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Conserved domains on  [gi|4557445|ref|NP_001259|]
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RCC1 and BTB domain-containing protein 2 isoform 2 [Homo sapiens]

Protein Classification

RCC1 and BTB domain-containing protein( domain architecture ID 13420772)

RCC1 (Regulator of chromosome condensation) and BTB (BR-C, ttk and bab)/POZ (Pox virus and Zinc finger) domain-containing protein is a chromosome condensation regulator-like guanine nucleotide exchange factor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 374-490 4.28e-86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 261.80  E-value: 4.28e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  374 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI 453
Cdd:cd18354   1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4557445  454 SLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEE 490
Cdd:cd18354  81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-335 5.85e-72

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


:

Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 233.33  E-value: 5.85e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445   71 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 149
Cdd:COG5184  73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  150 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 229
Cdd:COG5184 149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  230 GYNGNGQLGLGNSGNQPTPCRVAALQGirVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDr 309
Cdd:COG5184 224 GSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG- 300

                       250       260
                ....*....|....*....|....*.
gi 4557445  310 IIEIAAcHSTHTSAAKTqGGHVYMWG 335
Cdd:COG5184 301 VVAVAA-GSSHTCALLT-DGTVWCWG 324
BACK_RCBTB2 cd18529
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 ...
 487-551 1.10e-39

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.


:

Pssm-ID: 350604  Cd Length: 65  Bit Score: 138.51  E-value: 1.10e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557445  487 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 551
Cdd:cd18529   1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65
 
Name Accession Description Interval E-value
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 374-490 4.28e-86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 261.80  E-value: 4.28e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  374 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI 453
Cdd:cd18354   1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4557445  454 SLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEE 490
Cdd:cd18354  81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-335 5.85e-72

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 233.33  E-value: 5.85e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445   71 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 149
Cdd:COG5184  73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  150 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 229
Cdd:COG5184 149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  230 GYNGNGQLGLGNSGNQPTPCRVAALQGirVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDr 309
Cdd:COG5184 224 GSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG- 300

                       250       260
                ....*....|....*....|....*.
gi 4557445  310 IIEIAAcHSTHTSAAKTqGGHVYMWG 335
Cdd:COG5184 301 VVAVAA-GSSHTCALLT-DGTVWCWG 324
BACK_RCBTB2 cd18529
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 ...
 487-551 1.10e-39

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.


Pssm-ID: 350604  Cd Length: 65  Bit Score: 138.51  E-value: 1.10e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557445  487 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 551
Cdd:cd18529   1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 395-487 4.96e-19

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 81.97  E-value: 4.96e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445     395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN----EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 470
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 4557445     471 RENRLKKLCQQTIKQGI 487
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 384-485 2.34e-17

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 77.68  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445    384 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDD----IVEMSEFSYPVYRAFLEYLYTDSIsLSPEE 459
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESEssvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 4557445    460 AVGLLDLATFYRENRLKKLCQQTIKQ 485
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
224-272 1.57e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 70.62  E-value: 1.57e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4557445    224 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVL 272
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
PHA03098 PHA03098
kelch-like protein; Provisional
 398-537 2.68e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445   398 FLVDGKYIYAHKVLLKIRCEHFRSSLEDN--EDDIveMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRL 475
Cdd:PHA03098  16 IVNGGGIIKVHKIILSSSSEYFKKMFKNNfkENEI--NLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557445   476 KKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVtqtsgfaEMDHDLLK 537
Cdd:PHA03098  94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-------YNDPDFIY 148
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 492-541 2.29e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 37.71  E-value: 2.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 4557445     492 AIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFIS 541
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLS 50
 
Name Accession Description Interval E-value
BTB_POZ_RCBTB2_CHC1L cd18354
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 374-490 4.28e-86

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2 is also called chromosome condensation 1-like (CHC1-L), RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2. It is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349663 [Multi-domain]  Cd Length: 117  Bit Score: 261.80  E-value: 4.28e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  374 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI 453
Cdd:cd18354   1 PDDHLTVAESLKREFDNPDTADLKFLVDGKYIYVHKVLLKIRCEHFRSLLNENEEEIIEMSQFSYPVYRAFLEYLYTDSI 80

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4557445  454 SLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEE 490
Cdd:cd18354  81 SLSPEDAIGLLDLATFYRENRLKKLCQQTIKQGICEE 117
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-335 5.85e-72

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 233.33  E-value: 5.85e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445   71 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNL 149
Cdd:COG5184  73 GNNSYGQLGDGTTTDRTTPVKVPGLTGvVAVAA---GYY-HSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGL 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  150 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVW 229
Cdd:COG5184 149 SG--VVAIAAGGYHTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LSG--VVAVAAGGDHSCALKSDGTVWCW 223

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  230 GYNGNGQLGLGNSGNQPTPCRVAALQGirVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDr 309
Cdd:COG5184 224 GSNSSGQLGDGTTTDRATPVQVAGLTG--VVAIAAGGSHTCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVKVPGLSG- 300

                       250       260
                ....*....|....*....|....*.
gi 4557445  310 IIEIAAcHSTHTSAAKTqGGHVYMWG 335
Cdd:COG5184 301 VVAVAA-GSSHTCALLT-DGTVWCWG 324
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-336 1.38e-67

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 222.16  E-value: 1.38e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445   71 GTNCCGCLGLGDVQSTIEPRRLDSLNG-KKIAClsyGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIStNL 149
Cdd:COG5184  23 GDNSYGQLGDGTTTDRSTPVRVPGLSNvVAVAA---GGD-HTCALKADGTVWCWGNNSYGQLGDGTTTDRTTPVKVP-GL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  150 SNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNkvVVTIACGQMCCMAVVDTGEVYVW 229
Cdd:COG5184  98 TG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSG--VVAIAAGGYHTCALKSDGTVWCW 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  230 GYNGNGQLGLGNSGNQPTPCRVAALQGirVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDr 309
Cdd:COG5184 174 GANSYGQLGDGTTTDRPTPVQVGGLSG--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAGLTG- 250

                       250       260
                ....*....|....*....|....*..
gi 4557445  310 IIEIAAchSTHTSAAKTQGGHVYMWGQ 336
Cdd:COG5184 251 VVAIAA--GGSHTCALKSDGTVWCWGD 275
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 110-335 1.59e-64

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 214.07  E-value: 1.59e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIStNLSNkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGST 189
Cdd:COG5184   9 HSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVP-GLSN--VVAVAAGGDHTCALKADGTVWCWGNNSYGQLGDGTT 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  190 VNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAAlQGIRVQRVACGYAHT 269
Cdd:COG5184  86 TDRTTPVKVPG-LTG--VVAVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDA-GLSGVVAIAAGGYHT 161

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4557445  270 LVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTvEKDRIIEIAAchSTHTSAAKTQGGHVYMWG 335
Cdd:COG5184 162 CALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVG-GLSGVVAVAA--GGDHSCALKSDGTVWCWG 224
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 71-301 4.22e-60

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 202.51  E-value: 4.22e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445   71 GTNCCGCLGLGDVQSTIEPRRLDsLNGKKIACLSYGSGpHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTnLS 150
Cdd:COG5184 123 GDNSSGQLGDGTTTNRLTPVQVD-AGLSGVVAIAAGGY-HTCALKSDGTVWCWGANSYGQLGDGTTTDRPTPVQVGG-LS 199

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  151 NkqVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWG 230
Cdd:COG5184 200 G--VVAVAAGGDHSCALKSDGTVWCWGSNSSGQLGDGTTTDRATPVQVAG-LTG--VVAIAAGGSHTCALKSDGTVWCWG 274

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4557445  231 YNGNGQLGLGNSGNQPTPCRVAALQGirVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPT 301
Cdd:COG5184 275 DNSYGQLGDGTTTDRSTPVKVPGLSG--VVAVAAGSSHTCALLTDGTVWCWGDNAYGQLGDGTTTDRSTPV 343
BTB_POZ_RCBTB1_CLLD7 cd18353
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 375-486 5.54e-59

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1 is also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), CLL deletion region gene 7 protein, regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5. It is a novel chromosome condensation regulator-like guanine nucleotide exchange factor that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. RCBTB1 may also be a substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy. It contains an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349662 [Multi-domain]  Cd Length: 117  Bit Score: 191.70  E-value: 5.54e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  375 DDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DNEDDIVEMSEFSYPVYRAFLEYLYT 450
Cdd:cd18353   2 DDFLTVAESLKKEFDSPETSDLKFRVDGKYIHVHKAVLKIRCEHFRTMFQshwnEDMKEVIEIDQFSYPVYRAFLEYLYT 81

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4557445  451 DSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQG 486
Cdd:cd18353  82 DSVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRG 117
BTB_POZ_RCBTB1_2 cd18298
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 382-485 2.65e-56

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349607 [Multi-domain]  Cd Length: 108  Bit Score: 183.99  E-value: 2.65e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  382 ESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN----EDDIVEMSEFSYPVYRAFLEYLYTDSISLSP 457
Cdd:cd18298   1 DSLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHwnedDKNVIEIDQYSYPVYYAFLRYLYTDQVDLPP 80

                        90       100
                ....*....|....*....|....*...
gi 4557445  458 EEAVGLLDLATFYRENRLKKLCQQTIKQ 485
Cdd:cd18298  81 EDAIGLLDLANSYCEERLKKLCEDIIKQ 108
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 155-335 4.91e-52

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 180.94  E-value: 4.91e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  155 IEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGcLQNkvVVTIACGQMCCMAVVDTGEVYVWGYNGN 234
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPG-LSN--VVAVAAGGDHTCALKADGTVWCWGNNSY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  235 GQLGLGNSGNQPTPCRVAALQGIRvqRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIA 314
Cdd:COG5184  78 GQLGDGTTTDRTTPVKVPGLTGVV--AVAAGYYHSCALKSDGTVWCWGDNSSGQLGDGTTTNRLTPVQVDAGLSGVVAIA 155

                       170       180
                ....*....|....*....|.
gi 4557445  315 AchSTHTSAAKTQGGHVYMWG 335
Cdd:COG5184 156 A--GGYHTCALKSDGTVWCWG 174
BACK_RCBTB2 cd18529
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 ...
 487-551 1.10e-39

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 2 (RCBTB2); RCBTB2, also called chromosome condensation 1-like (CHC1-L), or RCC1-like G exchanging factor, or regulator of chromosome condensation and BTB domain-containing protein 2, is a chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.


Pssm-ID: 350604  Cd Length: 65  Bit Score: 138.51  E-value: 1.10e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557445  487 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 551
Cdd:cd18529   1 ISEENAIALLSAAVKYEAQDLEEFCFKFCINHMTVVTQTQAFADMDHDLLKNFISKASKVGAFKN 65
BACK_RCBTB1_2 cd18498
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, ...
 487-550 1.77e-30

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors.


Pssm-ID: 350573  Cd Length: 64  Bit Score: 113.14  E-value: 1.77e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4557445  487 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFK 550
Cdd:cd18498   1 ITVENAAFLYAAAIKYNAKELEEFCFKFAVNHLTAVVQTEAFSKLDESTLKDFIVKAAEAGAFK 64
BACK_RCBTB1 cd18528
BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 ...
 486-551 5.34e-30

BACK (BTB and C-terminal Kelch) domain found in RCC1 and BTB domain-containing protein 1 (RCBTB1); RCBTB1, also called chronic lymphocytic leukemia deletion region gene 7 protein (CLLD7), or CLL deletion region gene 7 protein, or regulator of chromosome condensation and BTB domain-containing protein 1, or E4.5, is a novel chromosome condensation regulator-like guanine nucleotide exchange factor (GEF) that may be involved in cell cycle regulation by chromatin remodeling. It may also function as a tumor suppressor that regulates pathways of DNA damage/repair and apoptosis. Moreover, RCBTB1 acts as a putative substrate adaptor for a cullin3 (CUL3) E3 ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Biallelic mutations in RCBTB1 may cause isolated and syndromic retinal dystrophy.


Pssm-ID: 350603  Cd Length: 66  Bit Score: 111.92  E-value: 5.34e-30
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4557445  486 GICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 551
Cdd:cd18528   1 GITVENAFSLLSAAVRYDAEDLEEFCFKFCVNHLTEVTQTAAFWQMDGNLLKEFIAKASKCGAFKN 66
BTB_POZ_ABTB2-like cd18297
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 388-491 4.76e-21

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2) and similar proteins; This family includes ABTB2, BTBD11, plant ARM repeat protein interacting with ABF2 (ARIA), and similar proteins. ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349606 [Multi-domain]  Cd Length: 117  Bit Score: 88.48  E-value: 4.76e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  388 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DNEDDIVEMSEFSYPVYRAFLEYLYT---DSISLSPEEA 460
Cdd:cd18297   7 VNNPEMSDVTFLVEGRPFYAHKIVLVTASDRFKSMLSsgstEAQTPVIEIPDIRYDIFQLMMQYLYTggvESLDVAQDDA 86

                        90       100       110
                ....*....|....*....|....*....|.
gi 4557445  461 VGLLDLATFYRENRLKKLCQQTIKQGICEEN 491
Cdd:cd18297  87 LELLRAASFFQLDGLKRHCEILLSQQIDLDN 117
BTB_POZ_BTBD19 cd18294
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 381-483 1.29e-20

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB domain-containing protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349603 [Multi-domain]  Cd Length: 111  Bit Score: 87.30  E-value: 1.29e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  381 AESLKREFDNPDTADLKFLV--DGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEF---SYP--VYRAFLEYLYTDSI 453
Cdd:cd18294   2 AADMKSLINNPEFSDVKFLVgpERQEIFAHKCILAARCEVFRAMFLTGPQKESTQSPLvlsDIEpeVFRAVLEFIYTNCV 81

                        90       100       110
                ....*....|....*....|....*....|
gi 4557445  454 SLSPEEAVGLLDLATFYRENRLKKLCQQTI 483
Cdd:cd18294  82 TLSNHTVIEVLAAAVEYGLDELRKLCERFI 111
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 395-487 4.96e-19

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 81.97  E-value: 4.96e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445     395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN----EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 470
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDfkesDKSEIYLDDVSPEDFRALLNFLYTGKLDLPEENVEELLELADYL 80

                           90
                   ....*....|....*..
gi 4557445     471 RENRLKKLCQQTIKQGI 487
Cdd:smart00225  81 QIPGLVELCEEFLLKLL 97
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 388-483 1.44e-17

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 78.44  E-value: 1.44e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  388 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEH----FRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPE-EAVG 462
Cdd:cd18300   4 LNKGLFSDVTFIVEDGTIPAHKALLVARCDVmaamFGGNFRESSAKEVELPGVSKETFLALLEYLYTDQAPILEDgDCVG 83

                        90       100
                ....*....|....*....|.
gi 4557445  463 LLDLATFYRENRLKKLCQQTI 483
Cdd:cd18300  84 LIVLANRLCLPRLVALCEQYI 104
BTB pfam00651
BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain ...
 384-485 2.34e-17

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.


Pssm-ID: 395526 [Multi-domain]  Cd Length: 107  Bit Score: 77.68  E-value: 2.34e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445    384 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDD----IVEMSEFSYPVYRAFLEYLYTDSIsLSPEE 459
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESEssvsEITLDDVSPEDFEALLEFMYTGKL-ISEEN 79

                          90       100
                  ....*....|....*....|....*.
gi 4557445    460 AVGLLDLATFYRENRLKKLCQQTIKQ 485
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLIK 105
BTB_POZ_ZBTB_KLHL-like cd18186
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 394-470 2.77e-16

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349497 [Multi-domain]  Cd Length: 82  Bit Score: 73.74  E-value: 2.77e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  394 ADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF 469
Cdd:cd18186   2 CDVTLVVGGREFPAHRAVLAARSPYFRamfsSGMKESSSSEIELDDVSPEAFEALLDYIYTGELELSEENVEELLAAADK 81


                .
gi 4557445  470 Y 470
Cdd:cd18186  82 L 82
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
224-272 1.57e-15

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 70.62  E-value: 1.57e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4557445    224 GEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVL 272
Cdd:pfam00415   2 GRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVAL 50
BTB_POZ_ARIA_plant cd18352
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 389-491 1.84e-15

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant ARM repeat protein interacting with ABF2 (ARIA) and similar proteins; ARIA is an armadillo (ARM) repeat and BTB domain-containing protein that acts as a positive regulator of ABA response via the modulation of the transcriptional activity of ABF2, a transcription factor which controls ABA-dependent gene expression via the G-box-type ABA-responsive elements. ARIA is a novel abscisic acid signaling component. It negatively regulates seed germination and young seedling growth. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349661 [Multi-domain]  Cd Length: 116  Bit Score: 72.51  E-value: 1.84e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLE----DNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLL 464
Cdd:cd18352   9 NNATLSDVTFLVEGRRFYAHRIALLASSDAFRAMFDggyrEKEARDIEIPNIRWEVFELMMRFIYTGSVDITNDIAKDLL 88

                        90       100
                ....*....|....*....|....*..
gi 4557445  465 DLATFYRENRLKKLCQQTIKQGICEEN 491
Cdd:cd18352  89 RAADQYLLEGLKRLCEYTIAQDLTLEN 115
ATS1 COG5184
Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, ...
 260-336 7.92e-15

Alpha-tubulin suppressor ATS1 and related RCC1 domain-containing proteins [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton];


Pssm-ID: 444065 [Multi-domain]  Cd Length: 343  Bit Score: 75.78  E-value: 7.92e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4557445  260 QRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDrIIEIAAchSTHTSAAKTQGGHVYMWGQ 336
Cdd:COG5184   1 TQVAAGGSHSCALKSDGTVWCWGDNSYGQLGDGTTTDRSTPVRVPGLSN-VVAVAA--GGDHTCALKADGTVWCWGN 74
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
170-220 5.37e-14

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 66.39  E-value: 5.37e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4557445    170 DGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKvVVTIACGQMCCMAV 220
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK-VVQVACGGDHTVAL 50
BTB_POZ_BTBD17 cd18292
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 377-481 8.33e-14

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349601 [Multi-domain]  Cd Length: 114  Bit Score: 67.70  E-value: 8.33e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  377 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIVEMSE--FSYPVYRAFLEYLY 449
Cdd:cd18292   1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLsndwwSESKQSEIELVEdpECAAVFEKFLRYLY 80

                        90       100       110
                ....*....|....*....|....*....|..
gi 4557445  450 TDSISLSPEEAVGLLDLATFYRENRLKKLCQQ 481
Cdd:cd18292  81 TGQISVNLETALPLLMLADKYNVTDLKQLCVD 112
BTB2_POZ_ABTB1_BPOZ1 cd18296
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 389-488 1.81e-13

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349605 [Multi-domain]  Cd Length: 121  Bit Score: 66.94  E-value: 1.81e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN---------EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEE 459
Cdd:cd18296  13 QELSFPDVCFQVEGHRFPCHKAFFCGRSDYFKALLRDHfaeseenngSIPVVTLHDVSPEVFAIVLYYIYTDDTDLPPEN 92

                        90       100
                ....*....|....*....|....*....
gi 4557445  460 AVGLLDLATFYRENRLKKLCQQTIKQGIC 488
Cdd:cd18296  93 AYDVLYVADMYLLPGLKRLCGTVLAQSLD 121
BTB_POZ_BTBD11 cd18351
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 388-493 6.31e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 11 (BTBD11); BTBD11, also called ankyrin repeat and BTB/POZ domain-containing protein BTBD11, is a BTB-domain-containing protein. The BTBD11 gene has been recently identified as an all-trans retinoic acid (atRA)-responsive gene that lies downstream of atRA and its receptors in the regulation of neurite outgrowth and cell adhesion in neural as well as non-neural tissues. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349660 [Multi-domain]  Cd Length: 131  Bit Score: 65.77  E-value: 6.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  388 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED---NEDDIVEMSEFSYPVYRAFLEYLY---TDSISLSPEEAV 461
Cdd:cd18351  19 LNNKEMSDVTFLVEGRPFYAHKVLLFTASPRFKALLSNkpsAENTCIEISYVKYHIFQLVMQYLYcggTESLLIKNNEIM 98

                        90       100       110
                ....*....|....*....|....*....|..
gi 4557445  462 GLLDLATFYRENRLKKLCQQTIKQGICEENAI 493
Cdd:cd18351  99 ELLSAAKFFQLEALQRHCEIICAKSINTENCV 130
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
117-167 6.48e-13

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 63.31  E-value: 6.48e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 4557445    117 EGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKqVIEVACGSYHSLVL 167
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNK-VVQVACGGDHTVAL 50
BTB_POZ_ABTB2_BPOZ2 cd18350
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 389-493 6.95e-13

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 2 (ABTB2); ABTB2, also called bood POZ containing gene type 2 (BPOZ-2), is a scaffold protein that controls the degradation of many biological proteins with various functions ranging from embryonic development to tumor progression. It may be involved in the initiation of hepatocyte growth. It inhibits the aggregation of alpha-synuclein, with implications for Parkinson's disease. ABTB2 functions as an adaptor protein for the E3 ubiquitin ligase scaffold protein Cullin-3. It directly binds to eukaryotic elongation factor 1A1 (eEF1A1) to promote eEF1A1 ubiquitylation and degradation, and prevent translation. It is also involved in the growth suppressive effect of the phosphatase and tensin homolog (PTEN). It contains an ankyrin repeat, BTB/POZ, and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349659 [Multi-domain]  Cd Length: 134  Bit Score: 66.02  E-value: 6.95e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHF------RSSLEDNEDDIVEMSEFSYPVYRAFLEYLY---TDSISLSPEE 459
Cdd:cd18350  20 NNKEMSDVTFLVEGKLFYAHKVLLVTASNRFkslltnKSEQESQGSKTIEISDIKYHIFQMLMQYLYyggTESMEIPIAD 99

                        90       100       110
                ....*....|....*....|....*....|....
gi 4557445  460 AVGLLDLATFYRENRLKKLCQQTIKQGICEENAI 493
Cdd:cd18350 100 VLELLSAASLFQLDALQRHCEILCSQTINLENAV 133
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 376-509 1.20e-12

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 64.57  E-value: 1.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  376 DHLT-VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIvEMSEFSYPVYRAFLEYLY 449
Cdd:cd18287   4 DHVHfLSEDIGALFLNEEYSDVTFVVEEKRFPAHRVILAARSEYFRALLyggmrESQQSEI-ELKDTNAEAFKALLKYIY 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  450 TdsislspeeavGLLDLATFYrenrlkklcqqtikqgicEENAIALLSAAVKYDAQDLEE 509
Cdd:cd18287  83 T-----------GRLTLTDLK------------------EDVLLDVLGLAHQYGFEELEA 113
RCC1 pfam00415
Regulator of chromosome condensation (RCC1) repeat;
275-323 2.09e-12

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 395335 [Multi-domain]  Cd Length: 50  Bit Score: 61.76  E-value: 2.09e-12
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4557445    275 EGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 323
Cdd:pfam00415   1 DGRVYTWGRNDYGQLGLGTTENVLVPQKVEGLSGNKVVQVACGGDHTVA 49
BTB_POZ_BPM_plant cd18280
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 389-480 1.73e-10

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349589 [Multi-domain]  Cd Length: 121  Bit Score: 58.49  E-value: 1.73e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI----------- 453
Cdd:cd18280  10 ESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSmlfgPMREENEGEIVIEDVEPPVFKALLHFIYKDELpddvepagsds 89

                        90       100
                ....*....|....*....|....*...
gi 4557445  454 -SLSPEEAVGLLDLATFYRENRLKKLCQ 480
Cdd:cd18280  90 sSLDTTMAQHLLAAADRYALERLRLLCE 117
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
154-183 1.83e-10

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 55.89  E-value: 1.83e-10
                          10        20        30
                  ....*....|....*....|....*....|
gi 4557445    154 VIEVACGSYHSLVLTSDGEVFAWGYNNSGQ 183
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BACK cd14733
BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal ...
 488-541 9.83e-10

BACK (BTB and C-terminal Kelch) domain; The BACK domain is found in architectures C-terminal to a BTB domain, in a diverse set of architectures together with Kelch, MATH, and/or TAZ domains. It is involved in interactions with the Cullin3 (Cul3) ubiquitin ligase complex, as well as in homo-oligomerization. Most proteins containing the BACK domain are understood to function as adaptor proteins that play a role in ubiquitination of various substrates.


Pssm-ID: 350515 [Multi-domain]  Cd Length: 55  Bit Score: 54.20  E-value: 9.83e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 4557445  488 CEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFIS 541
Cdd:cd14733   1 DPENCLGILELADLYNLEELKEKALKFILENFEEVSKSEEFLELSVELLLELLS 54
BTB_POZ_Rank-5 cd18303
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 388-496 1.30e-09

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in rabankyrin-5 (Rank-5); Rank-5, also called ankyrin repeat and FYVE domain-containing protein 1 (ANKFY1) or ankyrin repeats hooked to a zinc finger motif (ANKHZN), is a Rab5 effector that regulates and coordinates different endocytic mechanisms. It contains an N-terminal BTB domain, followed by a BACK domain, several ankyrin (ANK) repeats and a C-terminal FYVE domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349612 [Multi-domain]  Cd Length: 120  Bit Score: 56.18  E-value: 1.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  388 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEhFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLsPEEAVGLLDLA 467
Cdd:cd18303  13 FDKELYSDITIKLADKSIPAHKFVLAARSE-KWSNENLASTNELDLSDISYEVVLALLRWLYTDELDL-TLDDEFLLELM 90

                        90       100
                ....*....|....*....|....*....
gi 4557445  468 TFYRENRLKKLcqqtikQGICEENAIALL 496
Cdd:cd18303  91 KAAKRFQLTDL------VERCERALMSSV 113
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 388-479 1.46e-09

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 55.04  E-value: 1.46e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  388 FDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIVeMSEFSYPVYRAFLEYLYTDSISLSPEEAVG 462
Cdd:cd18314   1 YNDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLtgsmiESNLKEVT-LEDVEPEIFETVLKYMYTGQVTLSEENVLD 79

                        90
                ....*....|....*..
gi 4557445  463 LLDLATFYRENRLKKLC 479
Cdd:cd18314  80 LLMLASKYQVPDLEKLC 96
BTB2_POZ_LZTR1 cd18309
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 391-491 2.11e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in leucine-zipper-like transcriptional regulator 1 (LZTR-1); LZTR-1 is a golgi BTB-kelch protein that is degraded upon induction of apoptosis. It may also function as a transcriptional regulator that plays a crucial role in embryogenesis. Germline loss-of-function mutations in LZTR-1 predispose to an inherited disorder of multiple schwannomas. LZTR-1 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349618 [Multi-domain]  Cd Length: 126  Bit Score: 55.47  E-value: 2.11e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  391 PDTADLKFLVDGKYIYAHKVLLKIRCEH----FRSSLEdnEDDIVEMS--EFSyPVYRAF---LEYLYTDSISLSPEEAV 461
Cdd:cd18309  18 GDFCDITLLLDGHPIPAHKAILAARCSYfeamFRSFMP--EDNTVNISigEMV-PSRQAFdslLRYIYYGDVTMPPEDSL 94

                        90       100       110
                ....*....|....*....|....*....|..
gi 4557445  462 GLLDLATFY--RENRLKKLCQQTIKQGICEEN 491
Cdd:cd18309  95 YLFSAPYFYgfTNNRLQAYCKQNLEMNVSFEN 126
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
259-288 2.56e-09

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 52.43  E-value: 2.56e-09
                          10        20        30
                  ....*....|....*....|....*....|
gi 4557445    259 VQRVACGYAHTLVLTDEGQVYAWGANSYGQ 288
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BTB2_POZ_RHOBTB3 cd18360
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 384-483 6.64e-09

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 3 (RhoBTB3); RhoBTB3 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB3 is a Golgi-associated Rho-related ATPase that regulates the S/G2 transition of the cell cycle by targeting cyclin E for ubiquitylation. It is involved in vesicle trafficking and in targeting proteins for degradation in the proteasome. It binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network. It also promotes proteasomal degradation of Hypoxia-inducible factor alpha (HIFalpha) through facilitating hydroxylation and suppresses the Warburg effect. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349669 [Multi-domain]  Cd Length: 110  Bit Score: 53.70  E-value: 6.64e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  384 LKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDS-ISLSPE 458
Cdd:cd18360   1 LGLFFNSPLLADVVFKIQGTTVPAHRAVLVARCEvmaaMFNGNYAEAKSFLVPIYGVSKDTFLSFLEYLYTDScCPASIL 80

                        90       100
                ....*....|....*....|....*
gi 4557445  459 EAVGLLDLATFYRENRLKKLCQQTI 483
Cdd:cd18360  81 QAMALLICAEMYQVSRLQHICELYI 105
BTB2_POZ_BTBD8 cd18286
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 381-488 2.55e-08

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 8 (BTBD8); BTBD8 is a BTB-domain-containing Kelch-like protein that may play a role in developmental processes. It may also act as a protein-protein adaptor in a transcription complex and thus be involved in brain development. BTBD8 contains two BTB domains. This model corresponds to the second domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349595 [Multi-domain]  Cd Length: 121  Bit Score: 52.26  E-value: 2.55e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  381 AESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIvEMSEFSYPVYRAFLEYLYTDSISL 455
Cdd:cd18286   5 GKDLLQLFLNGEDSDITIKVDGKTFKAHRCILCARSSYFAAMLsgswaESNSSEI-TLTGVSHAAVSFVLLFIYGGVLDL 83

                        90       100       110
                ....*....|....*....|....*....|....
gi 4557445  456 SPEEAVG-LLDLATFYRENRLKKLCQQTIKQGIC 488
Cdd:cd18286  84 PDDVNLGeLLSLADMYGLDGLKDVVAYTLRRDYC 117
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 397-470 9.07e-08

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 49.59  E-value: 9.07e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4557445  397 KFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 470
Cdd:cd01165   2 VLVVEGEKFHVNKELLAQSSEYFRalfrGGFRESGQAEINLRDISPEDFRALLEFLYGGKRDLDASNLLELLEAANFL 79
BTB_POZ_NPR_plant cd18310
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 383-465 6.46e-07

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in plant regulatory proteins, NPR1-4, and similar proteins; NPR1 and NPR2 are essential for pathogenicity and the utilization of many nitrogen sources. NPR1 is also called nitrogen pathogenicity regulation protein NPR1, non-inducible immunity protein 1 (Nim1), nonexpresser of PR genes 1, or salicylic acid insensitive 1 (Sai1). It acts as a transcription coactivator that plays dual roles in regulating plant immunity. NPR3 and NPR4 are involved in negative regulation of defense responses against pathogens in plant. NPR proteins contain a BTB domain, DUF3420, ankyrin (ANK) repeats, and a conserved C-terminal domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349619 [Multi-domain]  Cd Length: 145  Bit Score: 48.84  E-value: 6.46e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  383 SLKREFDNPDT--ADLKFLVD-GKYIYAHKVLLKIRCEHFRSSL------EDNE------DDIVEMSEFSYPVYRAFLEY 447
Cdd:cd18310   6 DLENLLDSPDLfySDAEIIVEgGRPVPVHRCILAARSPFFRDIFasakaeGANTkpklelRELIPGGIVGYDAFMLVLSY 85

                        90
                ....*....|....*...
gi 4557445  448 LYTDSISLSPEEAVGLLD 465
Cdd:cd18310  86 LYSGRLRLVPKEGSACVD 103
BTB2_POZ_IBtk cd18302
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 389-487 1.10e-06

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor or negative regulator of Bruton tyrosine kinase (Btk), which is required for B-cell differentiation and development. IBtk binds to the PH domain of Btk and down-regulates the Btk kinase activity. It contains two BTB domains. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349611 [Multi-domain]  Cd Length: 113  Bit Score: 47.36  E-value: 1.10e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  389 DNPDTADLKFL-VDGKYIYAHKVLLKIRCEHFRSSL-----EDNEDDIVEMsEFSYPVYRAFLEYLYTDSISLSPE---- 458
Cdd:cd18302   1 KHSDLYDVTIVsEDGKEFPCHKCVLVARLEYFHSMLssswiEASSCSALTM-PIPSDILEIILDYLYTDEASAVKEsqnv 79

                        90       100       110
                ....*....|....*....|....*....|
gi 4557445  459 EAV-GLLDLATFYRENRLKKLCQQTIKQGI 487
Cdd:cd18302  80 EFLcNVLVIADQLLITRLKEICEVALVELL 109
BTB_POZ_ZBTB41 cd18226
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-469 1.51e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 41 (ZBTB41); ZBTB41, also called FRBZ1, may be involved in transcriptional regulation. Its specific function is as yet unknown. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349535 [Multi-domain]  Cd Length: 114  Bit Score: 47.10  E-value: 1.51e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN-EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF 469
Cdd:cd18226  24 DLVITVEGKEFSAHKVVVAVGSSYFHACLSKNpNTDAVTLDHVSYSVFQHLLEFLYTSEFFVYENEIPLVLEAAKF 99
BTB_POZ_roadkill-like cd18345
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 377-492 1.82e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349654 [Multi-domain]  Cd Length: 121  Bit Score: 47.15  E-value: 1.82e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  377 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDS 452
Cdd:cd18345   2 ECRLSDDLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPvfnaMFEHEMEERKQNRVEITDVDHEVMREMLRFIYTGK 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 4557445  453 ISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENA 492
Cdd:cd18345  82 APNLDKMADDLLAAADKYALERLKVMCEEALCSNLSVENV 121
BTB_POZ_SPOPL cd18343
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 380-491 6.00e-06

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349652 [Multi-domain]  Cd Length: 123  Bit Score: 45.77  E-value: 6.00e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  380 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRC----EHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISL 455
Cdd:cd18343   8 LAEDLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSpvfnAMFEHEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPN 87

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4557445  456 SPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEEN 491
Cdd:cd18343  88 LDKMADNLLAAADKYALERLKVMCEEALCNNLSVEN 123
BTB_POZ_BTBD1_2 cd18281
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 379-491 1.01e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349590 [Multi-domain]  Cd Length: 127  Bit Score: 45.12  E-value: 1.01e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  379 TVAESLKREFDNPDTADLKFLVdGK-----YIYAHKVLLKIRC----EHFRSSLEDNEDDIvEMSEFSYPVYRAFLEYLY 449
Cdd:cd18281   8 TVKERFAFLFNNETLSDVHFIV-GKgdneqRIPAHKFVLSIGSavfdAMFNGGMATTSAEI-ELPDVEPAAFLALLRFLY 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4557445  450 TDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEEN 491
Cdd:cd18281  86 SDEVQIGPETVMTTLYTAKKYAVPALESACVEFLKKNLSSDN 127
BTB1_POZ_ABTB1_BPOZ1 cd18295
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 382-481 1.04e-05

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein or bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homolog (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes. ABTB1 contains an ankyrin repeat and two BTB domains. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349604 [Multi-domain]  Cd Length: 119  Bit Score: 44.93  E-value: 1.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  382 ESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED--NEDDIVEMSE--FSYPVYRAFLEYLYTDSISLSP 457
Cdd:cd18295   8 EFLRRLLEQGSYSDVTFNVHGESFPAHRCILSARSPYFAEMFETkwKDKREINLKHplVNPDAFRALLQYLYTGRLEIHV 87

                        90       100
                ....*....|....*....|....
gi 4557445  458 EEAVGLLDLAtfyRENRLKKLCQQ 481
Cdd:cd18295  88 DDVEDCKRLA---KQCRLEELIEE 108
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-491 1.30e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 44.79  E-value: 1.30e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIrCEH-----FRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF 469
Cdd:cd18237  23 DVILIVEGREIKAHRVVLAA-ASHffhlmFTSNMTESKSSEVELKDAEPDIIELLVEFAYTARISVNSNNVQSLLDAANQ 101

                        90       100
                ....*....|....*....|..
gi 4557445  470 YRENRLKKLCQQTIKQGICEEN 491
Cdd:cd18237 102 YQIEPVKKMCVDFLKEQLDASN 123
BTB_POZ_ZBTB17_MIZ1 cd18206
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-480 1.33e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17); ZBTB1 is also called c-Myc-interacting zinc finger protein 1 (Miz-1), zinc finger protein 151, or zinc finger protein 60. It is a poly-Cys2His2 zinc finger (ZF) transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. ZBTB17 has been implicated in cardiomyopathy and is important in cardiac stress response. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349515 [Multi-domain]  Cd Length: 112  Bit Score: 44.54  E-value: 1.33e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDnEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENR 474
Cdd:cd18206  24 DCTFVVDGVDFKAHKAVLAACSEYFRMLFVD-QKDVVHLDISNAAGLGQVLEFMYTAKLSLSPENVDDVLAVATFLQMQD 102


                ....*.
gi 4557445  475 LKKLCQ 480
Cdd:cd18206 103 IVTACH 108
BTB_POZ_KLHL16_gigaxonin cd18245
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 389-479 2.98e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349554 [Multi-domain]  Cd Length: 111  Bit Score: 43.48  E-value: 2.98e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  389 DNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN--EDD----IVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVG 462
Cdd:cd18245  10 EEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLNYNppKDDgstyKIELEGISVEVMEEILDYIYTGQIKLSEDNIQD 89

                        90
                ....*....|....*..
gi 4557445  463 LLDLATFYRENRLKKLC 479
Cdd:cd18245  90 IVQAADLLLMTDLKDLC 106
BTB_POZ_SPOP-like cd18279
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 380-491 3.90e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP) and similar proteins; This family includes speckle-type POZ protein (SPOP), speckle-type POZ protein-like (SPOPL), TD and POZ domain-containing proteins (TDPOZ), Drosophila melanogaster protein roadkill and similar proteins. Both, SPOP and SPOPL, serve as adaptors of cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and proteasomal degradation of target proteins. TDPOZ is a family of bipartite animal and plant proteins that contain a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domains. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349588 [Multi-domain]  Cd Length: 120  Bit Score: 43.29  E-value: 3.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  380 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISL 455
Cdd:cd18279   5 LAEDLGNLWENSRFTDCCLCVGGQEFQAHKAILAARSPVFSAmfehEMEESKKNRVEINDVDPEVFKEMMRFIYTGKAPN 84

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4557445  456 SPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEEN 491
Cdd:cd18279  85 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVEN 120
BTB_POZ_KBTBD11 cd18275
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-496 4.56e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 11 (KBTBD11); KBTBD11 is also called chronic myelogenous leukemia-associated protein (CMLAP) or Kelch domain-containing protein 7B, or KLHDC7C. It is a BTB-Kelch family protein whose function remains unclear. A novel polymorphism rs11777210 in KBTBD11 is significantly associated with colorectal cancer risk. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349584 [Multi-domain]  Cd Length: 104  Bit Score: 42.47  E-value: 4.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLednEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENR 474
Cdd:cd18275   6 DLVIEVSGQRIRAHKSVLAAKSDYFRARL---SRDILKVKGLSYATLRLLVDYVYSGRMAVSKDNVVEVVAGARFLQMPC 82

                        90       100
                ....*....|....*....|..
gi 4557445  475 LKKLCQQTIKQGICEENAIALL 496
Cdd:cd18275  83 AAQCAVDAVRAQLCLGNCYEVL 104
BTB_POZ_BAB-like cd18315
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 394-467 7.87e-05

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster proteins bric-a-brac 1 (BAB1), bric-a-brac 2 (BAB2), modifier of mdg4 (doom), and similar proteins; BAB1 and BAB2 probably act as transcriptional regulators that are required for specification of the tarsal segment and are involved in antenna development. Doom is a product of the Drosophila mod(mdg4) gene. It induces apoptosis and binds to baculovirus inhibitor-of-apoptosis proteins. This subfamily also includes Drosophila melanogaster sex determination protein fruitless (FRU), protein jim lovell (LOV), zinc finger protein chinmo, transcription factor GAGA, transcription factor Ken, and longitudinals lacking proteins (LOLA). FRU probably acts as a transcriptional regulator that plays a role in male courtship behavior and sexual orientation, and enhances male-specific expression of takeout in brain-associated fat body. LOV, also called tyrosine kinase-related (TKR), has a regulatory role during midline cell development. Chinmo is a functional effector of the JAK/STAT pathway that regulates eye development, tumor formation, and stem cell self-renewal in Drosophila. GAGA is a transcriptional activator that functions by regulating chromatin structure. Ken, also termed protein Ken and Barbie, is a transcription factor required for Terminalia development. LOLA proteins are putative transcription factors required for axon growth and guidance in the central and peripheral nervous systems. Proteins in this subfamily contain a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349624 [Multi-domain]  Cd Length: 85  Bit Score: 41.38  E-value: 7.87e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4557445  394 ADLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN---EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLA 467
Cdd:cd18315   2 VDVTLACEGGSLKAHKLVLAAASPYFAALLKETppdEHPVIILPDVPYSELKALLDFIYTGEVNVSQEQLESLLKLA 78
BTB_POZ_SPOP cd18342
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 380-492 8.71e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein (SPOP); SPOP, also called HIB homolog 1 or Roadkill homolog 1, is a novel nuclear speckle-type protein which serves as an adaptor of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and proteasomal degradation of target proteins, such as BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349651 [Multi-domain]  Cd Length: 125  Bit Score: 42.40  E-value: 8.71e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  380 VAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRC----EHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISL 455
Cdd:cd18342   9 LADELGGLWENSRFTDCCLCVAGQEFQAHKAILAARSpvfsAMFEHEMEESKKNRVEINDVEPEVFKEMMCFIYTGKAPN 88

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 4557445  456 SPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENA 492
Cdd:cd18342  89 LDKMADDLLAAADKYALERLKVMCEDALCSNLSVENA 125
BTB_POZ_BTBD3_6 cd18282
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 388-481 8.78e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD3 and BTBD6; This family includes BTB/POZ domain-containing proteins BTBD3 and BTBD6, both of which are BTB-domain-containing Kelch-like proteins. BTBD3 controls dendrite orientation toward active axons in mammalian neocortex. BTBD6 is required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349591 [Multi-domain]  Cd Length: 108  Bit Score: 42.00  E-value: 8.78e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  388 FDNPDTADLKFLVDGKY----IYAHKVLLKIRCE----HFRSSLEDNEDDIvEMSEFSYPVYRAFLEYLYTDSISLSPEE 459
Cdd:cd18282   2 FNNELMADVHFIVGPPGgtqrIPAHKYVLATGSSvfyaMFYGGLAENKNEI-EIPDVEPAAFLNLLRYLYCDEIDLEPDT 80

                        90       100
                ....*....|....*....|..
gi 4557445  460 AVGLLDLATFYRENRLKKLCQQ 481
Cdd:cd18282  81 VLATLYAAKKYLVPHLARACVQ 102
BTB_POZ_ZBTB19_PATZ1 cd18207
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 407-485 9.39e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349516 [Multi-domain]  Cd Length: 128  Bit Score: 42.26  E-value: 9.39e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  407 AHKVLLKIRCEHFRSSLEDNEDDI-----VEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQ 481
Cdd:cd18207  41 AHRAVLAACSEYFESVFSAQEGDGgtpreLEMHTISSKVFGDILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQE 120


                ....
gi 4557445  482 TIKQ 485
Cdd:cd18207 121 VIKQ 124
BACK_IBtk cd18500
BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); ...
 491-545 1.01e-04

BACK (BTB and C-terminal Kelch) domain found in inhibitor of Bruton tyrosine kinase (IBtk); IBtk is an inhibitor of Bruton's tyrosine kinase (Btk), thereby playing a role in B-cell development.


Pssm-ID: 350575  Cd Length: 60  Bit Score: 40.19  E-value: 1.01e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 4557445  491 NAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNfISKASR 545
Cdd:cd18500   5 NVAELLEFADIYNADQLKESCLQFICLNLETLLESRLLDNLDEDLLKE-LSKYYR 58
BTB_POZ_M2BP cd18304
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 378-481 1.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Mac-2-binding protein (MAC2BP/M2BP); M2BP is also called galectin-3-binding protein, basement membrane autoantigen p105, lectin galactoside-binding soluble 3-binding protein (LGALS3BP), or tumor-associated antigen 90K. It promotes integrin-mediated cell adhesion and may stimulate host defense against viruses and tumor cells. It contains a scavenger receptor cysteine-rich domain, followed by BTB and BACK domains. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349613 [Multi-domain]  Cd Length: 114  Bit Score: 41.70  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  378 LTVAESLKREFDNPDTADLKFLV-------DGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYT 450
Cdd:cd18304   2 MELSEDLGLLYDSQQGCDFNISVltaggeeEELTFCAHRVILMLSPEANFLHKTGSSNITLDVDEECLPHVPDFLRYFYT 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 4557445  451 DSISLSPEEAVGLLDLATFYRENRLKKLCQQ 481
Cdd:cd18304  82 RQIDITLTSVKCFHKLASIYGVRKLREYCGQ 112
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-479 1.64e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 41.68  E-value: 1.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 470
Cdd:cd18265  25 DVVLLVDGKDFPCHRATLSANSAYFRAmfggHLKESRQAVVEIQKVSAAAMEVLLDYMYGGGLRIQEDNVESVLEASDLL 104


                ....*....
gi 4557445  471 RENRLKKLC 479
Cdd:cd18265 105 QVSKLREAC 113
BTB_POZ_ZBTB44 cd18228
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-487 1.75e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 44 (ZBTB44); ZBTB44, also called BTB/POZ domain-containing protein 15 (BTBD15) or zinc finger protein 851 (ZNF851), may be involved in transcriptional regulation. Single-nucleotide polymorphisms of ZBTB44 showed a suggestive association with disease progression of Crohn's disease. ZBTB44 has also preferentially been recognized by sera of patients with peripheral T-cell lymphoma (PTCL). It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349537 [Multi-domain]  Cd Length: 126  Bit Score: 41.38  E-value: 1.75e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSL-----------EDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGL 463
Cdd:cd18228  21 DVTIRVQDKIFRAHKVVLAACSDFFRSKLvgqasprlvlvSPAGKCVLDLHHVTVTGFAPLLEYAYTSTLSINTENIIDV 100

                        90       100
                ....*....|....*....|....
gi 4557445  464 LDLATFYRENRLKKLCQQTIKQGI 487
Cdd:cd18228 101 LAAASYMQMFNVANTCSEFMKSSI 124
BTB_POZ_TDPOZ cd18344
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 375-492 2.04e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in TD and POZ domain-containing proteins (TDPOZ); TDPOZ is a family of bipartite animal and plant proteins that contains a tumor necrosis factor receptor-associated factor (TRAF) domain (TD) and a POZ/BTB domain. TDPOZ proteins may be nuclear scaffold proteins probably involved in transcription regulation in early development and other cellular processes. This subfamily contains only mammalian members. Plant TDPOZ proteins contain a MATH domain at the N-terminal region and are named "BTB/POZ and MATH domain-containing proteins (BPM)", not included in this subfamily. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349653 [Multi-domain]  Cd Length: 128  Bit Score: 41.48  E-value: 2.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  375 DDHLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRS----SLEDNEDDIVEMSEFSYPVYRAFLEYLYT 450
Cdd:cd18344   5 DPRHMLTDDLGELWENSLFTDCCLLVAGHEFRAHKAILAARSPVFRAmfehEMEERLKNPIEIHDLDPQVFKEMMGFIYT 84

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4557445  451 DSISL--SPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENA 492
Cdd:cd18344  85 GKAPHlhSHSMACDVLAAADKYGLEGLKVLCEDALCRNLSVENA 128
BACK_ABTB1_BPOZ cd18497
BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing ...
 487-531 2.31e-04

BACK (BTB and C-terminal Kelch) domain found in ankyrin repeat and BTB/POZ domain-containing protein 1 (ABTB1); ABTB1, also called elongation factor 1A-binding protein, or Bood POZ containing gene type 1 (BPOZ-1), is an anti-proliferative factor that may act as a mediator of the phosphatase and tensin homologue (PTEN) growth-suppressive signaling pathway. It may play a role in developmental processes.


Pssm-ID: 350572  Cd Length: 72  Bit Score: 39.84  E-value: 2.31e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*
gi 4557445  487 ICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEM 531
Cdd:cd18497   1 LDEDNVIDVLRTARLFNLPRLEDQCTEFMAKNLEELVDDEEFAEL 45
BTB1_POZ_RhoBTB cd18299
first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 388-450 2.35e-04

first BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. In vertebrates, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the first BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349608 [Multi-domain]  Cd Length: 103  Bit Score: 40.66  E-value: 2.35e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557445  388 FDNPDTADLKFLVDGKY-IYAHKVLLKIRCEHFRSSLedNEDDIVEMSE-FSYPVYRAFLEYLYT 450
Cdd:cd18299   7 LHSPSCADVVFILQGGVrIFAHRIVLAAASSVFADLF--LMMTVVTLDSdITPEAFRRVLEFLYT 69
BTB_POZ_ZBTB37 cd18222
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-487 2.62e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 37 (ZBTB37); ZBTB37 may be involved in transcriptional regulation. It is differentially expressed in aryl hydrocarbon receptor (AhR)-KO mice compared with WT mice, and may potentially contribute to the aging phenotype of AhR-KO mice. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349531 [Multi-domain]  Cd Length: 123  Bit Score: 40.80  E-value: 2.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDNEDDIVEMSEFSYP-VYRAFLEYLYTDSISLSPEEAVGLLDLATFYREN 473
Cdd:cd18222  27 DIVVNVQGQSFRAHKVVLAASSPYFRDHMSLNEMSTVSISVIKNPtVFEQLLSFCYTGRICLQLADIISYLTAASFLQMQ 106

                        90
                ....*....|....
gi 4557445  474 RLKKLCQQtIKQGI 487
Cdd:cd18222 107 HIIDKCTQ-ILEGI 119
PHA03098 PHA03098
kelch-like protein; Provisional
 398-537 2.68e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.60  E-value: 2.68e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445   398 FLVDGKYIYAHKVLLKIRCEHFRSSLEDN--EDDIveMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRL 475
Cdd:PHA03098  16 IVNGGGIIKVHKIILSSSSEYFKKMFKNNfkENEI--NLNIDYDSFNEVIKYIYTGKINITSNNVKDILSIANYLIIDFL 93

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557445   476 KKLCQQTIKQGICEENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVtqtsgfaEMDHDLLK 537
Cdd:PHA03098  94 INLCINYIIKIIDDNNCIDIYRFSFFYGCKKLYSAAYNYIRNNIELI-------YNDPDFIY 148
BTB_POZ_KLHL22 cd18251
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-491 3.40e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 22 (KLHL22); KLHL22 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for chromosome alignment and localization of polo-like kinase 1 (PLK1) at kinetochores. The BCR(KLHL22) ubiquitin ligase complex mediates mono-ubiquitination of PLK1, leading to PLK1 dissociation from phosphoreceptor proteins and subsequent removal from kinetochores, allowing silencing of the spindle assembly checkpoint (SAC) and chromosome segregation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349560 [Multi-domain]  Cd Length: 125  Bit Score: 40.57  E-value: 3.40e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 470
Cdd:cd18251  25 DVVLVVEGKPIEAHRILLAASCDYFRgmfaGGLREMQQTEVLIHGVSYNAMCKILDFIYTSELELSLDNVQETLTAACQL 104

                        90       100
                ....*....|....*....|.
gi 4557445  471 RENRLKKLCQQTIKQGICEEN 491
Cdd:cd18251 105 QIPEVIGFCCDFLMSWVDNEN 125
BTB_POZ_BTBD12_SLX4 cd18288
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 381-480 3.42e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Structure-specific endonuclease subunit SLX4; SLX4, also called BTB/POZ domain-containing protein 12 (BTBD12), is a Holliday junction resolvase subunit that binds multiple DNA repair/recombination endonucleases and is required for DNA repair. Mutations of the SLX4 gene are found in Fanconi anemia. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349597 [Multi-domain]  Cd Length: 116  Bit Score: 40.52  E-value: 3.42e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  381 AESLKREFDNPDTADLKFLVD-GKYIYAHKVLLKIRCEHF-----RSSLEDNEDDI-----VEMSEFSYPVYRAFLEYLY 449
Cdd:cd18288   6 AADFSAMVNNPHLSDVQFQTDsGEVLYAHSFVLYARCPLLiqmvhSEGFSVEEEGGvttrrVLLGDVSGEAARCFLQYLY 85

                        90       100       110
                ....*....|....*....|....*....|.
gi 4557445  450 TDSISLSPEEAVGLLDLATFYRENRLKKLCQ 480
Cdd:cd18288  86 TADTGLPPGLSPHVSELADRFGVSELVHLCE 116
BTB_POZ_KBTBD3_BKLHD3 cd18271
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-479 4.43e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349580 [Multi-domain]  Cd Length: 130  Bit Score: 40.59  E-value: 4.43e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHFRSSLEDN----EDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATFY 470
Cdd:cd18271  26 DFNIIVKDETIPCHRCVLAACSDFFRAMFEVNmkerDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVEMFFQMSSFL 105


                ....*....
gi 4557445  471 RENRLKKLC 479
Cdd:cd18271 106 QVSLLSKAC 114
BTB_POZ_KBTBD2_BKLHD1 cd18270
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 378-496 6.10e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 2 (KBTBD2); KBTBD2, also called BTB and kelch domain-containing protein 1 (BKLHD1), plays an essential role in the regulation of insulin-signaling pathway. It is a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase, which targets p85alpha, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85alpha ubiquitination and proteasome-mediated degradation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349579 [Multi-domain]  Cd Length: 133  Bit Score: 39.99  E-value: 6.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  378 LTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSI 453
Cdd:cd18270  11 VSLLEQLKFFYEQQLLTDIVLIVEGTEFPCHKMVLATCSSYFRamfmSGLSESKQTHVHLRNVDAATLQIIITYAYTGNL 90

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 4557445  454 SLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALL 496
Cdd:cd18270  91 AINDSTVEQLYETACFLQVEDVLQRCREYLIKKINAENCVRLL 133
BTB_POZ_ZBTB35_ZNF131 cd18221
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 385-461 8.20e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349530 [Multi-domain]  Cd Length: 113  Bit Score: 39.21  E-value: 8.20e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4557445  385 KREFDNpdTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED-NEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAV 461
Cdd:cd18221  12 QRELDQ--FTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDfTQEPLVEIEGVSNMAFRHLIEFTYTAKLMVQGEEEA 87
BTB_POZ_KBTBD4 cd18272
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 394-481 9.11e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 4 (KBTBD4); KBTBD4, also called BTB and kelch domain-containing protein 4 (BKLHD4), is a BTB-BACK-Kelch domain protein belonging to a large family of cullin-RING ubiquitin ligase adaptors that facilitate the ubiquitination of target substrates. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349581 [Multi-domain]  Cd Length: 140  Bit Score: 39.88  E-value: 9.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  394 ADLKFLVDGKYIYAHKVLLKIRCEHFR----SSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLATF 469
Cdd:cd18272  33 ADVTISVEGKEFQLHRLVLSAQSCFFRsmftSNLKEARNRVIELKDVSESVFQLLVDYIYHGTVKLRVEELQETYEVADM 112

                        90
                ....*....|..
gi 4557445  470 YRENRLKKLCQQ 481
Cdd:cd18272 113 YQLTALFEECSR 124
BTB_POZ_KLHL29_KBTBD9 cd18258
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 395-493 1.04e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 29 (KLHL29); KLHL29 is also called Kelch repeat and BTB domain-containing protein 9 (KBTBD9). A novel fusion transcript NR5A2-KLHL29FT, resulting from transchromosomal insertion, may influence the origin or progression of colon cancer. KLHL29 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349567 [Multi-domain]  Cd Length: 125  Bit Score: 39.19  E-value: 1.04e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  395 DLKFLVDGKYIYAHKVLLKIRCEHF-----RSSLEDNEDDIVE--MSEFSYPVYRAFLEYLYTDSISLSPEEAVGLLDLA 467
Cdd:cd18258  19 DLKIIVEGKEFEVHQNVLASCSLYFkdlikRSSRDSGGGEKLEltMSNINADVLELLLEFVYTGSLIIDSANAKTLLEAA 98

                        90       100
                ....*....|....*....|....*.
gi 4557445  468 TFYRENRLKKLCQQTIKQGICEENAI 493
Cdd:cd18258  99 NKFQFHTFCKVCVSFLEKQLTASNCL 124
RCC1_2 pfam13540
Regulator of chromosome condensation (RCC1) repeat;
207-236 1.39e-03

Regulator of chromosome condensation (RCC1) repeat;


Pssm-ID: 463914 [Multi-domain]  Cd Length: 30  Bit Score: 36.25  E-value: 1.39e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 4557445    207 VVTIACGQMCCMAVVDTGEVYVWGYNGNGQ 236
Cdd:pfam13540   1 VVSVAAGDNHTLALTSDGRVYCWGDNSYGQ 30
BACK smart00875
BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are ...
 492-541 2.29e-03

BTB And C-terminal Kelch; The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues.


Pssm-ID: 197943 [Multi-domain]  Cd Length: 101  Bit Score: 37.71  E-value: 2.29e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 4557445     492 AIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFIS 541
Cdd:smart00875   1 CLGIRRFADAHGLEELAEKALRFILQNFSEVSSSEEFLELPLEQLLELLS 50
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 377-463 2.41e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 38.41  E-value: 2.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  377 HLTVAESLKREFDNPDTADLKFLVDGKYIYAHKVLLKIRCE----HFRSSLEDNEDDIVEMSEFSYPVYRAFLEYLYTDS 452
Cdd:cd18358   4 HVRKANRIKECLSKGTFSDVTFKLDDGTINAHKPLLICSCEwmaaMFGGSFIESANSEVVLPNISKVSMQAVLDYLYTKQ 83

                        90
                ....*....|....*
gi 4557445  453 IS----LSPEEAVGL 463
Cdd:cd18358  84 LSptadLDPLELIAL 98
BTB_POZ_BTBD3 cd18348
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 379-496 2.70e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349657 [Multi-domain]  Cd Length: 131  Bit Score: 38.08  E-value: 2.70e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  379 TVAESLKREFDNPDTADLKFLVD----GKYIYAHKVLLKIRCEHFRS----SLEDNEDDIvEMSEFSYPVYRAFLEYLYT 450
Cdd:cd18348   7 TIRERNAVMFNNDLMADIHFVVGppggTQRLPGHKYVLAVGSSVFHAmfygELAEDKDEI-RIPDVEPAAFLAMLKYIYC 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 4557445  451 DSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALL 496
Cdd:cd18348  86 DEIDLAADTVLATLYAAKKYIVPHLARACVNFLETSLSAKNACVLL 131
BTB_POZ_BTBD6 cd18349
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 388-479 4.35e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349658 [Multi-domain]  Cd Length: 109  Bit Score: 37.27  E-value: 4.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557445  388 FDNPDTADLKFLV----DGKYIYAHKVLL----KIRCEHFRSSLEDNEDDIvEMSEFSYPVYRAFLEYLYTDSISLSPEE 459
Cdd:cd18349   3 FNNELMADVHFIVgppgASQRVPAHKYVLavgsSVFYAMFYGDLAEVKSEI-HIPDVEPAAFLILLKYMYSDEIDLEADT 81

                        90       100
                ....*....|....*....|
gi 4557445  460 AVGLLDLATFYRENRLKKLC 479
Cdd:cd18349  82 VLATLYAAKKYIVPALAKAC 101
BACK_BTBD19 cd18494
BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); ...
 490-536 6.26e-03

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 19 (BTBD19); BTBD19 is a BTB-domain-containing Kelch-like protein. Its function remains unclear.


Pssm-ID: 350569  Cd Length: 73  Bit Score: 35.75  E-value: 6.26e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 4557445  490 ENAIALLSAAVKYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLL 536
Cdd:cd18494   3 ETACEALQAAVTYGQDELKERCLAFIEEHTEEVFKTKGFHELSDEAL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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