|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
16-441 |
3.43e-158 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 453.23 E-value: 3.43e-158
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 16 AIMLFMACLLSYMMRVNLSINIIAMVEDTSSHENGTEVEA---LPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLA 92
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTSTDkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 93 EMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGK-FVASLMGGTFGT 171
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRlTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 172 VITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVadtpaqhstislkereyiesslgdtlsnkkkwppykelvlsL 251
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV-----------------------------------------L 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 252 PFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRRGWLSVTRMRKAFCL 331
Cdd:cd17318 200 PVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRKLFTS 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 332 PSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTK 411
Cdd:cd17318 280 IGFLGPGVFLIALGYLGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVK 359
|
410 420 430
....*....|....*....|....*....|
gi 442624296 412 NENTIDQWHWVFIIGAAAYILPALFFWVFG 441
Cdd:cd17318 360 NDQTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
15-441 |
3.18e-76 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 243.92 E-value: 3.18e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 15 LAIMLFMACLLSYMMRVNLSINIIAMVEDTSSHENGTEVEALPDY-----------GPRYNWTQSDQALLLGAYFYGYMI 83
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSNACPEHssspsvehnetGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 84 TSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVA- 162
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTi 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 163 SLMGGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVadtpaqhstislkereyiesslgdtlsnkkkwp 242
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLV--------------------------------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 243 pykelvlsLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRRGWLSV 322
Cdd:cd17381 208 --------MPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQNFST 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 323 TRMRKAFCLPSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFS 402
Cdd:cd17381 280 VCVRKIFTLIGMIGPAVFLLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVG 359
|
410 420 430
....*....|....*....|....*....|....*....
gi 442624296 403 PLIVAAFTKNeNTIDQWHWVFIIGAAAYILPALFFWVFG 441
Cdd:cd17381 360 PVIAKSLTHN-NTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
4-454 |
1.30e-72 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 236.56 E-value: 1.30e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 4 MPCFYVPKR--INLAIMLFMACLLSYMM------RVNLSINIIAMVEDTSSH--ENGTEVEALPD-YGPRYNWTQSDQAL 72
Cdd:TIGR00894 1 MENVFASTKlpYFCSFRLFLSFLLHICNviiiaqRICLSLTMVAMVNKENSTdlACLSAENELDNiKNPNFKWSGALQGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 73 LLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGFLNGVVYPCCHSLVSKWS 152
Cdd:TIGR00894 81 ILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 153 PPDEKGKFVASLMGG-TFGTVITWPISGVIIE-NLGWDWAFYIVGIFVLVVVAIWFYLVADTPAQHSTISLKEREYIESS 230
Cdd:TIGR00894 161 PPKERSRLLGMSTSGfQLGTFIFLPISGWLCEsWGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 231 LGDTLSNKKKWPPYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAV 310
Cdd:TIGR00894 241 LQGQKGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYL 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 311 ADWIRRRGWLSVTRMRKAFCLPSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYagtlYGI 390
Cdd:TIGR00894 321 ADFLKSSKTLSLTAARKIFNGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRF----LGF 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442624296 391 INCVGTTPGIFSPLIVAAFTKNENTID---QWHWVFIIGAAAYILPALFFWVFGSGKIQKW-NEVQTT 454
Cdd:TIGR00894 397 IKGITGLPGFIGGLIASTLAGNILSQDsknVWLIVFLIMAFVNILCVIFYLIFGSAERQDWaKEEKDT 464
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
16-441 |
1.94e-66 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 217.98 E-value: 1.94e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 16 AIMLFMACLLSYMMRVNLSINIIAMVEDTSSHENGTEVEalpdYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEML 95
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIV----HKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKF 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 96 GARNVAGYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVA-SLMGGTFGTVIT 174
Cdd:cd17382 77 AANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATtAFCGSYAGAVVG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 175 WPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLvadtpaqhstislkereyiesslgdtlsnkkkwppykelvlSLPFW 254
Cdd:cd17382 157 MPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV-----------------------------------------SMPVY 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 255 SLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPH-VARLLCAFGfGAVADWIRRRGWLSVTRMRKAFCLPS 333
Cdd:cd17382 196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHlVMTIIVPIG-GQLADYLRSRGILSTTAVRKIFNCGG 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 334 HILPGVMLIILAYfGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTKNe 413
Cdd:cd17382 275 FGMEATFLLVVAF-SHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKH- 352
|
410 420
....*....|....*....|....*...
gi 442624296 414 NTIDQWHWVFIIGAAAYILPALFFWVFG 441
Cdd:cd17382 353 KTREEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-441 |
9.37e-61 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 202.40 E-value: 9.37e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 17 IMLFMACLLSYMMRVNLSINIIAMvedtsSHEngtevealpdygprYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLG 96
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPM-----AKE--------------FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFG 62
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 97 ARNVAGYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVASLMGGT-FGTVITW 175
Cdd:cd17380 63 GKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSyLGTLLGG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 176 PISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVadtpaqhstislkereyiesslgdtlsnkkkwppykelvlsLPFWS 255
Cdd:cd17380 143 LIGPLLLEYYGWPSVFYFFGLLGLLWALVWLIYL-----------------------------------------PPVWA 181
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 256 LMMLHYGSMWGLFFLITATPKFLSEVLGfNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRRGWlSVTRMRKAFCLPSHI 335
Cdd:cd17380 182 IIVAHFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFL 259
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 336 LPGVMLIILAYFgRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTkneNT 415
Cdd:cd17380 260 GPALFLLLLSHT-DSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYIL---EA 335
|
410 420
....*....|....*....|....*.
gi 442624296 416 IDQWHWVFIIGAAAYILPALFFWVFG 441
Cdd:cd17380 336 TGSWSLVFVLAAVVNLVGAVVFLLFG 361
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
8-441 |
5.67e-40 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 147.32 E-value: 5.67e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 8 YVPKRINLAIMLFMACLLSYMMRVNLSINIIAMVEDtsshengtevealpdygprYNWTQSDQALLLGAYFYGYMITSLP 87
Cdd:COG2271 4 PSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQAD-------------------LGLSAAQLGLLASAFFLGYALGQIP 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 88 AGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVA-SLMG 166
Cdd:COG2271 65 AGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF--WQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGiFNAG 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 167 GTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAiwfylvadtpaqhstislkereyiesslgdtlsnkkkwppyke 246
Cdd:COG2271 143 GPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL------------------------------------------- 179
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 247 lvlsLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRRgwlsvtrmR 326
Cdd:COG2271 180 ----LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------R 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 327 KAFCLPSHILPGVMLIILAYFGrDPYVCVAIMTISLGFNGAATASNLANSQDLAP-NYAGTLYGIINCVGTTPGIFSPLI 405
Cdd:COG2271 248 KLVLAIGLLLAALALLLLALLP-SPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLL 326
|
410 420 430
....*....|....*....|....*....|....*.
gi 442624296 406 VAAFTknenTIDQWHWVFIIGAAAYILPALFFWVFG 441
Cdd:COG2271 327 VGYLL----DATGYQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
12-439 |
1.20e-37 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 140.78 E-value: 1.20e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 12 RINLAIMLFMACLLSYMMRVNLSINIIAMVEDTsshengtevealpdygpryNWTQSDQALLLGAYFYGYMITSLPAGTL 91
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDL-------------------GLSPTQYGLIASAFFLGYALFQVPGGWL 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 92 AEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVASLMGGT-FG 170
Cdd:cd17319 62 LDRFGARKVLAVSMLLWSLFTALTGFATSL--TSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGApLG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 171 TVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADtpaqhstislkereyiesslgdtlsnkkkwppykelvls 250
Cdd:cd17319 140 AAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ--------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 251 lpFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWI--RRRGWLSVTRMrka 328
Cdd:cd17319 181 --VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLlrGARRLVIIIGL--- 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 329 fclpshiLPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAP-NYAGTLYGIINCVGTTPGIFSPLIVA 407
Cdd:cd17319 256 -------LLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPgEAAATAGGLINSGGNLGGFVAPLLIG 328
|
410 420 430
....*....|....*....|....*....|..
gi 442624296 408 AFtknENTIDQWHWVFIIGAAAYILPALFFWV 439
Cdd:cd17319 329 YL---VDATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
17-440 |
2.11e-35 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 135.39 E-value: 2.11e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 17 IMLFMACLLSYMMRVNLSINIIAMVEDtsshengtevealpdygprYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLG 96
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEE-------------------FGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFG 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 97 ARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVA-SLMGGTFGTVITW 175
Cdd:COG2223 69 PRRVLLIGLLLLGIGLLLLALAVSY--WLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGlAAGGGNLGAAVAA 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 176 PISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPAqhstislkereyiesslGDTLSNKKKWPPYKELVLSLPFWS 255
Cdd:COG2223 147 FLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPA-----------------GAAAAAKASLRDQLEALRDPRFWL 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 256 LMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRRGWLSVtrmrkafclpSHI 335
Cdd:COG2223 210 LSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI----------VFA 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 336 LPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAP-NYAGTLYGIINCVGTTPGIFSPLIVAAFTkneN 414
Cdd:COG2223 280 LMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPtKNAGAVYGLVGAAGGLGGFLGPLLFGALL---D 356
|
410 420
....*....|....*....|....*.
gi 442624296 415 TIDQWHWVFIIGAAAYILPALFFWVF 440
Cdd:COG2223 357 ATGSYTAAFLVFAVLALVALVLTLLL 382
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
75-440 |
1.50e-31 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 124.76 E-value: 1.50e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 75 GAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPP 154
Cdd:TIGR00893 36 SAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAGAY--VSLYILRVLLGAAEAPFFPGIILIVASWFPA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 155 DEKGKFVASLMGGT-FGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPaQHSTISLKEREYIESSLGD 233
Cdd:TIGR00893 114 SERATAVSIFNSAQgLGGIIGGPLVGWILIHFSWQWAFIIEGVLGIIWGVLWLKFIPDPP-QKAKWLTEEEKYIVVGGLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 234 TLSNKK-----KWPPYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFG 308
Cdd:TIGR00893 193 AEQQGKgpstpKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGG 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 309 AVADWIRRRGWlSVTRMRKAFCLPSHILpgVMLIILAYFGRDPYVCVAIMTISLGFNGAATASnLANSQDLAPNY-AGTL 387
Cdd:TIGR00893 273 RLSDLLLRRGK-SLVFARKTAIIAGLVL--SLLMFATNYVNIPYAALALVALGFFGLGAGAIG-WALISDNAPGNiAGLT 348
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 442624296 388 YGIINCVGTTPGIFSPLIVAAFtknENTIDQWHWVFIIGAAAYILPALFFWVF 440
Cdd:TIGR00893 349 GGLINSLGNLGGIVGPIVIGAI---AATTGSFAGALMVVAALALIGALSYLLL 398
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
55-395 |
9.69e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 110.45 E-value: 9.69e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 55 ALPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIG 134
Cdd:COG2814 32 ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSL--WLLLAARFLQG 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 135 FLNGVVYPCCHSLVSKWSPPDEKGKFVASLM-GGTFGTVITWPISGVIIENLGWDWAFYIVGIF-VLVVVAIWFYLVADT 212
Cdd:COG2814 110 LGAGALFPAALALIADLVPPERRGRALGLLGaGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLaLLALLLLLRLLPESR 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 213 PAQHStislkereyiesslgdtlsnkKKWPPYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFL 292
Cdd:COG2814 190 PAARA---------------------RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 293 SSLPHVARLLCAFGFGAVADWIRRRGWLsvtrmrkafcLPSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASN 372
Cdd:COG2814 249 LALFGLGGVLGALLAGRLADRFGRRRLL----------LIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQ 318
|
330 340
....*....|....*....|...
gi 442624296 373 LANSQDLAPNYAGTLYGIINCVG 395
Cdd:COG2814 319 ALVAELAPPEARGRASGLYNSAF 341
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
63-403 |
2.80e-25 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 105.96 E-value: 2.80e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 63 YNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVYP 142
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSL--WLLLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 143 CCHSLVSKWSPPDEKGKFVASLMGGT-FGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLvaDTPAQHSTISL 221
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFgLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLP--RPPPESKRPKP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 222 KEREYIESSLGdtlsnkkkwppyKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLsEVLGFNLSSAGFLSSLPHVARL 301
Cdd:pfam07690 183 AEEARLSLIVA------------WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQ-EVLGLSALLAGLLLGLGGLLGA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 302 LCAFGFGAVADWIRRRGwlsvtrmRKAFCLPSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAP 381
Cdd:pfam07690 250 IGRLLLGRLSDRLGRRR-------RLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPK 322
|
330 340
....*....|....*....|..
gi 442624296 382 NYAGTLYGIINCVGTTPGIFSP 403
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
55-438 |
3.20e-25 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 106.74 E-value: 3.20e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 55 ALPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIG 134
Cdd:cd06174 18 LLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSF--WLLLLGRFLLG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 135 FLNGVVYPCCHSLVSKWSPPDEKGKFVASL-MGGTFGTVITWPISGVIIENL--GWDWAFYIVGIFVLVVVAIWFYLVAD 211
Cdd:cd06174 96 LGSGLIDPAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILASSLgfGWRAVFLIAAALALLAAILLLLVVPD 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 212 TPAQHstislkereyieSSLGDTLSNKKKWPPYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGF 291
Cdd:cd06174 176 PPESA------------RAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 292 LSSLPHVARLLCAFGFGAVADWIRRRGWLSVTRMrkafclpshILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATAS 371
Cdd:cd06174 244 LLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGL---------LLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLS 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442624296 372 NLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTkneNTIDQWHWVFIIGAAAYILPALFFW 438
Cdd:cd06174 315 FALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL---AATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
72-440 |
3.27e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 86.09 E-value: 3.27e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 72 LLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVYPCCHSLVSKW 151
Cdd:cd17325 35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSY--WQLLLARFLQGLASAAVWPAAMALIADI 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 152 SPPDEKGKFVASLMGGTF-GTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPAQHSTislkereyiess 230
Cdd:cd17325 113 APPEERGRAMGIFSSAIGlGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK------------ 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 231 lgDTLSNKKKWPPYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAV 310
Cdd:cd17325 181 --RAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 311 ADWIRRRGWLsvtrmrkafcLPSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTLYGI 390
Cdd:cd17325 259 SDRIGRKPLI----------LIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 442624296 391 INCVGTTPGIFSPLIVAAFTKNENtidqWHWVFIIGAAAYILPALFFWVF 440
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLYDAFG----FATPFLAAAALLLLAAVLFLLL 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
55-421 |
2.81e-17 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 83.19 E-value: 2.81e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 55 ALPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIG 134
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSL--WVMAALWALNG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 135 FLNGVVYPCCHSLVSKWSPPDEKGKFVASL-MGGTFGTVITWPISGVII-ENLGWDWAFYIVGIFVLVVVAIWFYLVADT 212
Cdd:TIGR00881 95 IFQGMGWPPCGRTVTKWFSRSERGTWVSFWnCSHNVGGGLLPPLVLFGIaELYSWHWVFIVPGIIAIIVSLICFLLLRDS 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 213 PaQHSTISLKEREYIESSLGDTLSNKKKWPPYK----ELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSS 288
Cdd:TIGR00881 175 P-QSCGLPPAEEMPNEEPDGDAEKKEEELTKKQiflqYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEK 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 289 AGFLSSLPHVARLLCAFGFGAVADWI--RRRGWLSVTRMRKAFClpshilpGVMLIILAYFGRDPYVCVAIMTISLGFNG 366
Cdd:TIGR00881 254 ASWAFTLYELGGLVGTLLAGWLSDKLfnGRRGPLAVFFMALIIV-------SLLVYWLNPAANPLMDLICLFALGFLVYG 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 442624296 367 AATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFtknentIDQWHW 421
Cdd:TIGR00881 327 PQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYL------ADGFGW 375
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
63-436 |
3.93e-14 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 73.80 E-value: 3.93e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 63 YNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGI----LTALTPAAAAWDKYAVFAvrfliGFLNG 138
Cdd:cd17353 33 LGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLgfilSAFAISLPLLFLGYGVLG-----GIGAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 139 VVYPCCHSLVSKWSPpDEKGkfVAS---LMGGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPAQ 215
Cdd:cd17353 108 IGYITPVSTAVKWFP-DKRG--LATgivIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPPKG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 216 hstislKEREYIESSLGDTLSNKKKWPPyKELVLSLPFWSL-MMLHYGSMWGLFFLITATPkFLSEVLGFNLSSAGFLSS 294
Cdd:cd17353 185 ------WVPPGVDPLANNAENSPRDYTP-REMLRTPTFWLLwLMFFLNATAGLMLIGQAKP-IGQEFAGLDAGIAALAVS 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 295 LPHVARLLCAFGFGAVADWIRRRGWLSVtrmrkAFclpshILPGVMLIILAYFGRDpYVCVAIMTISLGFNGAATASNLA 374
Cdd:cd17353 257 ILSIFNGGGRPFWGWLSDKIGRKNTLSI-----AF-----LIQGVAMFLLPFIGSV-AVLFVLGVALIGFCYGGGFALFP 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442624296 375 N--SQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTKNEntidQWHWVFIIGAAAYILPALF 436
Cdd:cd17353 326 AltADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTG----GYNAAFIIAAALSLVALAL 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
71-438 |
4.34e-14 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 73.35 E-value: 4.34e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 71 ALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAaaWDKYAVFAVRFLIGFLNGVVYPCCHSLVSK 150
Cdd:cd17324 37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA--PSFALLLLARALAGLAHGGFWAIAAAYAAD 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 151 WSPPDEKGKFVASLMGG-TFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPAQHSTislkeREYIES 229
Cdd:cd17324 115 LVPPEKRGRAIGLVFSGlTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPG-----SLGLLS 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 230 SLGDTLSNKKkwppykelvlslpFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGA 309
Cdd:cd17324 190 SLLLLLRNPR-------------LRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGR 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 310 VADWIRRRGWLSVtrmrkafclpSHILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQ--DLAPNYAGTL 387
Cdd:cd17324 257 LADRGGRRALLIA----------LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRlaPEARGLASSL 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 442624296 388 Y-GIINCVGTTPGIFSPLIVAAFTknentidqWHWVFIIGAAAYILPALFFW 438
Cdd:cd17324 327 YlAAYNLGGALGAALGGLVLDHGG--------WAGVGWVGAALLLLALLLAL 370
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
73-407 |
8.34e-13 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 69.69 E-value: 8.34e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 73 LLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFavRFLIGFLNGVVYPCCHSLVSKWS 152
Cdd:TIGR00895 57 LFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLIL--RFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 153 PPDEKGKFVASLMGG-TFGTVITWPISGVIIENLGWDWAFYIVGI---FVLVVVAIWF-----YLVADTPAQHSTISLKE 223
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGyPIGAAVGGFLAGWLIPVFGWRSLFYVGGIaplLLLLLLMRFLpesidFLVSKRPETVRRIVNAI 214
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 224 REYIESSLGDTLSNKKKWPPYKELVLSLPFWSLMMLHYGSMWGL--------FFLITATPKFLSEvLGFNLSSAGFLSSL 295
Cdd:TIGR00895 215 APQMQAEAQSALPEQKSTQGTKRSVFKALFQGKTARITVLLWLLyfmllvgvYFLTNWLPKLMVE-LGFSLSLAATGGAL 293
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 296 PHVARLLCAFGFGAVADWIRRRGWLSVtrmrkafclpshILPGVMLIILAYFGRDPYVCVAIMTISLG-FNGAATASNLA 374
Cdd:TIGR00895 294 FNFGGVIGSIIFGWLADRLGPRVTALL------------LLLGAVFAVLVGSTLFSPTLLLLLGAIAGfFVNGGQSGLYA 361
|
330 340 350
....*....|....*....|....*....|....
gi 442624296 375 NSQDLAPNYA-GTLYGIINCVGTTPGIFSPLIVA 407
Cdd:TIGR00895 362 LMALFYPTAIrATGVGWAIGIGRLGAIIGPILAG 395
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
66-440 |
1.81e-12 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 68.45 E-value: 1.81e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 66 TQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAwdkYAVFAV-RFLIGFLNGVVYPCC 144
Cdd:cd17312 36 SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTS---LWFFAVlWGLNGLFQSMGWPPC 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 145 HSLVSKWSPPDEKGKFVASLMGG-TFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPaqhstislke 223
Cdd:cd17312 113 VKLLGNWFSKKERGTVYGIWSTShNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP---------- 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 224 reyiesslgdtlsnkkkwpPYKeLVLSLPFWSLMMLHYG-SMWGlfflitatPKFLSEVLGFNLSSAGFLSSLPHVARLL 302
Cdd:cd17312 183 -------------------PYV-WVLSLAYAFVYIVRYAcLDWG--------PLYLYEVKGYSLIDAGWFSSLYEVGGIA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 303 CAFGFGAVAD--WIRRRGWLSVtrmrkafclpSHILPGVMLIILAYFGRDPYVCVAIMTISLGF--NGAATASNLANSQD 378
Cdd:cd17312 235 GTILAGLLSDklFGGRRAPIAV----------IYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFfvGGPINLIGGAAAQD 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442624296 379 LAPNYA-GTLYGIINCVGTTPGIFSPLIVAAFTKNENtidqWHWVFIIGAAAYILPALFFWVF 440
Cdd:cd17312 305 IGRKEAaGTATGFVGLFGYLGASLAGLPLGYIIDHYG----WSTVFYFLISAALLSVLLLLSL 363
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
15-405 |
8.28e-12 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 66.50 E-value: 8.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 15 LAIMLFMACLLSYMMRVNLSINIIA-MVEDTssHENGTEvealpdygprYNWTQSdqalllgAYFYGYMITSLPAGTLAE 93
Cdd:cd17327 6 ILPLLCILYFLQYLDKSNISNAAVMgMKEDL--KLVGNQ----------YNWGNT-------VFYVGYIIFELPGNLLLQ 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 94 MLGARNVagYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGK-----FVASLMGGT 168
Cdd:cd17327 67 RFPPSKW--LSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKriaffYAAAGLGSI 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 169 FGTVITwpiSGVI-IENL----GWDWAFYIVGIFVLVVVAIWFYLVADTPAQHSTISLKEREY----IESSLGDTLSNKK 239
Cdd:cd17327 145 FGGLLA---YGVFkILGVgglaGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELaverLRANQTGKGDQKF 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 240 KWPPYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEvLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRRGW 319
Cdd:cd17327 222 KWKQIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKS-LGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGL 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 320 LSVtrmrkAFCLPshILPGvmLIILAYFGRDPYVCVAIMTISLGFnGAATASNLANSQDLAPNYAG--TLYGIINCVGTT 397
Cdd:cd17327 301 FAI-----FACVL--ALVG--SIILLAAPNPPGAYFAAYILGGGS-YAGFPILLSWISSNCAGYTKraTVLAIMLIFYNV 370
|
....*...
gi 442624296 398 PGIFSPLI 405
Cdd:cd17327 371 GNIVAPQI 378
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
55-440 |
1.22e-10 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 62.95 E-value: 1.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 55 ALPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIG 134
Cdd:COG0738 30 LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSY--PLLLLALFLLG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 135 FLNGVVYPCCHSLVSKWSPpdEKGKFVASLMGGTF--GTVITWPISGVII---ENLGWDWAFYIVGIfVLVVVAIWFYLV 209
Cdd:COG0738 108 LGLGLLDVAANPYVAALGP--ETAASRLNLLHAFFslGALLGPLLGGLLIllgLSLSWHLPYLILAV-LLLLLALLFLRS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 210 adtpaqhstiSLKEREYIESSLGDTLSNKKKWPPYKELVLSLPFWSLMMLHYGSMWGLFflitatPKFLSEVLGFNLSSA 289
Cdd:COG0738 185 ----------KLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWL------PLYLKDVLGLSEATA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 290 GFLSSLPHVARLLCAFGFGAVADWIRRRGWLSVtrmrkafclpSHILPGVMLIILAYFGRDPYVCVAIMTISLGF-NGAA 368
Cdd:COG0738 249 ALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRL----------SALLAAVGLLLALLAPGPWLALIGLALVGLGLsLMFP 318
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442624296 369 TASNLANsqDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFtknentIDQW--HWVFIIGAAAYILPALFFWVF 440
Cdd:COG0738 319 TIFSLAL--DGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL------ADAFglRAAFLVPLVCYLLILLLALAL 384
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
56-446 |
1.56e-10 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 62.58 E-value: 1.56e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 56 LPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGF 135
Cdd:COG2807 41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSV--ALLLAGTALIGA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 136 LNGVVYPCCHSLVSKWSPpdEKGKFVASL--MGGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTP 213
Cdd:COG2807 119 GIAVGNVLLPGLIKRWFP--DRVGLMTGLytAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 214 AQHSTISlkereyIESSLGDTLSNKKKWppykelvlslpfwsLMMLHYGSMWGLFFLITA-TPKFLSEvLGFNLSSAGFL 292
Cdd:COG2807 197 AAAAAAP------AAASLRSLWRSPLAW--------------LLTLFFGLQSLLYYAVVAwLPPILRD-AGLSAATAGLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 293 SSLPHVARLLCAFGFGAVADWIRRRGWLSVtrmrkaFCLPSHILpGVMLIILAyFGRDPYVCVAIMTISLGFN---GAAT 369
Cdd:COG2807 256 LSLFQLAGIPGSLLVPLLADRLGDRRPLLL------LLGLLGLA-GLLGLLLA-PGSLPWLWAVLLGLGQGGLfplALTL 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 370 ASNLANSqdlaPNYAGTLYGIINCVGTTPGIFSPLIVAAFtknentIDQ---WHWVFIIGAAAYILPALFFWVFGSGKIQ 446
Cdd:COG2807 328 IGLRART----PAEAAALSGMAQSVGYLLAALGPLLVGAL------HDAtgsWTAALLLLAALAVLMLVAGLLAGRPYVE 397
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
63-366 |
4.67e-10 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 61.10 E-value: 4.67e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 63 YNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVYP 142
Cdd:cd17475 26 LHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSY--PVLLVLLFLVGAGYGSVQP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 143 CCHSLVSKWSPPDEKGkFVASL--MGGTFGTVITWPISGVIIENLGWDWAFYIVGIfVLVVVAIWFYLVADTPAQHSTis 220
Cdd:cd17475 104 GGGRAIMRWFPPRERG-LAMGIrqTGVPLGGALAAALLPPLALHYGWRAAFVVAGL-VSILAAVLFWLFYREPPAASA-- 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 221 lkereyiesslgDTLSNKKKWPPYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVAR 300
Cdd:cd17475 180 ------------ATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGG 247
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442624296 301 LLCAFGFGAVADWIRRrgwlsvtRMRKAFCLPSHILPGVMLIILA--YFGRDPYVCVAIMTIS----LGFNG 366
Cdd:cd17475 248 ALGRIGLGRVSDRVFG-------GRRRPVLVITAAIAAAALLVLSllSPGTPLWLLVLLLILLglfaIGWNG 312
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
66-432 |
1.01e-09 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.92 E-value: 1.01e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 66 TQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFavRFLIGFLNGVVYPCCH 145
Cdd:cd17316 34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVL--RFLQGIGIGGEYPGAS 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 146 SLVSKWSPPDEKGK-----FVASLMGGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWfylvadtpaqhstis 220
Cdd:cd17316 112 TYVAEFAPSKRRGFalgllQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPALLALLLR--------------- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 221 lkereyiesslgdtlsnkkkwppyKELVLSLPFWSLMMLhygsmwGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVAR 300
Cdd:cd17316 177 ------------------------RRTLLLILLWFFISF------GYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGA 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 301 LLCAFGFGAVADWIRRRGWLSVtrmrkafclpSHILPGVMLIILAYFGR-DPYVCVAIMTISLGFNGAATASNLANSQDL 379
Cdd:cd17316 227 LVGALIAGLLSDRIGRKKTLVI----------GLILSGILALPLFYLLSgSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 442624296 380 AP-NYAGTLYGIINCVGTTPGIFSPLIVAAFTKNENTIDQWHWVFIIGAAAYIL 432
Cdd:cd17316 297 FPtEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVALI 350
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
71-440 |
1.58e-09 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 59.55 E-value: 1.58e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 71 ALLLGAYFYGYMITSLPAGTLAEMLGARNV-----AGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVYPCCH 145
Cdd:cd06173 37 GLVLAAFFLPFLLFSPFAGVLADRFDRRRLliladLLRALLAAVLALLALLGSLSL--WLLLVLAFLLGIASAFFGPARQ 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 146 SLVSKWSPPDEKGKFVA-SLMGGTFGTVITWPISGVIIENLGWDWAFYIVGI-FVLVVVAIWFYLVADTPAQHSTISLKE 223
Cdd:cd06173 115 ALLPELVPKEQLVRANAlNSLATQLARIIGPALGGLLVALLGPGGAFAINALsFLLSALLLLFIRRPPPAAPGESSSLLL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 224 REYIEsslgdtlsnkkkwppYKELVLSLPFWSLMMLHYGSMWGLFFLITA-TPKFLSEVLGFNLSSAGFLSSlphvarll 302
Cdd:cd06173 195 RDLRE---------------GLRYLRRSPLLRLLLLALALFALLGGALTVlLPLLAKEVLGGGAAGYGLLLA-------- 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 303 cAFGFGAVAdwirrrGWLSVTRMRKAFCLPSHILPGV----MLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQD 378
Cdd:cd06173 252 -AFGVGALL------GALLLGRLSKRRRRGRLLLIGAlllgLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQL 324
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442624296 379 LAPN-YAGTLYGIINCVGTTPGIFSPLIVAAFTKNENtidqWHWVFIIGAAAYILPALFFWVF 440
Cdd:cd06173 325 RVPDeLRGRVFSVYNALNSGAMPLGALLAGLLADALG----LSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
72-441 |
6.16e-09 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 57.58 E-value: 6.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 72 LLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAawDKYAVFAVRFLIGFLNGVVYPCCHSLVSKW 151
Cdd:cd17473 39 LLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLD--SLYALLASRALLGIGVAGIMTLATALIGDY 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 152 SPPDEKGKFVA-SLMGGTFGTVITWPISGVIIEnLGWDWAFYIVGIFVLVVVAIWFYLVADTPAQHSTISLKereyieSS 230
Cdd:cd17473 117 FEGEERAKMLGlQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPARKSKSAASPG------AA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 231 LGDTLSNKKKWPPYkelvlslpfwslmMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAV 310
Cdd:cd17473 190 TAAALPWKRVLPIY-------------FLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 311 ADWIRRRGWLSVtrmrkAFclpshILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTLYGI 390
Cdd:cd17473 257 KRRLGKRRLLAI-----GF-----ALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 442624296 391 INCVGTTPGIFSPLIVAAFTKNENTIDQwhwVFIIGAAAYILPALFFWVFG 441
Cdd:cd17473 327 VTSAFFLGQFLSPLVLGPLVNLTGGLSG---AFLILGVLALVLAIVLLLLR 374
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
126-440 |
1.44e-08 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 56.83 E-value: 1.44e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 126 VFAVRFLIGFLNGVVYPCCHSLVSKWSP-PDEKGK-----FVASLMGGTFGTVITWPISGVIIEN--LGWDWAFYIVGIF 197
Cdd:COG2211 113 ALVTYLLLGLAYTLVNIPYSALGAELTPdYEERTRlsswrFAFAGLGGLLASVLPPPLVAAFGGDaaLGYRLTALIFAVL 192
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 198 VLVVVAIWFYLVADTP-AQHSTISLKEreyiesSLGDTLSNKkkwppykelvlslPFWSLMMLHYGSMWGLFFLITATPK 276
Cdd:COG2211 193 GLLAFLLTFFGTKERPvPEEEKVSLKE------SLKALLKNR-------------PFLLLLLAYLLFFLALALVAALLLY 253
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 277 FLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRrgwlsvtrmRKAFCLpSHILPGVMLIILAYFGRDPYVCVA 356
Cdd:COG2211 254 YFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK---------KKAFII-GLLLAALGLLLLFFLGPGNLWLLL 323
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 357 IMTISLGF-NGAATASNLANSQDLAP--------NYAGTLYGIINCVGTTPGIFSPLI----------VAAFTKNENTID 417
Cdd:COG2211 324 VLAALAGIgLGAILVLPWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALaglllalfgyVAGAAQSPSALT 403
|
330 340
....*....|....*....|...
gi 442624296 418 QWHWVFIIGAAAYILPALFFWVF 440
Cdd:COG2211 404 GIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
63-438 |
2.10e-08 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 56.11 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 63 YNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAwdKYAVF-AVRFLIGFLnGVVY 141
Cdd:cd17341 29 LGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVS--SYWGLlVLGFLLGFA-GANF 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 142 PCCHSLVSKWSPPDEKGKFVASL-----MGGTFGTVITWPISGVIIEN---LGWDWAFYIVGIFVLVVVAIWFYLVADTP 213
Cdd:cd17341 106 ASGQPWASFWFPKEKIGGAAGGIagagnMGVAVSQLLAPLIAGAIVFDggfVGWRNAFFVPGILLAIAAVLVLLFGDDLP 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 214 AQHSTISLKEREYIesslgDTLSNKKKWppykelvlslpfwsLMMLHYGSMWGLFFLITA-TPKFLSEVLGFNLSSAGFL 292
Cdd:cd17341 186 TGKASALEFLKVQL-----AVLKNYRTW--------------ILSLLYGVTFGSFVGFSNvLPTYFKTRFGLPLVTAGIL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 293 SSL-PHVARLLCAFGfGAVADWIRRRGWLSVtrmrkafclpSHILPGVMLIILAYFGRDP----YVCVAIMTISLGFNGA 367
Cdd:cd17341 247 AALfPLAGALARPAG-GWLSDRFGGRRRLWW----------LFIVMTIGAALLSLSLPTSgtnlVLFLALFVALGLGAGA 315
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442624296 368 ATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTKNENTIDQWHWVFiigAAAYILPALFFW 438
Cdd:cd17341 316 GNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLF---GVLAVACTLLVW 383
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
55-311 |
6.49e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 54.05 E-value: 6.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 55 ALPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGIltALTPAAAAWDKYAVFAVRFLIG 134
Cdd:COG0477 36 ALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL--ASLLCGLAPSPELLIAARALQG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 135 FLNGVVYPCCHSLVSKWSPPDEKGKFVASL-MGGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTP 213
Cdd:COG0477 114 IGAGGLMPGALALIAELFPARERGRALGLWgAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 214 AQHSTISLKEREYIESSLGDTLSNKKKWPPYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLS 293
Cdd:COG0477 194 LLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLA 273
|
250
....*....|....*...
gi 442624296 294 SLPHVARLLCAFGFGAVA 311
Cdd:COG0477 274 LLLALLLLLLLLLLLLLL 291
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
56-436 |
5.07e-07 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 51.55 E-value: 5.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 56 LPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVagILTALTPAAAAWDKYAVFAVRFLIGF 135
Cdd:cd17333 19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLL--ISLALALIFATPSIYLFVVLMFLAGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 136 LNGVVYPCCHSLVSKWSPpdEKGKFVASLMGGTFGT--VITWPISGVIIEN-LGWDWAFYIVGIFVLVVVAIWFYLVADt 212
Cdd:cd17333 97 GAGILDTGANTFVGALFE--ESSATRLNVLHGFFGLgaLIGPLIATSLLTSeLSWSWAYLIIGLIYLLLAILILLTLFP- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 213 PAQHSTISLKEREYIESSLGDTLSNKKKWppykelvlslPFWSLMMLHYGSMWGlffLITATPKFLSEVLGFNLSSAGFL 292
Cdd:cd17333 174 ELPSARNPQQSVGAFSASASRLLRNPSII----------LGALALFLYVGAETA---FSSWVPSYLVEKKHVSDGLAGYL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 293 SSLPHVARLLCAFGFGAVADWIRRRGWLSVtrmrkafclpshILPGVMLIILAYFGRDPYVCVAIMTISLGFNGAA---T 369
Cdd:cd17333 241 LSGFWVGITIGRLLGGPISRRIKPHTLLVL------------SGSGALLGLLILLLAPTLVVGLVATALLGLFMAAlfpT 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442624296 370 ASNLANSQdlAPNYAGTLYGIINCVGTTPGIFSPLIVaAFTKNENTIDQWHWVFIIGAAAYILPALF 436
Cdd:cd17333 309 ILSLGISN--LPYAKGKGTSVLLAAGSIGGAIIPFIM-GFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
127-364 |
1.19e-06 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 50.70 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 127 FAVRFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVA------SLMGGTFGTVITWpiSGVIIENLGWDWAFYIVGIFVLV 200
Cdd:cd17345 99 FILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSiwnishNVGGGLVGPLAGL--GLAIFGDGWWRGAFIFPAIIAII 176
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 201 VVAIWFYLVADTPAQHSTISLKE--REYIESSLGDTLSNK-KKWPPYKELVLSLPF-W-------SLMMLHYGsmwglff 269
Cdd:cd17345 177 VAVIVLFLGKDTPESEGLPPIEEykGDYPEEADGEEEEQElSAWEIFVKYVLKNKLlWyiaianvFVYLVRYG------- 249
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 270 LITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIR--RRGWLSVTRMrkafclpshilPGVMLIILAYF 347
Cdd:cd17345 250 ILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFkgRRAPTGIIFM-----------ILVIVALIVYW 318
|
250
....*....|....*..
gi 442624296 348 GRDPYVCVAIMTISLGF 364
Cdd:cd17345 319 LAPNVLVDLIALIALGF 335
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
66-408 |
1.23e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.28 E-value: 1.23e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 66 TQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAaaWDKYAVFAVRFLIGFLNGVVYPCCH 145
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFA--QSVLQLALLRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 146 SLVSKWSPPDEKGKFVASLMGG-TFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIwfylvadtpaqhstislker 224
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGyPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL-------------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 225 eyiesslgdtlsnkkkwppykeLVLSLPFWSLMMLhygSMWGLFFLITATPKFLSEVlGFNLSSAGFLSSLPHVARLLCA 304
Cdd:cd17365 170 ----------------------LRGTLLLWVTFFM---GLLLVYLLNSWLPKLMVEA-GYSLSQALTITLLLNIGGVIGS 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 305 FGFGAVADWIRRRGWLSVTRMRKAFCLpshilpgvmLIILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYA 384
Cdd:cd17365 224 LLLGWLADRFGPKRVLALFFALGAVSL---------ALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVR 294
|
330 340
....*....|....*....|....
gi 442624296 385 GTLYGIINCVGTTPGIFSPLIVAA 408
Cdd:cd17365 295 ATGVGWALGVGRLGAILGPLLGGL 318
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
63-213 |
1.84e-06 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 49.87 E-value: 1.84e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 63 YNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGFLNGVVYP 142
Cdd:COG2271 211 RGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFG 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442624296 143 CCHSLVSKWSPPDEKGKFVA-SLMGGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTP 213
Cdd:COG2271 291 LLWALAAELFPKKARGTASGlVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
62-209 |
3.17e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 49.11 E-value: 3.17e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 62 RYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVY 141
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSF--WLLLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442624296 142 PCCHSLVSKWSPPDEKGKFVASL-MGGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLV 209
Cdd:cd17325 307 PATLALLADIVPPEGRGTAMGLFnTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
55-204 |
5.00e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 48.34 E-value: 5.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 55 ALPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNV-------AGYSCLVAGILtaltpaaaaWDKYAVF 127
Cdd:cd17504 18 ALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVllivlaiYTAGSLLAAFA---------PNLPVLI 88
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442624296 128 AVRFLIGFLNGVVyPCCHSLVSKwSPPDEKGKFVASLMGGTF--GTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAI 204
Cdd:cd17504 89 AGRALQGIGGAVF-PLAFALVRE-EFPPERVPVAQGILSATFgiGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
86-320 |
6.83e-06 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 48.07 E-value: 6.83e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 86 LPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAwdKYAVFAV-RFLIGFLnGVVYPCCHSLVSKWSPPDEKGK---FV 161
Cdd:TIGR00886 55 IILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQ--SYSVLLLiRLFIGIA-GGSFASCMPWISFFFPKKIQGTalgLA 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 162 ASL--MGGTFGTVITWPISGVIIENLG------WDWAFYIV--GIFVLVVVAIWFYLVADTPAQHSTISLKEREYIessl 231
Cdd:TIGR00886 132 AGWgnMGGGVAQFVMPPIIGSLIFGGGqpahlaWGWAFVIVpaGILLLPALLIFFVGADTPPGKPATGKLSFKEAL---- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 232 gDTLSNKKKWppykelvlslpfwsLMMLHYGSMWGLFFLITAT-PKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAV 310
Cdd:TIGR00886 208 -KVFGNRHTW--------------ILALLYSVTFGSFLGVSSIfAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAI 272
|
250
....*....|.
gi 442624296 311 ADWI-RRRGWL 320
Cdd:TIGR00886 273 SDRLgGARKLL 283
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
56-405 |
7.18e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 47.94 E-value: 7.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 56 LPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAawDKYAVFAVRFLIGF 135
Cdd:cd17478 19 LPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAP--NYWLLLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 136 LNGVVYPCCHSLVSKWSPPDeKGKFVASLM-GGTFGTVItWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPA 214
Cdd:cd17478 97 GSAAFHPEGARLASQAAGGR-RGLAMSIFSvGGNLGFAL-GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 215 QHSTISLKEREyiesslgDTLSNKKKWPPykelvlSLPFWSLMMLHYgsmWGLFFLITATPKFLSEVlGFNLSSAGFLSS 294
Cdd:cd17478 175 PEAKKAAAKSS-------ARSTLKGVWRA------LLLLLIIVFLRS---WVLSSLTTFLPFYLVQR-GYSLVFAGLLLS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 295 LPHVARLLCAFGFGAVADWIRRRGWLSVtrmrkafclpSHILPGVMLIILAYFGrdPYVCVAIMTISLGFNGAATASNLA 374
Cdd:cd17478 238 LFLFAGAIGTLIGGPLSDRFGRRRVIIA----------SLLLAAPFLLLFLLTP--GIWSYILLVLAGFLLFASFPVTVV 305
|
330 340 350
....*....|....*....|....*....|..
gi 442624296 375 NSQDLAPNYAGTLYGIINCVG-TTPGIFSPLI 405
Cdd:cd17478 306 LAQELLPGNVGLASGLMMGLSfGLGGIGAPVL 337
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
71-438 |
1.01e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 47.57 E-value: 1.01e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 71 ALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAaawDKYAVFAV-RFLIGFLNGVVYPCCHSLVS 149
Cdd:cd17474 37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS---DSFALLLAgRALQGIGAAGLGPLALTLIG 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 150 KWSPPDEKGK---FVASLMGgtFGTVITwPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPAqhstislKEREY 226
Cdd:cd17474 114 DLFEGGERAKamgLYEAALG--LGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKE-------KAKSS 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 227 IESSLGDtlsnkkkwppYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFG 306
Cdd:cd17474 184 SATKLRD----------LKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLF 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 307 FGavadWIRRRGWLSVTRMRKAFCLpshiLPGVMLIILayFGRDPY---VCVAIMTISLGFNGAATASNLANsqdLAPNY 383
Cdd:cd17474 254 VG----RLLKKRFGARRILVIGLLL----YALSLLLLG--FVPSLAlllIAIVLFGLGLGLNLPLLTTLVTE---LAPEE 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 442624296 384 A-GTLYGIINCVGTTPGIFSPLIVAAFTKNENtidqWHWVFIIGAAAYILPALFFW 438
Cdd:cd17474 321 ErGTASSLYNFVRFLGQAVGPLLFGLLLEIFG----LSAPFLVGAAIALAAAVLLA 372
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
72-212 |
1.09e-05 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 44.95 E-value: 1.09e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 72 LLLGAYFYGYMITSLPAGTLAEMLGARNVagYSCLVAGILTALTPAAAAWDKYAVFAVRFLIGFLNGVVYPCCHSLVSKW 151
Cdd:TIGR00880 2 LLLAGYALGQLIYSPLSGLLTDRFGRKPV--LLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADI 79
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442624296 152 SPPDEKGKFVASLMGG-TFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLVADT 212
Cdd:TIGR00880 80 YPPEERGVALGLMSAGiALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
130-219 |
2.14e-05 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 46.60 E-value: 2.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 130 RFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVASL-MGGTFGTVITWPISGVIIENLGWDWAFYI---VGIFVLVVVaiW 205
Cdd:TIGR00711 97 RVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWgLTVLVAPALGPTLGGWIIENYHWRWIFLInvpIGIIVVVVA--F 174
|
90
....*....|....
gi 442624296 206 FYLVADTPAQHSTI 219
Cdd:TIGR00711 175 FILPRDKPAASENF 188
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
55-440 |
2.75e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 46.03 E-value: 2.75e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 55 ALPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNV--AGYSCLVAGILTALTPAAAAWdkyaVFAVRFL 132
Cdd:cd17320 21 ALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVllAGLLLFILASLLCALASSIEQ----LLIARFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 133 IGFLNGVVYPCCHSLVSKWSPPDEKGKFVASLMGGT-FGTVITWPISGVIIENLGWDWAFYIVGIF-VLVVVAIWFYLVa 210
Cdd:cd17320 97 QGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILaIAPALAPLLGGLLLLFFGWRAIFVFLALLgLLLLLLVLLFLP- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 211 dtpaqhSTISLKEREYIESSLGDTlsnkkkwppYKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAG 290
Cdd:cd17320 176 ------ETLPEEKRKPLLSSLLRA---------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 291 FLSSLPHVARLLCAFGFGAVAdwiRRRGwlSVTRMRKAFCLpsHILPGVMLIILAYFGRDPYVC-VAIMTISLGFNGAAT 369
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLV---RRFG--PRRLLRLGLLL--LLAAALVLLLAALLGGLSLWPlVAPLFLIFFGFGLIF 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442624296 370 ASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFtknentIDQWHWVFIIGAAAYILPALFFWVF 440
Cdd:cd17320 314 PNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLL------PNGTALPMGLLILVLGLLALLLLIL 378
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
68-213 |
9.45e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 44.57 E-value: 9.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 68 SDQALLLGAYFYGYMITSLPAGTLAEMLGARN--VAGYSCLVAGILTALTPAAAaWDKYAVFAVRFLIGFLNGVVYPCCH 145
Cdd:pfam00083 46 VLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKslLIANVLFVIGAVLQGAAKGK-WSVYQLIVGRVLVGIGVGGASVLAP 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442624296 146 SLVSKWSPPDEKGKFV-----ASLMGGTFGTVITWpISGVIIENLGWDWAFYIVGIFVlVVVAIWFYLVADTP 213
Cdd:pfam00083 125 MYISEIAPKKLRGALGslyqlAITFGILLAYIFGL-GLNKTSNSDGWRIPLGLQLVPA-LLLIIGLLFLPESP 195
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
70-206 |
1.44e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 44.24 E-value: 1.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 70 QALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFavRFLIGFLNGVVYPCCHSLVS 149
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF--RLLVGMGIGGIWVQAVVLNT 206
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 442624296 150 KWSPPDEKGKFvaSLMGGTFGTVITWPISGVIIENLGWDWAFYIVGI-FVLVVVAIWF 206
Cdd:TIGR00898 207 EFLPKKQRAIV--GTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLpTFLFFLLSWF 262
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
65-440 |
1.68e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.80 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 65 WTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNV-AGYSCLVAGILTALTPAAAAWDKYAVFAVrfLIGFLNGVVYPC 143
Cdd:cd17355 35 WSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVmLLGLLLLAAGLVLLALATSLWQLYLLWGL--LGGGGAGTLAAV 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 144 CHSLVSKWSPPDEKGKfVASLM--GGTFGTVITWPISGVIIENLGWDWAFYIVGIF-VLVVVAIWFYLVADTPAQHSTIS 220
Cdd:cd17355 113 AFATVAAWWFERRRGL-ALGILtaGGGLGSLVFLPLGAALIEAFGWRTALLVLALLaLLVLVPVLLLLRRRPADLALRAY 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 221 LKEREYiesSLGDTLsnkkkwppyKELVLSLPFWSLMMLHYGSMWGLFFLITATPKFLSEvLGFNLSSAGFLSSLPHVAR 300
Cdd:cd17355 192 DDASPA---SPGSTL---------KEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLAD-RGISPAAAAVALALIGLFN 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 301 LLCAFGFGAVADWIRRRgwlsvtrmrkAFCLPSHILPGVMLIILAYFGrDPYVCVAIMTISLGFNGAAT---ASNLAnSQ 377
Cdd:cd17355 259 IVGRLLSGWLGDRYSPR----------RLLAASYALRALGLALLLLLP-FPPLALLLFAALFGLGWGATvplTAALA-AR 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442624296 378 DLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTKNENTIDqwhWVFIIGAAAYILPALFFWVF 440
Cdd:cd17355 327 YFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYT---AAWALAVALGLIAALLVLPI 386
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
131-442 |
1.76e-04 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 43.86 E-value: 1.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 131 FLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVASL-----MGGTFGTVITwpisGVIIENLGWDWAFYIVGIFVLVVVAIW 205
Cdd:cd17343 99 FLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLstsmnLAGSLGPILA----TLLALSYGWRSTLSISGTVAVVMSVVC 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 206 FYLVADTPAQHSTISLKEREYIESSLGDTLSNKKkwppYKELVLSlPFWSLMMLHY---------GSMWGLFFLITAtpK 276
Cdd:cd17343 175 LLFIKNEPSDVGLNNIEEEESKGKKKKSPRGEST----LKELLLS-PFLWLLSLGYlvvfgvktaVTDWGQLFLIQD--K 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 277 FLSEVLGfnlssAGFLSSLpHVARLLCAFGFGAVADW-IRRRGWLSVTRMRKAFCLPSHILPGVMLIILAYF--GRDPYV 353
Cdd:cd17343 248 GQSALTG-----SSFMSSL-EVGGFVGSIAAGYLSDWaVAKHGSSSRGNPRMPLALVFMAGLTVSLHLFRVHitSDSSEL 321
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 354 CVAIMTISLGFN--GAATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTKNENtidqWHWVFIIGAAAYI 431
Cdd:cd17343 322 FILLLGFLIGFSlyGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYD----WRTAFLLLEILCA 397
|
330
....*....|.
gi 442624296 432 LPALFFWVFGS 442
Cdd:cd17343 398 ITVVILFLLRN 408
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
56-348 |
1.95e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 43.44 E-value: 1.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 56 LPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDKYAVFavRFLIGF 135
Cdd:cd17371 22 LPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLIL--RALAGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 136 LNGVVYPCCHSLVSKWSPPDEKGKFVASLM-----GGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYlVA 210
Cdd:cd17371 100 GFGGEWAAGAALMAEYVPARHRGKALGYVQsgwavGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALLVLFIRRF-VK 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 211 DTP----AQHSTISLKEREYIeSSLGDtlsnkkkwPPYKELVLslpFWSLMMLhyGSMWGLFFLITATPKFLSEVLGFNL 286
Cdd:cd17371 179 EPPqwqaARAARRHFADRPSL-RELFS--------PPLLRTTL---LASLLAT--GALGGYYGITTWLPSYLTGERGLSF 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442624296 287 SSAGFLSSLPHVARLLCAFGFGAVADWIRRRGWLSVTRMRKAFCLPSHIL----PGVMLIILAYFG 348
Cdd:cd17371 245 EGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFALGSAISILLYFFlplsPTLILILGFPLG 310
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
72-210 |
2.06e-04 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 43.33 E-value: 2.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 72 LLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAawDKYAVFAVRFLIGFLNGVVYPCCHSLVSKW 151
Cdd:cd17323 38 LGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP--NIAMLIILRFLQGFFGSSPLAIGAGTIADL 115
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442624296 152 SPPDEKGKFVASLMGGTF-GTVITWPISGVIIENLGWDWAFYIVGI---FVLVVVAIWFYLVA 210
Cdd:cd17323 116 FTPEERGKAMGVYSLGPLlGPALGPIIGGFITQSLGWRWIFWFLAIisgFCLILIFLFLPIVL 178
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
65-441 |
3.55e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 42.68 E-value: 3.55e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 65 WTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVagysCLVAGILTALTPAAAAW--DKYAVFAVRFLIGFLNGVVYP 142
Cdd:cd06180 31 LSYAQAGWIATANYAGYLVGALLASFLRRRGRARRL----IRGGLLLTVLLLAAMALtsGFAALLALRFLAGAASAFVFV 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 143 CCHSLVSKWSPPDEKGKFVASLMGGTfGTVITwpISGVII-----ENLGWDWAFYIVGIFVLVVVAIWFYLVADTPAQHS 217
Cdd:cd06180 107 FGSNLVLHHATAAGRGHLIGLLFAGV-GLGIA--LSGLLVpaglgGGLSWRAGWLALALLSAVLLLLSFLLLRRGPSAPT 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 218 TISlkereyiesslgdtlsnkkkwPPYKELVLSLPFWSLMMLhYGsMWGLFFLITATpkFLS---EVLGFNLSSAGFLSS 294
Cdd:cd06180 184 EAS---------------------AAESAPGLNRPLWRLALA-YG-LFGFGYIITAT--FLPliaRETGAGSLLAGLLWS 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 295 LPHVARLLCAFGFGAVADWIRRRGWLSVTRMRKAFClpshilpgvmliILAYFGRDPYVCVAIMTISLGFN-GAATASNL 373
Cdd:cd06180 239 LFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVG------------VLLPLLSPGPAGLVLSAVLFGGTfMAITALVM 306
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442624296 374 ANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTKNENTIDQwhwVFIIGAAAYILPALFFWVFG 441
Cdd:cd06180 307 ALARELAPPAAPRALALMTASFGVGQILGPLLAGWLADATGGFAP---ALILAAAALVVAALLALLVL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
56-205 |
7.83e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 7.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 56 LPDYGPRYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWDkYAVFAVRFLIGF 135
Cdd:cd17477 211 LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLP-LALLVLLFLWGG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442624296 136 LNGVVYPCCHSLVSKWSPPDEkgkfVASLMGG-----TFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIW 205
Cdd:cd17477 290 AAGPLYTLALALAGDRLPGDE----LVAANAAllllyGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
76-436 |
8.79e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 41.39 E-value: 8.79e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 76 AYFYGYMITSLPAGTLAEMLGARNVagyscLVAGIltaltpaaaawdkyAVFAV-----------------RFLIGFLNG 138
Cdd:cd17321 39 AYLLAFAALLLLAGRLGDRFGRKRV-----FLIGL--------------ALFGLasllcalapslafliaaRALQGIGAA 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 139 VVYPCCHSLVSKWSPPDEKGKFVASLMGGT-FGTVITWPISGVIIENLGWDWAFYIVGIFVLVVvaiwfylvadtpaqhs 217
Cdd:cd17321 100 AIMPASLALIAATFPGERRGRALGLWGAVVgIGAALGPLLGGLLLELFGWRWIFLINVPIGLVA---------------- 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 218 tislkereyiesslgdtlsnkkkwppykeLVLSLPFWS---LMMLHYGSMWGLFFLItatPKFLSEVLGFNLSSAGFLSS 294
Cdd:cd17321 164 -----------------------------LLLARTFSGavlAAFLLGAALGGLLFLL---PLYLQGVLGYSPLQAGLALL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 295 LPHVARLLCAFGFGAVADWIRRRgwlsvtrmrkAFCLPSHILPGVMLIILAYFGRD---PYVCVAIMTISLGFNGAATAS 371
Cdd:cd17321 212 PLALAMLVAAPLAGRLADRFGPR----------LVLVAGLLLTAVGLLLLALLGADssvWLLLPGLVLLGLGLGLFATPL 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 372 NLANSQDLAPNYAGTLYGIIN-------CVGTtpGIFSPLIVAAFTKN--------------ENTIDQWHWVFIIGAAAY 430
Cdd:cd17321 282 TNAALSSVPKEKAGAASGILNtarqlggALGV--ALLGALLTAGLSANlgdsgvaallsaaaAAFAAGFHLAFLVAAALA 359
|
....*.
gi 442624296 431 ILPALF 436
Cdd:cd17321 360 LLAALL 365
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
17-273 |
9.22e-04 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 41.45 E-value: 9.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 17 IMLFMACLLSYMMRVNLSINIIAMVEDTSSHengtevealpdygprynwtqSDQALLLGAYF-YGYMITSLPAGTLAEML 95
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLID--------------------DSLAGLLQTVFiISYMVLSPIFGYLGDRY 61
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 96 GARNVAGYSCLVAGILTALTPAAAAWDKYAVFavRFLIGFLNGVVYPCCHSLVSKWSPPDEKGKF---------VASLMG 166
Cdd:cd17328 62 NRKWILAVGILIWSAATLLSSFAPNFWQLLLF--RALVGIGEASYSPIAPTIIADLFPKEKRTRAlgvfyfaipLGSGLG 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 167 GTFGTVITwpisgviIENLGWDWAFYIVGIFVLVVVAIWFYLVADTPAQHSTISLKEREYIESSLGDTLSNKKKWPpykE 246
Cdd:cd17328 140 YVVGGLVA-------QATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPS---F 209
|
250 260
....*....|....*....|....*...
gi 442624296 247 LVLSLPFWSLMMLHYG-SMWGLFFLITA 273
Cdd:cd17328 210 ILSTLGFTAVSFVTGAlAFWAPTFFLRA 237
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
62-170 |
1.08e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 41.11 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 62 RYNWTQSDQALLLGAYFYGYMITSLPAGTLAEMLGARNVAGYSCLVAGILTALTPAAAAWdkYAVFAVRFLIGFLNGVVY 141
Cdd:COG2814 237 VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSL--WLLLLALFLLGFGFGLLF 314
|
90 100
....*....|....*....|....*....
gi 442624296 142 PCCHSLVSKWSPPDEKGKFVASLMGGTFG 170
Cdd:COG2814 315 PLLQALVAELAPPEARGRASGLYNSAFFL 343
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
254-440 |
2.51e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 40.27 E-value: 2.51e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 254 WSLMMLHYGSMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVAD-----WIRRRGWLSVTrmrka 328
Cdd:COG2211 13 LAYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtrWGRRRPWILIG----- 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 329 fclpshILPGVMLIILAYFGRD-------PYVCVAIMTISLGFNgAATASNLANSQDLAPNYA--GTLYGIINCVGTTPG 399
Cdd:COG2211 88 ------AIPLALSFVLLFTAPDlsptgklIYALVTYLLLGLAYT-LVNIPYSALGAELTPDYEerTRLSSWRFAFAGLGG 160
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 442624296 400 IFSPLIVAAFTKN--ENTIDQWHWVFIIGAAAYILPALFFWVF 440
Cdd:COG2211 161 LLASVLPPPLVAAfgGDAALGYRLTALIFAVLGLLAFLLTFFG 203
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
263-440 |
2.61e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 2.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 263 SMWGLFFLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRRGWLSVtrmrkafclpSHILPGVMLI 342
Cdd:pfam07690 8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLI----------GLLLFALGLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 343 ILAYFGRDPYVCVAIMTISLGFNGAATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTKNENtidqWHWV 422
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----WRAA 153
|
170
....*....|....*...
gi 442624296 423 FIIGAAAYILPALFFWVF 440
Cdd:pfam07690 154 FLILAILSLLAAVLLLLP 171
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
130-207 |
3.99e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.56 E-value: 3.99e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442624296 130 RFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVASLMGGTFGTVITWPISGVIIE-NLGWDWAFYIVGIFVLvVVAIWFY 207
Cdd:cd17391 300 RFLLGLATGGLLPAINSLLAKITPKEVAGRIFGYNQSFQYLGNVAGPLLGSAIAaHFGYRAVFVVTALLVL-LNAIWSF 377
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
131-209 |
5.06e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 5.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 131 FLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVAS-LMGGTFGTVITWPISGVIIENLGWDWAFYIVGIFVLVVVAIWFYLV 209
Cdd:cd17489 288 VLYGLGFGLLFPALQALAVDLVPPHRRGAANGTfFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
130-204 |
7.35e-03 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 38.71 E-value: 7.35e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442624296 130 RFLIGFLNGVVYPCCHSLVSKWSPPDEKGKFVASL-MGGTFGTVITWPISGVIIENLGWDWAFYI---VGIFVLVVVAI 204
Cdd:cd17503 91 RILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVgLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLLAPL 169
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
269-440 |
7.61e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.56 E-value: 7.61e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 269 FLITATPKFLSEVLGFNLSSAGFLSSLPHVARLLCAFGFGAVADWIRRRGWLSVTrmrkafclpshILPGVMLIILAYFG 348
Cdd:cd06174 13 GLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLG-----------LLLFALGALLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 349 RDPYVCVAIMTI-SLGFNGAATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTknENTIDQWHWVFIIGA 427
Cdd:cd06174 82 PSFWLLLLGRFLlGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILA--SSLGFGWRAVFLIAA 159
|
170
....*....|...
gi 442624296 428 AAYILPALFFWVF 440
Cdd:cd06174 160 ALALLAAILLLLV 172
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
124-439 |
7.89e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 7.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 124 YAVFAVRFLIGFLNGVVyPCCHSLVSKWSPPDEKGKfVASLMGGTF--GTVITWPISGVIIENLGWDWAFYIVGIF-VLV 200
Cdd:cd17330 88 WLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAK-AFGIISAAFglGFILGPALGGFLSTPYGYALPFLVAAALaLLN 165
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 201 VVAIWFYLvadtpaqhstislkereyiesslgdtlsnkkkwpPYKELVLSLPFwsLMMLHYGSMWGLFFLitatpkFLSE 280
Cdd:cd17330 166 LVLVLFFL----------------------------------PPLRRLLLVYF--LIALAFAGLESVFSL------FLKD 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 281 VLGFNLSSAGFLSSLphvARLLCAFGFGAVADWIRRRGWLsvtrmRKAFCLpSHILPGVMLIILAYFGRDPYVCVAIMTI 360
Cdd:cd17330 204 RFGFSPSQIGLLLAL---VGIAGILAQLLLIPRLAKRLGE-----RKLLRL-GLLLAIIGLLLLPFASSVPLLVLAAAIL 274
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250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442624296 361 SLGFNGAATASNLANSQDLAPNYAGTLYGIINCVGTTPGIFSPLIVAAFTKNENTidqwHWVFIIGAAAYILPALFFWV 439
Cdd:cd17330 275 AFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGP----GVPFLLAAGLLLIALFLLSL 349
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| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
62-208 |
8.17e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.33 E-value: 8.17e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442624296 62 RYNWTQSDQALLLGAYFYGYMITSLP-AGTLAEMLGARNVAGYSCLVAGILTALTPAAaaWDKYAVFAVRFLIGFLNGVV 140
Cdd:cd17330 204 RFGFSPSQIGLLLALVGIAGILAQLLlIPRLAKRLGERKLLRLGLLLAIIGLLLLPFA--SSVPLLVLAAAILAFGTGIV 281
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90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442624296 141 YPCCHSLVSKWSPPDEKGKFVASLMG-GTFGTVITWPISGVIIENLGwDWAFYIVGIFVLVVVAIWFYL 208
Cdd:cd17330 282 FPALSALLSKSVPSKEQGKAQGIIQSlQSLARIIGPLLAGPLYSFLG-PGVPFLLAAGLLLIALFLLSL 349
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