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Conserved domains on  [gi|442622654|ref|NP_001260759|]
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tetraspanin 42Ep, isoform B [Drosophila melanogaster]

Protein Classification

tetraspanin family protein( domain architecture ID 11992915)

tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)

Gene Ontology:  GO:0016020
PubMed:  15763890|11756464|19709882|16024509
SCOP:  4001512

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 91-183 4.27e-16

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


:

Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 71.38  E-value: 4.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654  91 YLQLHHYHSPSLRSPGGAWQQlelaWHGLDRDPELMHQYEASQHCCGYNGADDYKRLHLLVPASCYQAAVNDTAQQIYPS 170
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDE----YYVDDDFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCKGTDGNCGLNLYTE 76

                         90
                 ....*....|...
gi 442622654 171 GCLETLNRSQRYI 183
Cdd:cd03127   77 GCLEKLVDFLRSN 89
Tetraspanin pfam00335
Tetraspanin family;
23-213 5.06e-12

Tetraspanin family;


:

Pssm-ID: 459767  Cd Length: 183  Bit Score: 62.72  E-value: 5.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654   23 GIGVMSGAGLGLQMAEPNTPEHTYFVKSLVLGGSICMIVMFGCYGMVANLLCVNLIFTMFILIALAAE----YLQLHHYH 98
Cdd:pfam00335  21 GVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAElaagILAFVYRD 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654   99 SPSLRSPGGAWQQLELAWHGLDR----DPELMHQYEASQHCCGyngaddykrlhllvpascyqaavndtaqqiypsGCLE 174
Cdd:pfam00335 101 KLSGLLSNWLKKSLEDGYRDWLDlyscLNSALDSLQSEFGCCG---------------------------------GCKE 147

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 442622654  175 TLnrsQRYIQHRDKLYMWAIVGLEIFILLqTVALSVLLF 213
Cdd:pfam00335 148 KL---LEWLRKNLKIIGAGVIALGVIQLL-GIILACCLC 182
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 91-183 4.27e-16

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 71.38  E-value: 4.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654  91 YLQLHHYHSPSLRSPGGAWQQlelaWHGLDRDPELMHQYEASQHCCGYNGADDYKRLHLLVPASCYQAAVNDTAQQIYPS 170
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDE----YYVDDDFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCKGTDGNCGLNLYTE 76

                         90
                 ....*....|...
gi 442622654 171 GCLETLNRSQRYI 183
Cdd:cd03127   77 GCLEKLVDFLRSN 89
Tetraspanin pfam00335
Tetraspanin family;
23-213 5.06e-12

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 62.72  E-value: 5.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654   23 GIGVMSGAGLGLQMAEPNTPEHTYFVKSLVLGGSICMIVMFGCYGMVANLLCVNLIFTMFILIALAAE----YLQLHHYH 98
Cdd:pfam00335  21 GVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAElaagILAFVYRD 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654   99 SPSLRSPGGAWQQLELAWHGLDR----DPELMHQYEASQHCCGyngaddykrlhllvpascyqaavndtaqqiypsGCLE 174
Cdd:pfam00335 101 KLSGLLSNWLKKSLEDGYRDWLDlyscLNSALDSLQSEFGCCG---------------------------------GCKE 147

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 442622654  175 TLnrsQRYIQHRDKLYMWAIVGLEIFILLqTVALSVLLF 213
Cdd:pfam00335 148 KL---LEWLRKNLKIIGAGVIALGVIQLL-GIILACCLC 182
 
Name Accession Description Interval E-value
tetraspanin_LEL cd03127
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ...
 91-183 4.27e-16

Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins.


Pssm-ID: 239401 [Multi-domain]  Cd Length: 90  Bit Score: 71.38  E-value: 4.27e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654  91 YLQLHHYHSPSLRSPGGAWQQlelaWHGLDRDPELMHQYEASQHCCGYNGADDYKRLHLLVPASCYQAAVNDTAQQIYPS 170
Cdd:cd03127    1 FVYRDQLESLVSDTLNDAWDE----YYVDDDFQEAMDALQSTFECCGVNGPTDYLDLRLLVPSSCCKGTDGNCGLNLYTE 76

                         90
                 ....*....|...
gi 442622654 171 GCLETLNRSQRYI 183
Cdd:cd03127   77 GCLEKLVDFLRSN 89
Tetraspanin pfam00335
Tetraspanin family;
23-213 5.06e-12

Tetraspanin family;


Pssm-ID: 459767  Cd Length: 183  Bit Score: 62.72  E-value: 5.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654   23 GIGVMSGAGLGLQMAEPNTPEHTYFVKSLVLGGSICMIVMFGCYGMVANLLCVNLIFTMFILIALAAE----YLQLHHYH 98
Cdd:pfam00335  21 GVGVWLLSAFSLLLLGLSEASAYIPILLIVLGAVIFLVGFLGCCGALKENRCLLLTYFVLLLLLFLAElaagILAFVYRD 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442622654   99 SPSLRSPGGAWQQLELAWHGLDR----DPELMHQYEASQHCCGyngaddykrlhllvpascyqaavndtaqqiypsGCLE 174
Cdd:pfam00335 101 KLSGLLSNWLKKSLEDGYRDWLDlyscLNSALDSLQSEFGCCG---------------------------------GCKE 147

                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 442622654  175 TLnrsQRYIQHRDKLYMWAIVGLEIFILLqTVALSVLLF 213
Cdd:pfam00335 148 KL---LEWLRKNLKIIGAGVIALGVIQLL-GIILACCLC 182
CD37_CD82_like_LEL cd03160
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. ...
 135-176 3.76e-03

Tetraspanin, extracellular domain or large extracellular loop (LEL), CD37_CD82_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD37 is a leukocyte-specific protein, and its restricted expression pattern suggests a role in the immune system. A regulatory role in T-cell proliferation has been suggested. CD82 is a metastasis suppressor implicated in biological processes ranging from fusion, adhesion, and migration to apoptosis and alterations of cell morphology.


Pssm-ID: 239413  Cd Length: 117  Bit Score: 36.21  E-value: 3.76e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442622654 135 CCGYNGADDYKRLHL-------LVPASCY-QAAVND--------------TAQQIYPSGCLETL 176
Cdd:cd03160   45 CCGWTGPQDWTDNSLiknssepLYPCSCCnSSATADsprpskgfceapasLDWPVYQEGCMEKL 108
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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