|
Name |
Accession |
Description |
Interval |
E-value |
| Smoothelin |
pfam12510 |
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ... |
3127-3176 |
2.32e-16 |
|
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.
Pssm-ID: 463614 [Multi-domain] Cd Length: 50 Bit Score: 75.81 E-value: 2.32e-16
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 442615314 3127 SSSSAPVTRTTCDIEEIWDEQVLKQLLEQASTYEERRKIRARLRELMAER 3176
Cdd:pfam12510 1 EETSAASKLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
|
|
| Smoothelin |
pfam12510 |
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ... |
2594-2636 |
2.19e-14 |
|
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.
Pssm-ID: 463614 [Multi-domain] Cd Length: 50 Bit Score: 70.03 E-value: 2.19e-14
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 442615314 2594 SDLELEIEEIFDLQRLEKLLETVASYEMRRRIRAQMRLIRKNM 2636
Cdd:pfam12510 8 KLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1394-1702 |
4.26e-11 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 69.72 E-value: 4.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1394 PKEEDSPKYPKGPETPKSPRNDQR--------IPSIPKKGQSPVQFKTEETPRYPQEQER--YPKEPETSQYPK--ESPR 1461
Cdd:PTZ00449 582 PKDPKHPKDPEEPKKPKRPRSAQRptrpkspkLPELLDIPKSPKRPESPKSPKRPPPPQRpsSPERPEGPKIIKspKPPK 661
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1462 NPK----------------------EDAETININEETTIVITKEGSKSPSPRWSPSPERRVPK-------SQQPPSPTAS 1512
Cdd:PTZ00449 662 SPKppfdpkfkekfyddyldaaaksKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlprdeefPFEPIGDPDA 741
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1513 PSVSPVSGRKIPNEvESNFVTEKIIDCRGKTVVEKISQRP----RTPSPTTPKKNTK-PSQKIPERVPETESEPEKDSES 1587
Cdd:PTZ00449 742 EQPDDIEFFTPPEE-ERTFFHETPADTPLPDILAEEFKEEdihaETGEPDEAMKRPDsPSEHEDKPPGDHPSLPKKRHRL 820
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1588 EtkkttSVSVTKTETERRNSRTTK--TKQPLPLKEPQSKVPAGKSPRKDSLTGRKRDSLVEEtritttttttrQGRKPSD 1665
Cdd:PTZ00449 821 D-----GLALSTTDLESDAGRIAKdaSGKIVKLKRSKSFDDLTTVEEAEEMGAEARKIVVDD-----------DGTEADD 884
|
330 340 350
....*....|....*....|....*....|....*..
gi 442615314 1666 TNGSPSiKDRLRSSPRKQKTSPQQTRTPTPAQTRNPE 1702
Cdd:PTZ00449 885 EDTHPP-EEKHKSEVRRRRPPKKPSKPKKPSKPKKPK 920
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3916 |
8.13e-08 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 59.18 E-value: 8.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQLQREQLQREQLQRDQL 3889
Cdd:COG1196 671 LAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEE 750
|
90 100
....*....|....*....|....*..
gi 442615314 3890 QLQQQQQAAAAVQIERQRRQELERQLR 3916
Cdd:COG1196 751 EALEELPEPPDLEELERELERLEREIE 777
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
566-1191 |
3.23e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 57.26 E-value: 3.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 566 YQEP--QRSPQKLREAPTPSWEQPATRRQPveedfsthgfPSVRTTTTSTRPDQPDGEVLHtsktvSRNQSANRktNTER 643
Cdd:PHA03247 2480 YRRPaeARFPFAAGAAPDPGGGGPPDPDAP----------PAPSRLAPAILPDEPVGEPVH-----PRMLTWIR--GLEE 2542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 644 IIETQVEHPNAPSHSTPRSGSPRRSQPRDDYASSPRGPAGKPSQSRPSNTGGSTTTKTTTTSEPLTRRQLQKerevdaah 723
Cdd:PHA03247 2543 LASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP-------- 2614
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 724 rafaaslrSSSPADSTTsvgshhqtPRSSVSSNRTFRREMREGSHDSQAPSESSRissttvtRHTTGGNVTSNTIKTKTT 803
Cdd:PHA03247 2615 --------SPLPPDTHA--------PDPPPPSPSPAANEPDPHPPPTVPPPERPR-------DDPAPGRVSRPRRARRLG 2671
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 804 KPVKTASEPRSPTPKAGGSvttttttittksspspapaspttaapptsapassappdnklsqytytTTKPGDIFSLPPTT 883
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARP-----------------------------------------------TVGSLTSLADPPPP 2704
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 884 PPTINNEPTLTTTRNTTTTTTTTTTATSDNLQNHPKKSAIEPATDTDSQPIRKVKLSANEAKVVEEAPCVRRQyyqlgne 963
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA------- 2777
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 964 GENPETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETtfegrrvsqdreisideliLIEETSGAPGS 1043
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP-------------------LPPPTSAQPTA 2838
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1044 PKIPSPRAQS---------PGKPATRSQSPEKPQPR-ATPRQSPEKE--QPAFKQTHEVYtpSQPEKQFPRARSPE-KTP 1110
Cdd:PHA03247 2839 PPPPPGPPPPslplggsvaPGGDVRRRPPSRSPAAKpAAPARPPVRRlaRPAVSRSTESF--ALPPDQPERPPQPQaPPP 2916
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1111 GWTQPQVSPRQSPEKQLPRAQSPEKvPAVRQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQS 1190
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQP-PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
|
.
gi 442615314 1191 P 1191
Cdd:PHA03247 2996 L 2996
|
|
| PTZ00266 |
PTZ00266 |
NIMA-related protein kinase; Provisional |
3810-3882 |
1.64e-06 |
|
NIMA-related protein kinase; Provisional
Pssm-ID: 173502 [Multi-domain] Cd Length: 1021 Bit Score: 54.74 E-value: 1.64e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442615314 3810 QREQSQRDQNQRELSKREQFQR-EQLQREQLQREQLQRekLQREQLQREQLQREQLQREQLQREQLQReqLQRE 3882
Cdd:PTZ00266 441 EKENAHRKALEMKILEKKRIERlEREERERLERERMER--IERERLERERLERERLERDRLERDRLDR--LERE 510
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1035-1421 |
2.03e-06 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 54.31 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1035 EETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQfpraRSPEKTPGWTQ 1114
Cdd:PTZ00449 502 EDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKE----HKPSKIPTLSK 577
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1115 PQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRqSPEK----QIPDPKTRDQGPGLPR--------ISPRQSPEKQLPKD 1182
Cdd:PTZ00449 578 KPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPK-SPKLpellDIPKSPKRPESPKSPKrppppqrpSSPERPEGPKIIKS 656
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1183 VPQKSRQSPEKDLTNQQRREEEIFRSTITTTQKRTTNNLNEEFITNERDNQNQ----PISEKKPQIPANAEPNTKPSETI 1258
Cdd:PTZ00449 657 PKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPEtpgtPFTTPRPLPPKLPRDEEFPFEPI 736
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1259 ESPDGGFPSK----TTEVEAQPEVKESPTYRK-KGLTRRETFEDRCRQILGMEEDG----DTQGTYTERPNNEQEDVNVS 1329
Cdd:PTZ00449 737 GDPDAEQPDDieffTPPEEERTFFHETPADTPlPDILAEEFKEEDIHAETGEPDEAmkrpDSPSEHEDKPPGDHPSLPKK 816
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1330 HTTIETIQVKIEDCPND------DEDDKP------RRVTETYVVRTQPKIKVEEELFV---DVTEAEDVEilVNPSK--- 1391
Cdd:PTZ00449 817 RHRLDGLALSTTDLESDagriakDASGKIvklkrsKSFDDLTTVEEAEEMGAEARKIVvddDGTEADDED--THPPEekh 894
|
410 420 430
....*....|....*....|....*....|....*..
gi 442615314 1392 -------KSPKEEDSPKYPKGPETPKSPrNDQRIPSI 1421
Cdd:PTZ00449 895 ksevrrrRPPKKPSKPKKPSKPKKPKKP-DSAFIPSI 930
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
2080-2248 |
2.12e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 48.21 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 2080 RQSEPERELDEESEPELDRDTDVEDDDQTSQLETEEEITQTVTKKETLKEFKQQTKETRETRRDSKAEPEKLQKKSPQTK 2159
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK 1660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 2160 VKEES----ARVPKYQAKVSQKVSQWEPKKQPQREPKVTQKETPLEPKKQPLSKVKdEPEKVNKREPKVPQKESQTKLKE 2235
Cdd:PTZ00121 1661 IKAAEeakkAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAEEAKKEA 1739
|
170
....*....|...
gi 442615314 2236 EPERVTKKTPQKE 2248
Cdd:PTZ00121 1740 EEDKKKAEEAKKD 1752
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
926-1184 |
7.58e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.91 E-value: 7.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 926 ATDTDSQPIRKVKLSANEAKVVEEAPC----VRRQYYQLGNEGENPETPESSGTpankKPHQMRRPHDEPEpqlrrsSKS 1001
Cdd:pfam03154 49 AASTSSNDSKAESMKKSSKKIKEEAPSplksAKRQREKGASDTEEPERATAKKS----KTQEISRPNSPSE------GEG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1002 PSVEPRQVQRETTFEGRRVSQDREISidelilieetsgapgSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQ 1081
Cdd:pfam03154 119 ESSDGRSVNDEGSSDPKDIDQDNRST---------------SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1082 PAFKQTHEVYTPSQPEKQFPRARSPEKTPGWTQPQVSP----------RQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPE 1151
Cdd:pfam03154 184 PSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTqstaaphtliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSP 263
|
250 260 270
....*....|....*....|....*....|...
gi 442615314 1152 KQIPDPKTRDQGPGLPRisPRQSPEKQLPKDVP 1184
Cdd:pfam03154 264 QPLPQPSLHGQMPPMPH--SLQTGPSHMQHPVP 294
|
|
| DUF4659 |
pfam15558 |
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ... |
3815-3913 |
9.25e-04 |
|
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 45.03 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3815 QRDQNQRELSKREQFQREQLQR-EQLQREQLQREKLQREQLQREQLQREQLQReqlqREQLQREQLQREQLQRDQLQLQQ 3893
Cdd:pfam15558 18 KEEQRMRELQQQAALAWEELRRrDQKRQETLERERRLLLQQSQEQWQAEKEQR----KARLGREERRRADRREKQVIEKE 93
|
90 100
....*....|....*....|
gi 442615314 3894 QQQAAAAVQIERQRRQELER 3913
Cdd:pfam15558 94 SRWREQAEDQENQRQEKLER 113
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
4126-4601 |
1.40e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.31 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4126 KRPSLPNAMDPGTAAPPrqvyqaPPPPTNIS-------FTYADFPPVRRPQGASAHNYRSQPCLTSAVDQVEALTNPLGA 4198
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPD------PPPPSPSPaanepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR 2682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4199 PlvltssNPTYLPPPgsrrfdyiSSPVDVDADSPPNSPTSfmtMPNPTLMTDNTDDDLDLDSDNNMLEYRAETKVMRKPR 4278
Cdd:PHA03247 2683 P------RRRAARPT--------VGSLTSLADPPPPPPTP---EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP 2745
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4279 SQTAVRVADRRNAhmsddevygknSRAAKSllytmkqlggGPGNAsvgnsgqrrqplTAPSSPKSGCLSPDGRPYQAPLV 4358
Cdd:PHA03247 2746 AGPATPGGPARPA-----------RPPTTA----------GPPAP------------APPAAPAAGPPRRLTRPAVASLS 2792
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4359 EPLFPQLSTFEPKRQPQFANSPMSTPPAVSMPSinyqanPTYTPPrsnqnsnsylgetnTSYVVTYPLDDSGDEPEPESM 4438
Cdd:PHA03247 2793 ESRESLPSPWDPADPPAAVLAPAAALPPAASPA------GPLPPP--------------TSAQPTAPPPPPGPPPPSLPL 2852
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4439 ATSVSQ----RLRRTSEhsnassslslgstswTANPVHNTVPSVPLDSAMGPPVDRSTKPQVSQPVGPKMPQHVAQKQIP 4514
Cdd:PHA03247 2853 GGSVAPggdvRRRPPSR---------------SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4515 QQLPNQLPQQIPQQLPKQLPQQIPQQLPQQLPQQLPKQLPQQIPPQLPKQLPQQIPQP--ELPQQLPnnlPRHAPKLSSR 4592
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrfRVPQPAP---SREAPASSTP 2994
|
....*....
gi 442615314 4593 SHTIQGDSG 4601
Cdd:PHA03247 2995 PLTGHSLSR 3003
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
1008-1255 |
2.37e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 44.37 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1008 QVQRETTFEGRRVSQDREISIDELILIEETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQT 1087
Cdd:NF033839 254 KVEIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVK 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1088 HEVYTP-----SQPEKQFPRAR-SPEKTPGWTQPQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPEKQIPDPKTRD 1161
Cdd:NF033839 334 PQPEKPkpevkPQLETPKPEVKpQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQP 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1162 QGPGlPRISPrqSPEKQLPKDVPQKSRQSPEKDLTNQQRREE-----EIFRSTITTTQKRTTNNLNEEFITNERDNQNQP 1236
Cdd:NF033839 414 EKPK-PEVKP--QPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkpqpETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQ 490
|
250
....*....|....*....
gi 442615314 1237 ISEKKPQIPANAEPNTKPS 1255
Cdd:NF033839 491 ADDKKPSTPNNLSKDKQPS 509
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
1000-1192 |
3.35e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 43.60 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1000 KSPSVEPRQVQRETTFEGRRVSQDREISIDELILIEETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEK 1079
Cdd:NF033839 290 KKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPEVKPQP 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1080 EQPAFKQTHEVYTPSQPEKQFPRARSPEKTPGWTQPQVSPRQSPEKqlpraQSPEKVPAVRQPSVSPRQSPEKQIPDPKT 1159
Cdd:NF033839 370 EKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEK-----PKPEVKPQPEKPKPEVKPQPEKPKPEVKP 444
|
170 180 190
....*....|....*....|....*....|...
gi 442615314 1160 RDQGPGlPRISPRqsPEKQLPKDVPQKSRQSPE 1192
Cdd:NF033839 445 QPEKPK-PEVKPQ--PETPKPEVKPQPEKPKPE 474
|
|
| GBP_C |
cd16269 |
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ... |
3810-3882 |
4.67e-03 |
|
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.
Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 42.56 E-value: 4.67e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQlQREKLQREQlQREQLQREQLQREQLQRE-QLQREQLQRE 3882
Cdd:cd16269 215 KLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEE-ERENLLKEQ-ERALESKLKEQEALLEEGfKEQAELLQEE 286
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| Smoothelin |
pfam12510 |
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ... |
3127-3176 |
2.32e-16 |
|
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.
Pssm-ID: 463614 [Multi-domain] Cd Length: 50 Bit Score: 75.81 E-value: 2.32e-16
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 442615314 3127 SSSSAPVTRTTCDIEEIWDEQVLKQLLEQASTYEERRKIRARLRELMAER 3176
Cdd:pfam12510 1 EETSAASKLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
|
|
| Smoothelin |
pfam12510 |
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ... |
2594-2636 |
2.19e-14 |
|
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.
Pssm-ID: 463614 [Multi-domain] Cd Length: 50 Bit Score: 70.03 E-value: 2.19e-14
10 20 30 40
....*....|....*....|....*....|....*....|...
gi 442615314 2594 SDLELEIEEIFDLQRLEKLLETVASYEMRRRIRAQMRLIRKNM 2636
Cdd:pfam12510 8 KLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1394-1702 |
4.26e-11 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 69.72 E-value: 4.26e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1394 PKEEDSPKYPKGPETPKSPRNDQR--------IPSIPKKGQSPVQFKTEETPRYPQEQER--YPKEPETSQYPK--ESPR 1461
Cdd:PTZ00449 582 PKDPKHPKDPEEPKKPKRPRSAQRptrpkspkLPELLDIPKSPKRPESPKSPKRPPPPQRpsSPERPEGPKIIKspKPPK 661
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1462 NPK----------------------EDAETININEETTIVITKEGSKSPSPRWSPSPERRVPK-------SQQPPSPTAS 1512
Cdd:PTZ00449 662 SPKppfdpkfkekfyddyldaaaksKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlprdeefPFEPIGDPDA 741
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1513 PSVSPVSGRKIPNEvESNFVTEKIIDCRGKTVVEKISQRP----RTPSPTTPKKNTK-PSQKIPERVPETESEPEKDSES 1587
Cdd:PTZ00449 742 EQPDDIEFFTPPEE-ERTFFHETPADTPLPDILAEEFKEEdihaETGEPDEAMKRPDsPSEHEDKPPGDHPSLPKKRHRL 820
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1588 EtkkttSVSVTKTETERRNSRTTK--TKQPLPLKEPQSKVPAGKSPRKDSLTGRKRDSLVEEtritttttttrQGRKPSD 1665
Cdd:PTZ00449 821 D-----GLALSTTDLESDAGRIAKdaSGKIVKLKRSKSFDDLTTVEEAEEMGAEARKIVVDD-----------DGTEADD 884
|
330 340 350
....*....|....*....|....*....|....*..
gi 442615314 1666 TNGSPSiKDRLRSSPRKQKTSPQQTRTPTPAQTRNPE 1702
Cdd:PTZ00449 885 EDTHPP-EEKHKSEVRRRRPPKKPSKPKKPSKPKKPK 920
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3916 |
8.13e-08 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 59.18 E-value: 8.13e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQLQREQLQREQLQRDQL 3889
Cdd:COG1196 671 LAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEE 750
|
90 100
....*....|....*....|....*..
gi 442615314 3890 QLQQQQQAAAAVQIERQRRQELERQLR 3916
Cdd:COG1196 751 EALEELPEPPDLEELERELERLEREIE 777
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
566-1191 |
3.23e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 57.26 E-value: 3.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 566 YQEP--QRSPQKLREAPTPSWEQPATRRQPveedfsthgfPSVRTTTTSTRPDQPDGEVLHtsktvSRNQSANRktNTER 643
Cdd:PHA03247 2480 YRRPaeARFPFAAGAAPDPGGGGPPDPDAP----------PAPSRLAPAILPDEPVGEPVH-----PRMLTWIR--GLEE 2542
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 644 IIETQVEHPNAPSHSTPRSGSPRRSQPRDDYASSPRGPAGKPSQSRPSNTGGSTTTKTTTTSEPLTRRQLQKerevdaah 723
Cdd:PHA03247 2543 LASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP-------- 2614
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 724 rafaaslrSSSPADSTTsvgshhqtPRSSVSSNRTFRREMREGSHDSQAPSESSRissttvtRHTTGGNVTSNTIKTKTT 803
Cdd:PHA03247 2615 --------SPLPPDTHA--------PDPPPPSPSPAANEPDPHPPPTVPPPERPR-------DDPAPGRVSRPRRARRLG 2671
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 804 KPVKTASEPRSPTPKAGGSvttttttittksspspapaspttaapptsapassappdnklsqytytTTKPGDIFSLPPTT 883
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARP-----------------------------------------------TVGSLTSLADPPPP 2704
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 884 PPTINNEPTLTTTRNTTTTTTTTTTATSDNLQNHPKKSAIEPATDTDSQPIRKVKLSANEAKVVEEAPCVRRQyyqlgne 963
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA------- 2777
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 964 GENPETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETtfegrrvsqdreisideliLIEETSGAPGS 1043
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP-------------------LPPPTSAQPTA 2838
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1044 PKIPSPRAQS---------PGKPATRSQSPEKPQPR-ATPRQSPEKE--QPAFKQTHEVYtpSQPEKQFPRARSPE-KTP 1110
Cdd:PHA03247 2839 PPPPPGPPPPslplggsvaPGGDVRRRPPSRSPAAKpAAPARPPVRRlaRPAVSRSTESF--ALPPDQPERPPQPQaPPP 2916
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1111 GWTQPQVSPRQSPEKQLPRAQSPEKvPAVRQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQS 1190
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQP-PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995
|
.
gi 442615314 1191 P 1191
Cdd:PHA03247 2996 L 2996
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1381-1768 |
7.76e-07 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 55.85 E-value: 7.76e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1381 EDVEILVNPSKK---SPKEEDSPKY---PKGPET----PKSP---------RNDQRIPSIPKKGQSPVQFKTEETPRYP- 1440
Cdd:PTZ00449 483 QEIKKLIKKSKKklaPIEEEDSDKHdepPEGPEAsglpPKAPgdkegeegeHEDSKESDEPKEGGKPGETKEGEVGKKPg 562
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1441 -------------QEQERYPKEPETSQYPKE-----SPRNPKEDAETININEETTIVITKegskSPSPRWSPSPERRVPK 1502
Cdd:PTZ00449 563 pakehkpskiptlSKKPEFPKDPKHPKDPEEpkkpkRPRSAQRPTRPKSPKLPELLDIPK----SPKRPESPKSPKRPPP 638
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1503 SQQPPSPTASPSVSPVSGRKIPNEVESNF---VTEKIID------CRGKTVV------EKISQRPRTPSPTTPKKNTKPS 1567
Cdd:PTZ00449 639 PQRPSSPERPEGPKIIKSPKPPKSPKPPFdpkFKEKFYDdyldaaAKSKETKttvvldESFESILKETLPETPGTPFTTP 718
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1568 QKIPERVPETESEP-----EKDSES------------------ETKKTTSVSVTKTETERRNSRTTKTKQP-LPLKEPQS 1623
Cdd:PTZ00449 719 RPLPPKLPRDEEFPfepigDPDAEQpddiefftppeeertffhETPADTPLPDILAEEFKEEDIHAETGEPdEAMKRPDS 798
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1624 KVPAGKSPRKDSLTGRKRDSLVEETRITTTTTTTRQGRKPSDTNGSPSIKDRLRSSprKQKTSPQQTRTPTPAQTRNPED 1703
Cdd:PTZ00449 799 PSEHEDKPPGDHPSLPKKRHRLDGLALSTTDLESDAGRIAKDASGKIVKLKRSKSF--DDLTTVEEAEEMGAEARKIVVD 876
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442615314 1704 DVDGDSSSPDASPTrvgnERRRSSNISVHTEIIIDHMAPKSPKTERRSQGGTGNVPSPIRKLPVT 1768
Cdd:PTZ00449 877 DDGTEADDEDTHPP----EEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDSAFIPSIIAIFLVS 937
|
|
| PTZ00266 |
PTZ00266 |
NIMA-related protein kinase; Provisional |
3810-3882 |
1.64e-06 |
|
NIMA-related protein kinase; Provisional
Pssm-ID: 173502 [Multi-domain] Cd Length: 1021 Bit Score: 54.74 E-value: 1.64e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442615314 3810 QREQSQRDQNQRELSKREQFQR-EQLQREQLQREQLQRekLQREQLQREQLQREQLQREQLQREQLQReqLQRE 3882
Cdd:PTZ00266 441 EKENAHRKALEMKILEKKRIERlEREERERLERERMER--IERERLERERLERERLERDRLERDRLDR--LERE 510
|
|
| PTZ00449 |
PTZ00449 |
104 kDa microneme/rhoptry antigen; Provisional |
1035-1421 |
2.03e-06 |
|
104 kDa microneme/rhoptry antigen; Provisional
Pssm-ID: 185628 [Multi-domain] Cd Length: 943 Bit Score: 54.31 E-value: 2.03e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1035 EETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQfpraRSPEKTPGWTQ 1114
Cdd:PTZ00449 502 EDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKE----HKPSKIPTLSK 577
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1115 PQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRqSPEK----QIPDPKTRDQGPGLPR--------ISPRQSPEKQLPKD 1182
Cdd:PTZ00449 578 KPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPK-SPKLpellDIPKSPKRPESPKSPKrppppqrpSSPERPEGPKIIKS 656
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1183 VPQKSRQSPEKDLTNQQRREEEIFRSTITTTQKRTTNNLNEEFITNERDNQNQ----PISEKKPQIPANAEPNTKPSETI 1258
Cdd:PTZ00449 657 PKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPEtpgtPFTTPRPLPPKLPRDEEFPFEPI 736
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1259 ESPDGGFPSK----TTEVEAQPEVKESPTYRK-KGLTRRETFEDRCRQILGMEEDG----DTQGTYTERPNNEQEDVNVS 1329
Cdd:PTZ00449 737 GDPDAEQPDDieffTPPEEERTFFHETPADTPlPDILAEEFKEEDIHAETGEPDEAmkrpDSPSEHEDKPPGDHPSLPKK 816
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1330 HTTIETIQVKIEDCPND------DEDDKP------RRVTETYVVRTQPKIKVEEELFV---DVTEAEDVEilVNPSK--- 1391
Cdd:PTZ00449 817 RHRLDGLALSTTDLESDagriakDASGKIvklkrsKSFDDLTTVEEAEEMGAEARKIVvddDGTEADDED--THPPEekh 894
|
410 420 430
....*....|....*....|....*....|....*..
gi 442615314 1392 -------KSPKEEDSPKYPKGPETPKSPrNDQRIPSI 1421
Cdd:PTZ00449 895 ksevrrrRPPKKPSKPKKPSKPKKPKKP-DSAFIPSI 930
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
970-1207 |
2.52e-06 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 54.30 E-value: 2.52e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 970 PESSGTPaNKKPHqmrrPHDEPEPQLRRSSKSPSVEPRQVQRETTFEGRRVSQDREISIDELIL--------IEETSGAP 1041
Cdd:PHA03378 590 PSYAQTP-WPVPH----PSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFptphqppqVEITPYKP 664
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1042 GSPKIPSPRAQ-SPGKPAT---RSQSPE--KPQPRATPRQSPEKEQPAFKQthevytpsQPEKQFPRARSPEKTPGWTQP 1115
Cdd:PHA03378 665 TWTQIGHIPYQpSPTGANTmlpIQWAPGtmQPPPRAPTPMRPPAAPPGRAQ--------RPAAATGRARPPAAAPGRARP 736
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1116 qvsPRQSPEKQLPRAQSPekvPAVRQPSVSPRQSPEKQI----PDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQSP 1191
Cdd:PHA03378 737 ---PAAAPGRARPPAAAP---GRARPPAAAPGRARPPAAapgaPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLM 810
|
250
....*....|....*.
gi 442615314 1192 EKDLTNQQRREEEIFR 1207
Cdd:PHA03378 811 PRAAPGQQGPTKQILR 826
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
967-1283 |
2.85e-06 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 54.17 E-value: 2.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 967 PETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVE-PRQVQRETTFEG---------RRVSQDREISIDELilieE 1036
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrPRRARRLGRAAQassppqrprRRAARPTVGSLTSL----A 2699
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1037 TSGAPGSPKIPSPRAQSPGKP---ATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVY----TPSQPEKQF-PRARSPEK 1108
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPlppGPAAARQASPALPAAPAPPAVPAGPATPGGPARParppTTAGPPAPApPAAPAAGP 2779
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1109 TPGWTQPQVSPRQSPEKQLPRAQSPEKVPAV---RQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVP- 1184
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAvlaPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPg 2859
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1185 ------QKSRQSPEKDLTNQQRREEEIFRSTITttqkrttnnlneefitneRDNQNQPISEKKPQIPANAEPNTKPSETI 1258
Cdd:PHA03247 2860 gdvrrrPPSRSPAAKPAAPARPPVRRLARPAVS------------------RSTESFALPPDQPERPPQPQAPPPPQPQP 2921
|
330 340
....*....|....*....|....*
gi 442615314 1259 ESPDGGFPSKTTEVEAQPEVKESPT 1283
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPT 2946
|
|
| tolA |
PRK09510 |
cell envelope integrity inner membrane protein TolA; Provisional |
3809-3882 |
3.03e-05 |
|
cell envelope integrity inner membrane protein TolA; Provisional
Pssm-ID: 236545 [Multi-domain] Cd Length: 387 Bit Score: 49.80 E-value: 3.03e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442615314 3809 YQREQSQRDQNQRElSKREQFQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQLQREQLQRE 3882
Cdd:PRK09510 64 YNRQQQQQKSAKRA-EEQRKKKEQQQAEELQQKQAAEQERLKQLEKERLAAQEQKKQAEEAAKQAALKQKQAEE 136
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
921-1463 |
3.87e-05 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 50.47 E-value: 3.87e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 921 SAIEPATDTDSQPIRKVKLSAN--EAKVVEEAPCVRRQYYQLGNEGENPETPESSGTPANKKPHQMRRPHDE----PEPQ 994
Cdd:PRK10263 324 AAATTATQSWAAPVEPVTQTPPvaSVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEplqqPVQP 403
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 995 LRRSSKSPSVEPRQVQRETTFEGRRVSQDREISIDELILIEETSGA--PGSPKIPSPRAQSPGK-PATRSQSPEKPQPRA 1071
Cdd:PRK10263 404 QQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAeeQQSTFAPQSTYQTEQTyQQPAAQEPLYQQPQP 483
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1072 TPRQSPEKEQPAFKQTHevytPSQP------EKQFPRARSPEKTPGWTQPQVSPRQSPEKQLP--RAQSPEKVPAVRQ-P 1142
Cdd:PRK10263 484 VEQQPVVEPEPVVEETK----PARPplyyfeEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSslKAPSVAAVPPVEAaA 559
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1143 SVSPRQSPEKQ----------IPDPKTRDQGPGLPRISPRQSPEKQLPKdvPQKSRQSPEKDLTN------QQRREEEIF 1206
Cdd:PRK10263 560 AVSPLASGVKKatlatgaaatVAAPVFSLANSGGPRPQVKEGIGPQLPR--PKRIRVPTRRELASygiklpSQRAAEEKA 637
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1207 RSTITTTQKRTTNNLNEEFITNERDNQNQPISEKKPQIPANAEPNTKPSETIESPDGGfpskttEVEAQPEVKESPTYRK 1286
Cdd:PRK10263 638 REAQRNQYDSGDQYNDDEIDAMQQDELARQFAQTQQQRYGEQYQHDVPVNAEDADAAA------EAELARQFAQTQQQRY 711
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1287 KGltrretfedrcrqilgmeedgdtqgtytERPNNEQEdVNVSHTTIETIQVKIEDCPNddeddkprrvtetyvvrtqpk 1366
Cdd:PRK10263 712 SG----------------------------EQPAGANP-FSLDDFEFSPMKALLDDGPH--------------------- 741
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1367 ikveEELFVDVTEAEDVEILVNPSKKSPKEEDSPKYPKG----PETPKSPRNDQRIPSIPKKGQSpvQFKTEETPRYPQE 1442
Cdd:PRK10263 742 ----EPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPqyqqPQQPVAPQPQYQQPQQPVAPQP--QYQQPQQPVAPQP 815
|
570 580
....*....|....*....|.
gi 442615314 1443 QERYPKEPETSQYPKESPRNP 1463
Cdd:PRK10263 816 QYQQPQQPVAPQPQYQQPQQP 836
|
|
| PTZ00266 |
PTZ00266 |
NIMA-related protein kinase; Provisional |
3812-3876 |
3.87e-05 |
|
NIMA-related protein kinase; Provisional
Pssm-ID: 173502 [Multi-domain] Cd Length: 1021 Bit Score: 50.51 E-value: 3.87e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442615314 3812 EQSQRDQNQR-ELSKREQFQREQLQREQLQREQLQREKLQREQLQReqLQREQLQReqLQREQLQR 3876
Cdd:PTZ00266 461 ERLEREERERlERERMERIERERLERERLERERLERDRLERDRLDR--LERERVDR--LERDRLEK 522
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3918 |
4.94e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 49.94 E-value: 4.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQREKLQREQLQRE----QLQREQLQREQLQREQLQREQLQREQLQ 3885
Cdd:COG1196 305 ARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEEleeaEAELAEAEEALLEAEAELAEAEEELEEL 384
|
90 100 110
....*....|....*....|....*....|...
gi 442615314 3886 RDQLQLQQQQQAAAAVQIERQRRQELERQLRLE 3918
Cdd:COG1196 385 AEELLEALRAAAELAAQLEELEEAEEALLERLE 417
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3917 |
7.79e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 49.16 E-value: 7.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQfQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQLQREQLQREQLQRDQL 3889
Cdd:COG1196 368 LEAEAELAEAEEELEELAE-ELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446
|
90 100
....*....|....*....|....*...
gi 442615314 3890 QLQQQQQAAAAVQIERQRRQELERQLRL 3917
Cdd:COG1196 447 AAEEEAELEEEEEALLELLAELLEEAAL 474
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3917 |
9.38e-05 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 49.16 E-value: 9.38e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQREKLQ-REQLQREQLQREQLQREQLQREQLQREQLQREQLQRDQ 3888
Cdd:COG1196 322 EEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEaEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQ 401
|
90 100
....*....|....*....|....*....
gi 442615314 3889 LQLQQQQQAAAAVQIERQRRQELERQLRL 3917
Cdd:COG1196 402 LEELEEAEEALLERLERLEEELEELEEAL 430
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3917 |
1.99e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 48.01 E-value: 1.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQL--QREQLQREQLQRD 3887
Cdd:COG1196 355 EAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLeeELEELEEALAELE 434
|
90 100 110
....*....|....*....|....*....|
gi 442615314 3888 QLQLQQQQQAAAAVQIERQRRQELERQLRL 3917
Cdd:COG1196 435 EEEEEEEEALEEAAEEEAELEEEEEALLEL 464
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
2080-2248 |
2.12e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 48.21 E-value: 2.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 2080 RQSEPERELDEESEPELDRDTDVEDDDQTSQLETEEEITQTVTKKETLKEFKQQTKETRETRRDSKAEPEKLQKKSPQTK 2159
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK 1660
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 2160 VKEES----ARVPKYQAKVSQKVSQWEPKKQPQREPKVTQKETPLEPKKQPLSKVKdEPEKVNKREPKVPQKESQTKLKE 2235
Cdd:PTZ00121 1661 IKAAEeakkAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAEEAKKEA 1739
|
170
....*....|...
gi 442615314 2236 EPERVTKKTPQKE 2248
Cdd:PTZ00121 1740 EEDKKKAEEAKKD 1752
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3917 |
5.32e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 46.47 E-value: 5.32e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQLQREQLQREQLQRDQL 3889
Cdd:COG1196 277 EELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEA 356
|
90 100
....*....|....*....|....*...
gi 442615314 3890 QLQQQQQAAAAVQIERQRRQELERQLRL 3917
Cdd:COG1196 357 EAELAEAEEALLEAEAELAEAEEELEEL 384
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
2080-2254 |
6.73e-04 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 46.29 E-value: 6.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 2080 RQSEPERELDEESEPELDRDTDVEDDDQTSQLETEEEitQTVTKKETLKefKQQTKETRETRRDSKAEPEKLQKKSPQTK 2159
Cdd:PTZ00121 1621 KAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE--ENKIKAAEEA--KKAEEDKKKAEEAKKAEEDEKKAAEALKK 1696
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 2160 VKEESARVPKYQAKVSQKVSQWEP--KKQPQREPKVTQ-KETPLEPKKQPLSKVKDEPEKVNKREPKVPQKESQTKLKEE 2236
Cdd:PTZ00121 1697 EAEEAKKAEELKKKEAEEKKKAEElkKAEEENKIKAEEaKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKE 1776
|
170
....*....|....*...
gi 442615314 2237 PERVTKKTPQKEPRKEPL 2254
Cdd:PTZ00121 1777 KEAVIEEELDEEDEKRRM 1794
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
961-1157 |
6.90e-04 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 46.32 E-value: 6.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 961 GNEGENPETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETTFEGRRVSQDREISIDELILIEETSGA 1040
Cdd:PHA03307 250 GPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST 329
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1041 PGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKqfPRARSPEKTPGWTQ--PQVS 1118
Cdd:PHA03307 330 SSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTR--RRARAAVAGRARRRdaTGRF 407
|
170 180 190
....*....|....*....|....*....|....*....
gi 442615314 1119 PRQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPEKQIPDP 1157
Cdd:PHA03307 408 PAGRPRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPP 446
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1041-1127 |
7.53e-04 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 46.23 E-value: 7.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1041 PGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQFPRARSPEKT----PGWTQPQ 1116
Cdd:PRK10263 755 PQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPvapqPQYQQPQ 834
|
90
....*....|.
gi 442615314 1117 VSPRQSPEKQL 1127
Cdd:PRK10263 835 QPVAPQPQDTL 845
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
926-1184 |
7.58e-04 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 45.91 E-value: 7.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 926 ATDTDSQPIRKVKLSANEAKVVEEAPC----VRRQYYQLGNEGENPETPESSGTpankKPHQMRRPHDEPEpqlrrsSKS 1001
Cdd:pfam03154 49 AASTSSNDSKAESMKKSSKKIKEEAPSplksAKRQREKGASDTEEPERATAKKS----KTQEISRPNSPSE------GEG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1002 PSVEPRQVQRETTFEGRRVSQDREISidelilieetsgapgSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQ 1081
Cdd:pfam03154 119 ESSDGRSVNDEGSSDPKDIDQDNRST---------------SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASP 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1082 PAFKQTHEVYTPSQPEKQFPRARSPEKTPGWTQPQVSP----------RQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPE 1151
Cdd:pfam03154 184 PSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTqstaaphtliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSP 263
|
250 260 270
....*....|....*....|....*....|...
gi 442615314 1152 KQIPDPKTRDQGPGLPRisPRQSPEKQLPKDVP 1184
Cdd:pfam03154 264 QPLPQPSLHGQMPPMPH--SLQTGPSHMQHPVP 294
|
|
| YhaN |
COG4717 |
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown]; |
3810-3916 |
8.20e-04 |
|
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
Pssm-ID: 443752 [Multi-domain] Cd Length: 641 Bit Score: 45.91 E-value: 8.20e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLqREQLQREKLQREQLQREQLQREQLQREQLQREQlQREQLQREQLQRDQL 3889
Cdd:COG4717 108 EAELEELREELEKLEKLLQLLPLYQELEAL-EAELAELPERLEELEERLEELRELEEELEELEA-ELAELQEELEELLEQ 185
|
90 100 110
....*....|....*....|....*....|.
gi 442615314 3890 QLQQQQQAAAAVQIE----RQRRQELERQLR 3916
Cdd:COG4717 186 LSLATEEELQDLAEEleelQQRLAELEEELE 216
|
|
| DUF4659 |
pfam15558 |
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ... |
3815-3913 |
9.25e-04 |
|
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 45.03 E-value: 9.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3815 QRDQNQRELSKREQFQREQLQR-EQLQREQLQREKLQREQLQREQLQREQLQReqlqREQLQREQLQREQLQRDQLQLQQ 3893
Cdd:pfam15558 18 KEEQRMRELQQQAALAWEELRRrDQKRQETLERERRLLLQQSQEQWQAEKEQR----KARLGREERRRADRREKQVIEKE 93
|
90 100
....*....|....*....|
gi 442615314 3894 QQQAAAAVQIERQRRQELER 3913
Cdd:pfam15558 94 SRWREQAEDQENQRQEKLER 113
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1034-1146 |
1.09e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 45.36 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1034 IEETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAfkQTHEVYTPSQPEKQFPRARSPEKTPG-W 1112
Cdd:PRK07764 392 GAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAP--PSPAGNAPAGGAPSPPPAAAPSAQPApA 469
|
90 100 110
....*....|....*....|....*....|....
gi 442615314 1113 TQPQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSP 1146
Cdd:PRK07764 470 PAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP 503
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
940-1190 |
1.15e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 45.25 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 940 SANEAKVVEEAPCVRRQYYQLGNEGENPETPESSGTPANKKPHQMRRPhdepepqlrrSSKSPSVEPRQVQRETTFEGRR 1019
Cdd:PRK12323 376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAP----------ARRSPAPEALAAARQASARGPG 445
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1020 VSQdreisideliliEETSGAPGSP--KIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSqpe 1097
Cdd:PRK12323 446 GAP------------APAPAPAAAPaaAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPA--- 510
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1098 kqfPRARSPEKTPGWTQPQVSPRQSPEKQLPRAQSPEKVPAvrqPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPE- 1176
Cdd:PRK12323 511 ---PAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA---PAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPAl 584
|
250
....*....|....*..
gi 442615314 1177 -KQLP-KDVPQK-SRQS 1190
Cdd:PRK12323 585 aARLPvRGLAQQlARQS 601
|
|
| DUF4670 |
pfam15709 |
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins ... |
3810-3910 |
1.19e-03 |
|
Domain of unknown function (DUF4670); This family of proteins is found in eukaryotes. Proteins in this family are typically between 373 and 763 amino acids in length.
Pssm-ID: 464815 [Multi-domain] Cd Length: 522 Bit Score: 44.94 E-value: 1.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKR-----EQFQREQLQREQLQREQLQREKLQREQLQREQ--------LQREQLQREQLQREQLQR 3876
Cdd:pfam15709 329 EQEKASRDRLRAERAEMrrlevERKRREQEEQRRLQQEQLERAEKMREELELEQqrrfeeirLRKQRLEEERQRQEEEER 408
|
90 100 110
....*....|....*....|....*....|....
gi 442615314 3877 EQLQREQLQRDQLQLQQQQQAAAAVQIERQRRQE 3910
Cdd:pfam15709 409 KQRLQLQAAQERARQQQEEFRRKLQELQRKKQQE 442
|
|
| PRK10263 |
PRK10263 |
DNA translocase FtsK; Provisional |
1047-1180 |
1.38e-03 |
|
DNA translocase FtsK; Provisional
Pssm-ID: 236669 [Multi-domain] Cd Length: 1355 Bit Score: 45.46 E-value: 1.38e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1047 PSPRAQSPG-KPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQFPRARSPEktPGWTQPQVSPRQSPEK 1125
Cdd:PRK10263 740 PHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ--PQYQQPQQPVAPQPQY 817
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 442615314 1126 QLPRaQSPEKVPAVRQPSVSPRQSPEKQIPDPKTRDQGPGlpriSPRQSPEKQLP 1180
Cdd:PRK10263 818 QQPQ-QPVAPQPQYQQPQQPVAPQPQDTLLHPLLMRNGDS----RPLHKPTTPLP 867
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
4126-4601 |
1.40e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 45.31 E-value: 1.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4126 KRPSLPNAMDPGTAAPPrqvyqaPPPPTNIS-------FTYADFPPVRRPQGASAHNYRSQPCLTSAVDQVEALTNPLGA 4198
Cdd:PHA03247 2609 RGPAPPSPLPPDTHAPD------PPPPSPSPaanepdpHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQR 2682
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4199 PlvltssNPTYLPPPgsrrfdyiSSPVDVDADSPPNSPTSfmtMPNPTLMTDNTDDDLDLDSDNNMLEYRAETKVMRKPR 4278
Cdd:PHA03247 2683 P------RRRAARPT--------VGSLTSLADPPPPPPTP---EPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVP 2745
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4279 SQTAVRVADRRNAhmsddevygknSRAAKSllytmkqlggGPGNAsvgnsgqrrqplTAPSSPKSGCLSPDGRPYQAPLV 4358
Cdd:PHA03247 2746 AGPATPGGPARPA-----------RPPTTA----------GPPAP------------APPAAPAAGPPRRLTRPAVASLS 2792
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4359 EPLFPQLSTFEPKRQPQFANSPMSTPPAVSMPSinyqanPTYTPPrsnqnsnsylgetnTSYVVTYPLDDSGDEPEPESM 4438
Cdd:PHA03247 2793 ESRESLPSPWDPADPPAAVLAPAAALPPAASPA------GPLPPP--------------TSAQPTAPPPPPGPPPPSLPL 2852
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4439 ATSVSQ----RLRRTSEhsnassslslgstswTANPVHNTVPSVPLDSAMGPPVDRSTKPQVSQPVGPKMPQHVAQKQIP 4514
Cdd:PHA03247 2853 GGSVAPggdvRRRPPSR---------------SPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 4515 QQLPNQLPQQIPQQLPKQLPQQIPQQLPQQLPQQLPKQLPQQIPPQLPKQLPQQIPQP--ELPQQLPnnlPRHAPKLSSR 4592
Cdd:PHA03247 2918 QPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPrfRVPQPAP---SREAPASSTP 2994
|
....*....
gi 442615314 4593 SHTIQGDSG 4601
Cdd:PHA03247 2995 PLTGHSLSR 3003
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3917 |
1.50e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 44.93 E-value: 1.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQLQREQ--LQREQLQRD 3887
Cdd:COG1196 342 LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEalLERLERLEE 421
|
90 100 110
....*....|....*....|....*....|
gi 442615314 3888 QLQLQQQQQAAAAVQIERQRRQELERQLRL 3917
Cdd:COG1196 422 ELEELEEALAELEEEEEEEEEALEEAAEEE 451
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3882 |
1.62e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 44.93 E-value: 1.62e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQ---REKLQREQLQREQLQREQLQREQLQREQLQREQLQRE 3882
Cdd:COG1196 252 EAELEELEAELAELEAELEELRLELEELELELEEAQaeeYELLAELARLEQDIARLEERRRELEERLEELEEELAE 327
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
1040-1193 |
2.23e-03 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 44.48 E-value: 2.23e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1040 APGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAfkqthevytpsQPEKQFPRARSPEKTPGWTQPQVSP 1119
Cdd:PRK12323 373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAA-----------RAVAAAPARRSPAPEALAAARQASA 441
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442615314 1120 RQS-PEKQLPRAQSPEKVPAVRQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQSPEK 1193
Cdd:PRK12323 442 RGPgGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDA 516
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
1008-1255 |
2.37e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 44.37 E-value: 2.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1008 QVQRETTFEGRRVSQDREISIDELILIEETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQT 1087
Cdd:NF033839 254 KVEIENTVHKIFADMDAVVTKFKKGLTQDTPKEPGNKKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVK 333
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1088 HEVYTP-----SQPEKQFPRAR-SPEKTPGWTQPQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPEKQIPDPKTRD 1161
Cdd:NF033839 334 PQPEKPkpevkPQLETPKPEVKpQPEKPKPEVKPQPEKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQP 413
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1162 QGPGlPRISPrqSPEKQLPKDVPQKSRQSPEKDLTNQQRREE-----EIFRSTITTTQKRTTNNLNEEFITNERDNQNQP 1236
Cdd:NF033839 414 EKPK-PEVKP--QPEKPKPEVKPQPEKPKPEVKPQPEKPKPEvkpqpETPKPEVKPQPEKPKPEVKPQPEKPKPDNSKPQ 490
|
250
....*....|....*....
gi 442615314 1237 ISEKKPQIPANAEPNTKPS 1255
Cdd:NF033839 491 ADDKKPSTPNNLSKDKQPS 509
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
1033-1200 |
2.46e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 44.54 E-value: 2.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1033 LIEETSGAPGSPKIPSPRAQSPGKPaTRSQSPEKPQPRatprqspekeqpafkqthevytPSQPEKQfPRARSPEKTPGW 1112
Cdd:PHA03247 2540 LEELASDDAGDPPPPLPPAAPPAAP-DRSVPPPRPAPR----------------------PSEPAVT-SRARRPDAPPQS 2595
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1113 TQPQ--VSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPEKqipdpktrdqgpgLPRISPRQSPEKQLPKDVPQKSRQS 1190
Cdd:PHA03247 2596 ARPRapVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANE-------------PDPHPPPTVPPPERPRDDPAPGRVS 2662
|
170
....*....|
gi 442615314 1191 PEKDLTNQQR 1200
Cdd:PHA03247 2663 RPRRARRLGR 2672
|
|
| DUF4659 |
pfam15558 |
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins ... |
3810-3882 |
3.08e-03 |
|
Domain of unknown function (DUF4659); This family of proteins is found in eukaryotes. Proteins in this family are typically between 427 and 674 amino acids in length. There are two completely conserved residues (D and I) that may be functionally important.
Pssm-ID: 464768 [Multi-domain] Cd Length: 374 Bit Score: 43.49 E-value: 3.08e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442615314 3810 QREQSQR--DQNQRELSKREQFQREQLQREQLQREQLQR-EKLQREQLQREQLQREQLQREQLQREQLQREQLQRE 3882
Cdd:pfam15558 64 QAEKEQRkaRLGREERRRADRREKQVIEKESRWREQAEDqENQRQEKLERARQEAEQRKQCQEQRLKEKEEELQAL 139
|
|
| PspC_subgroup_2 |
NF033839 |
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, ... |
1000-1192 |
3.35e-03 |
|
pneumococcal surface protein PspC, LPXTG-anchored form; The pneumococcal surface protein PspC, as described in Streptococcus pneumoniae, is a repetitive and highly variable protein, recognized by a conserved N-terminal domain and also by genomic location. This form, subgroup 2, is anchored covalently after cleavage by sortase at a C-terminal LPXTG site. The other form, subgroup 1, has variable numbers of a choline-binding repeat in the C-terminal region, and is also known as choline-binding protein A.
Pssm-ID: 468202 [Multi-domain] Cd Length: 557 Bit Score: 43.60 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1000 KSPSVEPRQVQRETTFEGRRVSQDREISIDELILIEETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEK 1079
Cdd:NF033839 290 KKPSAPKPGMQPSPQPEKKEVKPEPETPKPEVKPQLEKPKPEVKPQPEKPKPEVKPQLETPKPEVKPQPEKPKPEVKPQP 369
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1080 EQPAFKQTHEVYTPSQPEKQFPRARSPEKTPGWTQPQVSPRQSPEKqlpraQSPEKVPAVRQPSVSPRQSPEKQIPDPKT 1159
Cdd:NF033839 370 EKPKPEVKPQPETPKPEVKPQPEKPKPEVKPQPEKPKPEVKPQPEK-----PKPEVKPQPEKPKPEVKPQPEKPKPEVKP 444
|
170 180 190
....*....|....*....|....*....|...
gi 442615314 1160 RDQGPGlPRISPRqsPEKQLPKDVPQKSRQSPE 1192
Cdd:NF033839 445 QPEKPK-PEVKPQ--PETPKPEVKPQPEKPKPE 474
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
967-1194 |
3.41e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 44.01 E-value: 3.41e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 967 PETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETTfegrrvsQDREISiDELILIEETSGAPGSPKI 1046
Cdd:PHA03307 120 TPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA-------SSRQAA-LPLSSPEETARAPSSPPA 191
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1047 PSPRAQSPGKPATRSQSPEKP--QPRATPRQSPEKEQ---PAFKQTHEVYTPSQPEKQFPRARSPEKTPGwtqPQVSPRQ 1121
Cdd:PHA03307 192 EPPPSTPPAAASPRPPRRSSPisASASSPAPAPGRSAaddAGASSSDSSSSESSGCGWGPENECPLPRPA---PITLPTR 268
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442615314 1122 spekqlPRAQSPEKVPAVRQPSVSPRQSPekQIPDPKTRDQGPGLPRISPRQSPEKQL---PKDVPQKSRQSPEKD 1194
Cdd:PHA03307 269 ------IWEASGWNGPSSRPGPASSSSSP--RERSPSPSPSSPGSGPAPSSPRASSSSsssRESSSSSTSSSSESS 336
|
|
| PTZ00266 |
PTZ00266 |
NIMA-related protein kinase; Provisional |
3824-3913 |
4.16e-03 |
|
NIMA-related protein kinase; Provisional
Pssm-ID: 173502 [Multi-domain] Cd Length: 1021 Bit Score: 43.57 E-value: 4.16e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3824 SKREQFQREQLQREQLQREQLQREKLQR-EQLQREQLQREQLQReqLQREQLQREQLQREqlqrdqlqlqqqqqaaaavq 3902
Cdd:PTZ00266 435 AERARIEKENAHRKALEMKILEKKRIERlEREERERLERERMER--IERERLERERLERE-------------------- 492
|
90
....*....|.
gi 442615314 3903 ieRQRRQELER 3913
Cdd:PTZ00266 493 --RLERDRLER 501
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3810-3917 |
4.27e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.77 E-value: 4.27e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQLQ--REKLQREQLQREQLQREQLQREQLQREQLQREQLQREQLQRD 3887
Cdd:COG1196 315 EERLEELEEELAELEEELEELEEELEELEEELEEAEeeLEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRA 394
|
90 100 110
....*....|....*....|....*....|
gi 442615314 3888 QLQlqqqqQAAAAVQIERQRRQELERQLRL 3917
Cdd:COG1196 395 AAE-----LAAQLEELEEAEEALLERLERL 419
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
479-750 |
4.35e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 43.62 E-value: 4.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 479 PTSRVVQKAPTPSYAPPSHSPRQSPAkdfSTHGFPSVRPNKATQEYPSQRPGIAGEEVVVVRSEKSRQVKQQTSSQRTIE 558
Cdd:PHA03307 175 PLSSPEETARAPSSPPAEPPPSTPPA---AASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGP 251
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 559 TEVVGDDYQEPQRSPQKLREAPTpsWEQPATRRQPVEEDfsthgfPSVRTTTTSTRPDQPDGEVLHTSKTVSRNQSANRK 638
Cdd:PHA03307 252 ENECPLPRPAPITLPTRIWEASG--WNGPSSRPGPASSS------SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 639 TNTERIIETqvehPNAPSHSTPRSGSPRRSQPRDDYASSPRGPAGKPSQSRPSNTGGSTTTKTTTTSEPLTRRQLQKERE 718
Cdd:PHA03307 324 SSSSSTSSS----SESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRAR 399
|
250 260 270
....*....|....*....|....*....|..
gi 442615314 719 VDAAHRAFAASLRSSSPADSTTSVGSHHQTPR 750
Cdd:PHA03307 400 RRDATGRFPAGRPRPSPLDAGAASGAFYARYP 431
|
|
| GBP_C |
cd16269 |
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ... |
3810-3882 |
4.67e-03 |
|
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.
Pssm-ID: 293879 [Multi-domain] Cd Length: 291 Bit Score: 42.56 E-value: 4.67e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 442615314 3810 QREQSQRDQNQRELSKREQFQREQLQREQLQREQlQREKLQREQlQREQLQREQLQREQLQRE-QLQREQLQRE 3882
Cdd:cd16269 215 KLLEEQQRELEQKLEDQERSYEEHLRQLKEKMEE-ERENLLKEQ-ERALESKLKEQEALLEEGfKEQAELLQEE 286
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3795-3913 |
5.45e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.39 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3795 REQRELREqlqreqyQREQSQRDQNQRELSKREQFQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQL 3874
Cdd:COG1196 377 AEEELEEL-------AEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAE 449
|
90 100 110
....*....|....*....|....*....|....*....
gi 442615314 3875 QREQLQREQLQRDQLQLQQQQQAAAAVQIERQRRQELER 3913
Cdd:COG1196 450 EEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3804-3916 |
5.45e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 43.39 E-value: 5.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3804 LqreqyQREQSQRDQNQRELSKREQfQREQLQREQLQREQLQREKLQREQLQREQLQREQLQREQLQREQLQREQLQREQ 3883
Cdd:COG1196 318 L-----EELEEELAELEEELEELEE-ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEA 391
|
90 100 110
....*....|....*....|....*....|...
gi 442615314 3884 LQRDQLQLQQQQQAAAAVQIERQRRQELERQLR 3916
Cdd:COG1196 392 LRAAAELAAQLEELEEAEEALLERLERLEEELE 424
|
|
| PRK07764 |
PRK07764 |
DNA polymerase III subunits gamma and tau; Validated |
1037-1204 |
7.59e-03 |
|
DNA polymerase III subunits gamma and tau; Validated
Pssm-ID: 236090 [Multi-domain] Cd Length: 824 Bit Score: 42.67 E-value: 7.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1037 TSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFK--QTHEVYTPSQPEKQFPRARSPEKTPGWTQ 1114
Cdd:PRK07764 617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGgdGWPAKAGGAAPAAPPPAPAPAAPAAPAGA 696
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 1115 PQVSPRQSPEKQLPRAQSPEKV---PAVRQPSVSPRQSPEKQIPDPKTRDQGPGlPRISPRQSPEKQLPKDVPQKSRQSP 1191
Cdd:PRK07764 697 APAQPAPAPAATPPAGQADDPAaqpPQAAQGASAPSPAADDPVPLPPEPDDPPD-PAGAPAQPPPPPAPAPAAAPAAAPP 775
|
170
....*....|...
gi 442615314 1192 EKDLTNQQRREEE 1204
Cdd:PRK07764 776 PSPPSEEEEMAED 788
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
2079-2309 |
7.73e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 42.82 E-value: 7.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 2079 SRQSEPERELDEESEPELDRDTDVEDDDQTSQLETE---EEI--TQTVTKKETLKEFKQQTK-ETRETRRDSKAEPEKLQ 2152
Cdd:PTZ00121 1242 AKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEArkaDELkkAEEKKKADEAKKAEEKKKaDEAKKKAEEAKKADEAK 1321
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 2153 KKSPQTKVKEESARVPKYQAKVSQKVSQWEPKKQPQREPKVTQKETPLEPKKQPLSKVKDEPEKvnkrepKVPQKESQTK 2232
Cdd:PTZ00121 1322 KKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKK------KAEEKKKADE 1395
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 442615314 2233 LKEEPERVTKKTPQKEPRKEPLRQSEDEPEFSPEEEFDDEPLPMTKTHTTAIEMKRQKDILNRPSVFGQRTPERKSS 2309
Cdd:PTZ00121 1396 AKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKA 1472
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3816-3917 |
8.24e-03 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 42.62 E-value: 8.24e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3816 RDQNQRELSKREQFQREQLQREQLQREQLQREKlQREQLqREQLQREQLQREQLQ-REQLQREQLQREQLQRDQLQLQQQ 3894
Cdd:COG1196 235 RELEAELEELEAELEELEAELEELEAELAELEA-ELEEL-RLELEELELELEEAQaEEYELLAELARLEQDIARLEERRR 312
|
90 100
....*....|....*....|...
gi 442615314 3895 QQAAAAVQIERQRRQELERQLRL 3917
Cdd:COG1196 313 ELEERLEELEEELAELEEELEEL 335
|
|
| TPH |
pfam13868 |
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of ... |
3810-3882 |
9.69e-03 |
|
Trichohyalin-plectin-homology domain; This family is a mixtrue of two different families of eukaryotic proteins. Trichoplein or mitostatin, was first defined as a meiosis-specific nuclear structural protein. It has since been linked with mitochondrial movement. It is associated with the mitochondrial outer membrane, and over-expression leads to reduction in mitochondrial motility whereas lack of it enhances mitochondrial movement. The activity appears to be mediated through binding the mitochondria to the actin intermediate filaments (IFs). The family is in the trichohyalin-plectin-homology domain.
Pssm-ID: 464007 [Multi-domain] Cd Length: 341 Bit Score: 41.83 E-value: 9.69e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615314 3810 QREQSQRDQNQRELSK-REQFQREQLQREQLQREQLQREKL-----QREQLQREQLQREQLQREQLQREQLQ---REQLQ 3880
Cdd:pfam13868 115 QAEAEEKLEKQRQLREeIDEFNEEQAEWKELEKEEEREEDErileyLKEKAEREEEREAEREEIEEEKEREIarlRAQQE 194
|
..
gi 442615314 3881 RE 3882
Cdd:pfam13868 195 KA 196
|
|
| |
