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Conserved domains on  [gi|442622689|ref|NP_001260763|]
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pawn, isoform C [Drosophila melanogaster]

Protein Classification

EGF_CA and EGF_2 domain-containing protein( domain architecture ID 11256704)

EGF_CA and EGF_2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1004-1053 8.96e-09

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 8.96e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 442622689   1004 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLRDpwadqparsGRECQ 1053
Cdd:smart00179    1 DIDECASG--NPCQNGGTCVNTVGSYRCECPPGYTD---------GRNCE 39
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1059-1087 8.56e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 8.56e-05
                           10        20
                   ....*....|....*....|....*....
gi 442622689  1059 VCNNHGTCSYAEDGaqlCTCDSSHYGAQC 1087
Cdd:pfam07974    1 ICSGRGTCVNQCGK---CVCDSGYQGATC 26
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 212-405 2.96e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622689  212 SGSPIRPSPSNTATSATAASATQAPH-SPRQNGNPDIQDIITGIVKLLN-----GNVNVHANTQGIRRPSASRINNRGP- 284
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSpSPAANEPDPHPPPTVPPPERPRddpapGRVSRPRRARRLGRAAQASSPPQRPr 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622689  285 PRISEAQNLPIDYEAQKPGtsmrPPPYPFDRPeRPFITGVPIPeqIVPVRPGFVSNRPPWYRNKPRPPIATSVGGN---- 360
Cdd:PHA03247 2685 RRAARPTVGSLTSLADPPP----PPPTPEPAP-HALVSATPLP--PGPAAARQASPALPAAPAPPAVPAGPATPGGparp 2757

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 442622689  361 -RRPLPQYKPLPAPPVQAPLQPQDPLDRKNEQEKEQNHQEQPQPTD 405
Cdd:PHA03247 2758 aRPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1004-1053 8.96e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 8.96e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 442622689   1004 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLRDpwadqparsGRECQ 1053
Cdd:smart00179    1 DIDECASG--NPCQNGGTCVNTVGSYRCECPPGYTD---------GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1004-1053 1.48e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 1.48e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 442622689 1004 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLrdpwadqparSGRECQ 1053
Cdd:cd00054     1 DIDECASG--NPCQNGGTCVNTVGSYRCSCPPGY----------TGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1004-1036 1.49e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.47  E-value: 1.49e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442622689  1004 DLDECQSPElNDCHSGASCSNTWGSFRCACEAG 1036
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCPDG 32
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1059-1087 8.56e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 8.56e-05
                           10        20
                   ....*....|....*....|....*....
gi 442622689  1059 VCNNHGTCSYAEDGaqlCTCDSSHYGAQC 1087
Cdd:pfam07974    1 ICSGRGTCVNQCGK---CVCDSGYQGATC 26
PHA03247 PHA03247
large tegument protein UL36; Provisional
 212-405 2.96e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622689  212 SGSPIRPSPSNTATSATAASATQAPH-SPRQNGNPDIQDIITGIVKLLN-----GNVNVHANTQGIRRPSASRINNRGP- 284
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSpSPAANEPDPHPPPTVPPPERPRddpapGRVSRPRRARRLGRAAQASSPPQRPr 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622689  285 PRISEAQNLPIDYEAQKPGtsmrPPPYPFDRPeRPFITGVPIPeqIVPVRPGFVSNRPPWYRNKPRPPIATSVGGN---- 360
Cdd:PHA03247 2685 RRAARPTVGSLTSLADPPP----PPPTPEPAP-HALVSATPLP--PGPAAARQASPALPAAPAPPAVPAGPATPGGparp 2757

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 442622689  361 -RRPLPQYKPLPAPPVQAPLQPQDPLDRKNEQEKEQNHQEQPQPTD 405
Cdd:PHA03247 2758 aRPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 284-408 4.26e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 4.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622689   284 PPRISEAQNLPIDYEAQKPGTSMRPPPYPFDRPERPFITGVPIPeqIVPVRPGFVSNRPPWYRNKPRPPIATSVGGnrrP 363
Cdd:pfam03154  431 PPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPP--ITPPSGPPTSTSSAMPGIQPPSSASVSSSG---P 505

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 442622689   364 LPQYKPLPAPPVQAplqPQDPLDRKNEQEKEQNHQEQPQPTDDVV 408
Cdd:pfam03154  506 VPAAVSCPLPPVQI---KEEALDEAEEPESPPPPPRSPSPEPTVV 547
 
Name Accession Description Interval E-value
EGF_CA smart00179
Calcium-binding EGF-like domain;
1004-1053 8.96e-09

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 52.25  E-value: 8.96e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|
gi 442622689   1004 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLRDpwadqparsGRECQ 1053
Cdd:smart00179    1 DIDECASG--NPCQNGGTCVNTVGSYRCECPPGYTD---------GRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1004-1053 1.48e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.48  E-value: 1.48e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 442622689 1004 DLDECQSPelNDCHSGASCSNTWGSFRCACEAGLrdpwadqparSGRECQ 1053
Cdd:cd00054     1 DIDECASG--NPCQNGGTCVNTVGSYRCSCPPGY----------TGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
1004-1036 1.49e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 51.47  E-value: 1.49e-08
                           10        20        30
                   ....*....|....*....|....*....|...
gi 442622689  1004 DLDECQSPElNDCHSGASCSNTWGSFRCACEAG 1036
Cdd:pfam07645    1 DVDECATGT-HNCPANTVCVNTIGSFECRCPDG 32
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 1059-1087 8.56e-05

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 8.56e-05
                           10        20
                   ....*....|....*....|....*....
gi 442622689  1059 VCNNHGTCSYAEDGaqlCTCDSSHYGAQC 1087
Cdd:pfam07974    1 ICSGRGTCVNQCGK---CVCDSGYQGATC 26
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1014-1036 2.93e-04

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 39.50  E-value: 2.93e-04
                           10        20
                   ....*....|....*....|...
gi 442622689  1014 NDCHSGASCSNTWGSFRCACEAG 1036
Cdd:pfam12947    6 GGCHPNATCTNTGGSFTCTCNDG 28
PHA03247 PHA03247
large tegument protein UL36; Provisional
 212-405 2.96e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.23  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622689  212 SGSPIRPSPSNTATSATAASATQAPH-SPRQNGNPDIQDIITGIVKLLN-----GNVNVHANTQGIRRPSASRINNRGP- 284
Cdd:PHA03247 2605 RGDPRGPAPPSPLPPDTHAPDPPPPSpSPAANEPDPHPPPTVPPPERPRddpapGRVSRPRRARRLGRAAQASSPPQRPr 2684

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622689  285 PRISEAQNLPIDYEAQKPGtsmrPPPYPFDRPeRPFITGVPIPeqIVPVRPGFVSNRPPWYRNKPRPPIATSVGGN---- 360
Cdd:PHA03247 2685 RRAARPTVGSLTSLADPPP----PPPTPEPAP-HALVSATPLP--PGPAAARQASPALPAAPAPPAVPAGPATPGGparp 2757

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 442622689  361 -RRPLPQYKPLPAPPVQAPLQPQDPLDRKNEQEKEQNHQEQPQPTD 405
Cdd:PHA03247 2758 aRPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 284-408 4.26e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 4.26e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622689   284 PPRISEAQNLPIDYEAQKPGTSMRPPPYPFDRPERPFITGVPIPeqIVPVRPGFVSNRPPWYRNKPRPPIATSVGGnrrP 363
Cdd:pfam03154  431 PPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPFVPGGPPP--ITPPSGPPTSTSSAMPGIQPPSSASVSSSG---P 505

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 442622689   364 LPQYKPLPAPPVQAplqPQDPLDRKNEQEKEQNHQEQPQPTDDVV 408
Cdd:pfam03154  506 VPAAVSCPLPPVQI---KEEALDEAEEPESPPPPPRSPSPEPTVV 547
EGF smart00181
Epidermal growth factor-like domain;
1007-1036 6.21e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.57  E-value: 6.21e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 442622689   1007 ECQSPelNDCHSGaSCSNTWGSFRCACEAG 1036
Cdd:smart00181    1 ECASG--GPCSNG-TCINTPGSYTCSCPPG 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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