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Conserved domains on  [gi|442628761|ref|NP_001260670|]
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uncharacterized protein Dmel_CG8671, isoform E [Drosophila melanogaster]

Protein Classification

N-terminal C2 domain-containing protein( domain architecture ID 10563649)

N-terminal C2 (NT-C2) domain-containing protein may be involved in the linking of actin/microfilament-binding adaptors to the membrane and may act as a link that tethers endosomal vesicles to the cytoskeleton in course of their intracellular trafficking

PubMed:  20713135

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 22-161 3.32e-29

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


:

Pssm-ID: 463058  Cd Length: 143  Bit Score: 113.57  E-value: 3.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628761   22 FNVEVQLQDLVEVALVNEVLFAKIRLLDGGSFQEYSSREEVRNHRVEWNRSFEFPCKMSANASTGVLDPCHLRISIRKEM 101
Cdd:pfam10358   7 FQFVLTIHELQNLPLVGGELFVKWRRGDKKGSSGTTEKALVNNGRAIFNEEFSIPVTLFLDKKGGKYEEKLLEFSVYKVT 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442628761  102 KGGRSyYKLGFIDLNLAEFAGAGL--TSRRFLLEGYDSrhrlDNSMLRVSIKMHMLSGDILF 161
Cdd:pfam10358  87 KKGKK-KVLGKASIDLAEYANLKKkpTTVRFLLKKSSK----KNATLSLSIQVLPLGEDPND 143
 
Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 22-161 3.32e-29

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


Pssm-ID: 463058  Cd Length: 143  Bit Score: 113.57  E-value: 3.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628761   22 FNVEVQLQDLVEVALVNEVLFAKIRLLDGGSFQEYSSREEVRNHRVEWNRSFEFPCKMSANASTGVLDPCHLRISIRKEM 101
Cdd:pfam10358   7 FQFVLTIHELQNLPLVGGELFVKWRRGDKKGSSGTTEKALVNNGRAIFNEEFSIPVTLFLDKKGGKYEEKLLEFSVYKVT 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442628761  102 KGGRSyYKLGFIDLNLAEFAGAGL--TSRRFLLEGYDSrhrlDNSMLRVSIKMHMLSGDILF 161
Cdd:pfam10358  87 KKGKK-KVLGKASIDLAEYANLKKkpTTVRFLLKKSSK----KNATLSLSIQVLPLGEDPND 143
 
Name Accession Description Interval E-value
NT-C2 pfam10358
N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally ...
 22-161 3.32e-29

N-terminal C2 in EEIG1 and EHBP1 proteins; This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.


Pssm-ID: 463058  Cd Length: 143  Bit Score: 113.57  E-value: 3.32e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628761   22 FNVEVQLQDLVEVALVNEVLFAKIRLLDGGSFQEYSSREEVRNHRVEWNRSFEFPCKMSANASTGVLDPCHLRISIRKEM 101
Cdd:pfam10358   7 FQFVLTIHELQNLPLVGGELFVKWRRGDKKGSSGTTEKALVNNGRAIFNEEFSIPVTLFLDKKGGKYEEKLLEFSVYKVT 86

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442628761  102 KGGRSyYKLGFIDLNLAEFAGAGL--TSRRFLLEGYDSrhrlDNSMLRVSIKMHMLSGDILF 161
Cdd:pfam10358  87 KKGKK-KVLGKASIDLAEYANLKKkpTTVRFLLKKSSK----KNATLSLSIQVLPLGEDPND 143
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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