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Conserved domains on  [gi|442615306|ref|NP_001259279|]
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uncharacterized protein Dmel_CG34417, isoform Q [Drosophila melanogaster]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Smoothelin pfam12510
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ...
3127-3176 8.27e-16

Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.


:

Pssm-ID: 463614 [Multi-domain]  Cd Length: 50  Bit Score: 73.50  E-value: 8.27e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 442615306  3127 SSSSAPVTRTTCDIEEIWDEQVLKQLLEQASTYEERRKIRARLRELMAER 3176
Cdd:pfam12510    1 EETSAASKLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
Smoothelin pfam12510
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ...
2594-2636 6.94e-14

Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.


:

Pssm-ID: 463614 [Multi-domain]  Cd Length: 50  Bit Score: 68.11  E-value: 6.94e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 442615306  2594 SDLELEIEEIFDLQRLEKLLETVASYEMRRRIRAQMRLIRKNM 2636
Cdd:pfam12510    8 KLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
1394-1702 2.78e-10

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 66.64  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1394 PKEEDSPKYPKGPETPKSPRNDQR--------IPSIPKKGQSPVQFKTEETPRYPQEQER--YPKEPETSQYPK--ESPR 1461
Cdd:PTZ00449  582 PKDPKHPKDPEEPKKPKRPRSAQRptrpkspkLPELLDIPKSPKRPESPKSPKRPPPPQRpsSPERPEGPKIIKspKPPK 661
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1462 NPK----------------------EDAETININEETTIVITKEGSKSPSPRWSPSPERRVPK-------SQQPPSPTAS 1512
Cdd:PTZ00449  662 SPKppfdpkfkekfyddyldaaaksKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlprdeefPFEPIGDPDA 741
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1513 PSVSPVSGRKIPNEvESNFVTEKIIDCRGKTVVEKISQRP----RTPSPTTPKKNTK-PSQKIPERVPETESEPEKDSES 1587
Cdd:PTZ00449  742 EQPDDIEFFTPPEE-ERTFFHETPADTPLPDILAEEFKEEdihaETGEPDEAMKRPDsPSEHEDKPPGDHPSLPKKRHRL 820
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1588 EtkkttSVSVTKTETERRNSRTTKTKQPLPLKEPQSKvpagksPRKDSLTGRKRDSLVEETRittTTTTTRQGRKPSDTN 1667
Cdd:PTZ00449  821 D-----GLALSTTDLESDAGRIAKDASGKIVKLKRSK------SFDDLTTVEEAEEMGAEAR---KIVVDDDGTEADDED 886
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 442615306 1668 GSPSiKDRLRSSPRKQKTSPQQTRTPTPAQTRNPE 1702
Cdd:PTZ00449  887 THPP-EEKHKSEVRRRRPPKKPSKPKKPSKPKKPK 920
PHA03247 super family cl33720
large tegument protein UL36; Provisional
566-1191 1.86e-07

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  566 YQEP--QRSPQKLREAPTPSWEQPATRRQPveedfsthgfPSVRTTTTSTRPDQPDGEVLHtsktvSRNQSANRktNTER 643
Cdd:PHA03247 2480 YRRPaeARFPFAAGAAPDPGGGGPPDPDAP----------PAPSRLAPAILPDEPVGEPVH-----PRMLTWIR--GLEE 2542
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  644 IIETQVEHPNAPSHSTPRSGSPRRSQPRDDYASSPRGPAGKPSQSRPSNTGGSTTTKTTTTSEPLTRRQLQKerevdaah 723
Cdd:PHA03247 2543 LASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP-------- 2614
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  724 rafaaslrSSSPADSTTsvgshhqtPRSSVSSNRTFRREMREGSHDSQAPSESSRissttvtRHTTGGNVTSNTIKTKTT 803
Cdd:PHA03247 2615 --------SPLPPDTHA--------PDPPPPSPSPAANEPDPHPPPTVPPPERPR-------DDPAPGRVSRPRRARRLG 2671
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  804 KPVKTASEPRSPTPKAGGSvttttttittksspspapaspttaapptsapassappdnklsqytytTTKPGDIFSLPPTT 883
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARP-----------------------------------------------TVGSLTSLADPPPP 2704
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  884 PPTINNEPTLTTTRNTTTTTTTTTTATSDNLQNHPKKSAIEPATDTDSQPIRKVKLSANEAKVVEEAPCVRRQyyqlgne 963
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA------- 2777
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  964 GENPETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETtfegrrvsqdreisideliLIEETSGAPGS 1043
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP-------------------LPPPTSAQPTA 2838
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1044 PKIPSPRAQS---------PGKPATRSQSPEKPQPR-ATPRQSPEKE--QPAFKQTHEVYtpSQPEKQFPRARSPE-KTP 1110
Cdd:PHA03247 2839 PPPPPGPPPPslplggsvaPGGDVRRRPPSRSPAAKpAAPARPPVRRlaRPAVSRSTESF--ALPPDQPERPPQPQaPPP 2916
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1111 GWTQPQVSPRQSPEKQLPRAQSPEKvPAVRQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQS 1190
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQP-PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995

                  .
gi 442615306 1191 P 1191
Cdd:PHA03247 2996 L 2996
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
1035-1421 1.04e-05

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1035 EETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQfpraRSPEKTPGWTQ 1114
Cdd:PTZ00449  502 EDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKE----HKPSKIPTLSK 577
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1115 PQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRqSPEK----QIPDPKTRDQGPGLPR--------ISPRQSPEKQLPKD 1182
Cdd:PTZ00449  578 KPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPK-SPKLpellDIPKSPKRPESPKSPKrppppqrpSSPERPEGPKIIKS 656
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1183 VPQKSRQSPEKDLTNQQRREEEIFRSTITTTQKRTTNNLNEEFITNERDNQNQ----PISEKKPQIPANAEPNTKPSETI 1258
Cdd:PTZ00449  657 PKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPEtpgtPFTTPRPLPPKLPRDEEFPFEPI 736
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1259 ESPDGGFPSK----TTEVEAQPEVKESPTYRK-KGLTRRETFEDRCRQILGMEEDG----DTQGTYTERPNNEQEDVNVS 1329
Cdd:PTZ00449  737 GDPDAEQPDDieffTPPEEERTFFHETPADTPlPDILAEEFKEEDIHAETGEPDEAmkrpDSPSEHEDKPPGDHPSLPKK 816
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1330 HTTIETIQVKIEDCPND------DEDDKPRRVTET------YVVRTQPKIKVEEELFV---DVTEAEDVEilVNPSK--- 1391
Cdd:PTZ00449  817 RHRLDGLALSTTDLESDagriakDASGKIVKLKRSksfddlTTVEEAEEMGAEARKIVvddDGTEADDED--THPPEekh 894
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 442615306 1392 -------KSPKEEDSPKYPKGPETPKSPrNDQRIPSI 1421
Cdd:PTZ00449  895 ksevrrrRPPKKPSKPKKPSKPKKPKKP-DSAFIPSI 930
PTZ00121 super family cl31754
MAEBL; Provisional
2080-2248 4.14e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 2080 RQSEPERELDEESEPELDRDTDVEDDDQTSQLETEEEITQTVTKKETLKEFKQQTKETRETRRDSKAEPEKLQKKSPQTK 2159
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK 1660
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 2160 VKEES----ARVPKYQAKVSQKVSQWEPKKQPQREPKVTQKETPLEPKKQPLSKVKdEPEKVNKREPKVPQKESQTKLKE 2235
Cdd:PTZ00121 1661 IKAAEeakkAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAEEAKKEA 1739
                         170
                  ....*....|...
gi 442615306 2236 EPERVTKKTPQKE 2248
Cdd:PTZ00121 1740 EEDKKKAEEAKKD 1752
 
Name Accession Description Interval E-value
Smoothelin pfam12510
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ...
3127-3176 8.27e-16

Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.


Pssm-ID: 463614 [Multi-domain]  Cd Length: 50  Bit Score: 73.50  E-value: 8.27e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 442615306  3127 SSSSAPVTRTTCDIEEIWDEQVLKQLLEQASTYEERRKIRARLRELMAER 3176
Cdd:pfam12510    1 EETSAASKLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
Smoothelin pfam12510
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ...
2594-2636 6.94e-14

Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.


Pssm-ID: 463614 [Multi-domain]  Cd Length: 50  Bit Score: 68.11  E-value: 6.94e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 442615306  2594 SDLELEIEEIFDLQRLEKLLETVASYEMRRRIRAQMRLIRKNM 2636
Cdd:pfam12510    8 KLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
1394-1702 2.78e-10

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 66.64  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1394 PKEEDSPKYPKGPETPKSPRNDQR--------IPSIPKKGQSPVQFKTEETPRYPQEQER--YPKEPETSQYPK--ESPR 1461
Cdd:PTZ00449  582 PKDPKHPKDPEEPKKPKRPRSAQRptrpkspkLPELLDIPKSPKRPESPKSPKRPPPPQRpsSPERPEGPKIIKspKPPK 661
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1462 NPK----------------------EDAETININEETTIVITKEGSKSPSPRWSPSPERRVPK-------SQQPPSPTAS 1512
Cdd:PTZ00449  662 SPKppfdpkfkekfyddyldaaaksKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlprdeefPFEPIGDPDA 741
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1513 PSVSPVSGRKIPNEvESNFVTEKIIDCRGKTVVEKISQRP----RTPSPTTPKKNTK-PSQKIPERVPETESEPEKDSES 1587
Cdd:PTZ00449  742 EQPDDIEFFTPPEE-ERTFFHETPADTPLPDILAEEFKEEdihaETGEPDEAMKRPDsPSEHEDKPPGDHPSLPKKRHRL 820
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1588 EtkkttSVSVTKTETERRNSRTTKTKQPLPLKEPQSKvpagksPRKDSLTGRKRDSLVEETRittTTTTTRQGRKPSDTN 1667
Cdd:PTZ00449  821 D-----GLALSTTDLESDAGRIAKDASGKIVKLKRSK------SFDDLTTVEEAEEMGAEAR---KIVVDDDGTEADDED 886
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 442615306 1668 GSPSiKDRLRSSPRKQKTSPQQTRTPTPAQTRNPE 1702
Cdd:PTZ00449  887 THPP-EEKHKSEVRRRRPPKKPSKPKKPSKPKKPK 920
PHA03247 PHA03247
large tegument protein UL36; Provisional
566-1191 1.86e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  566 YQEP--QRSPQKLREAPTPSWEQPATRRQPveedfsthgfPSVRTTTTSTRPDQPDGEVLHtsktvSRNQSANRktNTER 643
Cdd:PHA03247 2480 YRRPaeARFPFAAGAAPDPGGGGPPDPDAP----------PAPSRLAPAILPDEPVGEPVH-----PRMLTWIR--GLEE 2542
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  644 IIETQVEHPNAPSHSTPRSGSPRRSQPRDDYASSPRGPAGKPSQSRPSNTGGSTTTKTTTTSEPLTRRQLQKerevdaah 723
Cdd:PHA03247 2543 LASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP-------- 2614
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  724 rafaaslrSSSPADSTTsvgshhqtPRSSVSSNRTFRREMREGSHDSQAPSESSRissttvtRHTTGGNVTSNTIKTKTT 803
Cdd:PHA03247 2615 --------SPLPPDTHA--------PDPPPPSPSPAANEPDPHPPPTVPPPERPR-------DDPAPGRVSRPRRARRLG 2671
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  804 KPVKTASEPRSPTPKAGGSvttttttittksspspapaspttaapptsapassappdnklsqytytTTKPGDIFSLPPTT 883
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARP-----------------------------------------------TVGSLTSLADPPPP 2704
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  884 PPTINNEPTLTTTRNTTTTTTTTTTATSDNLQNHPKKSAIEPATDTDSQPIRKVKLSANEAKVVEEAPCVRRQyyqlgne 963
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA------- 2777
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  964 GENPETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETtfegrrvsqdreisideliLIEETSGAPGS 1043
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP-------------------LPPPTSAQPTA 2838
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1044 PKIPSPRAQS---------PGKPATRSQSPEKPQPR-ATPRQSPEKE--QPAFKQTHEVYtpSQPEKQFPRARSPE-KTP 1110
Cdd:PHA03247 2839 PPPPPGPPPPslplggsvaPGGDVRRRPPSRSPAAKpAAPARPPVRRlaRPAVSRSTESF--ALPPDQPERPPQPQaPPP 2916
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1111 GWTQPQVSPRQSPEKQLPRAQSPEKvPAVRQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQS 1190
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQP-PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995

                  .
gi 442615306 1191 P 1191
Cdd:PHA03247 2996 L 2996
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
1035-1421 1.04e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1035 EETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQfpraRSPEKTPGWTQ 1114
Cdd:PTZ00449  502 EDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKE----HKPSKIPTLSK 577
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1115 PQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRqSPEK----QIPDPKTRDQGPGLPR--------ISPRQSPEKQLPKD 1182
Cdd:PTZ00449  578 KPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPK-SPKLpellDIPKSPKRPESPKSPKrppppqrpSSPERPEGPKIIKS 656
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1183 VPQKSRQSPEKDLTNQQRREEEIFRSTITTTQKRTTNNLNEEFITNERDNQNQ----PISEKKPQIPANAEPNTKPSETI 1258
Cdd:PTZ00449  657 PKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPEtpgtPFTTPRPLPPKLPRDEEFPFEPI 736
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1259 ESPDGGFPSK----TTEVEAQPEVKESPTYRK-KGLTRRETFEDRCRQILGMEEDG----DTQGTYTERPNNEQEDVNVS 1329
Cdd:PTZ00449  737 GDPDAEQPDDieffTPPEEERTFFHETPADTPlPDILAEEFKEEDIHAETGEPDEAmkrpDSPSEHEDKPPGDHPSLPKK 816
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1330 HTTIETIQVKIEDCPND------DEDDKPRRVTET------YVVRTQPKIKVEEELFV---DVTEAEDVEilVNPSK--- 1391
Cdd:PTZ00449  817 RHRLDGLALSTTDLESDagriakDASGKIVKLKRSksfddlTTVEEAEEMGAEARKIVvddDGTEADDED--THPPEekh 894
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 442615306 1392 -------KSPKEEDSPKYPKGPETPKSPrNDQRIPSI 1421
Cdd:PTZ00449  895 ksevrrrRPPKKPSKPKKPSKPKKPKKP-DSAFIPSI 930
PTZ00121 PTZ00121
MAEBL; Provisional
2080-2248 4.14e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 2080 RQSEPERELDEESEPELDRDTDVEDDDQTSQLETEEEITQTVTKKETLKEFKQQTKETRETRRDSKAEPEKLQKKSPQTK 2159
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK 1660
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 2160 VKEES----ARVPKYQAKVSQKVSQWEPKKQPQREPKVTQKETPLEPKKQPLSKVKdEPEKVNKREPKVPQKESQTKLKE 2235
Cdd:PTZ00121 1661 IKAAEeakkAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAEEAKKEA 1739
                         170
                  ....*....|...
gi 442615306 2236 EPERVTKKTPQKE 2248
Cdd:PTZ00121 1740 EEDKKKAEEAKKD 1752
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
926-1184 1.05e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306   926 ATDTDSQPIRKVKLSANEAKVVEEAPC----VRRQYYQLGNEGENPETPESSGTpankKPHQMRRPHDEPEpqlrrsSKS 1001
Cdd:pfam03154   49 AASTSSNDSKAESMKKSSKKIKEEAPSplksAKRQREKGASDTEEPERATAKKS----KTQEISRPNSPSE------GEG 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  1002 PSVEPRQVQRETTFEGRRVSQDREISidelilieetsgapgSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQ 1081
Cdd:pfam03154  119 ESSDGRSVNDEGSSDPKDIDQDNRST---------------SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASP 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  1082 PAFKQTHEVYTPSQPEKQFPRARSPEKTPGWTQPQVSP----------RQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPE 1151
Cdd:pfam03154  184 PSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTqstaaphtliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSP 263
                          250       260       270
                   ....*....|....*....|....*....|...
gi 442615306  1152 KQIPDPKTRDQGPGLPRisPRQSPEKQLPKDVP 1184
Cdd:pfam03154  264 QPLPQPSLHGQMPPMPH--SLQTGPSHMQHPVP 294
 
Name Accession Description Interval E-value
Smoothelin pfam12510
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ...
3127-3176 8.27e-16

Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.


Pssm-ID: 463614 [Multi-domain]  Cd Length: 50  Bit Score: 73.50  E-value: 8.27e-16
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 442615306  3127 SSSSAPVTRTTCDIEEIWDEQVLKQLLEQASTYEERRKIRARLRELMAER 3176
Cdd:pfam12510    1 EETSAASKLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
Smoothelin pfam12510
Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is ...
2594-2636 6.94e-14

Smoothelin cytoskeleton protein; This domain family is found in eukaryotes, and is approximately 50 amino acids in length. The family is found in association with pfam00307. Smoothelin is a cytoskeletal protein specifically expressed in differentiated smooth muscle cells and has been shown to co-localize with smooth muscle alpha actin.


Pssm-ID: 463614 [Multi-domain]  Cd Length: 50  Bit Score: 68.11  E-value: 6.94e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 442615306  2594 SDLELEIEEIFDLQRLEKLLETVASYEMRRRIRAQMRLIRKNM 2636
Cdd:pfam12510    8 KLTAEELEAIEDEEVLDKLLETATDYEERRLIRAAIRELRKRK 50
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
1394-1702 2.78e-10

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 66.64  E-value: 2.78e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1394 PKEEDSPKYPKGPETPKSPRNDQR--------IPSIPKKGQSPVQFKTEETPRYPQEQER--YPKEPETSQYPK--ESPR 1461
Cdd:PTZ00449  582 PKDPKHPKDPEEPKKPKRPRSAQRptrpkspkLPELLDIPKSPKRPESPKSPKRPPPPQRpsSPERPEGPKIIKspKPPK 661
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1462 NPK----------------------EDAETININEETTIVITKEGSKSPSPRWSPSPERRVPK-------SQQPPSPTAS 1512
Cdd:PTZ00449  662 SPKppfdpkfkekfyddyldaaaksKETKTTVVLDESFESILKETLPETPGTPFTTPRPLPPKlprdeefPFEPIGDPDA 741
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1513 PSVSPVSGRKIPNEvESNFVTEKIIDCRGKTVVEKISQRP----RTPSPTTPKKNTK-PSQKIPERVPETESEPEKDSES 1587
Cdd:PTZ00449  742 EQPDDIEFFTPPEE-ERTFFHETPADTPLPDILAEEFKEEdihaETGEPDEAMKRPDsPSEHEDKPPGDHPSLPKKRHRL 820
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1588 EtkkttSVSVTKTETERRNSRTTKTKQPLPLKEPQSKvpagksPRKDSLTGRKRDSLVEETRittTTTTTRQGRKPSDTN 1667
Cdd:PTZ00449  821 D-----GLALSTTDLESDAGRIAKDASGKIVKLKRSK------SFDDLTTVEEAEEMGAEAR---KIVVDDDGTEADDED 886
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 442615306 1668 GSPSiKDRLRSSPRKQKTSPQQTRTPTPAQTRNPE 1702
Cdd:PTZ00449  887 THPP-EEKHKSEVRRRRPPKKPSKPKKPSKPKKPK 920
PHA03247 PHA03247
large tegument protein UL36; Provisional
566-1191 1.86e-07

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 57.64  E-value: 1.86e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  566 YQEP--QRSPQKLREAPTPSWEQPATRRQPveedfsthgfPSVRTTTTSTRPDQPDGEVLHtsktvSRNQSANRktNTER 643
Cdd:PHA03247 2480 YRRPaeARFPFAAGAAPDPGGGGPPDPDAP----------PAPSRLAPAILPDEPVGEPVH-----PRMLTWIR--GLEE 2542
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  644 IIETQVEHPNAPSHSTPRSGSPRRSQPRDDYASSPRGPAGKPSQSRPSNTGGSTTTKTTTTSEPLTRRQLQKerevdaah 723
Cdd:PHA03247 2543 LASDDAGDPPPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPP-------- 2614
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  724 rafaaslrSSSPADSTTsvgshhqtPRSSVSSNRTFRREMREGSHDSQAPSESSRissttvtRHTTGGNVTSNTIKTKTT 803
Cdd:PHA03247 2615 --------SPLPPDTHA--------PDPPPPSPSPAANEPDPHPPPTVPPPERPR-------DDPAPGRVSRPRRARRLG 2671
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  804 KPVKTASEPRSPTPKAGGSvttttttittksspspapaspttaapptsapassappdnklsqytytTTKPGDIFSLPPTT 883
Cdd:PHA03247 2672 RAAQASSPPQRPRRRAARP-----------------------------------------------TVGSLTSLADPPPP 2704
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  884 PPTINNEPTLTTTRNTTTTTTTTTTATSDNLQNHPKKSAIEPATDTDSQPIRKVKLSANEAKVVEEAPCVRRQyyqlgne 963
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAA------- 2777
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  964 GENPETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETtfegrrvsqdreisideliLIEETSGAPGS 1043
Cdd:PHA03247 2778 GPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGP-------------------LPPPTSAQPTA 2838
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1044 PKIPSPRAQS---------PGKPATRSQSPEKPQPR-ATPRQSPEKE--QPAFKQTHEVYtpSQPEKQFPRARSPE-KTP 1110
Cdd:PHA03247 2839 PPPPPGPPPPslplggsvaPGGDVRRRPPSRSPAAKpAAPARPPVRRlaRPAVSRSTESF--ALPPDQPERPPQPQaPPP 2916
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1111 GWTQPQVSPRQSPEKQLPRAQSPEKvPAVRQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQS 1190
Cdd:PHA03247 2917 PQPQPQPPPPPQPQPPPPPPPRPQP-PLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPP 2995

                  .
gi 442615306 1191 P 1191
Cdd:PHA03247 2996 L 2996
PHA03247 PHA03247
large tegument protein UL36; Provisional
967-1283 1.80e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 54.17  E-value: 1.80e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  967 PETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVE-PRQVQRETTFEG---------RRVSQDREISIDELilieE 1036
Cdd:PHA03247 2624 PDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSrPRRARRLGRAAQassppqrprRRAARPTVGSLTSL----A 2699
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1037 TSGAPGSPKIPSPRAQSPGKP---ATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVY----TPSQPEKQF-PRARSPEK 1108
Cdd:PHA03247 2700 DPPPPPPTPEPAPHALVSATPlppGPAAARQASPALPAAPAPPAVPAGPATPGGPARParppTTAGPPAPApPAAPAAGP 2779
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1109 TPGWTQPQVSPRQSPEKQLPRAQSPEKVPAV---RQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVP- 1184
Cdd:PHA03247 2780 PRRLTRPAVASLSESRESLPSPWDPADPPAAvlaPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPg 2859
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1185 ------QKSRQSPEKDLTNQQRREEEIFRSTITttqkrttnnlneefitneRDNQNQPISEKKPQIPANAEPNTKPSETI 1258
Cdd:PHA03247 2860 gdvrrrPPSRSPAAKPAAPARPPVRRLARPAVS------------------RSTESFALPPDQPERPPQPQAPPPPQPQP 2921
                         330       340
                  ....*....|....*....|....*
gi 442615306 1259 ESPDGGFPSKTTEVEAQPEVKESPT 1283
Cdd:PHA03247 2922 QPPPPPQPQPPPPPPPRPQPPLAPT 2946
PHA03378 PHA03378
EBNA-3B; Provisional
970-1207 3.55e-06

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 53.15  E-value: 3.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  970 PESSGTPaNKKPHqmrrPHDEPEPQLRRSSKSPSVEPRQVQRETTFEGRRVSQDREISIDELIL--------IEETSGAP 1041
Cdd:PHA03378  590 PSYAQTP-WPVPH----PSQTPEPPTTQSHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFptphqppqVEITPYKP 664
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1042 GSPKIPSPRAQ-SPGKPAT---RSQSPE--KPQPRATPRQSPEKEQPAFKQthevytpsQPEKQFPRARSPEKTPGWTQP 1115
Cdd:PHA03378  665 TWTQIGHIPYQpSPTGANTmlpIQWAPGtmQPPPRAPTPMRPPAAPPGRAQ--------RPAAATGRARPPAAAPGRARP 736
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1116 qvsPRQSPEKQLPRAQSPekvPAVRQPSVSPRQSPEKQI----PDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQSP 1191
Cdd:PHA03378  737 ---PAAAPGRARPPAAAP---GRARPPAAAPGRARPPAAapgaPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGPTSMQLM 810
                         250
                  ....*....|....*.
gi 442615306 1192 EKDLTNQQRREEEIFR 1207
Cdd:PHA03378  811 PRAAPGQQGPTKQILR 826
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
1381-1768 5.55e-06

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 52.38  E-value: 5.55e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1381 EDVEILVNPSKK---SPKEEDSPKY---PKGPET----PKSP---------RNDQRIPSIPKKGQSPVQFKTEETPRYP- 1440
Cdd:PTZ00449  483 QEIKKLIKKSKKklaPIEEEDSDKHdepPEGPEAsglpPKAPgdkegeegeHEDSKESDEPKEGGKPGETKEGEVGKKPg 562
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1441 -------------QEQERYPKEPETSQYPKE-----SPRNPKEDAETININEETTIVITKegskSPSPRWSPSPERRVPK 1502
Cdd:PTZ00449  563 pakehkpskiptlSKKPEFPKDPKHPKDPEEpkkpkRPRSAQRPTRPKSPKLPELLDIPK----SPKRPESPKSPKRPPP 638
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1503 SQQPPSPTASPSVSPVSGRKIPNEVESNF---VTEKIID------CRGKTVV------EKISQRPRTPSPTTPKKNTKPS 1567
Cdd:PTZ00449  639 PQRPSSPERPEGPKIIKSPKPPKSPKPPFdpkFKEKFYDdyldaaAKSKETKttvvldESFESILKETLPETPGTPFTTP 718
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1568 QKIPERVPETESEP-----EKDSES------------------ETKKTTSVSVTKTETERRNSRTTKTKQP-LPLKEPQS 1623
Cdd:PTZ00449  719 RPLPPKLPRDEEFPfepigDPDAEQpddiefftppeeertffhETPADTPLPDILAEEFKEEDIHAETGEPdEAMKRPDS 798
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1624 KVPAGKSPRKDSLTGRKRDSLVEETRITTTTTTTRQGRKPSDTNGSPSIKDRLRSSprKQKTSPQQTRTPTPAQTRNPED 1703
Cdd:PTZ00449  799 PSEHEDKPPGDHPSLPKKRHRLDGLALSTTDLESDAGRIAKDASGKIVKLKRSKSF--DDLTTVEEAEEMGAEARKIVVD 876
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442615306 1704 DVDGDSSSPDASPTrvgnERRRSSNISVHTEIIIDHMAPKSPKTERRSQGGTGNVPSPIRKLPVT 1768
Cdd:PTZ00449  877 DDGTEADDEDTHPP----EEKHKSEVRRRRPPKKPSKPKKPSKPKKPKKPDSAFIPSIIAIFLVS 937
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
1035-1421 1.04e-05

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 51.61  E-value: 1.04e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1035 EETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQfpraRSPEKTPGWTQ 1114
Cdd:PTZ00449  502 EDSDKHDEPPEGPEASGLPPKAPGDKEGEEGEHEDSKESDEPKEGGKPGETKEGEVGKKPGPAKE----HKPSKIPTLSK 577
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1115 PQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRqSPEK----QIPDPKTRDQGPGLPR--------ISPRQSPEKQLPKD 1182
Cdd:PTZ00449  578 KPEFPKDPKHPKDPEEPKKPKRPRSAQRPTRPK-SPKLpellDIPKSPKRPESPKSPKrppppqrpSSPERPEGPKIIKS 656
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1183 VPQKSRQSPEKDLTNQQRREEEIFRSTITTTQKRTTNNLNEEFITNERDNQNQ----PISEKKPQIPANAEPNTKPSETI 1258
Cdd:PTZ00449  657 PKPPKSPKPPFDPKFKEKFYDDYLDAAAKSKETKTTVVLDESFESILKETLPEtpgtPFTTPRPLPPKLPRDEEFPFEPI 736
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1259 ESPDGGFPSK----TTEVEAQPEVKESPTYRK-KGLTRRETFEDRCRQILGMEEDG----DTQGTYTERPNNEQEDVNVS 1329
Cdd:PTZ00449  737 GDPDAEQPDDieffTPPEEERTFFHETPADTPlPDILAEEFKEEDIHAETGEPDEAmkrpDSPSEHEDKPPGDHPSLPKK 816
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1330 HTTIETIQVKIEDCPND------DEDDKPRRVTET------YVVRTQPKIKVEEELFV---DVTEAEDVEilVNPSK--- 1391
Cdd:PTZ00449  817 RHRLDGLALSTTDLESDagriakDASGKIVKLKRSksfddlTTVEEAEEMGAEARKIVvddDGTEADDED--THPPEekh 894
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 442615306 1392 -------KSPKEEDSPKYPKGPETPKSPrNDQRIPSI 1421
Cdd:PTZ00449  895 ksevrrrRPPKKPSKPKKPSKPKKPKKP-DSAFIPSI 930
PRK10263 PRK10263
DNA translocase FtsK; Provisional
921-1463 2.81e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 50.08  E-value: 2.81e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  921 SAIEPATDTDSQPIRKVKLSAN--EAKVVEEAPCVRRQYYQLGNEGENPETPESSGTPANKKPHQMRRPHDE----PEPQ 994
Cdd:PRK10263  324 AAATTATQSWAAPVEPVTQTPPvaSVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVQYNEplqqPVQP 403
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  995 LRRSSKSPSVEPRQVQRETTFEGRRVSQDREISIDELILIEETSGA--PGSPKIPSPRAQSPGK-PATRSQSPEKPQPRA 1071
Cdd:PRK10263  404 QQPYYAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAeeQQSTFAPQSTYQTEQTyQQPAAQEPLYQQPQP 483
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1072 TPRQSPEKEQPAFKQTHevytPSQP------EKQFPRARSPEKTPGWTQPQVSPRQSPEKQLP--RAQSPEKVPAVRQ-P 1142
Cdd:PRK10263  484 VEQQPVVEPEPVVEETK----PARPplyyfeEVEEKRAREREQLAAWYQPIPEPVKEPEPIKSslKAPSVAAVPPVEAaA 559
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1143 SVSPRQSPEKQ----------IPDPKTRDQGPGLPRISPRQSPEKQLPKdvPQKSRQSPEKDLTN------QQRREEEIF 1206
Cdd:PRK10263  560 AVSPLASGVKKatlatgaaatVAAPVFSLANSGGPRPQVKEGIGPQLPR--PKRIRVPTRRELASygiklpSQRAAEEKA 637
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1207 RSTITTTQKRTTNNLNEEFITNERDNQNQPISEKKPQIPANAEPNTKPSETIESPDGGfpskttEVEAQPEVKESPTYRK 1286
Cdd:PRK10263  638 REAQRNQYDSGDQYNDDEIDAMQQDELARQFAQTQQQRYGEQYQHDVPVNAEDADAAA------EAELARQFAQTQQQRY 711
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1287 KGltrretfedrcrqilgmeedgdtqgtytERPNNEQEdVNVSHTTIETIQVKIEDCPNddeddkprrvtetyvvrtqpk 1366
Cdd:PRK10263  712 SG----------------------------EQPAGANP-FSLDDFEFSPMKALLDDGPH--------------------- 741
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1367 ikveEELFVDVTEAEDVEILVNPSKKSPKEEDSPKYPKG----PETPKSPRNDQRIPSIPKKGQSpvQFKTEETPRYPQE 1442
Cdd:PRK10263  742 ----EPLFTPIVEPVQQPQQPVAPQQQYQQPQQPVAPQPqyqqPQQPVAPQPQYQQPQQPVAPQP--QYQQPQQPVAPQP 815
                         570       580
                  ....*....|....*....|.
gi 442615306 1443 QERYPKEPETSQYPKESPRNP 1463
Cdd:PRK10263  816 QYQQPQQPVAPQPQYQQPQQP 836
PTZ00121 PTZ00121
MAEBL; Provisional
2080-2248 4.14e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 46.29  E-value: 4.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 2080 RQSEPERELDEESEPELDRDTDVEDDDQTSQLETEEEITQTVTKKETLKEFKQQTKETRETRRDSKAEPEKLQKKSPQTK 2159
Cdd:PTZ00121 1581 RKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENK 1660
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 2160 VKEES----ARVPKYQAKVSQKVSQWEPKKQPQREPKVTQKETPLEPKKQPLSKVKdEPEKVNKREPKVPQKESQTKLKE 2235
Cdd:PTZ00121 1661 IKAAEeakkAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKK-KAEELKKAEEENKIKAEEAKKEA 1739
                         170
                  ....*....|...
gi 442615306 2236 EPERVTKKTPQKE 2248
Cdd:PTZ00121 1740 EEDKKKAEEAKKD 1752
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
940-1190 4.19e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 46.02  E-value: 4.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  940 SANEAKVVEEAPCVRRQYYQLGNEGENPETPESSGTPANKKPHQMRRPhdepepqlrrSSKSPSVEPRQVQRETTFEGRR 1019
Cdd:PRK12323  376 TAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAP----------ARRSPAPEALAAARQASARGPG 445
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1020 VSQdreisideliliEETSGAPGSP--KIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSqpe 1097
Cdd:PRK12323  446 GAP------------APAPAPAAAPaaAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPA--- 510
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1098 kqfPRARSPEKTPGWTQPQVSPRQSPEKQLPRAQSPEKVPAvrqPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPE- 1176
Cdd:PRK12323  511 ---PAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAA---PAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPAl 584
                         250
                  ....*....|....*..
gi 442615306 1177 -KQLP-KDVPQK-SRQS 1190
Cdd:PRK12323  585 aARLPvRGLAQQlARQS 601
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
961-1157 4.54e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 46.32  E-value: 4.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  961 GNEGENPETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETTFEGRRVSQDREISIDELILIEETSGA 1040
Cdd:PHA03307  250 GPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRESSSSST 329
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1041 PGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKqfPRARSPEKTPGWTQ--PQVS 1118
Cdd:PHA03307  330 SSSSESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTR--RRARAAVAGRARRRdaTGRF 407
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 442615306 1119 PRQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPEKQIPDP 1157
Cdd:PHA03307  408 PAGRPRPSPLDAGAASGAFYARYPLLTPSGEPWPGSPPP 446
PRK10263 PRK10263
DNA translocase FtsK; Provisional
1041-1127 5.00e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 46.23  E-value: 5.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1041 PGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQFPRARSPEKT----PGWTQPQ 1116
Cdd:PRK10263  755 PQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPvapqPQYQQPQ 834
                          90
                  ....*....|.
gi 442615306 1117 VSPRQSPEKQL 1127
Cdd:PRK10263  835 QPVAPQPQDTL 845
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
1034-1146 6.70e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.36  E-value: 6.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1034 IEETSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAfkQTHEVYTPSQPEKQFPRARSPEKTPG-W 1112
Cdd:PRK07764  392 GAPAAAAPSAAAAAPAAAPAPAAAAPAAAAAPAPAAAPQPAPAPAPAPAP--PSPAGNAPAGGAPSPPPAAAPSAQPApA 469
                          90       100       110
                  ....*....|....*....|....*....|....
gi 442615306 1113 TQPQVSPRQSPEKQLPRAQSPEKVPAVRQPSVSP 1146
Cdd:PRK07764  470 PAAAPEPTAAPAPAPPAAPAPAAAPAAPAAPAAP 503
PRK10263 PRK10263
DNA translocase FtsK; Provisional
1047-1180 8.94e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 45.08  E-value: 8.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1047 PSPRAQSPG-KPATRSQSPEKPQPRATPRQSPEKEQPAFKQTHEVYTPSQPEKQFPRARSPEktPGWTQPQVSPRQSPEK 1125
Cdd:PRK10263  740 PHEPLFTPIvEPVQQPQQPVAPQQQYQQPQQPVAPQPQYQQPQQPVAPQPQYQQPQQPVAPQ--PQYQQPQQPVAPQPQY 817
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 442615306 1126 QLPRaQSPEKVPAVRQPSVSPRQSPEKQIPDPKTRDQGPGlpriSPRQSPEKQLP 1180
Cdd:PRK10263  818 QQPQ-QPVAPQPQYQQPQQPVAPQPQDTLLHPLLMRNGDS----RPLHKPTTPLP 867
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
1040-1193 9.37e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.87  E-value: 9.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1040 APGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAfkqthevytpsQPEKQFPRARSPEKTPGWTQPQVSP 1119
Cdd:PRK12323  373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAA-----------RAVAAAPARRSPAPEALAAARQASA 441
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 442615306 1120 RQS-PEKQLPRAQSPEKVPAVRQPSVSPRQSPEKQIPDPKTRDQGPGLPRISPRQSPEKQLPKDVPQKSRQSPEK 1193
Cdd:PRK12323  442 RGPgGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPWEELPPEFASPAPAQPDA 516
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
926-1184 1.05e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 44.76  E-value: 1.05e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306   926 ATDTDSQPIRKVKLSANEAKVVEEAPC----VRRQYYQLGNEGENPETPESSGTpankKPHQMRRPHDEPEpqlrrsSKS 1001
Cdd:pfam03154   49 AASTSSNDSKAESMKKSSKKIKEEAPSplksAKRQREKGASDTEEPERATAKKS----KTQEISRPNSPSE------GEG 118
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  1002 PSVEPRQVQRETTFEGRRVSQDREISidelilieetsgapgSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQ 1081
Cdd:pfam03154  119 ESSDGRSVNDEGSSDPKDIDQDNRST---------------SPSIPSPQDNESDSDSSAQQQILQTQPPVLQAQSGAASP 183
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  1082 PAFKQTHEVYTPSQPEKQFPRARSPEKTPGWTQPQVSP----------RQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPE 1151
Cdd:pfam03154  184 PSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTqstaaphtliQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSP 263
                          250       260       270
                   ....*....|....*....|....*....|...
gi 442615306  1152 KQIPDPKTRDQGPGLPRisPRQSPEKQLPKDVP 1184
Cdd:pfam03154  264 QPLPQPSLHGQMPPMPH--SLQTGPSHMQHPVP 294
PTZ00121 PTZ00121
MAEBL; Provisional
2080-2254 1.46e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 1.46e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 2080 RQSEPERELDEESEPELDRDTDVEDDDQTSQLETEEEitQTVTKKETLKefKQQTKETRETRRDSKAEPEKLQKKSPQTK 2159
Cdd:PTZ00121 1621 KAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEE--ENKIKAAEEA--KKAEEDKKKAEEAKKAEEDEKKAAEALKK 1696
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 2160 VKEESARVPKYQAKVSQKVSQWEP--KKQPQREPKVTQ-KETPLEPKKQPLSKVKDEPEKVNKREPKVPQKESQTKLKEE 2236
Cdd:PTZ00121 1697 EAEEAKKAEELKKKEAEEKKKAEElkKAEEENKIKAEEaKKEAEEDKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKE 1776
                         170
                  ....*....|....*...
gi 442615306 2237 PERVTKKTPQKEPRKEPL 2254
Cdd:PTZ00121 1777 KEAVIEEELDEEDEKRRM 1794
PHA03247 PHA03247
large tegument protein UL36; Provisional
1033-1200 1.55e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1033 LIEETSGAPGSPKIPSPRAQSPGKPaTRSQSPEKPQPRatprqspekeqpafkqthevytPSQPEKQfPRARSPEKTPGW 1112
Cdd:PHA03247 2540 LEELASDDAGDPPPPLPPAAPPAAP-DRSVPPPRPAPR----------------------PSEPAVT-SRARRPDAPPQS 2595
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1113 TQPQ--VSPRQSPEKQLPRAQSPEKVPAVRQPSVSPRQSPEKqipdpktrdqgpgLPRISPRQSPEKQLPKDVPQKSRQS 1190
Cdd:PHA03247 2596 ARPRapVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANE-------------PDPHPPPTVPPPERPRDDPAPGRVS 2662
                         170
                  ....*....|
gi 442615306 1191 PEKDLTNQQR 1200
Cdd:PHA03247 2663 RPRRARRLGR 2672
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
967-1194 2.29e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  967 PETPESSGTPANKKPHQMRRPHDEPEPQLRRSSKSPSVEPRQVQRETTfegrrvsQDREISiDELILIEETSGAPGSPKI 1046
Cdd:PHA03307  120 TPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAA-------SSRQAA-LPLSSPEETARAPSSPPA 191
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1047 PSPRAQSPGKPATRSQSPEKP--QPRATPRQSPEKEQ---PAFKQTHEVYTPSQPEKQFPRARSPEKTPGwtqPQVSPRQ 1121
Cdd:PHA03307  192 EPPPSTPPAAASPRPPRRSSPisASASSPAPAPGRSAaddAGASSSDSSSSESSGCGWGPENECPLPRPA---PITLPTR 268
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 442615306 1122 spekqlPRAQSPEKVPAVRQPSVSPRQSPekQIPDPKTRDQGPGLPRISPRQSPEKQL---PKDVPQKSRQSPEKD 1194
Cdd:PHA03307  269 ------IWEASGWNGPSSRPGPASSSSSP--RERSPSPSPSSPGSGPAPSSPRASSSSsssRESSSSSTSSSSESS 336
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
479-750 2.34e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 44.01  E-value: 2.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  479 PTSRVVQKAPTPSYAPPSHSPRQSPAkdfSTHGFPSVRPNKATQEYPSQRPGIAGEEVVVVRSEKSRQVKQQTSSQRTIE 558
Cdd:PHA03307  175 PLSSPEETARAPSSPPAEPPPSTPPA---AASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGP 251
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  559 TEVVGDDYQEPQRSPQKLREAPTpsWEQPATRRQPVEEDfsthgfPSVRTTTTSTRPDQPDGEVLHTSKTVSRNQSANRK 638
Cdd:PHA03307  252 ENECPLPRPAPITLPTRIWEASG--WNGPSSRPGPASSS------SSPRERSPSPSPSSPGSGPAPSSPRASSSSSSSRE 323
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306  639 TNTERIIETqvehPNAPSHSTPRSGSPRRSQPRDDYASSPRGPAGKPSQSRPSNTGGSTTTKTTTTSEPLTRRQLQKERE 718
Cdd:PHA03307  324 SSSSSTSSS----SESSRGAAVSPGPSPSRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRAR 399
                         250       260       270
                  ....*....|....*....|....*....|..
gi 442615306  719 VDAAHRAFAASLRSSSPADSTTSVGSHHQTPR 750
Cdd:PHA03307  400 RRDATGRFPAGRPRPSPLDAGAASGAFYARYP 431
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
1037-1204 4.30e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 42.67  E-value: 4.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1037 TSGAPGSPKIPSPRAQSPGKPATRSQSPEKPQPRATPRQSPEKEQPAFK--QTHEVYTPSQPEKQFPRARSPEKTPGWTQ 1114
Cdd:PRK07764  617 APAAPAAPAAPAPAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGgdGWPAKAGGAAPAAPPPAPAPAAPAAPAGA 696
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442615306 1115 PQVSPRQSPEKQLPRAQSPEKV---PAVRQPSVSPRQSPEKQIPDPKTRDQGPGlPRISPRQSPEKQLPKDVPQKSRQSP 1191
Cdd:PRK07764  697 APAQPAPAPAATPPAGQADDPAaqpPQAAQGASAPSPAADDPVPLPPEPDDPPD-PAGAPAQPPPPPAPAPAAAPAAAPP 775
                         170
                  ....*....|...
gi 442615306 1192 EKDLTNQQRREEE 1204
Cdd:PRK07764  776 PSPPSEEEEMAED 788
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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