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bicaudal D, isoform D [Drosophila melanogaster]
Protein Classification
List of domain hits
Name
Accession
Description
Interval
E-value
BicD super family
cl25513 Microtubule-associated protein Bicaudal-D; BicD proteins consist of three coiled-coiled ...
83-741
3.69e-124
Microtubule-associated protein Bicaudal-D; BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta pfam05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells.
pfam09730 :Pssm-ID: 462863 [Multi-domain]
Cd Length: 717
Bit Score: 389.22
E-value: 3.69e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 83 T S Q K VTNKT G IEQ E DA LL N ESA AR E TSLNLQ I FD L E NELKQ L R HE L ERVRN E RD R MLQENSDFGRDKSDS E AD R L R LKS E 162
Cdd:pfam09730 5 S S H K KVAAD G ESR E ES LL Q ESA SK E AYYAQR I LE L Q NELKQ A R AV L SNTQA E NE R LASLSQELKEECECV E LQ R G R MRD E 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 163 L K DL K F RE T R M L SE YSELEEENISLQKQVS S L RSS QVEFEG A KHEI R R LT EE V ELLN Q Q VD E LAN L KK IAE K Q ME EALET 242
Cdd:pfam09730 85 I K EY K V RE A R L L QD YSELEEENISLQKQVS V L KQN QVEFEG L KHEI T R KE EE T ELLN S Q LE E AIR L RE IAE R Q LD EALET 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 243 L QG ERE A K YA L K KEL DGHLNRESMYHI S N L AY S I ----------------- RSNME D NAS N NSD G EEENLALK R LEADLS 305
Cdd:pfam09730 165 L KT ERE Q K NS L R KEL SHYMTLNDFDYV S H L SI S L dglkfsedegagtepnn DGEAM D GGE N GGG G LKNSGLDN R TSTPRK 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 306 T E LKS P - DGTKC DL F SE IHLN E LK KL EK QL ESM E S EK TH L TAN L R E A Q TS L DKSQNE L QNFMSRLAL L AAHVD A LVQ L -- 382
Cdd:pfam09730 245 S E VFP P a PSLVS DL L SE LNIS E IQ KL KQ QL IQV E R EK VS L LST L Q E S Q KQ L EQAKGA L SEQQEKVNR L TENLE A MRG L qa 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 383 - K KQI D VKEQG K EGGQKK D ELEQQL ----- RA L ISQ Y ANWFTLSAKEIDG LK TDI A ELQKGL - N Y TDAT T TLRN E VTN L K 455
Cdd:pfam09730 325 s K ERQ D ALDSE K DRDSHE D GDYYEV dingp EI L ECK Y RVAVEEAGELREE LK ALK A RYNTLE e R Y KEEK T RWEA E AQD L A 404
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 456 N K LLAT E QK S ------- LD L QSDVQTLTHISQNAGQ SL GS A RST LV AL S DD LA Q LYH L VC TV N G ETP T RV L LD H ---- KT 524
Cdd:pfam09730 405 E K IRQL E KA S hqdqeri AH L EKELGKTRKVAGESEG SL SV A QDE LV TF S EE LA N LYH H VC MC N N ETP N RV M LD Y yreg AG 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 525 DDMSFENDSLTAIQ S QFKSDVFIAKPQIVEDLQG ------------------ LADSVE I KKY V DTVS DQIK Y L KT AV EH T 586
Cdd:pfam09730 485 ARARKSHQEPRGLR S PRLLTRGLFMGEVGTADTT snspspcsscpgsptsdf RREPMN I YNL V AIIR DQIK H L QV AV DR T 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 587 IDMNKHKIRSEG gda L EKVNTEEM E E L Q E Q I V KLKSLLS V KREQI G TLR N VLK S NKQTAEVAL T NLKSKYENEK II V SD T 666
Cdd:pfam09730 565 TELSRQRGAALE --- L STESDKDK E A L M E E I L KLKSLLS T KREQI A TLR T VLK A NKQTAEVAL A NLKSKYENEK AM V TE T 641
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628180 667 M S KLRNEL RL LKEDAATFSSLRAMFA A RC E EYVTQ V D DLN RQL E AAE E EKKTLN Q LLR L A V QQKLALTQRLE EM E 741
Cdd:pfam09730 642 M M KLRNEL KA LKEDAATFSSLRAMFA T RC D EYVTQ L D EMQ RQL A AAE D EKKTLN S LLR M A I QQKLALTQRLE DL E 716
SMC_prok_B super family
cl37069 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
10-138
6.86e-03
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
TIGR02168 :Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 40.04
E-value: 6.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 10 S ADQSVQD L QMEV E R L TR EL DQVSSAS A QSAQYGLS L LE E KSA L QQKCE ELE TLYDNT R H EL DITQ E A L TKFQ tsqkv TN 89
Cdd:TIGR02168 856 S LAAEIEE L EELI E E L ES EL EALLNER A SLEEALAL L RS E LEE L SEELR ELE SKRSEL R R EL EELR E K L AQLE ----- LR 930
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 442628180 90 KT G I E QEDAL L N E SAAR E T SL N L QIF ----- DL E NELKQL R HE L E R VR N ERDRM 138
Cdd:TIGR02168 931 LE G L E VRIDN L Q E RLSE E Y SL T L EEA ealen KI E DDEEEA R RR L K R LE N KIKEL 984
Name
Accession
Description
Interval
E-value
BicD
pfam09730 Microtubule-associated protein Bicaudal-D; BicD proteins consist of three coiled-coiled ...
83-741
3.69e-124
Microtubule-associated protein Bicaudal-D; BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta pfam05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells.
Pssm-ID: 462863 [Multi-domain]
Cd Length: 717
Bit Score: 389.22
E-value: 3.69e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 83 T S Q K VTNKT G IEQ E DA LL N ESA AR E TSLNLQ I FD L E NELKQ L R HE L ERVRN E RD R MLQENSDFGRDKSDS E AD R L R LKS E 162
Cdd:pfam09730 5 S S H K KVAAD G ESR E ES LL Q ESA SK E AYYAQR I LE L Q NELKQ A R AV L SNTQA E NE R LASLSQELKEECECV E LQ R G R MRD E 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 163 L K DL K F RE T R M L SE YSELEEENISLQKQVS S L RSS QVEFEG A KHEI R R LT EE V ELLN Q Q VD E LAN L KK IAE K Q ME EALET 242
Cdd:pfam09730 85 I K EY K V RE A R L L QD YSELEEENISLQKQVS V L KQN QVEFEG L KHEI T R KE EE T ELLN S Q LE E AIR L RE IAE R Q LD EALET 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 243 L QG ERE A K YA L K KEL DGHLNRESMYHI S N L AY S I ----------------- RSNME D NAS N NSD G EEENLALK R LEADLS 305
Cdd:pfam09730 165 L KT ERE Q K NS L R KEL SHYMTLNDFDYV S H L SI S L dglkfsedegagtepnn DGEAM D GGE N GGG G LKNSGLDN R TSTPRK 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 306 T E LKS P - DGTKC DL F SE IHLN E LK KL EK QL ESM E S EK TH L TAN L R E A Q TS L DKSQNE L QNFMSRLAL L AAHVD A LVQ L -- 382
Cdd:pfam09730 245 S E VFP P a PSLVS DL L SE LNIS E IQ KL KQ QL IQV E R EK VS L LST L Q E S Q KQ L EQAKGA L SEQQEKVNR L TENLE A MRG L qa 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 383 - K KQI D VKEQG K EGGQKK D ELEQQL ----- RA L ISQ Y ANWFTLSAKEIDG LK TDI A ELQKGL - N Y TDAT T TLRN E VTN L K 455
Cdd:pfam09730 325 s K ERQ D ALDSE K DRDSHE D GDYYEV dingp EI L ECK Y RVAVEEAGELREE LK ALK A RYNTLE e R Y KEEK T RWEA E AQD L A 404
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 456 N K LLAT E QK S ------- LD L QSDVQTLTHISQNAGQ SL GS A RST LV AL S DD LA Q LYH L VC TV N G ETP T RV L LD H ---- KT 524
Cdd:pfam09730 405 E K IRQL E KA S hqdqeri AH L EKELGKTRKVAGESEG SL SV A QDE LV TF S EE LA N LYH H VC MC N N ETP N RV M LD Y yreg AG 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 525 DDMSFENDSLTAIQ S QFKSDVFIAKPQIVEDLQG ------------------ LADSVE I KKY V DTVS DQIK Y L KT AV EH T 586
Cdd:pfam09730 485 ARARKSHQEPRGLR S PRLLTRGLFMGEVGTADTT snspspcsscpgsptsdf RREPMN I YNL V AIIR DQIK H L QV AV DR T 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 587 IDMNKHKIRSEG gda L EKVNTEEM E E L Q E Q I V KLKSLLS V KREQI G TLR N VLK S NKQTAEVAL T NLKSKYENEK II V SD T 666
Cdd:pfam09730 565 TELSRQRGAALE --- L STESDKDK E A L M E E I L KLKSLLS T KREQI A TLR T VLK A NKQTAEVAL A NLKSKYENEK AM V TE T 641
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628180 667 M S KLRNEL RL LKEDAATFSSLRAMFA A RC E EYVTQ V D DLN RQL E AAE E EKKTLN Q LLR L A V QQKLALTQRLE EM E 741
Cdd:pfam09730 642 M M KLRNEL KA LKEDAATFSSLRAMFA T RC D EYVTQ L D EMQ RQL A AAE D EKKTLN S LLR M A I QQKLALTQRLE DL E 716
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
12-747
2.45e-10
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 64.31
E-value: 2.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 12 D Q SV Q D L QMEVER L T R E L DQVSSASAQSAQYGLS L L EE KSA L QQ K C EEL ETLYDNTRH EL DITQEA L TKF qtsqkvtn KT 91
Cdd:TIGR02168 301 E Q QK Q I L RERLAN L E R Q L EELEAQLEELESKLDE L A EE LAE L EE K L EEL KEELESLEA EL EELEAE L EEL -------- ES 372
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 92 GI E QEDAL L NESAARETS L N LQI FD L E NE LKQ L RHE LER VRNE R D R ML QE NSDFGRDKSDS E ADR L RLKS E LKD lkfret 171
Cdd:TIGR02168 373 RL E ELEEQ L ETLRSKVAQ L E LQI AS L N NE IER L EAR LER LEDR R E R LQ QE IEELLKKLEEA E LKE L QAEL E ELE ------ 446
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 172 rmlseyseleeen IS L QKQVSS L RSSQVEF E GAKH E IRRLTEEVELLNQQVDE L ANLKKIA E KQM E EALETLQ G EREAKY 251
Cdd:TIGR02168 447 ------------- EE L EELQEE L ERLEEAL E ELRE E LEEAEQALDAAERELAQ L QARLDSL E RLQ E NLEGFSE G VKALLK 513
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 252 A l KKE L D G H L NR ------- ESM Y HISNL A Y s IRSNMEDNASN N SDGEEENL A L krleadlste LK SPDGTKCDLFSEIHL 324
Cdd:TIGR02168 514 N - QSG L S G I L GV lselisv DEG Y EAAIE A A - LGGRLQAVVVE N LNAAKKAI A F ---------- LK QNELGRVTFLPLDSI 581
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 325 NELKKLEKQL E SMESEKTH L TA n LREAQTSLD K SQNE L QNFMSRLALLAAHVD AL VQL KK -------------------- 384
Cdd:TIGR02168 582 KGTEIQGNDR E ILKNIEGF L GV - AKDLVKFDP K LRKA L SYLLGGVLVVDDLDN AL ELA KK lrpgyrivtldgdlvrpggv 660
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 385 -- QIDV K EQGKEGGQKK -- D ELE QQLRA L ISQY A N wftl SA K EIDG L KTDIA EL Q kglnyt DATTT LR N E VTN L KNKLL A 460
Cdd:TIGR02168 661 it GGSA K TNSSILERRR ei E ELE EKIEE L EEKI A E ---- LE K ALAE L RKELE EL E ------ EELEQ LR K E LEE L SRQIS A 730
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 461 TEQKSLD L QSD V QT L THISQNAGQS L GSARSTLVA L SDD L AQLYHLVCTVNG E tpt RVL L DHKTDDMSF E NDS L TAIQSQ 540
Cdd:TIGR02168 731 LRKDLAR L EAE V EQ L EERIAQLSKE L TELEAEIEE L EER L EEAEEELAEAEA E --- IEE L EAQIEQLKE E LKA L REALDE 807
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 541 FKSDVFIAKPQIVEDLQG L ADSVEIKKYVDTVSDQIKYLKTAVEHT I DMNKHK I RS -- E GGDA LE --- KVNTE E MEE L Q E 615
Cdd:TIGR02168 808 LRAELTLLNEEAANLRER L ESLERRIAATERRLEDLEEQIEELSED I ESLAAE I EE le E LIEE LE sel EALLN E RAS L E E 887
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 616 QIVK L K S L L SVKR E QIGT L RNVLKSNKQTA E v A L TNLKSKY E NE ---- KIIVSDTMSK L RN E LR L LK E D A ATFSSLRAMF 691
Cdd:TIGR02168 888 ALAL L R S E L EELS E ELRE L ESKRSELRREL E - E L REKLAQL E LR legl EVRIDNLQER L SE E YS L TL E E A EALENKIEDD 966
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628180 692 AARCEE yvt QVDD L NRQLE ------- AA E EE KKT L NQLLRLAVQ QK LA LT Q --- R LEE M -- E M DRE M R 747
Cdd:TIGR02168 967 EEEARR --- RLKR L ENKIK elgpvnl AA I EE YEE L KERYDFLTA QK ED LT E ake T LEE A ie E I DRE A R 1031
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
11-266
3.30e-09
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 60.72
E-value: 3.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 11 ADQSVQD L QM E V E R L TR EL DQVSSASAQSAQYGLS L LE E KSAL Q QKCE EL ETLYDNTRHELDITQ E AL t KFQTSQKVTNK 90
Cdd:COG1196 244 LEAELEE L EA E L E E L EA EL AELEAELEELRLELEE L EL E LEEA Q AEEY EL LAELARLEQDIARLE E RR - RELEERLEELE 322
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 91 TGIEQEDAL L N E SAARETS L NLQIFDL E N EL KQLRH EL ERVRNERDRMLQ E NSDFGRDKSDSEADR L RLKSELKD L KFRE 170
Cdd:COG1196 323 EELAELEEE L E E LEEELEE L EEELEEA E E EL EEAEA EL AEAEEALLEAEA E LAEAEEELEELAEEL L EALRAAAE L AAQL 402
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 171 TRMLSEYSE L E E ENIS L QKQVSS L RSSQV E F E GAKH E IRRLT EE VE lln QQVD EL ANLKKIAEKQME E A LE TLQGERE A K 250
Cdd:COG1196 403 EELEEAEEA L L E RLER L EEELEE L EEALA E L E EEEE E EEEAL EE AA --- EEEA EL EEEEEALLELLA E L LE EAALLEA A L 479
250
....*....|....*.
gi 442628180 251 YA L KK EL DGHLN R ESM 266
Cdd:COG1196 480 AE L LE EL AEAAA R LLL 495
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
10-138
6.86e-03
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 40.04
E-value: 6.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 10 S ADQSVQD L QMEV E R L TR EL DQVSSAS A QSAQYGLS L LE E KSA L QQKCE ELE TLYDNT R H EL DITQ E A L TKFQ tsqkv TN 89
Cdd:TIGR02168 856 S LAAEIEE L EELI E E L ES EL EALLNER A SLEEALAL L RS E LEE L SEELR ELE SKRSEL R R EL EELR E K L AQLE ----- LR 930
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 442628180 90 KT G I E QEDAL L N E SAAR E T SL N L QIF ----- DL E NELKQL R HE L E R VR N ERDRM 138
Cdd:TIGR02168 931 LE G L E VRIDN L Q E RLSE E Y SL T L EEA ealen KI E DDEEEA R RR L K R LE N KIKEL 984
PRK05771
PRK05771 V-type ATP synthase subunit I; Validated
185-384
8.13e-03
V-type ATP synthase subunit I; Validated
Pssm-ID: 235600 [Multi-domain]
Cd Length: 646
Bit Score: 39.53
E-value: 8.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 185 IS L QKQVSS LRS S q VEFEGAKH E IRRLTEEVE L LNQQV D ELAN L K KI AE -- K QM EE ALET L QG E REAKYALKKE L ----- 257
Cdd:PRK05771 53 TK L SEALDK LRS Y - LPKLNPLR E EKKKVSVKS L EELIK D VEEE L E KI EK ei K EL EE EISE L EN E IKELEQEIER L epwgn 131
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 258 ---- DGH L NRESMYHI sn LAYSIRSNMEDNASNN SD ------- GEEEN ------ LA LK R L EADLST ELK SPDGTKCD L FS 320
Cdd:PRK05771 132 fdld LSL L LGFKYVSV -- FVGTVPEDKLEELKLE SD venveyi STDKG yvyvvv VV LK E L SDEVEE ELK KLGFERLE L EE 209
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628180 321 E IHLN E - LKKLEKQ LE SM E S E KTH L TAN L R E aqt SLD K SQN EL QNFMSR L ALLAAHVD AL VQLK K 384
Cdd:PRK05771 210 E GTPS E l IREIKEE LE EI E K E RES L LEE L K E --- LAK K YLE EL LALYEY L EIELERAE AL SKFL K 271
Name
Accession
Description
Interval
E-value
BicD
pfam09730 Microtubule-associated protein Bicaudal-D; BicD proteins consist of three coiled-coiled ...
83-741
3.69e-124
Microtubule-associated protein Bicaudal-D; BicD proteins consist of three coiled-coiled domains and are involved in dynein-mediated minus end-directed transport from the Golgi apparatus to the endoplasmic reticulum (ER). For full functioning they bind with GSK-3beta pfam05350 to maintain the anchoring of microtubules to the centromere. It appears that amino-acid residues 437-617 of BicD and the kinase activity of GSK-3 are necessary for the formation of a complex between BicD and GSK-3beta in intact cells.
Pssm-ID: 462863 [Multi-domain]
Cd Length: 717
Bit Score: 389.22
E-value: 3.69e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 83 T S Q K VTNKT G IEQ E DA LL N ESA AR E TSLNLQ I FD L E NELKQ L R HE L ERVRN E RD R MLQENSDFGRDKSDS E AD R L R LKS E 162
Cdd:pfam09730 5 S S H K KVAAD G ESR E ES LL Q ESA SK E AYYAQR I LE L Q NELKQ A R AV L SNTQA E NE R LASLSQELKEECECV E LQ R G R MRD E 84
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 163 L K DL K F RE T R M L SE YSELEEENISLQKQVS S L RSS QVEFEG A KHEI R R LT EE V ELLN Q Q VD E LAN L KK IAE K Q ME EALET 242
Cdd:pfam09730 85 I K EY K V RE A R L L QD YSELEEENISLQKQVS V L KQN QVEFEG L KHEI T R KE EE T ELLN S Q LE E AIR L RE IAE R Q LD EALET 164
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 243 L QG ERE A K YA L K KEL DGHLNRESMYHI S N L AY S I ----------------- RSNME D NAS N NSD G EEENLALK R LEADLS 305
Cdd:pfam09730 165 L KT ERE Q K NS L R KEL SHYMTLNDFDYV S H L SI S L dglkfsedegagtepnn DGEAM D GGE N GGG G LKNSGLDN R TSTPRK 244
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 306 T E LKS P - DGTKC DL F SE IHLN E LK KL EK QL ESM E S EK TH L TAN L R E A Q TS L DKSQNE L QNFMSRLAL L AAHVD A LVQ L -- 382
Cdd:pfam09730 245 S E VFP P a PSLVS DL L SE LNIS E IQ KL KQ QL IQV E R EK VS L LST L Q E S Q KQ L EQAKGA L SEQQEKVNR L TENLE A MRG L qa 324
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 383 - K KQI D VKEQG K EGGQKK D ELEQQL ----- RA L ISQ Y ANWFTLSAKEIDG LK TDI A ELQKGL - N Y TDAT T TLRN E VTN L K 455
Cdd:pfam09730 325 s K ERQ D ALDSE K DRDSHE D GDYYEV dingp EI L ECK Y RVAVEEAGELREE LK ALK A RYNTLE e R Y KEEK T RWEA E AQD L A 404
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 456 N K LLAT E QK S ------- LD L QSDVQTLTHISQNAGQ SL GS A RST LV AL S DD LA Q LYH L VC TV N G ETP T RV L LD H ---- KT 524
Cdd:pfam09730 405 E K IRQL E KA S hqdqeri AH L EKELGKTRKVAGESEG SL SV A QDE LV TF S EE LA N LYH H VC MC N N ETP N RV M LD Y yreg AG 484
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 525 DDMSFENDSLTAIQ S QFKSDVFIAKPQIVEDLQG ------------------ LADSVE I KKY V DTVS DQIK Y L KT AV EH T 586
Cdd:pfam09730 485 ARARKSHQEPRGLR S PRLLTRGLFMGEVGTADTT snspspcsscpgsptsdf RREPMN I YNL V AIIR DQIK H L QV AV DR T 564
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 587 IDMNKHKIRSEG gda L EKVNTEEM E E L Q E Q I V KLKSLLS V KREQI G TLR N VLK S NKQTAEVAL T NLKSKYENEK II V SD T 666
Cdd:pfam09730 565 TELSRQRGAALE --- L STESDKDK E A L M E E I L KLKSLLS T KREQI A TLR T VLK A NKQTAEVAL A NLKSKYENEK AM V TE T 641
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628180 667 M S KLRNEL RL LKEDAATFSSLRAMFA A RC E EYVTQ V D DLN RQL E AAE E EKKTLN Q LLR L A V QQKLALTQRLE EM E 741
Cdd:pfam09730 642 M M KLRNEL KA LKEDAATFSSLRAMFA T RC D EYVTQ L D EMQ RQL A AAE D EKKTLN S LLR M A I QQKLALTQRLE DL E 716
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
12-747
2.45e-10
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 64.31
E-value: 2.45e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 12 D Q SV Q D L QMEVER L T R E L DQVSSASAQSAQYGLS L L EE KSA L QQ K C EEL ETLYDNTRH EL DITQEA L TKF qtsqkvtn KT 91
Cdd:TIGR02168 301 E Q QK Q I L RERLAN L E R Q L EELEAQLEELESKLDE L A EE LAE L EE K L EEL KEELESLEA EL EELEAE L EEL -------- ES 372
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 92 GI E QEDAL L NESAARETS L N LQI FD L E NE LKQ L RHE LER VRNE R D R ML QE NSDFGRDKSDS E ADR L RLKS E LKD lkfret 171
Cdd:TIGR02168 373 RL E ELEEQ L ETLRSKVAQ L E LQI AS L N NE IER L EAR LER LEDR R E R LQ QE IEELLKKLEEA E LKE L QAEL E ELE ------ 446
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 172 rmlseyseleeen IS L QKQVSS L RSSQVEF E GAKH E IRRLTEEVELLNQQVDE L ANLKKIA E KQM E EALETLQ G EREAKY 251
Cdd:TIGR02168 447 ------------- EE L EELQEE L ERLEEAL E ELRE E LEEAEQALDAAERELAQ L QARLDSL E RLQ E NLEGFSE G VKALLK 513
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 252 A l KKE L D G H L NR ------- ESM Y HISNL A Y s IRSNMEDNASN N SDGEEENL A L krleadlste LK SPDGTKCDLFSEIHL 324
Cdd:TIGR02168 514 N - QSG L S G I L GV lselisv DEG Y EAAIE A A - LGGRLQAVVVE N LNAAKKAI A F ---------- LK QNELGRVTFLPLDSI 581
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 325 NELKKLEKQL E SMESEKTH L TA n LREAQTSLD K SQNE L QNFMSRLALLAAHVD AL VQL KK -------------------- 384
Cdd:TIGR02168 582 KGTEIQGNDR E ILKNIEGF L GV - AKDLVKFDP K LRKA L SYLLGGVLVVDDLDN AL ELA KK lrpgyrivtldgdlvrpggv 660
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 385 -- QIDV K EQGKEGGQKK -- D ELE QQLRA L ISQY A N wftl SA K EIDG L KTDIA EL Q kglnyt DATTT LR N E VTN L KNKLL A 460
Cdd:TIGR02168 661 it GGSA K TNSSILERRR ei E ELE EKIEE L EEKI A E ---- LE K ALAE L RKELE EL E ------ EELEQ LR K E LEE L SRQIS A 730
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 461 TEQKSLD L QSD V QT L THISQNAGQS L GSARSTLVA L SDD L AQLYHLVCTVNG E tpt RVL L DHKTDDMSF E NDS L TAIQSQ 540
Cdd:TIGR02168 731 LRKDLAR L EAE V EQ L EERIAQLSKE L TELEAEIEE L EER L EEAEEELAEAEA E --- IEE L EAQIEQLKE E LKA L REALDE 807
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 541 FKSDVFIAKPQIVEDLQG L ADSVEIKKYVDTVSDQIKYLKTAVEHT I DMNKHK I RS -- E GGDA LE --- KVNTE E MEE L Q E 615
Cdd:TIGR02168 808 LRAELTLLNEEAANLRER L ESLERRIAATERRLEDLEEQIEELSED I ESLAAE I EE le E LIEE LE sel EALLN E RAS L E E 887
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 616 QIVK L K S L L SVKR E QIGT L RNVLKSNKQTA E v A L TNLKSKY E NE ---- KIIVSDTMSK L RN E LR L LK E D A ATFSSLRAMF 691
Cdd:TIGR02168 888 ALAL L R S E L EELS E ELRE L ESKRSELRREL E - E L REKLAQL E LR legl EVRIDNLQER L SE E YS L TL E E A EALENKIEDD 966
730 740 750 760 770 780
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 442628180 692 AARCEE yvt QVDD L NRQLE ------- AA E EE KKT L NQLLRLAVQ QK LA LT Q --- R LEE M -- E M DRE M R 747
Cdd:TIGR02168 967 EEEARR --- RLKR L ENKIK elgpvnl AA I EE YEE L KERYDFLTA QK ED LT E ake T LEE A ie E I DRE A R 1031
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
11-266
3.30e-09
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 60.72
E-value: 3.30e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 11 ADQSVQD L QM E V E R L TR EL DQVSSASAQSAQYGLS L LE E KSAL Q QKCE EL ETLYDNTRHELDITQ E AL t KFQTSQKVTNK 90
Cdd:COG1196 244 LEAELEE L EA E L E E L EA EL AELEAELEELRLELEE L EL E LEEA Q AEEY EL LAELARLEQDIARLE E RR - RELEERLEELE 322
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 91 TGIEQEDAL L N E SAARETS L NLQIFDL E N EL KQLRH EL ERVRNERDRMLQ E NSDFGRDKSDSEADR L RLKSELKD L KFRE 170
Cdd:COG1196 323 EELAELEEE L E E LEEELEE L EEELEEA E E EL EEAEA EL AEAEEALLEAEA E LAEAEEELEELAEEL L EALRAAAE L AAQL 402
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 171 TRMLSEYSE L E E ENIS L QKQVSS L RSSQV E F E GAKH E IRRLT EE VE lln QQVD EL ANLKKIAEKQME E A LE TLQGERE A K 250
Cdd:COG1196 403 EELEEAEEA L L E RLER L EEELEE L EEALA E L E EEEE E EEEAL EE AA --- EEEA EL EEEEEALLELLA E L LE EAALLEA A L 479
250
....*....|....*.
gi 442628180 251 YA L KK EL DGHLN R ESM 266
Cdd:COG1196 480 AE L LE EL AEAAA R LLL 495
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
90-372
1.05e-07
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 55.83
E-value: 1.05e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 90 KTGI E QEDAL L N E SAARETS L NLQIFD LE NE L KQ LR H E LERVRN E RDRMLQ E NSDFGRDK S DS E ADRLR L KSE L KD L K fr 169
Cdd:TIGR02168 238 REEL E ELQEE L K E AEEELEE L TAELQE LE EK L EE LR L E VSELEE E IEELQK E LYALANEI S RL E QQKQI L RER L AN L E -- 315
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 170 etrmlsey SE LEE ENIS L QKQV S S L RSSQV E FEGAKHEIRR L T EE V E L L NQQVD EL ANLKKIA E KQM EE AL E T L QGE R EA 249
Cdd:TIGR02168 316 -------- RQ LEE LEAQ L EELE S K L DELAE E LAELEEKLEE L K EE L E S L EAELE EL EAELEEL E SRL EE LE E Q L ETL R SK 387
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 250 KYA L KKELDGHL N RES myhisnlay SIRSNM E DNASNNSDGEE E N lalkrle AD L STE L KSPDGTKCDLFS E IHLN EL KK 329
Cdd:TIGR02168 388 VAQ L ELQIASLN N EIE --------- RLEARL E RLEDRRERLQQ E I ------- EE L LKK L EEAELKELQAEL E ELEE EL EE 451
250 260 270 280
....*....|....*....|....*....|....*....|...
gi 442628180 330 L EKQ LE SM E SEKTH L TAN L R EA QTS LD KSQN EL QNFMS RL AL L 372
Cdd:TIGR02168 452 L QEE LE RL E EALEE L REE L E EA EQA LD AAER EL AQLQA RL DS L 494
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
11-263
1.27e-06
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 52.25
E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 11 ADQSVQD L QM E V E RLTR E LDQVSSAS A QSA Q YGLS L L E EKSA L QQKC EELE TLYDNTRH EL DITQ E A L TKFQTSQKVTNK 90
Cdd:COG1196 272 LRLELEE L EL E L E EAQA E EYELLAEL A RLE Q DIAR L E E RRRE L EERL EELE EELAELEE EL EELE E E L EELEEELEEAEE 351
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 91 T g I E QED A L L N E SAARETSLNLQIFDL E N EL KQ L RH EL ERVRNERDRMLQENSDFGRDKSDSEADRL RL KS EL KD L kfr E 170
Cdd:COG1196 352 E - L E EAE A E L A E AEEALLEAEAELAEA E E EL EE L AE EL LEALRAAAELAAQLEELEEAEEALLERLE RL EE EL EE L --- E 427
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 171 TRMLSEYS E L EEE NIS L QKQVSSLRSSQV E F E GAKHEIRR L T EE VE LL NQQVD EL a NLKKIAEKQMEEA L ETLQGER E AK 250
Cdd:COG1196 428 EALAELEE E E EEE EEA L EEAAEEEAELEE E E E ALLELLAE L L EE AA LL EAALA EL - LEELAEAAARLLL L LEAEADY E GF 506
250
....*....|...
gi 442628180 251 YALK K ELDGHLNR 263
Cdd:COG1196 507 LEGV K AALLLAGL 519
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
106-741
5.80e-06
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 49.94
E-value: 5.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 106 RE T SL NL Q - IF D LEN EL - K QL RH - E LERVRN ER D R M L Q E nsdfgrdksds E ADR L RLKSE L KD L KFR E TRMLSEYS ELEE 182
Cdd:COG1196 182 EA T EE NL E r LE D ILG EL e R QL EP l E RQAEKA ER Y R E L K E ----------- E LKE L EAELL L LK L REL E AELEELEA ELEE 250
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 183 ENIS L QKQVSS L RSSQV E F E GAKH E IRR L TE E V E LLNQQVD EL ANLKKIA E KQMEEAL E TLQGER E AKYA L KK EL D ghln 262
Cdd:COG1196 251 LEAE L EELEAE L AELEA E L E ELRL E LEE L EL E L E EAQAEEY EL LAELARL E QDIARLE E RRRELE E RLEE L EE EL A ---- 326
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 263 resmyhis N L AYSIRSNM E DNASNNSDG EE ENLA L KRL EA D L STELK spdgtkcdlfseihln E L KKL E KQ L ESM E S E KT 342
Cdd:COG1196 327 -------- E L EEELEELE E ELEELEEEL EE AEEE L EEA EA E L AEAEE ---------------- A L LEA E AE L AEA E E E LE 382
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 343 H L TAN L R EA QTSLDKSQNE L QNFMSRLAL L AAHVDA L VQLKKQIDVKEQGK E gg QKKD E L E QQ L RALISQY A NWFTLSAK 422
Cdd:COG1196 383 E L AEE L L EA LRAAAELAAQ L EELEEAEEA L LERLER L EEELEELEEALAEL E -- EEEE E E E EA L EEAAEEE A ELEEEEEA 460
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 423 EIDG L KTDIA E LQKGLNYTDATTTLRN E VTNLKNK LL AT E QKSLDLQSD V QTLTHISQNA G -- QSLGSARSTLV A LSDD L 500
Cdd:COG1196 461 LLEL L AELLE E AALLEAALAELLEELA E AAARLLL LL EA E ADYEGFLEG V KAALLLAGLR G la GAVAVLIGVEA A YEAA L 540
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 501 ----- A Q L YHL V C -- TVNGETPTRV L LDH K TDDMS F E nd S L TA I QSQFKSDVFI A KPQ I VEDLQGL A DSVEIKKYVDT V S 573
Cdd:COG1196 541 eaala A A L QNI V V ed DEVAAAAIEY L KAA K AGRAT F L -- P L DK I RARAALAAAL A RGA I GAAVDLV A SDLREADARYY V L 618
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 574 DQIKYLK T A V EHTIDMNKHKIRSEG G DAL E K vn T E E M E ELQEQIVKLKSLLSVKREQIGTLRNV L KSNKQTAEVALTN L K 653
Cdd:COG1196 619 GDTLLGR T L V AARLEAALRRAVTLA G RLR E V -- T L E G E GGSAGGSLTGGSRRELLAALLEAEAE L EELAERLAEEELE L E 696
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 654 SKYEN E KIIVSDTMSKLRNE L RLLK E DA A TFSS L R A MFAARC EE YVTQVDD L NRQLEAAEE E KKT L NQ L lrlav QQK L A - 732
Cdd:COG1196 697 EALLA E EEEERELAEAEEER L EEEL E EE A LEEQ L E A EREELL EE LLEEEEL L EEEALEELP E PPD L EE L ----- ERE L E r 771
....*....
gi 442628180 733 L TQRL E EME 741
Cdd:COG1196 772 L EREI E ALG 780
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
105-409
8.63e-06
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 49.68
E-value: 8.63e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 105 A RETS L NLQIFD L EN EL KQ L RH EL E R VR N ER D RML QE N SD FG R DKSDS E ADRLR L KS E LKD LK F R ETRMLSEY S eleeen 184
Cdd:TIGR02169 674 A ELQR L RERLEG L KR EL SS L QS EL R R IE N RL D ELS QE L SD AS R KIGEI E KEIEQ L EQ E EEK LK E R LEELEEDL S ------ 747
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 185 i SL QKQVSSLR S SQV E F E G akh E I RR L T E EVEL L NQQVDE L - A N L KKIAEKQMEEA L ET L QG E REAKY A LKK E LDGH LNR 263
Cdd:TIGR02169 748 - SL EQEIENVK S ELK E L E A --- R I EE L E E DLHK L EEALND L e A R L SHSRIPEIQAE L SK L EE E VSRIE A RLR E IEQK LNR 823
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 264 ESM yhisnlaysi RSNMEDNASNNS dg E E ENLA LK RLEADLST E LKSPD G T K CD L FS E I -- HLNE L KK LE KQ L ESMES E K 341
Cdd:TIGR02169 824 LTL ---------- EKEYLEKEIQEL -- Q E QRID LK EQIKSIEK E IENLN G K K EE L EE E L ee LEAA L RD LE SR L GDLKK E R 891
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628180 342 TH L T A N LRE AQTSLDKSQNELQNFMS RL AL L A A HVD AL VQLKKQ I D - V K EQGK E GG ---------- QKKDEL E QQL RAL 409
Cdd:TIGR02169 892 DE L E A Q LRE LERKIEELEAQIEKKRK RL SE L K A KLE AL EEELSE I E d P K GEDE E IP eeelsledvq AELQRV E EEI RAL 970
COG4913
COG4913 Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
326-745
9.14e-06
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain]
Cd Length: 1089
Bit Score: 49.53
E-value: 9.14e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 326 E L KK LE KQ LE SMES E KTH L T A N L REAQTS LD KSQN EL QNF ms RLALLAAHV D A L V QL KKQ I DVK E QGK E GGQKK - DE LE Q 404
Cdd:COG4913 289 R L EL LE AE LE ELRA E LAR L E A E L ERLEAR LD ALRE EL DEL -- EAQIRGNGG D R L E QL ERE I ERL E REL E ERERR r AR LE A 366
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 405 Q L R AL --- ISQY A NW F TLSAK E IDG L KTDIA E LQKG L N yt D A TTTLRNEVTN L KNK L -- L AT E QK SL DLQSD ------ VQ 473
Cdd:COG4913 367 L L A AL glp LPAS A EE F AALRA E AAA L LEALE E ELEA L E -- E A LAEAEAALRD L RRE L re L EA E IA SL ERRKS niparl LA 444
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 474 TLTHISQNA G QS --------------------------- LG SARS TL VALSDDL A QL ------ Y HL VCTVNG E tpt RV - L 519
Cdd:COG4913 445 LRDALAEAL G LD eaelpfvgelievrpeeerwrgaierv LG GFAL TL LVPPEHY A AA lrwvnr L HL RGRLVY E --- RV r T 521
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 520 LDHKTDDMSFEN DSL TA ------------ IQSQFKSDVFIAKPQIV E D L QGLADSV eikkyvd T VSD Q I K YLK T AV E HTI 587
Cdd:COG4913 522 GLPDPERPRLDP DSL AG kldfkphpfraw LEAELGRRFDYVCVDSP E E L RRHPRAI ------- T RAG Q V K GNG T RH E KDD 594
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 588 dmn KHK IRS E --- G G D ALE K VNT -- E E ME EL Q E QIVKLKSL L SVKREQIGT L RNVLKSNKQT AE VALTNLKSKYENEK I i 662
Cdd:COG4913 595 --- RRR IRS R yvl G F D NRA K LAA le A E LA EL E E ELAEAEER L EALEAELDA L QERREALQRL AE YSWDEIDVASAERE I - 670
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 663 vsdtm SK L RN EL RL L KEDAATFSS L RA mfaa RC EE YVTQVDD L NRQ L EAAEE E KKT L NQL L RL A VQQKLA L TQ RLE EM E M 742
Cdd:COG4913 671 ----- AE L EA EL ER L DASSDDLAA L EE ---- QL EE LEAELEE L EEE L DELKG E IGR L EKE L EQ A EEELDE L QD RLE AA E D 741
...
gi 442628180 743 DRE 745
Cdd:COG4913 742 LAR 744
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
10-458
1.13e-05
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 49.16
E-value: 1.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 10 SADQSVQD L QMEV E R L TR EL DQVSSASAQSAQYGLS L L EE KSALQQKC EE L E TLYDNTRHE L DITQEA L TKFQTSQKVTN 89
Cdd:COG1196 306 RLEERRRE L EERL E E L EE EL AELEEELEELEEELEE L E EE LEEAEEEL EE A E AELAEAEEA L LEAEAE L AEAEEELEELA 385
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 90 KTGI E QED A LLN ------ E SAAR E TS L NLQIFD LE N EL KQ L RHE L ERVRN E RDRMLQENSDFGRDKSDS E ADRLR L KSE L 163
Cdd:COG1196 386 EELL E ALR A AAE laaqle E LEEA E EA L LERLER LE E EL EE L EEA L AELEE E EEEEEEALEEAAEEEAEL E EEEEA L LEL L 465
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 164 KD L KFRETRMLSEYS EL E EE NISLQKQVSS L RSSQVEF EG AKHEIRRLTEEVE L -- L NQQ V DE L ANLKKIA E KQM E E AL - 240
Cdd:COG1196 466 AE L LEEAALLEAALA EL L EE LAEAAARLLL L LEAEADY EG FLEGVKAALLLAG L rg L AGA V AV L IGVEAAY E AAL E A AL a 545
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 241 -------- E TLQGERE A KYA LK KELD G ----- H L NRESMYHISNL A YSIRSNMEDNASNN SD GE E ENLALKR L EAD L S - T 306
Cdd:COG1196 546 aalqnivv E DDEVAAA A IEY LK AAKA G ratfl P L DKIRARAALAA A LARGAIGAAVDLVA SD LR E ADARYYV L GDT L L g R 625
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 307 E L KSPDGTKCDLFSEIHLNE L KKLEKQL E SMESEKTHLTANL RE AQTS L DKSQN EL QNFMS RLA -- L L AAHVDA L VQLKK 384
Cdd:COG1196 626 T L VAARLEAALRRAVTLAGR L REVTLEG E GGSAGGSLTGGSR RE LLAA L LEAEA EL EELAE RLA ee E L ELEEAL L AEEEE 705
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442628180 385 QIDVK E QGK E GGQKKD E L E QQLRA L ISQYAN wft L SAKEIDGLKTDIA E LQKG L NYTDATTT L RN E VTN L KNKL 458
Cdd:COG1196 706 ERELA E AEE E RLEEEL E E E ALEEQ L EAEREE --- L LEELLEEEELLEE E ALEE L PEPPDLEE L ER E LER L EREI 776
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
46-257
1.93e-05
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 48.39
E-value: 1.93e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 46 L LE E KSA L QQKC EELE TLYDNTRH EL DITQEA L TKFQTSQKVTNKT g I E QED A LLN E SA A RETS L NLQ I FD LE NELKQ L R 125
Cdd:COG1196 237 L EA E LEE L EAEL EELE AELEELEA EL AELEAE L EELRLELEELELE - L E EAQ A EEY E LL A ELAR L EQD I AR LE ERRRE L E 315
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 126 HE LE RVRN E RDRMLQ E NSDFGRDKSDS E ADRLRLKS EL KDLKFRETRMLSEYS E L E E E NISLQKQVSS L RSSQV E FEG A K 205
Cdd:COG1196 316 ER LE ELEE E LAELEE E LEELEEELEEL E EELEEAEE EL EEAEAELAEAEEALL E A E A E LAEAEEELEE L AEELL E ALR A A 395
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 442628180 206 H E IRRLT EE V E lln QQVDE L ANLKKIA E KQM EE AL E T L QGER E AKYALKKE L 257
Cdd:COG1196 396 A E LAAQL EE L E --- EAEEA L LERLERL E EEL EE LE E A L AELE E EEEEEEEA L 444
Smc
COG1196 Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
10-250
5.53e-05
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain]
Cd Length: 983
Bit Score: 46.85
E-value: 5.53e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 10 SADQSV QD LQMEV ER LTRELDQVSSASAQS A Q ygls L L EE KSA L QQKC EELE TLYDNTRH EL DITQEA L TKFQTSQKVTN 89
Cdd:COG1196 296 ELARLE QD IARLE ER RRELEERLEELEEEL A E ---- L E EE LEE L EEEL EELE EELEEAEE EL EEAEAE L AEAEEALLEAE 371
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 90 KTGI E Q E DA L LNESAARETS L N l QIFD L ENE L KQ L RHEL E RVRNERD R MLQ E NSDFGRDKSDS E ADRLRLKSE L KDLKFR 169
Cdd:COG1196 372 AELA E A E EE L EELAEELLEA L R - AAAE L AAQ L EE L EEAE E ALLERLE R LEE E LEELEEALAEL E EEEEEEEEA L EEAAEE 450
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 170 E TR mlseyseleeenis L QKQVSS L RSSQV E feg AKH E IRR L TEEVEL L NQQVD E L A NLKKIAEKQMEEALET L Q G ERE A 249
Cdd:COG1196 451 E AE -------------- L EEEEEA L LELLA E --- LLE E AAL L EAALAE L LEELA E A A ARLLLLLEAEADYEGF L E G VKA A 513
.
gi 442628180 250 K 250
Cdd:COG1196 514 L 514
YhaN
COG4717 Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
321-745
3.95e-04
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain]
Cd Length: 641
Bit Score: 43.99
E-value: 3.95e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 321 E IH L N ELK K LE KQ L ESM E SEKTH --- L TAN L R E AQTS L DKSQN EL QNFMSR L AL L AAHVDA L VQLKKQIDVKEQGK E GGQ 397
Cdd:COG4717 67 E LN L K ELK E LE EE L KEA E EKEEE yae L QEE L E E LEEE L EELEA EL EELREE L EK L EKLLQL L PLYQELEALEAELA E LPE 146
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 398 KKD ELE QQ L RA L ISQYANWFT L S A k E IDG L KTDIA EL QKG L NYTDATT --------- T L RNEVTN L KNK L LATEQKSLD L 468
Cdd:COG4717 147 RLE ELE ER L EE L RELEEELEE L E A - E LAE L QEELE EL LEQ L SLATEEE lqdlaeele E L QQRLAE L EEE L EEAQEELEE L 225
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 469 QSDVQT L -- THISQNAGQS L GS AR ST L VALS ddlaqlyh LVCTVN G ETPTRVL L DHKTDDMS F ENDS L T A IQSQFKSDVF 546
Cdd:COG4717 226 EEELEQ L en ELEAAALEER L KE AR LL L LIAA -------- ALLALL G LGGSLLS L ILTIAGVL F LVLG L L A LLFLLLAREK 297
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 547 IAKPQIV E D LQ G L ADSV E IKKY vdtvsd QIKY L KT A VEHTI D MNKHKIR segg DA L EKV nt EE ME EL QEQIVK L KSL L SV 626
Cdd:COG4717 298 ASLGKEA E E LQ A L PALE E LEEE ------ ELEE L LA A LGLPP D LSPEELL ---- EL L DRI -- EE LQ EL LREAEE L EEE L QL 365
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 627 KREQI g TLRNV L KSNKQTA E VA L TNLKSKY E NEK iivsdtms K L RN EL RL L K E D - AATFSS L RAMFA A RC EE YV - TQVDD 704
Cdd:COG4717 366 EELEQ - EIAAL L AEAGVED E EE L RAALEQA E EYQ -------- E L KE EL EE L E E Q l EELLGE L EELLE A LD EE EL e EELEE 436
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 442628180 705 L NRQ LE AA EEE KKT L N qllrlav QQKLA L TQR LE EM E M D R E 745
Cdd:COG4717 437 L EEE LE EL EEE LEE L R ------- EELAE L EAE LE QL E E D G E 470
DR0291
COG1579 Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
112-258
4.05e-04
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];
Pssm-ID: 441187 [Multi-domain]
Cd Length: 236
Bit Score: 42.60
E-value: 4.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 112 LQIFD LE NE LK Q L RH EL ERVRN E RDRMLQENSDFGRDKS D S E ADRL RL KS E LKDLKF R ETR mlseyseleeenis LQK Q V 191
Cdd:COG1579 17 SELDR LE HR LK E L PA EL AELED E LAALEARLEAAKTELE D L E KEIK RL EL E IEEVEA R IKK -------------- YEE Q L 82
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442628180 192 SSL R SSQ v E F E GAKH EI RR L TEEVEL L NQQVD EL ANLKKIA E KQME E ALET L QGEREAKYAL K K ELD 258
Cdd:COG1579 83 GNV R NNK - E Y E ALQK EI ES L KRRISD L EDEIL EL MERIEEL E EELA E LEAE L AELEAELEEK K A ELD 148
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
21-259
5.84e-04
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 43.52
E-value: 5.84e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 21 E VE R LTRELDQVSS -- AS AQSAQ yglsll E EK SALQQKC EE LETLYDNTRHE L DITQ E A L TKFQTSQKV tnktgie QE D A 98
Cdd:TIGR02169 288 E QL R VKEKIGELEA ei AS LERSI ------ A EK ERELEDA EE RLAKLEAEIDK L LAEI E E L EREIEEERK ------- RR D K 354
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 99 L LN E S A ARETS L NLQIFD LE ---------- N ELK QL R HE LE RVRN E RDRMLQ E NSDFGRDKSDSEADRLR L KSELKDLKF 168
Cdd:TIGR02169 355 L TE E Y A ELKEE L EDLRAE LE evdkefaetr D ELK DY R EK LE KLKR E INELKR E LDRLQEELQRLSEELAD L NAAIAGIEA 434
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 169 RETRMLS E YSELEE E nis LQ KQ VSS L RSSQVEFEGAKH E IRR L T EE VELLNQQVDE L ANLKKI AE K Q MEEAL E TLQ G E R E 248
Cdd:TIGR02169 435 KINELEE E KEDKAL E --- IK KQ EWK L EQLAADLSKYEQ E LYD L K EE YDRVEKELSK L QRELAE AE A Q ARASE E RVR G G R A 511
250
....*....|.
gi 442628180 249 AKYA LK KELD G 259
Cdd:TIGR02169 512 VEEV LK ASIQ G 522
YhaN
COG4717 Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
18-471
7.77e-04
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain]
Cd Length: 641
Bit Score: 42.83
E-value: 7.77e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 18 LQ M EV ERL TR E L D QVSSASAQSAQYG L SL L E E KSALQQKC EE L E TL Y DNTRH EL DITQ E A L TKFQTSQKVT nktgieqed 97
Cdd:COG4717 44 RA M LL ERL EK E A D ELFKPQGRKPELN L KE L K E LEEELKEA EE K E EE Y AELQE EL EELE E E L EELEAELEEL --------- 114
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 98 alln ESAARETSLN LQ IFD L EN EL KQ L RH EL ERVRNERDRMLQENSDF grdk SDS E ADRLR L KS EL KD L KFRETRM L SEY 177
Cdd:COG4717 115 ---- REELEKLEKL LQ LLP L YQ EL EA L EA EL AELPERLEELEERLEEL ---- REL E EELEE L EA EL AE L QEELEEL L EQL 186
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 178 S ELE EE N is LQ KQVSS L RSS Q VEFEGAKH E IRRLT EE V E L L NQQVDE L A N LKKI A EKQME - EALET L QGERE A KY AL KKE 256
Cdd:COG4717 187 S LAT EE E -- LQ DLAEE L EEL Q QRLAELEE E LEEAQ EE L E E L EEELEQ L E N ELEA A ALEER l KEARL L LLIAA A LL AL LGL 264
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 257 LDGH L NRESMYH -------- ISN L AYSIRSNMEDNASNNSDGEEENL AL KR LE ADLST EL KSPD G TKC DL f S EIH L N EL K 328
Cdd:COG4717 265 GGSL L SLILTIA gvlflvlg LLA L LFLLLAREKASLGKEAEELQALP AL EE LE EEELE EL LAAL G LPP DL - S PEE L L EL L 343
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 329 KLEKQ L ESMES E KTH L TAN L R eaqts L DKSQN E LQNF msrla L LA A H V DALVQ L KKQIDVK E QGK E GGQKKD ELE Q QL RA 408
Cdd:COG4717 344 DRIEE L QELLR E AEE L EEE L Q ----- L EELEQ E IAAL ----- L AE A G V EDEEE L RAALEQA E EYQ E LKEELE ELE E QL EE 413
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442628180 409 L ISQYANW ft L S A KEIDG L KTDIA EL QKG L N ytdatt T L RN E VTN L KNK L LAT E QKSLD L QS D 471
Cdd:COG4717 414 L LGELEEL -- L E A LDEEE L EEELE EL EEE L E ------ E L EE E LEE L REE L AEL E AELEQ L EE D 468
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
321-503
9.33e-04
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 42.74
E-value: 9.33e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 321 E IHLN EL KK LE KQ LE SMES E KTH L TANLR E A Q TS L DKSQ NE LQNFMSRLAL L AAHVDA L VQLKKQID vk E Q GK E GGQ K K D 400
Cdd:TIGR02168 256 E ELTA EL QE LE EK LE ELRL E VSE L EEEIE E L Q KE L YALA NE ISRLEQQKQI L RERLAN L ERQLEELE -- A Q LE E LES K L D 333
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 401 EL EQQ L RA L isqyanwftls AKEIDG LK TDIAE L QKG L nytdat TT L RN E VTN L KNK L LAT E QKSLD L Q S D V QT L T hisq 480
Cdd:TIGR02168 334 EL AEE L AE L ----------- EEKLEE LK EELES L EAE L ------ EE L EA E LEE L ESR L EEL E EQLET L R S K V AQ L E ---- 392
170 180
....*....|....*....|...
gi 442628180 481 nag QSLG S ARSTLVA L SDD L AQ L 503
Cdd:TIGR02168 393 --- LQIA S LNNEIER L EAR L ER L 412
COG4913
COG4913 Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
56-249
1.15e-03
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
Pssm-ID: 443941 [Multi-domain]
Cd Length: 1089
Bit Score: 42.59
E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 56 KCEEL E T L ydn T RH ELD IT QEALT K FQTSQKVTNKTGIEQEDAL L NESAAR etslnl QIFD LE N EL KQ L RH EL ERVRNER 135
Cdd:COG4913 563 CVDSP E E L --- R RH PRA IT RAGQV K GNGTRHEKDDRRRIRSRYV L GFDNRA ------ KLAA LE A EL AE L EE EL AEAEERL 633
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 136 DRM lqensdfg RDKS D SEAD R LRLKSE L KDLKFR E TRML S EYS E LE eeni S L QKQVSS L RS S QVEFEGAKHEIRR L TE E V 215
Cdd:COG4913 634 EAL -------- EAEL D ALQE R REALQR L AEYSWD E IDVA S AER E IA ---- E L EAELER L DA S SDDLAALEEQLEE L EA E L 701
170 180 190
....*....|....*....|....*....|....
gi 442628180 216 E L L NQQV DEL ANLKKIA EK QM E E A L E T L QGEREA 249
Cdd:COG4913 702 E E L EEEL DEL KGEIGRL EK EL E Q A E E E L DELQDR 735
YhaN
COG4717 Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
21-415
3.00e-03
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain]
Cd Length: 641
Bit Score: 40.91
E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 21 E VER L TR EL DQVSSASAQS A Q ygls L L EE KSA L QQKC EELE TLYDNT R H EL DITQEA L TKFQTS Q KVTN ktg I E Q E D A L L 100
Cdd:COG4717 72 E LKE L EE EL KEAEEKEEEY A E ---- L Q EE LEE L EEEL EELE AELEEL R E EL EKLEKL L QLLPLY Q ELEA --- L E A E L A E L 144
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 101 N E SAARETSLNLQIFD LE N EL KQ L RH EL ERVRN E RDRM L QEN S -------- D FGRDKSDSEADRLR L KS EL KDLKFR --- 169
Cdd:COG4717 145 P E RLEELEERLEELRE LE E EL EE L EA EL AELQE E LEEL L EQL S lateeelq D LAEELEELQQRLAE L EE EL EEAQEE lee 224
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 170 ----- E TRMLSEYSELE EE NISLQKQVSSLRSSQVEFE G AKHEIRR L TEEV ------------- EL L NQQVDELANL K KI 231
Cdd:COG4717 225 leeel E QLENELEAAAL EE RLKEARLLLLIAAALLALL G LGGSLLS L ILTI agvlflvlgllal LF L LLAREKASLG K EA 304
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 232 A E K Q MEE ALE T L QG E REAKYALKKE L DGH L NR E SMYHISNLAYSIRSNMEDNAS nnsdg E EE N L A L KR LE ADLSTE L KSP 311
Cdd:COG4717 305 E E L Q ALP ALE E L EE E ELEELLAALG L PPD L SP E ELLELLDRIEELQELLREAEE ----- L EE E L Q L EE LE QEIAAL L AEA 379
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 312 DGTKCDLFSEI -- HLN E LKK L EKQ LE SM E SEKTH L TAN L R E AQTS LD KSQ -- N EL QNFMSR L AL L AAHVDA L VQLKKQID 387
Cdd:COG4717 380 GVEDEEELRAA le QAE E YQE L KEE LE EL E EQLEE L LGE L E E LLEA LD EEE le E EL EELEEE L EE L EEELEE L REELAELE 459
410 420
....*....|....*....|....*...
gi 442628180 388 VKEQGK E GGQKKD EL E Q Q L RA L ISQYAN 415
Cdd:COG4717 460 AELEQL E EDGELA EL L Q E L EE L KAELRE 487
SMC_prok_B
TIGR02168 chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
10-138
6.86e-03
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274008 [Multi-domain]
Cd Length: 1179
Bit Score: 40.04
E-value: 6.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 10 S ADQSVQD L QMEV E R L TR EL DQVSSAS A QSAQYGLS L LE E KSA L QQKCE ELE TLYDNT R H EL DITQ E A L TKFQ tsqkv TN 89
Cdd:TIGR02168 856 S LAAEIEE L EELI E E L ES EL EALLNER A SLEEALAL L RS E LEE L SEELR ELE SKRSEL R R EL EELR E K L AQLE ----- LR 930
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 442628180 90 KT G I E QEDAL L N E SAAR E T SL N L QIF ----- DL E NELKQL R HE L E R VR N ERDRM 138
Cdd:TIGR02168 931 LE G L E VRIDN L Q E RLSE E Y SL T L EEA ealen KI E DDEEEA R RR L K R LE N KIKEL 984
CCDC158
pfam15921 Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
116-722
7.50e-03
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.
Pssm-ID: 464943 [Multi-domain]
Cd Length: 1112
Bit Score: 40.10
E-value: 7.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 116 DL E N E L KQLR HELE RVRNERDR ML QE nsdfgrdk S DSEADR LR LKSELKDLKFR E T R - M L SEYS E LEEEN I SLQKQV S SL 194
Cdd:pfam15921 142 DL R N Q L QNTV HELE AAKCLKED ML ED -------- S NTQIEQ LR KMMLSHEGVLQ E I R s I L VDFE E ASGKK I YEHDSM S TM 213
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 195 RSSQVEFEGA K H e I R R L TE E VEL L NQQV ---- D E L AN LK KIAEKQM E EA L ETL Q g E R EAKYALKK E LDGHLNR E SMYHIS 270
Cdd:pfam15921 214 HFRSLGSAIS K I - L R E L DT E ISY L KGRI fpve D Q L EA LK SESQNKI E LL L QQH Q - D R IEQLISEH E VEITGLT E KASSAR 291
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 271 NL A Y SI R S NM E --- DN A S N NSDGEEEN L A - L KRLEAD L ST EL KSP dgtkcdlf SEIHLNELKK LEKQL ESME SE kthlta 346
Cdd:pfam15921 292 SQ A N SI Q S QL E iiq EQ A R N QNSMYMRQ L S d L ESTVSQ L RS EL REA -------- KRMYEDKIEE LEKQL VLAN SE ------ 357
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 347 n L R EA Q T SL D KSQN E LQ N FMSR L AL L A A hvdalvqlkkqi D VKEQG KE GGQK K del EQ QL R ALISQYA N WF T LS -- AK E I 424
Cdd:pfam15921 358 - L T EA R T ER D QFSQ E SG N LDDQ L QK L L A ------------ D LHKRE KE LSLE K --- EQ NK R LWDRDTG N SI T ID hl RR E L 421
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 425 D GLKTDIAE L QKG L N ytdatt TLRN E VTNLKNKLL A TE Q KSLDLQSD V QT LT HISQNAGQS L GSARST L V A LSDD L AQLY 504
Cdd:pfam15921 422 D DRNMEVQR L EAL L K ------ AMKS E CQGQMERQM A AI Q GKNESLEK V SS LT AQLESTKEM L RKVVEE L T A KKMT L ESSE 495
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 505 HL V CTVNGE tptrvl L DH K TDDMSFE N DSL T AIQ S QFKSD vfiakpqi VED LQ G L ADSVEIKKY V D T VSDQI K YLKTAVE 584
Cdd:pfam15921 496 RT V SDLTAS ------ L QE K ERAIEAT N AEI T KLR S RVDLK -------- LQE LQ H L KNEGDHLRN V Q T ECEAL K LQMAEKD 561
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 585 HT I DMNKHK I ----------- R SE G GDAL EK VNT E em E E LQEQIVK L KSLLSV K REQIGTL R NVLK -- S NKQTAE V A L T N 651
Cdd:pfam15921 562 KV I EILRQQ I enmtqlvgqhg R TA G AMQV EK AQL E -- K E INDRRLE L QEFKIL K DKKDAKI R ELEA rv S DLELEK V K L V N 639
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 442628180 652 LK S K ------- YEN E KIIVSDTMSKL RNEL RL L K ED aat FSS L RAM F AARC EE YV T QVDD L NR QL EA A EE E - KK T L N Q L 722
Cdd:pfam15921 640 AG S E rlravkd IKQ E RDQLLNEVKTS RNEL NS L S ED --- YEV L KRN F RNKS EE ME T TTNK L KM QL KS A QS E l EQ T R N T L 715
SMC_prok_A
TIGR02169 chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
107-475
7.85e-03
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]
Pssm-ID: 274009 [Multi-domain]
Cd Length: 1164
Bit Score: 40.05
E-value: 7.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 107 E TSL N LQIF DL E ne LKQL R HE LER V R N ER D rmlqensdfgrdksds E A D R LR - L KS E LKDLKFR E trmlseyseleeeni 185
Cdd:TIGR02169 181 E VEE N IERL DL I -- IDEK R QQ LER L R R ER E ---------------- K A E R YQ a L LK E KREYEGY E --------------- 227
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 186 s L Q K QVSS L RSSQVEF E G akh EIRR L T EE V E L L NQQVD EL anlkkia EK QM EE ALET L Q gereakyalkkeldg H LN RES 265
Cdd:TIGR02169 228 - L L K EKEA L ERQKEAI E R --- QLAS L E EE L E K L TEEIS EL ------- EK RL EE IEQL L E --------------- E LN KKI 281
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 266 MYHISNLAYSIRSNMED nasnn SDG E EEN la L K R LE A DLST EL KSPDGTKCD L FS EI H -- L N E LKK LE KQL E SMESEKTH 343
Cdd:TIGR02169 282 KDLGEEEQLRVKEKIGE ----- LEA E IAS -- L E R SI A EKER EL EDAEERLAK L EA EI D kl L A E IEE LE REI E EERKRRDK 354
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 344 LT ANLR E AQTS L DKSQN EL QNFMSRL A LL aah V D A L VQLKKQID - V K EQGK E GGQKK D E L EQQ L RA L ISQY A N wftl SAK 422
Cdd:TIGR02169 355 LT EEYA E LKEE L EDLRA EL EEVDKEF A ET --- R D E L KDYREKLE k L K REIN E LKREL D R L QEE L QR L SEEL A D ---- LNA 427
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 442628180 423 E I D G LKTD I A EL QKGLNYTDA - TTTLRNEVTN L KNK L LAT EQ KSL DL QSDVQTL 475
Cdd:TIGR02169 428 A I A G IEAK I N EL EEEKEDKAL e IKKQEWKLEQ L AAD L SKY EQ ELY DL KEEYDRV 481
PRK05771
PRK05771 V-type ATP synthase subunit I; Validated
185-384
8.13e-03
V-type ATP synthase subunit I; Validated
Pssm-ID: 235600 [Multi-domain]
Cd Length: 646
Bit Score: 39.53
E-value: 8.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 185 IS L QKQVSS LRS S q VEFEGAKH E IRRLTEEVE L LNQQV D ELAN L K KI AE -- K QM EE ALET L QG E REAKYALKKE L ----- 257
Cdd:PRK05771 53 TK L SEALDK LRS Y - LPKLNPLR E EKKKVSVKS L EELIK D VEEE L E KI EK ei K EL EE EISE L EN E IKELEQEIER L epwgn 131
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 258 ---- DGH L NRESMYHI sn LAYSIRSNMEDNASNN SD ------- GEEEN ------ LA LK R L EADLST ELK SPDGTKCD L FS 320
Cdd:PRK05771 132 fdld LSL L LGFKYVSV -- FVGTVPEDKLEELKLE SD venveyi STDKG yvyvvv VV LK E L SDEVEE ELK KLGFERLE L EE 209
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442628180 321 E IHLN E - LKKLEKQ LE SM E S E KTH L TAN L R E aqt SLD K SQN EL QNFMSR L ALLAAHVD AL VQLK K 384
Cdd:PRK05771 210 E GTPS E l IREIKEE LE EI E K E RES L LEE L K E --- LAK K YLE EL LALYEY L EIELERAE AL SKFL K 271
DUF5401
pfam17380 Family of unknown function (DUF5401); This is a family of unknown function found in ...
19-258
8.36e-03
Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.
Pssm-ID: 375164 [Multi-domain]
Cd Length: 722
Bit Score: 39.72
E-value: 8.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 19 Q ME V ERL TR E LDQV ssas A QSAQYGLS L L E EKS A L Q QKCEELETL Y - DNT R HELDITQ E a L TKFQTSQKVTNKTG I E QE D 97
Cdd:pfam17380 295 K ME Q ERL RQ E KEEK ---- A REVERRRK L E E AEK A R Q AEMDRQAAI Y a EQE R MAMERER E - L ERIRQEERKRELER I R QE E 369
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 98 ALLNE S AA RE tsln L QIFDL E NEL K -- QL R H ELE RV R N ------ ER D R ML Q ENS - DFGRDKSDS E AD R L R LKSE L KDLKF 168
Cdd:pfam17380 370 IAMEI S RM RE ---- L ERLQM E RQQ K ne RV R Q ELE AA R K vkilee ER Q R KI Q QQK v EMEQIRAEQ E EA R Q R EVRR L EEERA 445
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442628180 169 RE TRMLSEYSELEEENIS - L QK Q VSSLRSSQV E F E GA K HEIR R LT E -------- E V E LLN Q QVD E LANLK K IA EK Q MEE - 238
Cdd:pfam17380 446 RE MERVRLEEQERQQQVE r L RQ Q EEERKRKKL E L E KE K RDRK R AE E qrrkilek E L E ERK Q AMI E EERKR K LL EK E MEE r 525
250 260
....*....|....*....|..
gi 442628180 239 -- A LETLQGE REA KYALK K ELD 258
Cdd:pfam17380 526 qk A IYEEERR REA EEERR K QQE 547
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
