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Conserved domains on  [gi|442627132|ref|NP_001260308|]
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uncharacterized protein Dmel_CG31712, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARGLU super family cl38471
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 135-189 7.18e-11

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


The actual alignment was detected with superfamily member pfam15346:

Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 59.29  E-value: 7.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442627132  135 KELEQKTIEEEAAKRIEMLVKKRVEEELEKRRDEIEQEVNRRVETAKAEMEREMM 189
Cdd:pfam15346   1 KEAESKLLEEETARRVEEAVAKRVEEELEKRKDEIEAEVERRVEEARKIMEKQVL 55
 
Name Accession Description Interval E-value
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 135-189 7.18e-11

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 59.29  E-value: 7.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442627132  135 KELEQKTIEEEAAKRIEMLVKKRVEEELEKRRDEIEQEVNRRVETAKAEMEREMM 189
Cdd:pfam15346   1 KEAESKLLEEETARRVEEAVAKRVEEELEKRKDEIEAEVERRVEEARKIMEKQVL 55
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 126-187 6.72e-04

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 39.39  E-value: 6.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442627132 126 AEMERQRRAKELEQKTIEEEAAKRIEMlVKKRVEEELEKRRDEIEQEVNRRVETAKAEMERE 187
Cdd:COG0711   48 EEAEAALAEYEEKLAEARAEAAEIIAE-ARKEAEAIAEEAKAEAEAEAERIIAQAEAEIEQE 108
PTZ00121 PTZ00121
MAEBL; Provisional
 98-188 9.45e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 9.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627132   98 EQESQRSKQKRSRFKKLDEQNQMQVERLAEMERQRRAKELEQKTIEEEAAKRIEMLVKKRVE-EELEKRRDEIEQEVNRR 176
Cdd:PTZ00121 1639 KKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEaKKAEELKKKEAEEKKKA 1718

                          90
                  ....*....|..
gi 442627132  177 VETAKAEMEREM 188
Cdd:PTZ00121 1719 EELKKAEEENKI 1730
SPFH_like_u3 cd03406
Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...
 96-185 1.10e-03

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259804 [Multi-domain]  Cd Length: 293  Bit Score: 39.97  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627132  96 YSEQESQRSKQKrsrfkkLDEQNQMQVERLAEMERQRrakeleQKTIEEEAAKRIEMLVKKRVEE-ELEKRRDEIEQEVN 174
Cdd:cd03406  168 YEAMEAEKTKLL------IAEQHQKVVEKEAETERKR------AVIEAEKDAEVAKIQMQQKIMEkEAEKKISEIEDEMH 235

                         90
                 ....*....|.
gi 442627132 175 RRVETAKAEME 185
Cdd:cd03406  236 LAREKARADAE 246
 
Name Accession Description Interval E-value
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 135-189 7.18e-11

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 59.29  E-value: 7.18e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442627132  135 KELEQKTIEEEAAKRIEMLVKKRVEEELEKRRDEIEQEVNRRVETAKAEMEREMM 189
Cdd:pfam15346   1 KEAESKLLEEETARRVEEAVAKRVEEELEKRKDEIEAEVERRVEEARKIMEKQVL 55
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 99-187 4.79e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 41.65  E-value: 4.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627132   99 QESQRSKQKRSRFKKLDEQNQMQVERLAEMERQRRAKELEQktiEEEAAKRIEMLVKKRVEEELEKRRDEIEQEVNRRVE 178
Cdd:pfam17380 441 EEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEK---EKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKL 517


                  ....*....
gi 442627132  179 TAKAEMERE 187
Cdd:pfam17380 518 LEKEMEERQ 526
ATP-synt_B pfam00430
ATP synthase B/B' CF(0); Part of the CF(0) (base unit) of the ATP synthase. The base unit is ...
 123-187 4.92e-04

ATP synthase B/B' CF(0); Part of the CF(0) (base unit) of the ATP synthase. The base unit is thought to translocate protons through membrane (inner membrane in mitochondria, thylakoid membrane in plants, cytoplasmic membrane in bacteria). The B subunits are thought to interact with the stalk of the CF(1) subunits. This domain should not be confused with the ab CF(1) proteins (in the head of the ATP synthase) which are found in pfam00006


Pssm-ID: 425677 [Multi-domain]  Cd Length: 132  Bit Score: 39.22  E-value: 4.92e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442627132  123 ERLAEMERQRRAKELEQKTIEEEAAkRIEMLVKKRVEEELEKRRDEIEQEVNRRVETAKAEMERE 187
Cdd:pfam00430  44 ERRKDAAAALAEAEQQLKEARAEAQ-EIIENAKKRAEKLKEEIVAAAEAEAERIIEQAAAEIEQE 107
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
 126-187 6.72e-04

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 39.39  E-value: 6.72e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 442627132 126 AEMERQRRAKELEQKTIEEEAAKRIEMlVKKRVEEELEKRRDEIEQEVNRRVETAKAEMERE 187
Cdd:COG0711   48 EEAEAALAEYEEKLAEARAEAAEIIAE-ARKEAEAIAEEAKAEAEAEAERIIAQAEAEIEQE 108
PTZ00121 PTZ00121
MAEBL; Provisional
 98-188 9.45e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 9.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627132   98 EQESQRSKQKRSRFKKLDEQNQMQVERLAEMERQRRAKELEQKTIEEEAAKRIEMLVKKRVE-EELEKRRDEIEQEVNRR 176
Cdd:PTZ00121 1639 KKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEaKKAEELKKKEAEEKKKA 1718

                          90
                  ....*....|..
gi 442627132  177 VETAKAEMEREM 188
Cdd:PTZ00121 1719 EELKKAEEENKI 1730
SPFH_like_u3 cd03406
Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This ...
 96-185 1.10e-03

Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; This model summarizes an uncharacterized family of proteins similar to stomatin, prohibitin, flotillin, HflK/C (SPFH) and podocin. The conserved domain common to the SPFH superfamily has also been referred to as the Band 7 domain. Many superfamily members are associated with lipid rafts. Individual proteins of the SPFH superfamily may cluster to form membrane microdomains which may in turn recruit multiprotein complexes. Microdomains formed from flotillin proteins may in addition be dynamic units with their own regulatory functions. Flotillins have been implicated in signal transduction, vesicle trafficking, cytoskeleton rearrangement and are known to interact with a variety of proteins. Stomatin interacts with and regulates members of the degenerin/epithelia Na+ channel family in mechanosensory cells of Caenorhabditis elegans and vertebrate neurons and participates in trafficking of Glut1 glucose transporters. Prohibitin may act as a chaperone for the stabilization of mitochondrial proteins. Prokaryotic HflK/C plays a role in the decision between lysogenic and lytic cycle growth during lambda phage infection. Flotillins have been implicated in the progression of prion disease, in the pathogenesis of neurodegenerative diseases such as Parkinson's and Alzheimer's disease and, in cancer invasion and metastasis. Mutations in the podocin gene give rise to autosomal recessive steroid resistant nephritic syndrome.


Pssm-ID: 259804 [Multi-domain]  Cd Length: 293  Bit Score: 39.97  E-value: 1.10e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627132  96 YSEQESQRSKQKrsrfkkLDEQNQMQVERLAEMERQRrakeleQKTIEEEAAKRIEMLVKKRVEE-ELEKRRDEIEQEVN 174
Cdd:cd03406  168 YEAMEAEKTKLL------IAEQHQKVVEKEAETERKR------AVIEAEKDAEVAKIQMQQKIMEkEAEKKISEIEDEMH 235

                         90
                 ....*....|.
gi 442627132 175 RRVETAKAEME 185
Cdd:cd03406  236 LAREKARADAE 246
ATP-synt_Fo_b cd06503
F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex ...
 123-187 1.44e-03

F-type ATP synthase, membrane subunit b; Membrane subunit b is a component of the Fo complex of FoF1-ATP synthase. The F-type ATP synthases (FoF1-ATPase) consist of two structural domains: the F1 (assembly factor one) complex containing the soluble catalytic core, and the Fo (oligomycin sensitive factor) complex containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. F1 is composed of alpha (or A), beta (B), gamma (C), delta (D) and epsilon (E) subunits with a stoichiometry of 3:3:1:1:1, while Fo consists of the three subunits a, b, and c (1:2:10-14). An oligomeric ring of 10-14 c subunits (c-ring) make up the Fo rotor. The flux of protons through the ATPase channel (Fo) drives the rotation of the c-ring, which in turn is coupled to the rotation of the F1 complex gamma subunit rotor due to the permanent binding between the gamma and epsilon subunits of F1 and the c-ring of Fo. The F-ATP synthases are primarily found in the inner membranes of eukaryotic mitochondria, in the thylakoid membranes of chloroplasts or in the plasma membranes of bacteria. The F-ATP synthases are the primary producers of ATP, using the proton gradient generated by oxidative phosphorylation (mitochondria) or photosynthesis (chloroplasts). Alternatively, under conditions of low driving force, ATP synthases function as ATPases, thus generating a transmembrane proton or Na(+) gradient at the expense of energy derived from ATP hydrolysis. This group also includes F-ATP synthase that has also been found in the archaea Candidatus Methanoperedens.


Pssm-ID: 349951 [Multi-domain]  Cd Length: 132  Bit Score: 37.80  E-value: 1.44e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442627132 123 ERLAEMERQRRAKELEQKTIEEEAAKRIEMlVKKRVEEELEKRRDEIEQEVNRRVETAKAEMERE 187
Cdd:cd06503   44 KAKEEAEELLAEYEEKLAEARAEAQEIIEE-ARKEAEKIKEEILAEAKEEAERILEQAKAEIEQE 107
tolA PRK09510
cell envelope integrity inner membrane protein TolA; Provisional
 95-189 1.89e-03

cell envelope integrity inner membrane protein TolA; Provisional


Pssm-ID: 236545 [Multi-domain]  Cd Length: 387  Bit Score: 39.40  E-value: 1.89e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627132  95 QYSEQESQRSKQKRSrfkklDEQNQMQVERLAEMERQRRAKELE-QKTIEEEAAKRIEMlvKKRVEEELEKRR---DEIE 170
Cdd:PRK09510  63 QYNRQQQQQKSAKRA-----EEQRKKKEQQQAEELQQKQAAEQErLKQLEKERLAAQEQ--KKQAEEAAKQAAlkqKQAE 135

                         90
                 ....*....|....*....
gi 442627132 171 QEVNRRVETAKAEMEREMM 189
Cdd:PRK09510 136 EAAAKAAAAAKAKAEAEAK 154
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 118-186 5.01e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 38.27  E-value: 5.01e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442627132 118 NQMqVERLAEMERQRRAKELEQKTIEEEAAKRIEMLVKK--RVEEELEKRRDEIEQEVNRRVETAKAEMER 186
Cdd:PRK00409 519 NEL-IASLEELERELEQKAEEAEALLKEAEKLKEELEEKkeKLQEEEDKLLEEAEKEAQQAIKEAKKEADE 588
YqiK COG2268
Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];
100-187 7.13e-03

Uncharacterized membrane protein YqiK, contains Band7/PHB/SPFH domain [Function unknown];


Pssm-ID: 441869 [Multi-domain]  Cd Length: 439  Bit Score: 37.54  E-value: 7.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442627132 100 ESQRSKQKRSRfKKLDEQNQMQVERLAEMERQRRAKELEQKTIEEEAAKRIEMLVKKRVEEELEKRRDEIEQEVNRRVET 179
Cdd:COG2268  207 EAERETEIAIA-QANREAEEAELEQEREIETARIAEAEAELAKKKAEERREAETARAEAEAAYEIAEANAEREVQRQLEI 285


                 ....*...
gi 442627132 180 AKAEMERE 187
Cdd:COG2268  286 AEREREIE 293
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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