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Conserved domains on  [gi|442614977|ref|NP_001259194|]
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period, isoform B [Drosophila melanogaster]

Protein Classification

PAS domain-containing protein kinase; PAS domain-containing sensor histidine kinase( domain architecture ID 12012811)

PAS domain-containing protein kinase may catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine and/or tyrosine residues on protein substrates| PAS domain-containing sensor histidine kinase, part of a two-component regulatory system, functions as a protein kinase that phosphorylates a target protein in response to various signals

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 388-495 2.77e-16

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


:

Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 75.75  E-value: 2.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  388 SPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQtagasFCSKPYRFLIQNGC 467
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGE-----PVTLEVRLRRKDGS 75

                          90       100
                  ....*....|....*....|....*...
gi 442614977  468 YVLLETEWTSFVNPWSRKLEFVVGHHRV 495
Cdd:cd00130    76 VIWVLVSLTPIRDEGGEVIGLLGVVRDI 103
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 238-333 1.61e-10

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


:

Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 59.35  E-value: 1.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977   238 DSFCCVISmHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSV-----PKDAKSTFC 312
Cdd:pfam00989   11 PDGIFVVD-EDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFevsfrVPDGRPRHV 89

                           90       100
                   ....*....|....*....|....
gi 442614977   313 VMLRRYRGLKSG---GFGVIGRPV 333
Cdd:pfam00989   90 EVRASPVRDAGGeilGFLGVLRDI 113
 
Name Accession Description Interval E-value
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 388-495 2.77e-16

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 75.75  E-value: 2.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  388 SPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQtagasFCSKPYRFLIQNGC 467
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGE-----PVTLEVRLRRKDGS 75

                          90       100
                  ....*....|....*....|....*...
gi 442614977  468 YVLLETEWTSFVNPWSRKLEFVVGHHRV 495
Cdd:cd00130    76 VIWVLVSLTPIRDEGGEVIGLLGVVRDI 103
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 391-495 1.71e-14

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 70.79  E-value: 1.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977   391 FAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMkkgQTAGASfCSKPYRFLIQNGCYVL 470
Cdd:pfam14598    4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREII---QTRGRA-TSPSYRLRLRDGDFLS 79

                           90       100
                   ....*....|....*....|....*
gi 442614977   471 LETEWTSFVNPWSRKLEFVVGHHRV 495
Cdd:pfam14598   80 VHTKSKLFLNQNSNQQPFIMCTHTI 104
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 238-333 1.61e-10

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 59.35  E-value: 1.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977   238 DSFCCVISmHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSV-----PKDAKSTFC 312
Cdd:pfam00989   11 PDGIFVVD-EDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFevsfrVPDGRPRHV 89

                           90       100
                   ....*....|....*....|....
gi 442614977   313 VMLRRYRGLKSG---GFGVIGRPV 333
Cdd:pfam00989   90 EVRASPVRDAGGeilGFLGVLRDI 113
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 388-445 8.88e-10

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 55.87  E-value: 8.88e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 442614977    388 SPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMK 445
Cdd:smart00091   10 LPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 238-294 5.63e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 45.08  E-value: 5.63e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 442614977    238 DSFCCVISmHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGI 294
Cdd:smart00091   11 PDGIFVLD-LDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLL 66
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 238-300 9.90e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 45.70  E-value: 9.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442614977  238 DSFCCVISmHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESR 300
Cdd:cd00130     2 PDGVIVLD-LDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPV 63
PAS COG2202
PAS domain [Signal transduction mechanisms];
248-473 6.89e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 43.09  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  248 DGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIpiaesrgsvpkDAKSTFCVMLRRYRglKSGG-- 325
Cdd:COG2202    30 DGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAAL-----------AGGGVWRGELRNRR--KDGSlf 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  326 ---------FGVIGRPVSYepfrLGL----TFREAPEEARpdnymvsngtnmllvicatpIKSSYKvpDEILSQKSPKFA 392
Cdd:COG2202    97 wvelsispvRDEDGEITGF----VGIardiTERKRAEEAL--------------------RESEER--LRLLVENAPDGI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  393 IRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGasfcSKPYRFLIQNGCYVLLE 472
Cdd:COG2202   151 FVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESY----ELELRLKDGDGRWVWVE 226


                  .
gi 442614977  473 T 473
Cdd:COG2202   227 A 227
 
Name Accession Description Interval E-value
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 388-495 2.77e-16

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 75.75  E-value: 2.77e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  388 SPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQtagasFCSKPYRFLIQNGC 467
Cdd:cd00130     1 LPDGVIVLDLDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGE-----PVTLEVRLRRKDGS 75

                          90       100
                  ....*....|....*....|....*...
gi 442614977  468 YVLLETEWTSFVNPWSRKLEFVVGHHRV 495
Cdd:cd00130    76 VIWVLVSLTPIRDEGGEVIGLLGVVRDI 103
PAS_11 pfam14598
PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), ...
 391-495 1.71e-14

PAS domain; This family includes the PAS-B domain of NCOA1 (Nuclear receptor coactivator 1), which binds to an LXXLL motif in the C-terminal region of STAT6 (Signal transducer and activator of transcription 6).


Pssm-ID: 464214 [Multi-domain]  Cd Length: 110  Bit Score: 70.79  E-value: 1.71e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977   391 FAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMkkgQTAGASfCSKPYRFLIQNGCYVL 470
Cdd:pfam14598    4 FTTRHDIDGKIISCDTRAPFSLGYEKDELVGRSIYDLVHPQDLRTAKSHLREII---QTRGRA-TSPSYRLRLRDGDFLS 79

                           90       100
                   ....*....|....*....|....*
gi 442614977   471 LETEWTSFVNPWSRKLEFVVGHHRV 495
Cdd:pfam14598   80 VHTKSKLFLNQNSNQQPFIMCTHTI 104
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 388-495 1.92e-14

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 70.52  E-value: 1.92e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977   388 SPKFAIRHTatGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKkgqtAGASFCSKPYRFLIQNGC 467
Cdd:pfam00989   12 DGIFVVDED--GRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALL----QGEESRGFEVSFRVPDGR 85

                           90       100
                   ....*....|....*....|....*...
gi 442614977   468 YVLLETEWTSFVNPWSRKLEFVVGHHRV 495
Cdd:pfam00989   86 PRHVEVRASPVRDAGGEILGFLGVLRDI 113
PAS pfam00989
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 238-333 1.61e-10

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya. This domain can bind gases (O2, CO and NO), FAD, 4-hydroxycinnamic acid and NAD+ (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 395786 [Multi-domain]  Cd Length: 113  Bit Score: 59.35  E-value: 1.61e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977   238 DSFCCVISmHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESRGSV-----PKDAKSTFC 312
Cdd:pfam00989   11 PDGIFVVD-EDGRILYVNAAAEELLGLSREEVIGKSLLDLIPEEDDAEVAELLRQALLQGEESRGFevsfrVPDGRPRHV 89

                           90       100
                   ....*....|....*....|....
gi 442614977   313 VMLRRYRGLKSG---GFGVIGRPV 333
Cdd:pfam00989   90 EVRASPVRDAGGeilGFLGVLRDI 113
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 388-445 8.88e-10

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 55.87  E-value: 8.88e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*...
gi 442614977    388 SPKFAIRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMK 445
Cdd:smart00091   10 LPDGIFVLDLDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLLS 67
PAS smart00091
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 238-294 5.63e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels.


Pssm-ID: 214512  Cd Length: 67  Bit Score: 45.08  E-value: 5.63e-06
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*..
gi 442614977    238 DSFCCVISmHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGI 294
Cdd:smart00091   11 PDGIFVLD-LDGRILYANPAAEELLGYSPEELIGKSLLELIHPEDRERVQEALQRLL 66
PAS cd00130
PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising ...
 238-300 9.90e-06

PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in signal transduction.


Pssm-ID: 238075 [Multi-domain]  Cd Length: 103  Bit Score: 45.70  E-value: 9.90e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 442614977  238 DSFCCVISmHDGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIPIAESR 300
Cdd:cd00130     2 PDGVIVLD-LDGRILYANPAAEQLLGYSPEELIGKSLLDLIHPEDREELRERLENLLSGGEPV 63
PAS_3 pfam08447
PAS fold; The PAS fold corresponds to the structural domain that has previously been defined ...
 401-491 8.39e-05

PAS fold; The PAS fold corresponds to the structural domain that has previously been defined as PAS and PAC motifs. The PAS fold appears in archaea, eubacteria and eukarya.


Pssm-ID: 430001 [Multi-domain]  Cd Length: 89  Bit Score: 42.33  E-value: 8.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977   401 ISHVDSAAVSALGYLPQDLIGR--SIMDFYHHEDLSVMKETYETVMKKGQTAgasfcSKPYRFLIQNGCYVLLETEWTSF 478
Cdd:pfam08447    1 IIYWSPRFEEILGYTPEELLGKgeSWLDLVHPDDRERVREALWEALKGGEPY-----SGEYRIRRKDGEYRWVEARARPI 75

                           90
                   ....*....|...
gi 442614977   479 VNpWSRKLEFVVG 491
Cdd:pfam08447   76 RD-ENGKPVRVIG 87
PAS COG2202
PAS domain [Signal transduction mechanisms];
248-473 6.89e-04

PAS domain [Signal transduction mechanisms];


Pssm-ID: 441804 [Multi-domain]  Cd Length: 258  Bit Score: 43.09  E-value: 6.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  248 DGIVLYTTPSITDVLGYPRDMWLGRSFIDFVHLKDRATFASQITTGIpiaesrgsvpkDAKSTFCVMLRRYRglKSGG-- 325
Cdd:COG2202    30 DGRILYVNPAFERLTGYSAEELLGKTLRDLLPPEDDDEFLELLRAAL-----------AGGGVWRGELRNRR--KDGSlf 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  326 ---------FGVIGRPVSYepfrLGL----TFREAPEEARpdnymvsngtnmllvicatpIKSSYKvpDEILSQKSPKFA 392
Cdd:COG2202    97 wvelsispvRDEDGEITGF----VGIardiTERKRAEEAL--------------------RESEER--LRLLVENAPDGI 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 442614977  393 IRHTATGIISHVDSAAVSALGYLPQDLIGRSIMDFYHHEDLSVMKETYETVMKKGQTAGasfcSKPYRFLIQNGCYVLLE 472
Cdd:COG2202   151 FVLDLDGRILYVNPAAEELLGYSPEELLGKSLLDLLHPEDRERLLELLRRLLEGGRESY----ELELRLKDGDGRWVWVE 226


                  .
gi 442614977  473 T 473
Cdd:COG2202   227 A 227
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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