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Conserved domains on  [gi|442625322|ref|NP_001259901|]
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defective proboscis extension response 3, isoform C [Drosophila melanogaster]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|10436082

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
243-329 1.00e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 1.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322   243 PRNITGRTGHTeAIIKCRVDSLHDKSVSWIRKRDLHILtvgtatytSDKRFQVTESKDSreWTLHVKAPLAKDSGIYECQ 322
Cdd:smart00410   1 PPSVTVKEGES-VTLSCEASGSPPPEVTWYKQGGKLLA--------ESGRFSVSRSGST--STLTISNVTPEDSGTYTCA 69

                   ....*..
gi 442625322   323 VNTEPKM 329
Cdd:smart00410  70 ATNSSGS 76
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
441-477 1.03e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442625322   441 GDTLKSRLRISNAQTTDTGNYTCQPTTAS---SASVLVHV 477
Cdd:smart00410  46 RSGSTSTLTISNVTPEDSGTYTCAATNSSgsaSSGTTLTV 85
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
243-329 1.00e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 1.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322   243 PRNITGRTGHTeAIIKCRVDSLHDKSVSWIRKRDLHILtvgtatytSDKRFQVTESKDSreWTLHVKAPLAKDSGIYECQ 322
Cdd:smart00410   1 PPSVTVKEGES-VTLSCEASGSPPPEVTWYKQGGKLLA--------ESGRFSVSRSGST--STLTISNVTPEDSGTYTCA 69

                   ....*..
gi 442625322   323 VNTEPKM 329
Cdd:smart00410  70 ATNSSGS 76
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
243-323 2.12e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 40.78  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322 243 PRNITGRTGHTeAIIKCRVDSLHDKS-VSWIRKRD------LHILTVGTATYTSD--KRFQVTESKDSReWTLHVKAPLA 313
Cdd:cd00099    5 PRSLSVQEGES-VTLSCEVSSSFSSTyIYWYRQKPgqgpefLIYLSSSKGKTKGGvpGRFSGSRDGTSS-FSLTISNLQP 82
                         90
                 ....*....|
gi 442625322 314 KDSGIYECQV 323
Cdd:cd00099   83 EDSGTYYCAV 92
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
243-331 2.29e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.52  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322  243 PRNITGRTGHTeAIIKCRVDSLHDK---SVSWIRKRDLHILTVGTATYTSD-------KRFQVTESKDSREWTLHVKAPL 312
Cdd:pfam07686   3 PREVTVALGGS-VTLPCTYSSSMSEastSVYWYRQPPGKGPTFLIAYYSNGseegvkkGRFSGRGDPSNGDGSLTIQNLT 81
                          90
                  ....*....|....*....
gi 442625322  313 AKDSGIYECQVNTEPKMSM 331
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGVF 100
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
441-477 1.03e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442625322   441 GDTLKSRLRISNAQTTDTGNYTCQPTTAS---SASVLVHV 477
Cdd:smart00410  46 RSGSTSTLTISNVTPEDSGTYTCAATNSSgsaSSGTTLTV 85
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
243-329 1.00e-06

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 46.73  E-value: 1.00e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322   243 PRNITGRTGHTeAIIKCRVDSLHDKSVSWIRKRDLHILtvgtatytSDKRFQVTESKDSreWTLHVKAPLAKDSGIYECQ 322
Cdd:smart00410   1 PPSVTVKEGES-VTLSCEASGSPPPEVTWYKQGGKLLA--------ESGRFSVSRSGST--STLTISNVTPEDSGTYTCA 69

                   ....*..
gi 442625322   323 VNTEPKM 329
Cdd:smart00410  70 ATNSSGS 76
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
243-323 2.12e-04

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 40.78  E-value: 2.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322 243 PRNITGRTGHTeAIIKCRVDSLHDKS-VSWIRKRD------LHILTVGTATYTSD--KRFQVTESKDSReWTLHVKAPLA 313
Cdd:cd00099    5 PRSLSVQEGES-VTLSCEVSSSFSSTyIYWYRQKPgqgpefLIYLSSSKGKTKGGvpGRFSGSRDGTSS-FSLTISNLQP 82
                         90
                 ....*....|
gi 442625322 314 KDSGIYECQV 323
Cdd:cd00099   83 EDSGTYYCAV 92
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
243-331 2.29e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 40.52  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322  243 PRNITGRTGHTeAIIKCRVDSLHDK---SVSWIRKRDLHILTVGTATYTSD-------KRFQVTESKDSREWTLHVKAPL 312
Cdd:pfam07686   3 PREVTVALGGS-VTLPCTYSSSMSEastSVYWYRQPPGKGPTFLIAYYSNGseegvkkGRFSGRGDPSNGDGSLTIQNLT 81
                          90
                  ....*....|....*....
gi 442625322  313 AKDSGIYECQVNTEPKMSM 331
Cdd:pfam07686  82 LSDSGTYTCAVIPSGEGVF 100
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
243-321 8.12e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 39.19  E-value: 8.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322 243 PRNITGRTGhTEAIIKCRVDSLHDkSVSWIRKRD------LHILTVGTATYTSD---KRFQVTESKDSReWTLHVKAPLA 313
Cdd:cd05899    5 PRYLIKRRG-QSVTLRCSQKSGHD-NMYWYRQDPgkglqlLFYSYGGGLNEEGDlpgDRFSASRPSLTR-SSLTIKSAEP 81

                 ....*...
gi 442625322 314 KDSGIYEC 321
Cdd:cd05899   82 EDSAVYLC 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
441-477 1.03e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 1.03e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 442625322   441 GDTLKSRLRISNAQTTDTGNYTCQPTTAS---SASVLVHV 477
Cdd:smart00410  46 RSGSTSTLTISNVTPEDSGTYTCAATNSSgsaSSGTTLTV 85
IgV_1_Necl_like cd05717
First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the ...
244-327 2.03e-03

First (N-terminal) immunoglobulin (Ig)-like domain of the nectin-like molecules; member of the V-set of Ig superfamily (IgSF) domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain of the nectin-like molecules Necl-1 (also known as cell adhesion molecule 3 (CADM3)), Necl-2 (CADM1), Necl-3 (CADM2), and similar proteins. At least five nectin-like molecules have been identified (Necl-1 to Necl-5). They all have an extracellular region containing three Ig-like domains, a transmembrane region, and a cytoplasmic region. The N-terminal Ig-like domain of the extracellular region belongs to the V-type subfamily of Ig domains, is essential to cell-cell adhesion, and plays a part in the interaction with the envelope glycoprotein D of various viruses. Necl-1, Necl-2, and Necl-3 have Ca(2+)-independent homophilic and heterophilic cell-cell adhesion activity. Necl-1 is specifically expressed in neural tissue, and is important to the formation of synapses, axon bundles, and myelinated axons. Necl-2 is expressed in a wide variety of tissues and is a putative tumour suppressor gene which is downregulated in aggressive neuroblastoma. Necl-3 accumulates in central and peripheral nervous system tissue and has been shown to selectively interact with oligodendrocytes. This group also contains Class-I MHC-restricted T-cell-associated molecule (CRTAM), whose expression pattern is consistent with its expression in Class-I MHC-restricted T-cells.


Pssm-ID: 409382  Cd Length: 94  Bit Score: 37.49  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322 244 RNITGRTGHTeAIIKCRVDSLHDKSVSWIRKRDlHILTVGTATYTSDKRFQVTESKDSrEWTLHVKAPLAKDSGIYECQV 323
Cdd:cd05717    4 QDVTVVEGET-LTLKCQVSLRDDSSLQWLNPNG-QTIYFNDKRALRDSRYQLLNHSAS-ELSISVSNVTLSDEGVYTCLH 80

                 ....
gi 442625322 324 NTEP 327
Cdd:cd05717   81 YTDP 84
I-set pfam07679
Immunoglobulin I-set domain;
243-323 8.54e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 35.70  E-value: 8.54e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625322  243 PRNITGRTGHTeAIIKCRVDSLHDKSVSWiRKRDLHIltvgtatyTSDKRFQVTESKDsrEWTLHVKAPLAKDSGIYECQ 322
Cdd:pfam07679   7 PKDVEVQEGES-ARFTCTVTGTPDPEVSW-FKDGQPL--------RSSDRFKVTYEGG--TYTLTISNVQPDDSGKYTCV 74

                  .
gi 442625322  323 V 323
Cdd:pfam07679  75 A 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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