down and out, isoform B [Drosophila melanogaster]
Protein Classification
SET domain-containing protein( domain architecture ID 1562517)
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| SET super family | cl40432 | SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ... |
459-657 | 2.16e-14 | ||||
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site. The actual alignment was detected with superfamily member cd10536: Pssm-ID: 394802 [Multi-domain] Cd Length: 218 Bit Score: 73.10 E-value: 2.16e-14
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| Name | Accession | Description | Interval | E-value | ||||
| SET_SMYD4 | cd10536 | SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ... |
459-657 | 2.16e-14 | ||||
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation. Pssm-ID: 380934 [Multi-domain] Cd Length: 218 Bit Score: 73.10 E-value: 2.16e-14
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| Name | Accession | Description | Interval | E-value | ||||
| SET_SMYD4 | cd10536 | SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing ... |
459-657 | 2.16e-14 | ||||
SET domain (including iSET domain and post-SET domain) found in SET and MYND domain-containing protein 4 (SMYD4) and similar proteins; SMYD4 functions as a potential tumor suppressor that plays a critical role in breast carcinogenesis at least partly through inhibiting the expression of PDGFR-alpha. In zebrafish, SMYD4 is ubiquitously expressed in early embryos and becomes enriched in the developing heart; mutants show a strong defect in cardiomyocyte proliferation, which lead to a severe cardiac malformation. Pssm-ID: 380934 [Multi-domain] Cd Length: 218 Bit Score: 73.10 E-value: 2.16e-14
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