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Conserved domains on  [gi|442625026|ref|NP_001259838|]
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coiled, isoform B [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFP_LU_ECD_Cold cd23599
extracellular domain (ECD) found in Drosophila melanogaster protein coiled and similar ...
 26-121 6.40e-43

extracellular domain (ECD) found in Drosophila melanogaster protein coiled and similar proteins; Coiled (Cold) is coded by the Drosophila cold gene that is expressed in a subset of glial cells. It is a member of the Drosophila Ly6 superfamily of extracellular ligands and could behave as a membrane component of the septate junctions (SJ). Cold is essential for tracheal morphogenesis and the organization of the insect SJ in a cell autonomous way. It is also required for organization of the blood-brain-barrier in the Drosophila nervous system. Coiled contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


:

Pssm-ID: 467128  Cd Length: 95  Bit Score: 137.43  E-value: 6.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625026  26 LECYVCSNQTGNTEKCLNTIKTCEPFENVCGTEIRWGSQPYFSEGALKQYYVSKRCMTKEQCQsKRKRYMQLYCTHIWYE 105
Cdd:cd23599    1 LECYVCKNQEGNKDKCIKTVKQCEPEEDACITYIRWGSPPYWTPRGERQHYISKGCDTLERCQ-KQREATEPYCQRDWYN 79

                         90
                 ....*....|....*.
gi 442625026 106 DWACNECCKGDRCNYF 121
Cdd:cd23599   80 DWECVECCQGDLCNYY 95
 
Name Accession Description Interval E-value
TFP_LU_ECD_Cold cd23599
extracellular domain (ECD) found in Drosophila melanogaster protein coiled and similar ...
 26-121 6.40e-43

extracellular domain (ECD) found in Drosophila melanogaster protein coiled and similar proteins; Coiled (Cold) is coded by the Drosophila cold gene that is expressed in a subset of glial cells. It is a member of the Drosophila Ly6 superfamily of extracellular ligands and could behave as a membrane component of the septate junctions (SJ). Cold is essential for tracheal morphogenesis and the organization of the insect SJ in a cell autonomous way. It is also required for organization of the blood-brain-barrier in the Drosophila nervous system. Coiled contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467128  Cd Length: 95  Bit Score: 137.43  E-value: 6.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625026  26 LECYVCSNQTGNTEKCLNTIKTCEPFENVCGTEIRWGSQPYFSEGALKQYYVSKRCMTKEQCQsKRKRYMQLYCTHIWYE 105
Cdd:cd23599    1 LECYVCKNQEGNKDKCIKTVKQCEPEEDACITYIRWGSPPYWTPRGERQHYISKGCDTLERCQ-KQREATEPYCQRDWYN 79

                         90
                 ....*....|....*.
gi 442625026 106 DWACNECCKGDRCNYF 121
Cdd:cd23599   80 DWECVECCQGDLCNYY 95
 
Name Accession Description Interval E-value
TFP_LU_ECD_Cold cd23599
extracellular domain (ECD) found in Drosophila melanogaster protein coiled and similar ...
 26-121 6.40e-43

extracellular domain (ECD) found in Drosophila melanogaster protein coiled and similar proteins; Coiled (Cold) is coded by the Drosophila cold gene that is expressed in a subset of glial cells. It is a member of the Drosophila Ly6 superfamily of extracellular ligands and could behave as a membrane component of the septate junctions (SJ). Cold is essential for tracheal morphogenesis and the organization of the insect SJ in a cell autonomous way. It is also required for organization of the blood-brain-barrier in the Drosophila nervous system. Coiled contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467128  Cd Length: 95  Bit Score: 137.43  E-value: 6.40e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625026  26 LECYVCSNQTGNTEKCLNTIKTCEPFENVCGTEIRWGSQPYFSEGALKQYYVSKRCMTKEQCQsKRKRYMQLYCTHIWYE 105
Cdd:cd23599    1 LECYVCKNQEGNKDKCIKTVKQCEPEEDACITYIRWGSPPYWTPRGERQHYISKGCDTLERCQ-KQREATEPYCQRDWYN 79

                         90
                 ....*....|....*.
gi 442625026 106 DWACNECCKGDRCNYF 121
Cdd:cd23599   80 DWECVECCQGDLCNYY 95
TFP_LU_ECD_CinHb4_like cd23539
extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; ...
 26-119 2.68e-05

extracellular domain (ECD) found in Ciona intestinalis globin CinHb4 and similar proteins; Four distinct globin genes have been identified in the Ciona genome. CinHb4 is encoded by the fourth globin gene. It shows an unusual extension at its N-terminus, which reveals a conserved region with similarity to the extracellular domain (ECD) of the TGF-beta receptor type I/II protein family involved in signal transduction. The functional relevance of these matches is currently unknown. The ECD belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467069  Cd Length: 91  Bit Score: 40.48  E-value: 2.68e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625026  26 LECYVCSNQTGNTEkCLN--TIKTCEPFENVCGTEIRWGSQpyfsegalKQYYVSKRCMTKEQCQSKRKRYMQLY----- 98
Cdd:cd23539    1 LSCWTCDNASSNEE-CLAngTLVTCQSNEESCQTEVRRRGG--------GVYLISKGCKQRQACENNKKQNFKAAwnptq 71

                         90       100
                 ....*....|....*....|.
gi 442625026  99 CTHIWYEDwACNECCKGDRCN 119
Cdd:cd23539   72 CNPESPNS-VCRCCCSTDLCN 91
TFP cd00117
three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU ...
 26-119 1.76e-03

three-fingered protein (TFP) fold found in Ly6/uPAR (LU) and snake toxin superfamily; The LU (also known as Ly-6 antigen/uPA receptor)-like extracellular domain (ECD) occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family, CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. It is a structural domain involved in protein-protein interactions, tolerating an unusual degree of variation and binding with high specificity to a broad spectrum of targets. The snake toxin domain is present in short and long neurotoxins, cytotoxins, and short toxins, and in other miscellaneous venom peptides. The toxin acts by binding to the nicotinic acetylcholine receptors in the postsynaptic membrane of skeletal muscles and preventing the binding of acetylcholine, thereby blocking the excitation of muscles. Both the LU-like ECD and the snake toxin domain belong to three-fingered protein (TFP) fold, which is characterized by containing 70 to 100 amino acids including eight to ten cysteine residues spaced at conserved distances.


Pssm-ID: 467060  Cd Length: 81  Bit Score: 35.54  E-value: 1.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625026  26 LECYVC-SNQTGNTEKCLNTIKTCEPFENVCGTEIRWGSQpyfsegalKQYYVSKRCMTKEQCQskrkryMQLYCTHIWY 104
Cdd:cd00117    1 LKCYQCnSSNDPNCCNSSPTLVTCSSPETFCRKIVGKVGG--------GETLVIRGCATECECG------CTECCSGTGT 66

                         90
                 ....*....|....*
gi 442625026 105 EDWACNECCKGDRCN 119
Cdd:cd00117   67 SGTTCTSCCDTDLCN 81
TFP_LU_ECD_PLIG cd23588
extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma ...
 26-119 4.08e-03

extracellular domain (ECD) found in Elaphe quadrivirgata phospholipase A2 inhibitor gamma subunit (gamma-PLI) family; The gamma-PLI family includes gamma-PLI A and gamma-PLI B. Gamma-PLI inhibits the enzymatic activity of all phospholipase A2 (PA2) groups. Gamma-PLI A and gamma-PLI B form a heterodimer. Members in this family contain an extracellular domain (ECD) that belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467117  Cd Length: 82  Bit Score: 34.60  E-value: 4.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442625026  26 LECYVCSNqTGNTekCLNTIKTCEPFENVCGTeirwgSQPYFSEGALKQYYVSKRCMTKEQCQS--------KRKRYMql 97
Cdd:cd23588    1 LECEVCSG-TGTN--CTGPMETCSPGEDTCGI-----ILTESTLGGKKTQTVEKGCVSSSVCTLgpvsfnfgKGRTIR-- 70

                         90       100
                 ....*....|....*....|..
gi 442625026  98 ycTHIwyedwacnECCKGDRCN 119
Cdd:cd23588   71 --TSV--------SCCTGDACK 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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