may function as an oncogene. Loss of FOXP1 expression in breast cancer is associated with a worse outcome, suggesting that FOXP1 may function as a tumor suppressor in some tissues. Haploinsufficiency of the FOXP1 gene leads to a neurodevelopmental disorder termed FOXP1 syndrome, characterized by developmental delay, intellectual disability, autism spectrum disorder, speech delay, and dysmorphic features. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKgWQNSIRHNLSLNRYFIKVarsqdEPGKGSFWRIDp 532
Cdd:cd20064    4 RPPFTYASLIRQAILESPEKQLTLNEIYNWFTRMFAYFRRNAAT-WKNAVRHNLSLHKCFVRV-----ENVKGAVWTVD- 76

                         90
                 ....*....|....*
gi 442631649 533 dsgakliDHSYKKRR 547
Cdd:cd20064   77 -------EIEFQKRR 84

Forkhead (FH) domain found in the Forkhead box protein R (FOXR) subfamily; The FOXR subfamily includes two winged helix transcription factors, FOXR1-2. FOXR1, also called Forkhead box protein N5 (FOXN5), is required for proper cell division and survival possibly via the p21 and mTOR pathways. FOXR2, also called Forkhead box protein N6 (FOXN6), is an important player in a wide range of cellular processes such as proliferation, migration, differentiation, and apoptosis. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 451 NEKPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNkGWQNSIRHNLSLNRYFIKVARSQDEPG--KGSFW 528
Cdd:cd20036    1 WPKPPLSYPNLIALALRNSETGSLNVQEIYDFIRFHFPFFRTAPD-GWKNSVRHNLSFSDSFEKVPTSVSGYGgrRSCLW 79

                 ....*
gi 442631649 529 RIDPD 533
Cdd:cd20036   80 KLTPE 84

Forkhead (FH) domain found in Forkhead box protein P4 (FOXP4) and similar proteins; FOXP4, also called Forkhead-related protein-like A, is a transcriptional repressor that represses lung-specific expression. It is not required for T cell development, but is necessary for normal T cell cytokine recall responses to antigen following pathogenic infection. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631649 453 KPPYSYAQLIVQAISAAPDKQLTLSGIYSFIVKHYPYYRKETNKgWQNSIRHNLSLNRYFIKVarsqdEPGKGSFWRIDp 532
Cdd:cd20067    1 RPPFTYASLIRQAILETPDRQLTLNEIYNWFTRMFAYFRRNTAT-WKNAVRHNLSLHKCFVRV-----ENVKGAVWTVD- 73