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Conserved domains on  [gi|442617072|ref|NP_001259743|]
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uncharacterized protein Dmel_CG1504, isoform D [Drosophila melanogaster]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 12134568)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 73-200 2.08e-14

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


:

Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 69.50  E-value: 2.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072   73 IIKPDSFAGLRaLKKLSLDgNNITRIKQFAFRGLPRLKELSIQYTpLQMVAQFAFAGLqNLSTILLShNQIQRIEGNAFA 152
Cdd:pfam13306   2 SIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIP-SSLTSIGEYAFS 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 442617072  153 GTSNIKLILLTNNpLIRIDSSAFSSlTNVGHLILPSGIRSIEQDAFFG 200
Cdd:pfam13306  77 NCSNLKSITLPSN-LTSIGSYAFSN-CSLKSITIPSSVTTIGSYAFSN 122
 
Name Accession Description Interval E-value
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 73-200 2.08e-14

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 69.50  E-value: 2.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072   73 IIKPDSFAGLRaLKKLSLDgNNITRIKQFAFRGLPRLKELSIQYTpLQMVAQFAFAGLqNLSTILLShNQIQRIEGNAFA 152
Cdd:pfam13306   2 SIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIP-SSLTSIGEYAFS 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 442617072  153 GTSNIKLILLTNNpLIRIDSSAFSSlTNVGHLILPSGIRSIEQDAFFG 200
Cdd:pfam13306  77 NCSNLKSITLPSN-LTSIGSYAFSN-CSLKSITIPSSVTTIGSYAFSN 122
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-275 1.58e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072  53 PLRQLPAtVENLALTKNNFPIIkPDSFAGLRALKKLSLDGNNITRIKQfAFRGLPRLKELSIQYTPLQMVAQfaFAGLQN 132
Cdd:COG4886  177 ELGNLTN-LKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTN 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072 133 LSTILLSHNQIQRIEgnAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHLILPSGIRSIEQDAFFGMDTVGLLKLAYM 212
Cdd:COG4886  252 LEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442617072 213 DLKEVAPFTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNFTSTAA 275
Cdd:COG4886  330 LKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-170 2.67e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072  69 NNFpIIKPDSFAGLRALKKLSLDGNNITRIKQfaFRGLPRLKELSIQYTPLQMVAQFAF--------------------- 127
Cdd:cd21340   55 NNQ-IEKIENLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTFdprslaalsnslrvlnisgnn 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442617072 128 -------AGLQNLSTILLSHNQIQRIE--GNAFAGTSNIKLILLTNNPLIRI 170
Cdd:cd21340  132 idsleplAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKK 183
 
Name Accession Description Interval E-value
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 73-200 2.08e-14

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 69.50  E-value: 2.08e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072   73 IIKPDSFAGLRaLKKLSLDgNNITRIKQFAFRGLPRLKELSIQYTpLQMVAQFAFAGLqNLSTILLShNQIQRIEGNAFA 152
Cdd:pfam13306   2 SIGSYAFYNCS-LTSITIP-SSLTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNC-SLTSITIP-SSLTSIGEYAFS 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 442617072  153 GTSNIKLILLTNNpLIRIDSSAFSSlTNVGHLILPSGIRSIEQDAFFG 200
Cdd:pfam13306  77 NCSNLKSITLPSN-LTSIGSYAFSN-CSLKSITIPSSVTTIGSYAFSN 122
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 96-200 2.38e-12

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 63.72  E-value: 2.38e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072   96 TRIKQFAFRGLPrLKELSIQYTpLQMVAQFAFAGLQNLSTILLSHNqIQRIEGNAFAGTSNIKLILLTNnpLIRIDSSAF 175
Cdd:pfam13306   1 TSIGSYAFYNCS-LTSITIPSS-LTSIGEYAFSNCTSLKSITLPSS-LTSIGSYAFYNCSLTSITIPSS--LTSIGEYAF 75

                          90       100
                  ....*....|....*....|....*
gi 442617072  176 SSLTNVGHLILPSGIRSIEQDAFFG 200
Cdd:pfam13306  76 SNCSNLKSITLPSNLTSIGSYAFSN 100
LRR_8 pfam13855
Leucine rich repeat;
107-167 1.65e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.68  E-value: 1.65e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442617072  107 PRLKELSIQYTPLQMVAQFAFAGLQNLSTILLSHNQIQRIEGNAFAGTSNIKLILLTNNPL 167
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
83-143 3.20e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 3.20e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 442617072   83 RALKKLSLDGNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQFAFAGLQNLSTILLSHNQI 143
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-275 1.58e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.48  E-value: 1.58e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072  53 PLRQLPAtVENLALTKNNFPIIkPDSFAGLRALKKLSLDGNNITRIKQfAFRGLPRLKELSIQYTPLQMVAQfaFAGLQN 132
Cdd:COG4886  177 ELGNLTN-LKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTN 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072 133 LSTILLSHNQIQRIEgnAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHLILPSGIRSIEQDAFFGMDTVGLLKLAYM 212
Cdd:COG4886  252 LEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442617072 213 DLKEVAPFTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNFTSTAA 275
Cdd:COG4886  330 LKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
62-186 2.51e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 55.71  E-value: 2.51e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072  62 ENLALTKNNFPIIkPDSFAGLRALKKLSLDGNNITRIkQFAFRGLPRLKELSIQYTPLQMVAQfAFAGLQNLSTILLSHN 141
Cdd:COG4886  116 ESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNN 192

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 442617072 142 QIQRIeGNAFAGTSNIKLILLTNNPLIRIDSSaFSSLTNVGHLIL 186
Cdd:COG4886  193 QITDL-PEPLGNLTNLEELDLSGNQLTDLPEP-LANLTNLETLDL 235
LRR_8 pfam13855
Leucine rich repeat;
60-119 2.66e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 2.66e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072   60 TVENLALTKNNFPIIKPDSFAGLRALKKLSLDGNNITRIKQFAFRGLPRLKELSIQYTPL 119
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
76-286 2.75e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 52.24  E-value: 2.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072  76 PDSFAGLRALKKLSLDGNNITRIKQfAFRGLPRLKELSIQYTPLQMVAQfAFAGLQNLSTILLSHNQIQRIeGNAFAGTS 155
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGNLT 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072 156 NIKLILLTNNPLIRIdSSAFSSLTNVGHLIlpsgirsieqdaffgmdtvgllkLAYMDLKEVaPFTFRGLSNVLLLTLQE 235
Cdd:COG4886  183 NLKELDLSNNQITDL-PEPLGNLTNLEELD-----------------------LSGNQLTDL-PEPLANLTNLETLDLSN 237

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 442617072 236 SDLGVIcaDAFTGLTQVETLQILNNKIDSIEELnfTSTAAIKHLKFFGNHV 286
Cdd:COG4886  238 NQLTDL--PELGNLTNLEELDLSNNQLTDLPPL--ANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
53-270 1.85e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.93  E-value: 1.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072  53 PLRQLPAtVENLALTKNNFPIIkPDSFAGLRALKKLSLDGNNITRIKQFAfrGLPRLKELSIQYTPLQMVAqfAFAGLQN 132
Cdd:COG4886  200 PLGNLTN-LEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDLPELG--NLTNLEELDLSNNQLTDLP--PLANLTN 273

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072 133 LSTILLSHNQIQRIEGNAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHLILPSGIRSIEQDAFFGMDTVGLLKLAYM 212
Cdd:COG4886  274 LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLL 353

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 442617072 213 DLKEVAPFTFRGLSNVLLLTLQESDLGVICADAFTGLTQVETLQILNNKIDSIEELNF 270
Cdd:COG4886  354 LLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAV 411
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 69-170 2.67e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 45.16  E-value: 2.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072  69 NNFpIIKPDSFAGLRALKKLSLDGNNITRIKQfaFRGLPRLKELSIQYTPLQMVAQFAF--------------------- 127
Cdd:cd21340   55 NNQ-IEKIENLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHIENQRLPPGEKLTFdprslaalsnslrvlnisgnn 131

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 442617072 128 -------AGLQNLSTILLSHNQIQRIE--GNAFAGTSNIKLILLTNNPLIRI 170
Cdd:cd21340  132 idsleplAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKK 183
LRR_8 pfam13855
Leucine rich repeat;
131-186 2.73e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 2.73e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 442617072  131 QNLSTILLSHNQIQRIEGNAFAGTSNIKLILLTNNPLIRIDSSAFSSLTNVGHLIL 186
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR_5 pfam13306
BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich ...
 69-158 4.72e-05

BspA type Leucine rich repeat region (6 copies); This family includes a number of leucine rich repeats. This family contains a large number of BSPA-like surface antigens from Trichomonas vaginalis.


Pssm-ID: 463839 [Multi-domain]  Cd Length: 127  Bit Score: 42.92  E-value: 4.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072   69 NNFPIIKPDSFAGLrALKKLSLDgNNITRIKQFAFRGLPRLKELSIQYTpLQMVAQFAFAGLqNLSTILLShNQIQRIEG 148
Cdd:pfam13306  43 SSLTSIGSYAFYNC-SLTSITIP-SSLTSIGEYAFSNCSNLKSITLPSN-LTSIGSYAFSNC-SLKSITIP-SSVTTIGS 117

                          90
                  ....*....|
gi 442617072  149 NAFAGTSNIK 158
Cdd:pfam13306 118 YAFSNCSNLK 127
LRR_9 pfam14580
Leucine-rich repeat;
59-143 1.31e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 39.36  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442617072   59 ATVENLALTKNNFPII--------KPDSFAGLRALKKLSLDGNNITRIKQFAFRGLPRLKELSIQYTPLQMVAQF-AFAG 129
Cdd:pfam14580  32 PIIENLGATLDQFDTIdfsdneirKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLdPLAS 111

                          90
                  ....*....|....
gi 442617072  130 LQNLSTILLSHNQI 143
Cdd:pfam14580 112 LKKLTFLSLLRNPV 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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