Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442630827  164 CKESNGGCSQVCNNLPGEFICTCNSGFEIDEsDEKTC 200
Cdd:pfam14670   1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQD-DGRTC 36

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442630827  124 CRIDNGGCAHICNRS--THKCECYEGYTLNStDLRSC 158
Cdd:pfam14670   1 CSVNNGGCSHLCLNTpgGYTCSCPEGYELQD-DGRTC 36

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 442630827   340 CPLFKGPANGKASCDKylqNGFNY-TRCNITCNAGYIMQGSQFAVCGHTGLWSSPEAKC 397
Cdd:smart00032   1 CPPPPDIENGTVTSSS---GTYSYgDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 442630827 158 CNDIDECKESNGGCSQVCNNLPGEFICTCNSGFEIDEsDEKT 199
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLE-DNKT 224

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442630827  124 CRIDNGGCAHICNRS--THKCECYEGYTLNStDLRSC 158
Cdd:pfam14670   1 CSVNNGGCSHLCLNTpgGYTCSCPEGYELQD-DGRTC 36

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 442630827 264 CQDINECDLADIDsdswrmtyryCEHKCENTVGSYICHCPQGYHLLDDQ 312
Cdd:cd01475  184 CVVPDLCATLSHV----------CQQVCISTPGSYLCACTEGYALLEDN 222

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.

                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 442630827   340 CPLFKGPANGKASCDKylqNGFNY-TRCNITCNAGYIMQGSQFAVCGHTGLWSSPEAKC 397
Cdd:smart00032   1 CPPPPDIENGTVTSSS---GTYSYgDTVTYSCDPGYTLIGSSTITCLENGTWSPPPPTC 56

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 442630827 158 CNDIDECKESNGGCSQVCNNLPGEFICTCNSGFEIDEsDEKT 199
Cdd:cd01475  184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLE-DNKT 224

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 442630827  124 CRIDNGGCAHICNRS--THKCECYEGYTLNStDLRSC 158
Cdd:pfam14670   1 CSVNNGGCSHLCLNTpgGYTCSCPEGYELQD-DGRTC 36

Calcium-binding EGF-like domain;

                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 442630827   266 DINECDLADIdsdswrmtyryCEH--KCENTVGSYICHCPQGYH 307
Cdd:smart00179   1 DIDECASGNP-----------CQNggTCVNTVGSYRCECPPGYT 33

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.

                          10        20        30
                  ....*....|....*....|....*....|..
gi 442630827  164 CKESNGGCSQ--VCNNLPGEFICTCNSGFEID 193
Cdd:pfam12947   1 CSDNNGGCHPnaTCTNTGGSFTCTCNDGYTGD 32

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 442630827 266 DINECDLADIdsdswrmtyryCEH--KCENTVGSYICHCPQGYHL 308
Cdd:cd00054    1 DIDECASGNP-----------CQNggTCVNTVGSYRCSCPPGYTG 34