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Conserved domains on  [gi|1426138107|ref|NP_001258085|]
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zinc finger protein 41 homolog [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 13416207)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-182 1.21e-04

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 1.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 1426138107 157 NLLKHQKTHTGEKPYECTHCGKAFAY 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
85-198 1.88e-04

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426138107  85 KPYECSECGRIFKHKTDHIRHQR--VHTGE--KPFKC--AQCGKAFRHSSDVTKHQRTHTGEKPFKC------------- 145
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspll 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1426138107 146 ------------------------GECGKAFNCGSNLLKHQKTHTGEKPYEC--THCGKAFAYSSCLIRHQKRHPRKKP 198
Cdd:COG5048   368 nneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 8-72 3.37e-03

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 37.75  E-value: 3.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1426138107   8 KKKTPTPREEADVQKSALREEKVSGDRKP--PERPTVPRKPR-TEPCLSPEDEEHVFDAFDASFKDDF 72
Cdd:PTZ00449  608 RPKSPKLPELLDIPKSPKRPESPKSPKRPppPQRPSSPERPEgPKIIKSPKPPKSPKPPFDPKFKEKF 675
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-182 1.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 1.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 1426138107 157 NLLKHQKTHTGEKPYECTHCGKAFAY 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-198 1.88e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426138107  85 KPYECSECGRIFKHKTDHIRHQR--VHTGE--KPFKC--AQCGKAFRHSSDVTKHQRTHTGEKPFKC------------- 145
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspll 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1426138107 146 ------------------------GECGKAFNCGSNLLKHQKTHTGEKPYEC--THCGKAFAYSSCLIRHQKRHPRKKP 198
Cdd:COG5048   368 nneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
104-126 5.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 5.88e-04
                          10        20
                  ....*....|....*....|...
gi 1426138107 104 RHQRVHTGEKPFKCAQCGKAFRH 126
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 8-72 3.37e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 37.75  E-value: 3.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1426138107   8 KKKTPTPREEADVQKSALREEKVSGDRKP--PERPTVPRKPR-TEPCLSPEDEEHVFDAFDASFKDDF 72
Cdd:PTZ00449  608 RPKSPKLPELLDIPKSPKRPESPKSPKRPppPQRPSSPERPEgPKIIKSPKPPKSPKPPFDPKFKEKF 675
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
157-182 1.21e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 1.21e-04
                          10        20
                  ....*....|....*....|....*.
gi 1426138107 157 NLLKHQKTHTGEKPYECTHCGKAFAY 182
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
85-198 1.88e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426138107  85 KPYECSECGRIFKHKTDHIRHQR--VHTGE--KPFKC--AQCGKAFRHSSDVTKHQRTHTGEKPFKC------------- 145
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEkllnssskfspll 367

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1426138107 146 ------------------------GECGKAFNCGSNLLKHQKTHTGEKPYEC--THCGKAFAYSSCLIRHQKRHPRKKP 198
Cdd:COG5048   368 nneppqslqqykdlkndkksetlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
84-194 2.90e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.83  E-value: 2.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1426138107  84 KKPYECSECGRIFKHKTDHIRHQRVHTGEKPFKCAQ--CGKAFRHSSDVTKHQRTHTGEKPFkcgecgkaFNCGSNLLKH 161
Cdd:COG5048    31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSD--------LNSKSLPLSN 102

                          90       100       110
                  ....*....|....*....|....*....|...
gi 1426138107 162 QKTHTGEKPYECTHCGKAFAYSSCLIRHQKRHP 194
Cdd:COG5048   103 SKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDP 135
zf-H2C2_2 pfam13465
Zinc-finger double domain;
104-126 5.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 5.88e-04
                          10        20
                  ....*....|....*....|...
gi 1426138107 104 RHQRVHTGEKPFKCAQCGKAFRH 126
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
132-154 6.96e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 6.96e-04
                          10        20
                  ....*....|....*....|...
gi 1426138107 132 KHQRTHTGEKPFKCGECGKAFNC 154
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 8-72 3.37e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 37.75  E-value: 3.37e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1426138107   8 KKKTPTPREEADVQKSALREEKVSGDRKP--PERPTVPRKPR-TEPCLSPEDEEHVFDAFDASFKDDF 72
Cdd:PTZ00449  608 RPKSPKLPELLDIPKSPKRPESPKSPKRPppPQRPSSPERPEgPKIIKSPKPPKSPKPPFDPKFKEKF 675
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 171-193 3.40e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 3.40e-03
                          10        20
                  ....*....|....*....|...
gi 1426138107 171 YECTHCGKAFAYSSCLIRHQKRH 193
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 115-137 3.71e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 3.71e-03
                          10        20
                  ....*....|....*....|...
gi 1426138107 115 FKCAQCGKAFRHSSDVTKHQRTH 137
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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