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Conserved domains on  [gi|432134275|ref|NP_001258918|]
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centrosomal protein of 76 kDa isoform b [Homo sapiens]

Protein Classification

centrosomal protein of 76 kDa( domain architecture ID 10634909)

centrosomal protein of 76 kDa (CEP76) that during interphase is involved in regulation of centriole duplication, and that during mitosis is involved in suppressing the aberrant activation and ectopic aggregation of cytoplasmic serine/threonine-protein kinase PLK1, a regulator of mitotic progression; contains a CEP76 C2 domain

Gene Ontology:  GO:0046599
PubMed:  19460342

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CEP76-C2 pfam15627
CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ...
 96-183 2.37e-39

CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.


:

Pssm-ID: 464781  Cd Length: 157  Bit Score: 141.32  E-value: 2.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432134275   96 LKKSDGTRMADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTSLTVELMGVGTESKVSVGILNIKL 175
Cdd:pfam15627  70 LPTEAGSAMADATDLLSISDPIHLVLIKTDTAGETTLLSSHFLEWRRVLCSPNGKTGLTVELRGVGAEAKVPAGILDLQL 149


                  ....*...
gi 432134275  176 EMYPPLNQ 183
Cdd:pfam15627 150 ELLPRKRT 157
 
Name Accession Description Interval E-value
CEP76-C2 pfam15627
CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ...
 96-183 2.37e-39

CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.


Pssm-ID: 464781  Cd Length: 157  Bit Score: 141.32  E-value: 2.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432134275   96 LKKSDGTRMADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTSLTVELMGVGTESKVSVGILNIKL 175
Cdd:pfam15627  70 LPTEAGSAMADATDLLSISDPIHLVLIKTDTAGETTLLSSHFLEWRRVLCSPNGKTGLTVELRGVGAEAKVPAGILDLQL 149


                  ....*...
gi 432134275  176 EMYPPLNQ 183
Cdd:pfam15627 150 ELLPRKRT 157
 
Name Accession Description Interval E-value
CEP76-C2 pfam15627
CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ...
 96-183 2.37e-39

CEP76 C2 domain; Many ciliary proteins are involved in ciliogenesis and implicated for ciliophathies. A recent study has shown that many of them contain various new versions of C2 domains which are predicted to mediate membrane localizations for Y-shaped linkers of transition zone of cilia. This is the new C2 domain that is contained by ciliary CEP76 proteins.


Pssm-ID: 464781  Cd Length: 157  Bit Score: 141.32  E-value: 2.37e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 432134275   96 LKKSDGTRMADSTTMLSISDPIHMVLIKTDIFGETTLVASYFLEWRSVLGSENGVTSLTVELMGVGTESKVSVGILNIKL 175
Cdd:pfam15627  70 LPTEAGSAMADATDLLSISDPIHLVLIKTDTAGETTLLSSHFLEWRRVLCSPNGKTGLTVELRGVGAEAKVPAGILDLQL 149


                  ....*...
gi 432134275  176 EMYPPLNQ 183
Cdd:pfam15627 150 ELLPRKRT 157
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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