F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 404312677   6 SCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22125    1 SCLFPEILAMIFSYLDVRDKGRAAQVCTAWRDAAYHKSVWR 41

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677  90 ANIESLNLSGCYNLtDNGLGHafVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQ 169
Cdd:cd09293   28 SGLEWLELYMCPIS-DPPLDQ--LSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677 170 RLKSLNLRscRHLSdvgiGHLagmtrsaaegclgleqltlqdcqkLTDLSLKHISRGLTGLRLLNLSFCgGISDAGLLHL 249
Cdd:cd09293  105 KLQTINLG--RHRN----GHL------------------------ITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWEL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 404312677 250 S--HMGSLRSLNLRSCDNISDTGIMHLAMGSL--RLSGLDVSFCDKVGDQS 296
Cdd:cd09293  154 AsgCSKSLERLSLNNCRNLTDQSIPAILASNYfpNLSVLEFRGCPLITDFS 204

F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 404312677   6 SCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22125    1 SCLFPEILAMIFSYLDVRDKGRAAQVCTAWRDAAYHKSVWR 41

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677  90 ANIESLNLSGCYNLtDNGLGHafVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQ 169
Cdd:cd09293   28 SGLEWLELYMCPIS-DPPLDQ--LSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677 170 RLKSLNLRscRHLSdvgiGHLagmtrsaaegclgleqltlqdcqkLTDLSLKHISRGLTGLRLLNLSFCgGISDAGLLHL 249
Cdd:cd09293  105 KLQTINLG--RHRN----GHL------------------------ITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWEL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 404312677 250 S--HMGSLRSLNLRSCDNISDTGIMHLAMGSL--RLSGLDVSFCDKVGDQS 296
Cdd:cd09293  154 AsgCSKSLERLSLNNCRNLTDQSIPAILASNYfpNLSVLEFRGCPLITDFS 204

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677 122 LNLSLCKQITDSSLGRIAQ----YLKGLEVLELGGcsniTNTGLLLIAWGLQRLKSLNLRSCRHLSDVGIGHLaGMTRSA 197
Cdd:COG5238  119 LRRIMAKTLEDSLILYLALprriNLIQVLKDPLGG----NAVHLLGLAARLGLLAAISMAKALQNNSVETVYL-GCNQIG 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677 198 AEGCLGL-EQLTLQDCQKLTDLSLKHIS-----------RGLTGLRLLNLSFcGGISDAGLL----HLSHMGSLRSLNLr 261
Cdd:COG5238  194 DEGIEELaEALTQNTTVTTLWLKRNPIGdegaeilaealKGNKSLTTLDLSN-NQIGDEGVIalaeALKNNTTVETLYL- 271

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677 262 SCDNISDTGIMHLA---MGSLRLSGLDVSFcDKVGDQSLAYIAQGLDG---LKSLSLCSCHISDDGINRMVRQMHGLRTL 335
Cdd:COG5238  272 SGNQIGAEGAIALAkalQGNTTLTSLDLSV-NRIGDEGAIALAEGLQGnktLHTLNLAYNGIGAQGAIALAKALQENTTL 350

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 404312677 336 NIGQCV--RITDKGLELIAEHL---SQLTGIDLyGCTRITKRGLERIT---QLPCLKVLNLGLWQMTDSEKVR 400
Cdd:COG5238  351 HSLDLSdnQIGDEGAIALAKYLegnTTLRELNL-GKNNIGKQGAEALIdalQTNRLHTLILDGNLIGAEAQQR 422

Leucine-rich repeat - CC (cysteine-containing) subfamily;

                           10        20
                   ....*....|....*....|....
gi 404312677   252 MGSLRSLNLRSCDNISDTGIMHLA 275
Cdd:smart00367   1 CPNLRELDLSGCTNITDEGLQALA 24

F-box domain found in F-box/LRR-repeat protein 14 (FBXL14) and similar proteins; FBXL14, also called F-box and leucine-rich repeat protein 14, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complex, which acts by mediating ubiquitination and subsequent degradation of SNAIL1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 404312677   6 SCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22125    1 SCLFPEILAMIFSYLDVRDKGRAAQVCTAWRDAAYHKSVWR 41

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677  90 ANIESLNLSGCYNLtDNGLGHafVQEIGSLRALNLSLCKQITDSSLGRIAQYLKGLEVLELGGCSNITNTGLLLIAWGLQ 169
Cdd:cd09293   28 SGLEWLELYMCPIS-DPPLDQ--LSNCNKLKKLILPGSKLIDDEGLIALAQSCPNLQVLDLRACENITDSGIVALATNCP 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677 170 RLKSLNLRscRHLSdvgiGHLagmtrsaaegclgleqltlqdcqkLTDLSLKHISRGLTGLRLLNLSFCgGISDAGLLHL 249
Cdd:cd09293  105 KLQTINLG--RHRN----GHL------------------------ITDVSLSALGKNCTFLQTVGFAGC-DVTDKGVWEL 153

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 404312677 250 S--HMGSLRSLNLRSCDNISDTGIMHLAMGSL--RLSGLDVSFCDKVGDQS 296
Cdd:cd09293  154 AsgCSKSLERLSLNNCRNLTDQSIPAILASNYfpNLSVLEFRGCPLITDFS 204

F-box-like; This is an F-box-like family.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 404312677    5 ISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:pfam12937   1 LSSLPDEILLQIFSYLDPKDLLRLALVCRRWRELASDDSLWR 42

F-box domain found in F-box only protein 33 (FBXO33) and similar proteins; FBXO33, also called FBX33, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. It exerts similar functions as F-box involved in polyQ pathogenesis (FipoQ) in modulating the ubiquitination and solubility of expanded SCA3-polyQ proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 404312677  11 ELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22104    7 VVLVHIFSYLPPRDRLRASSTCRRWREALFHPSLWR 42

Leucine-rich repeat (LRR) protein [Transcription];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677  74 QILSLRRSLSYVIQGMANIESLNLSGCyNLTDngLGHAFVQeIGSLRALNLSLCkQITD--SSLGRiaqyLKGLEVLELG 151
Cdd:COG4886   97 NLTELDLSGNEELSNLTNLESLDLSGN-QLTD--LPEELAN-LTNLKELDLSNN-QLTDlpEPLGN----LTNLKSLDLS 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 404312677 152 GCsNITNTGLLLiaWGLQRLKSLNLRSCRhLSDVGiGHLAGMTRsaaegclgLEQLTLQDCQkLTDLSLKhISRgLTGLR 231
Cdd:COG4886  168 NN-QLTDLPEEL--GNLTNLKELDLSNNQ-ITDLP-EPLGNLTN--------LEELDLSGNQ-LTDLPEP-LAN-LTNLE 231

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 404312677 232 LLNLSFCgGISDagLLHLSHMGSLRSLNLRSCdNISD 268
Cdd:COG4886  232 TLDLSNN-QLTD--LPELGNLTNLEELDLSNN-QLTD 264

F-box domain found in F-box/LRR-repeat protein 16 (FBXL16) and similar proteins; FBXL16, also called F-box and leucine-rich repeat protein 16, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a repressor of one of the earliest steps in the cardiogenic lineage: FLK1+ progenitor formation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 404312677   7 CLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRG 47
Cdd:cd22127    2 LLDEKFLNRLFWYFSPCERCVLAQVCKKWRDVLYQPKFWRG 42

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                         10        20        30
                 ....*....|....*....|....*....|....*
gi 404312677   6 SCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAY 40
Cdd:cd09917    1 SDLPDEILLKILSYLDPRDLLRLSLVCKRWRELAS 35

F-box domain found in F-box/LRR-repeat protein 12 (FBXL12) and similar proteins; FBXL12, also called F-box and leucine-rich repeat protein 12, or F-box protein FBL12, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It mediates the polyubiquitination and proteasomal degradation of calcium/calmodulin dependent protein kinase I (CAMK1) leading to disruption of cyclin D1/CDK4 complex assembly, which results in G1 cell cycle arrest in lung epithelia. It regulates T-cell differentiation in a cell-autonomous manner. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 404312677   5 ISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22123    1 LDQLPENVLLEILSYLPVRDLLRISRVCKRWRRLVYDKTLWR 42

F-box domain found in Arabidopsis thaliana F-box protein GID2 and similar proteins; AtGID2, also called protein SLEEPY 1, is an essential component of the SCF-type E3 ligase complex, SCF(GID2), a complex that positively regulates the gibberellin signaling pathway. Upon gibberellin treatment, the SCF(GID2) complex mediates the ubiquitination and subsequent degradation of DELLA proteins (GAI, RGA and RGL2), some repressors of the gibberellin pathway, leading to the activation of the pathway. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 404312677   6 SCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22151    1 RKLPDDLLQEIFKRLDPKSLARAACVCRRWRAAARSESLWE 41

F-box domain found in F-box/LRR-repeat protein 6 (FBXL6) and similar proteins; FBXL6, also called F-box and leucine-rich repeat protein 6, or F-box protein FBL6 (FBL6A), is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 404312677  10 PELLAMIFGYLdVRDKG------RAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22119    6 PEILVKIFQFA-VATEGavpllcRLSRVCRLWREVALDPSLWT 47

F-box domain found in F-box only protein 39 (FBXO39) and similar proteins; FBXO39, also called FBX39, likely functions as the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. It acts as a cancer/testis antigen from colon cancer patients by serological analysis of recombinant cDNA expression libraries (SEREX). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 404312677  10 PEL-LAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22108    5 PDVcLRHVFRWLGDRDRSRAALVCKRWNQAMYSPALWR 42

F-box domain found in F-box/LRR-repeat protein 13 (FBXL13) and similar proteins; FBXL13, also called F-box and leucine-rich repeat protein 13, or dynein regulatory complex subunit 6, is a component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. It is also the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 404312677   5 ISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVW 45
Cdd:cd22124    1 ISLLPRKAALKIFSYLDLRDLARCAQVCRSWKVITQSSSLW 41

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 404312677    5 ISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42

F-box domain found in F-box/LRR-repeat protein 3 (FBXL3) and similar proteins; FBXL3, also called F-box and leucine-rich repeat protein 3A, or F-box/LRR-repeat protein 3A, is the substrate-recognition component of the SCF(FBXL3) E3 ubiquitin ligase complex that mainly acts in the nucleus and mediates ubiquitination and subsequent degradation of CRY1 and CRY2, and thus, is involved in circadian rhythm function. It plays a key role in the maintenance of both the speed and the robustness of the circadian clock oscillation. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 404312677   8 LFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVW 45
Cdd:cd22178    6 LLQDIILQIFQYLPLLDRAHASQVCRNWNQVFHMPDLW 43

F-box domain found in epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 404312677   8 LFPELLAM-IFGYLDVRDKGRAAQVCTAWRDAAYHKSVWRG 47
Cdd:cd22173    5 VLPRFLSLyIFSFLDPRSLCRAAQVSWHWKFLAEQDCLWMP 45

F-box domain found in F-box/WD repeat-containing protein 7 (FBXW7) and similar proteins; FBXW7, also called Archipelago homolog (Ago), F-box and WD-40 domain-containing protein 7, F-box protein FBX30, SEL-10, or Cdc4, is the substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 404312677   5 ISCLFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:cd22133   18 ISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWR 59

F-box domain found in F-box only protein 16 (FBXO16), epithelial cell-transforming sequence 2 oncogene-like (ECT2L) and similar proteins; This family includes FBXO16 and ECT2L. FBXO16, also called FBX16, is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It functions as a tumor suppressor by attenuating nuclear beta-catenin function. ECT2L, also called lung-specific F-box and DH domain-containing protein, or putative guanine nucleotide exchange factor LFDH, may act as a guanine nucleotide exchange factor (GEF). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 404312677   9 FPELLAM-IFGYLDVRDKGRAAQVCTAWRDAAYHKSVW 45
Cdd:cd22094    6 LPRFLSLyIFSYLDPRSLCRAAQVSWYWKFLCESDELW 43

A Receptor for Ubiquitination Targets;

                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 404312677     8 LFPELLAMIFGYLDVRDKGRAAQVCTAWRDAAYHKSVWR 46
Cdd:smart00256   1 LPDEILEEILSKLDPKDLLRLRKVSRKWRSLIDSHDFWF 39