NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|442631568|ref|NP_001261683|]
View 

uncharacterized protein Dmel_CG8003, isoform B [Drosophila melanogaster]

Protein Classification

zf-MYND domain-containing protein( domain architecture ID 12790888)

zf-MYND domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-131 3.31e-19

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.32  E-value: 3.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  18 LLDHLAKNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINLnQHGADYTPLHFAALSGNTHVC 97
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGNLEIV 169

                         90       100       110
                 ....*....|....*....|....*....|....
gi 442631568  98 RLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVE 131
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203
zf-MYND pfam01753
MYND finger;
333-370 7.18e-12

MYND finger;


:

Pssm-ID: 460312  Cd Length: 39  Bit Score: 59.74  E-value: 7.18e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442631568  333 CSTCGAE-KPDKKCSKCKAVQYCDRECQRLHWFMHKKNC 370
Cdd:pfam01753   1 CAVCGKEaLKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-131 3.31e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.32  E-value: 3.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  18 LLDHLAKNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINLnQHGADYTPLHFAALSGNTHVC 97
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGNLEIV 169

                         90       100       110
                 ....*....|....*....|....*....|....
gi 442631568  98 RLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVE 131
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203
Ank_2 pfam12796
Ankyrin repeats (3 copies);
21-111 2.23e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.52  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568   21 HLA--KNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDmGADINLNQHGadYTPLHFAALSGNTHVCR 98
Cdd:pfam12796   2 HLAakNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNG--RTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 442631568   99 LLLDAGIKPGSIN 111
Cdd:pfam12796  79 LLLEKGADINVKD 91
zf-MYND pfam01753
MYND finger;
333-370 7.18e-12

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 59.74  E-value: 7.18e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442631568  333 CSTCGAE-KPDKKCSKCKAVQYCDRECQRLHWFMHKKNC 370
Cdd:pfam01753   1 CAVCGKEaLKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 6-116 1.15e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568   6 KKIVQLddvqrqLLDHLAK-NDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINL-NQHGadYT 83
Cdd:PHA03100 156 LKILKL------LIDKGVDiNAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLvNKYG--DT 227

                         90       100       110
                 ....*....|....*....|....*....|...
gi 442631568  84 PLHFAALSGNTHVCRLLLDAGikpGSINSVNRT 116
Cdd:PHA03100 228 PLHIAILNNNKEIFKLLLNNG---PSIKTIIET 257
zf-HIT cd23020
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain ...
 333-362 3.44e-03

zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes.


Pssm-ID: 467792  Cd Length: 31  Bit Score: 34.79  E-value: 3.44e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 442631568 333 CSTCGAEKPDKKCSKCKaVQYCDRECQRLH 362
Cdd:cd23020    2 CGICGGYPGKYKCPRCG-VPYCSLECYRKH 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 81-107 3.45e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.45e-03
                           10        20
                   ....*....|....*....|....*..
gi 442631568    81 DYTPLHFAALSGNTHVCRLLLDAGIKP 107
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
18-131 3.31e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 87.32  E-value: 3.31e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  18 LLDHLAKNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINLnQHGADYTPLHFAALSGNTHVC 97
Cdd:COG0666   91 LHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNA-QDNDGNTPLHLAAANGNLEIV 169

                         90       100       110
                 ....*....|....*....|....*....|....
gi 442631568  98 RLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVE 131
Cdd:COG0666  170 KLLLEAGADVNARDNDGETPLHLAAENGHLEIVK 203
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
39-133 2.16e-18

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 85.01  E-value: 2.16e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  39 NVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINlNQHGADYTPLHFAALSGNTHVCRLLLDAGIKPGSINSVNRTAA 118
Cdd:COG0666  145 DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVN-ARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223

                         90
                 ....*....|....*
gi 442631568 119 QMAAFVGNHACVETI 133
Cdd:COG0666  224 DLAAENGNLEIVKLL 238
Ank_2 pfam12796
Ankyrin repeats (3 copies);
21-111 2.23e-13

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 65.52  E-value: 2.23e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568   21 HLA--KNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDmGADINLNQHGadYTPLHFAALSGNTHVCR 98
Cdd:pfam12796   2 HLAakNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNG--RTALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 442631568   99 LLLDAGIKPGSIN 111
Cdd:pfam12796  79 LLLEKGADINVKD 91
zf-MYND pfam01753
MYND finger;
333-370 7.18e-12

MYND finger;


Pssm-ID: 460312  Cd Length: 39  Bit Score: 59.74  E-value: 7.18e-12
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 442631568  333 CSTCGAE-KPDKKCSKCKAVQYCDRECQRLHWFMHKKNC 370
Cdd:pfam01753   1 CAVCGKEaLKLLRCSRCKSVYYCSKECQKADWPYHKKEC 39
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
21-131 1.37e-11

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 64.98  E-value: 1.37e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  21 HLA--KNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINL-NQHGadYTPLHFAALSGNTHVC 97
Cdd:COG0666  158 HLAaaNGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAkDNDG--KTALDLAAENGNLEIV 235

                         90       100       110
                 ....*....|....*....|....*....|....
gi 442631568  98 RLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVE 131
Cdd:COG0666  236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVK 269
Ank_2 pfam12796
Ankyrin repeats (3 copies);
51-133 2.77e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 2.77e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568   51 LAHASFKGNREAVQLLLDMGADINLNQHgADYTPLHFAALSGNTHVCRLLLDAGIkpGSINSVNRTAAQMAAFVGNHACV 130
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDK-NGRTALHLAAKNGHLEIVKLLLEHAD--VNLKDNGRTALHYAARSGHLEIV 77


                  ...
gi 442631568  131 ETI 133
Cdd:pfam12796  78 KLL 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
6-131 6.96e-09

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 56.50  E-value: 6.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568   6 KKIVQLDDVQRQLLDHLAKNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINLNQHGaDYTPL 85
Cdd:COG0666   13 AALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDG-GNTLL 91

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 442631568  86 HFAALSGNTHVCRLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVE 131
Cdd:COG0666   92 HAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK 137
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 6-116 1.15e-07

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 53.52  E-value: 1.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568   6 KKIVQLddvqrqLLDHLAK-NDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINL-NQHGadYT 83
Cdd:PHA03100 156 LKILKL------LIDKGVDiNAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLvNKYG--DT 227

                         90       100       110
                 ....*....|....*....|....*....|...
gi 442631568  84 PLHFAALSGNTHVCRLLLDAGikpGSINSVNRT 116
Cdd:PHA03100 228 PLHIAILNNNKEIFKLLLNNG---PSIKTIIET 257
Ank_4 pfam13637
Ankyrin repeats (many copies);
47-101 8.82e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 45.73  E-value: 8.82e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442631568   47 GMSCLAHASFKGNREAVQLLLDMGADINlNQHGADYTPLHFAALSGNTHVCRLLL 101
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADIN-AVDGNGETALHFAASNGNVEVLKLLL 54
PHA03095 PHA03095
ankyrin-like protein; Provisional
 63-134 1.02e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.79  E-value: 1.02e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442631568  63 VQLLLDMGADINLnQHGADYTPLHfAALSG---NTHVCRLLLDAGIKPGSINSVNRTAaqMAAFVGNH-ACVETIN 134
Cdd:PHA03095 100 IKLLIKAGADVNA-KDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTP--LAVLLKSRnANVELLR 171
PHA03095 PHA03095
ankyrin-like protein; Provisional
 12-132 1.36e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 50.41  E-value: 1.36e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  12 DDVQRQLLDHLA---KNDTSGFKQLLS---GVRNVNFVDDTGMSCLA-HASFKgnREAVQLLLDMGADINLnQHGADYTP 84
Cdd:PHA03095 184 DDRFRSLLHHHLqsfKPRARIVRELIRagcDPAATDMLGNTPLHSMAtGSSCK--RSLVLPLLIAGISINA-RNRYGQTP 260

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 442631568  85 LHFAALSGNTHVCRLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVET 132
Cdd:PHA03095 261 LHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRA 308
Ank_4 pfam13637
Ankyrin repeats (many copies);
82-131 2.23e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 2.23e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 442631568   82 YTPLHFAALSGNTHVCRLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVE 131
Cdd:pfam13637   2 LTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 61-116 7.03e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 7.03e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 442631568  61 EAVQLLLDMGADINLNQHGADYTPLHFAALSGNTHVCRLLLDAGIKPGSINSVNRT 116
Cdd:PHA02878 148 EITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNS 203
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 22-104 9.08e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 44.67  E-value: 9.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  22 LAKN--DTSGFKQLLSGVRNVNFVDDTGMSCLAHAS-FKGNREAVQLLLDMGADINLNQHgADYTPLHFAALSGNTHVCR 98
Cdd:PHA02876 314 MAKNgyDTENIRTLIMLGADVNAADRLYITPLHQAStLDRNKDIVITLLELGANVNARDY-CDKTPIHYAAVRNNVVIIN 392


                 ....*.
gi 442631568  99 LLLDAG 104
Cdd:PHA02876 393 TLLDYG 398
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 24-137 1.07e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 44.27  E-value: 1.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  24 KNDTSGFKQLLSGVRNVNFVDDTGMSCLaHASFKGNR---EAVQLLLDMGADIN-------LNQHGAD--------YTPL 85
Cdd:PHA03100 118 SNSYSIVEYLLDNGANVNIKNSDGENLL-HLYLESNKidlKILKLLIDKGVDINaknrvnyLLSYGVPinikdvygFTPL 196

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442631568  86 HFAALSGNTHVCRLLLDAGIKPGSINSVNRTAAQMAA----------FVGNHACVETINNYV 137
Cdd:PHA03100 197 HYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIlnnnkeifklLLNNGPSIKTIIETL 258
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 49-107 1.41e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 43.83  E-value: 1.41e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 442631568  49 SCLAHASFKGNREAVQLLLDMGADINLnQHGADYTPLHFAALSGNTHVCRLLLDAGIKP 107
Cdd:PHA02875 137 SPLHLAVMMGDIKGIELLIDHKACLDI-EDCCGCTPLIIAMAKGDIAICKMLLDSGANI 194
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 33-133 2.80e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.03  E-value: 2.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  33 LLSGVRnVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINLNQHGADYtPLHFAALSGNTHVCRLLLDAGIKPGSINS 112
Cdd:PHA02874 111 LDCGID-VNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCY-PIHIAIKHNFFDIIKLLLEKGAYANVKDN 188

                         90       100
                 ....*....|....*....|.
gi 442631568 113 VNRTAAQMAAFVGNHACVETI 133
Cdd:PHA02874 189 NGESPLHNAAEYGDYACIKLL 209
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 24-149 9.39e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.10  E-value: 9.39e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  24 KNDTSGFKQLLSGVRNVNFVDDTGMSCLaHASFKGNR-EAVQLLLDMGADINLNQHGADyTPLHFAALSGNTHVCRLLLD 102
Cdd:PHA02874 134 KGDLESIKMLFEYGADVNIEDDNGCYPI-HIAIKHNFfDIIKLLLEKGAYANVKDNNGE-SPLHNAAEYGDYACIKLLID 211

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 442631568 103 AGikPGSINSVNRTAAQM-AAFVGNHACVE-TINN-YVTQSSLEYYTQVH 149
Cdd:PHA02874 212 HG--NHIMNKCKNGFTPLhNAIIHNRSAIElLINNaSINDQDIDGSTPLH 259
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 23-101 1.02e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.42  E-value: 1.02e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442631568  23 AKNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINLNQHgADYTPLHFAALSGNTHVCRLLL 101
Cdd:PTZ00322  91 ASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDK-DGKTPLELAEENGFREVVQLLS 168
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 51-121 1.13e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 41.04  E-value: 1.13e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442631568  51 LAHASFKGNREAVQLLLDMGADINlnqhGADY---TPLHFAALSGNTHVCRLLLDAGIKPGSINSVNRTAAQMA 121
Cdd:PTZ00322  86 LCQLAASGDAVGARILLTGGADPN----CRDYdgrTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELA 155
zf-HIT cd23020
zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain ...
 333-362 3.44e-03

zinc finger HIT (zf-HIT) domain; The zinc finger HIT (zf-HIT) is a novel zinc-binding domain with about 50 amino acids. It is characterized by a fold in "treble-clef" through interleaved CCCC and CCHC zinc finger motifs that both bind a zinc ion. zf-HIT domain may function as a protein-protein interaction domain. It is mainly found in nuclear proteins involved in gene regulation and chromatin remodeling. The zf-HIT family includes six proteins containing zf-HIT domain present in human and three in yeast proteome, all belonging to multimodular RNA/protein complexes.


Pssm-ID: 467792  Cd Length: 31  Bit Score: 34.79  E-value: 3.44e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 442631568 333 CSTCGAEKPDKKCSKCKaVQYCDRECQRLH 362
Cdd:cd23020    2 CGICGGYPGKYKCPRCG-VPYCSLECYRKH 30
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 81-107 3.45e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.87  E-value: 3.45e-03
                           10        20
                   ....*....|....*....|....*..
gi 442631568    81 DYTPLHFAALSGNTHVCRLLLDAGIKP 107
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADI 28
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
39-118 4.27e-03

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 38.78  E-value: 4.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  39 NVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINLNQHgADYTPLHFAALSGNTHVCRLLLDAGIKPGSINSVNRTAA 118
Cdd:COG0666  211 DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDK-DGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 31-115 4.35e-03

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 38.88  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  31 KQLLSGVRNVNFVDDTGMSCLAHASFK--GNREAVQLLLDMGADINL-NQHGadYTPLHfAALSGNTH---VCRLLLDAG 104
Cdd:PHA03100  90 KLLLEYGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIkNSDG--ENLLH-LYLESNKIdlkILKLLIDKG 166

                         90
                 ....*....|.
gi 442631568 105 IKPGSINSVNR 115
Cdd:PHA03100 167 VDINAKNRVNY 177
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 47-75 5.02e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 34.49  E-value: 5.02e-03
                           10        20
                   ....*....|....*....|....*....
gi 442631568    47 GMSCLAHASFKGNREAVQLLLDMGADINL 75
Cdd:smart00248   2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02743 PHA02743
Viral ankyrin protein; Provisional
 63-131 5.84e-03

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 37.49  E-value: 5.84e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442631568  63 VQLLLDMGADINLNQHGADYTPLHFAALSGNTHVCRLLL-DAGIKPGSINSVNRTAAQMAAFVGNHACVE 131
Cdd:PHA02743  76 IELLVNMGADINARELGTGNTLLHIAASTKNYELAEWLCrQLGVNLGAINYQHETAYHIAYKMRDRRMME 145
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 82-107 6.42e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.16  E-value: 6.42e-03
                          10        20
                  ....*....|....*....|....*.
gi 442631568   82 YTPLHFAALSGNTHVCRLLLDAGIKP 107
Cdd:pfam13606   3 NTPLHLAARNGRLEIVKLLLENGADI 28
Ank_5 pfam13857
Ankyrin repeats (many copies);
36-88 7.19e-03

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 34.63  E-value: 7.19e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 442631568   36 GVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGADINL-NQHGadYTPLHFA 88
Cdd:pfam13857   5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLkDEEG--LTALDLA 56
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 82-111 9.26e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 33.80  E-value: 9.26e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 442631568   82 YTPLHFAALS-GNTHVCRLLLDAGIKPGSIN 111
Cdd:pfam00023   3 NTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH