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Conserved domains on  [gi|402244307|ref|NP_001257950|]
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1,5-anhydro-D-fructose reductase isoform 2 [Homo sapiens]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
1-263 0e+00

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19110:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 301  Bit Score: 511.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   1 MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19110    1 MEDIPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvqDLPLDESNMVIPSDTDFLDTWEAMEDLVI 160
Cdd:cd19110   81 KTACTRSLKALKLNYLDLYLIHWPMGFKPGEP-------------------DLPLDRSGMVIPSDTDFLDTWEAMEDLVI 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 161 TGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTN----------------------------------------------- 193
Cdd:cd19110  142 EGLVKNIGVSNFNHEQLERLLNKPGLRVKPVTNqiechpyltqkklisfcqsrnvsvtayrplggscegvdliddpviqr 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 194 ----------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFHIEY 263
Cdd:cd19110  222 iakkhgkspaQILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301
 
Name Accession Description Interval E-value
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
1-263 0e+00

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 511.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   1 MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19110    1 MEDIPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvqDLPLDESNMVIPSDTDFLDTWEAMEDLVI 160
Cdd:cd19110   81 KTACTRSLKALKLNYLDLYLIHWPMGFKPGEP-------------------DLPLDRSGMVIPSDTDFLDTWEAMEDLVI 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 161 TGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTN----------------------------------------------- 193
Cdd:cd19110  142 EGLVKNIGVSNFNHEQLERLLNKPGLRVKPVTNqiechpyltqkklisfcqsrnvsvtayrplggscegvdliddpviqr 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 194 ----------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFHIEY 263
Cdd:cd19110  222 iakkhgkspaQILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
4-249 1.33e-81

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 245.73  E-value: 1.33e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:COG0656    5 IPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHGYDDTLAA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMgfkpphpewimscselsfclshprvqdlpldesnmvipsDTDFLDTWEAMEDLVITGL 163
Cdd:COG0656   81 FEESLERLGLDYLDLYLIHWPG---------------------------------------PGPYVETWRALEELYEEGL 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGLrfKPLTNQIL----------------------------------------------- 196
Cdd:COG0656  122 IRAIGVSNFDPEHLEELLAETGV--KPAVNQVElhpylqqrellafcrehgivveaysplgrgkllddpvlaeiaekhgk 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 402244307 197 ------IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFP 249
Cdd:COG0656  200 tpaqvvLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERLGPDP 258
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
4-245 1.26e-51

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 169.48  E-value: 1.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKslVETA 83
Cdd:PRK11565  15 MPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKA----LKEASVAREELFITTKLWNDDHKR--PREA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAMEDLVITGL 163
Cdd:PRK11565  89 LEESLKKLQLDYVDLYLMHWPV-------------------------------------PAIDHYVEAWKGMIELQKEGL 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGL------------------------------RFKPLTN-------------------- 193
Cdd:PRK11565 132 IKSIGVCNFQIHHLQRLIDETGVtpvinqielhplmqqrqlhawnathkiqteSWSPLAQggkgvfdqkvirdladkygk 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 402244307 194 ---QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 245
Cdd:PRK11565 212 tpaQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKRL 266
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
6-255 1.65e-36

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 130.89  E-value: 1.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307    6 AVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYH---NEREVGAGIrckiKEGAVRREDLFIATKL------WCTCHK 76
Cdd:pfam00248   7 QLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVpdgdgpWPSGGS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   77 KSLVETACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAME 156
Cdd:pfam00248  83 KENIRKSLEESLKRLGTDYIDLYYLHWP--------------------------------------DPDTPIEETWDALE 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  157 DLVITGLVKNIGVSNFNHEQLERLLNKPGLRF----------KPLTNQILIRFQIQRNVIVIP------GSITPShIKEN 220
Cdd:pfam00248 125 ELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIvavqveynllRRRQEEELLEYCKKNGIPLIAysplggGLLTGK-YTRD 203
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 402244307  221 IQVFDFELTqHDMDNILSLNRNLRLAMFPITKNHK 255
Cdd:pfam00248 204 PDKGPGERR-RLLKKGTPLNLEALEALEEIAKEHG 237
 
Name Accession Description Interval E-value
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
1-263 0e+00

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 511.81  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   1 MGDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19110    1 MEDIPAVGLGTWKASPGEVTEAVKVAIDAGYRHFDCAYLYHNESEVGAGIREKIKEGVVRREDLFIVSKLWCTCHKKSLV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvqDLPLDESNMVIPSDTDFLDTWEAMEDLVI 160
Cdd:cd19110   81 KTACTRSLKALKLNYLDLYLIHWPMGFKPGEP-------------------DLPLDRSGMVIPSDTDFLDTWEAMEDLVI 141
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 161 TGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTN----------------------------------------------- 193
Cdd:cd19110  142 EGLVKNIGVSNFNHEQLERLLNKPGLRVKPVTNqiechpyltqkklisfcqsrnvsvtayrplggscegvdliddpviqr 221
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 194 ----------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFHIEY 263
Cdd:cd19110  222 iakkhgkspaQILIRFQIQRNVIVIPKSVTPSRIKENIQVFDFELTEHDMDNLLSLDRNLRLATFPITENHKDYPFHIEY 301
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
4-263 3.56e-141

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 398.71  E-value: 3.56e-141
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19107    4 MPILGLGTWKSPPGQVTEAVKVAIDAGYRHIDCAYVYQNENEVGEAIQEKIKEQVVKREDLFIVSKLWCTFHEKGLVKGA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKPPhpewimscSELsfclshprvqdLPLDESNMVIPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19107   84 CQKTLSDLKLDYLDLYLIHWPTGFKPG--------KEL-----------FPLDESGNVIPSDTTFLDTWEAMEELVDEGL 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGLRFKPLTNQI------------------------------------------------ 195
Cdd:cd19107  145 VKAIGVSNFNHLQIERILNKPGLKYKPAVNQIechpyltqekliqycqskgivvtaysplgspdrpwakpedpslledpk 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 196 ---------------LIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYPFH 260
Cdd:cd19107  225 ikeiaakhnkttaqvLIRFPIQRNLVVIPKSVTPERIAENFKVFDFELSSEDMATILSFNRNWRACALLSCSSHKDYPFH 304

                 ...
gi 402244307 261 IEY 263
Cdd:cd19107  305 AEY 307
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
4-244 4.07e-95

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 281.43  E-value: 4.07e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKAS---PGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19108   11 IPVLGFGTYAPEevpKSKALEATKLAIDAGFRHIDSAYLYQNEEEVGQAIRSKIADGTVKREDIFYTSKLWCTFHRPELV 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHpewimscselsfclshprvQDLPLDESNMVIPSDTDFLDTWEAMEDLVI 160
Cdd:cd19108   91 RPALEKSLKKLQLDYVDLYLIHFPVALKPGE-------------------ELFPKDENGKLIFDTVDLCATWEAMEKCKD 151
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 161 TGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQ---------------------------------------------- 194
Cdd:cd19108  152 AGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQvechpylnqsklldfckskdivlvaysalgsqrdkewvdqnspvll 231
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 402244307 195 ------------------ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 244
Cdd:cd19108  232 edpvlcalakkhkrtpalIALRYQLQRGVVVLAKSFNEKRIKENLQVFEFQLTSEDMKALDGLNRNLR 299
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
3-258 1.00e-93

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 278.11  E-value: 1.00e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEG-AVRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19106    6 KMPLIGLGTWKSKPGQVKAAVKYALDAGYRHIDCAAVYGNEQEVGEALKEKVGPGkAVPREDLFVTSKLWNTKHHPEDVE 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  82 TACRKSLKALKLNYLDLYLIHWPMGFKPPHpewimscselsfclshprvQDLPLDESNMVIPSDTDFLDTWEAMEDLVIT 161
Cdd:cd19106   86 PALRKTLKDLQLDYLDLYLIHWPYAFERGD-------------------NPFPKNPDGTIRYDSTHYKETWKAMEKLVDK 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 162 GLVKNIGVSNFNHEQLERLLNKPglRFKPLTN------------------------------------------------ 193
Cdd:cd19106  147 GLVKAIGLSNFNSRQIDDILSVA--RIKPAVLqvechpylaqneliahckarglvvtaysplgspdrpwakpdepvllee 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 194 ---------------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHKDYP 258
Cdd:cd19106  225 pkvkalakkynkspaQILLRWQVQRGVVVIPKSVTPSRIKQNIQVFDFTLSPEEMKQLDALNRNWRYIVPMITVDGKRVP 304
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
4-244 2.42e-93

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 276.86  E-value: 2.42e-93
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKA-SPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19116   11 IPAIALGTWKLkDDEGVRQAVKHAIEAGYRHIDTAYLYGNEAEVGEAIREKIAEGVVKREDLFITTKLWNSYHEREQVEP 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMGFKpphpewimscselsfclshprvQDLPLDESNMVIPSDTDFLDTWEAMEDLVITG 162
Cdd:cd19116   91 ALRESLKRLGLDYVDLYLIHWPVAFK----------------------ENNDSESNGDGSLSDIDYLETWRGMEDLVKLG 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLERLL-------------NKPGLRFKPL-------------------------------------- 191
Cdd:cd19116  149 LTRSIGVSNFNSEQINRLLsncnikpavnqieVHPTLTQEKLvaycqsngivvmayspfgrlvprgqtnppprlddptlv 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402244307 192 ---------TNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 244
Cdd:cd19116  229 aiakkygktTAQIVLRYLIDRGVVPIPKSSNKKRIKENIDIFDFQLTPEEVAALNSFNTNQR 290
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
4-236 2.40e-89

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 265.11  E-value: 2.40e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIkegaVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19071    1 MPLIGLGTYKLKPEETAEAVLAALEAGYRHIDTAAAYGNEAEVGEAIRESG----VPREELFITTKLWPTDHGYERVREA 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKPPhpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19071   77 LEESLKDLGLDYLDLYLIHWPVPGKEG--------------------------------GSKEARLETWRALEELVDEGL 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGLR------------------------------FKPLTN-------------------- 193
Cdd:cd19071  125 VRSIGVSNFNVEHLEELLAAARIKpavnqielhpylqqkelvefckehgivvqaYSPLGRgrrpllddpvlkeiakkygk 204
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 402244307 194 ---QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 236
Cdd:cd19071  205 tpaQVLLRWALQRGVVVIPKSSNPERIKENLDVFDFELSEEDMAAI 250
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
4-259 7.39e-86

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 258.19  E-value: 7.39e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGL---SSWKASP-GKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSL 79
Cdd:cd19109    4 IPIIGLgtySEPKTTPkGACAEAVKVAIDTGYRHIDGAYIYQNEHEVGQAIREKIAEGKVKREDIFYCGKLWNTCHPPEL 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  80 VETACRKSLKALKLNYLDLYLIHWPMGFKPphpewimscSELSFclshprvqdlPLDESNMVIPSDTDFLDTWEAMEDLV 159
Cdd:cd19109   84 VRPTLERTLKVLQLDYVDLYIIEMPMAFKP---------GDEIY----------PRDENGKWLYHKTNLCATWEALEACK 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 160 ITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTN---------------------------------------------- 193
Cdd:cd19109  145 DAGLVKSIGVSNFNRRQLELILNKPGLKHKPVSNqvechpyftqpkllefcqqhdivivaysplgtcrdpiwvnvssppl 224
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 194 ------------------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFPITKNHK 255
Cdd:cd19109  225 ledpllnsigkkynktaaQVVLRFNIQRGVVVIPKSFNPERIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRDHP 304

                 ....
gi 402244307 256 DYPF 259
Cdd:cd19109  305 EYPF 308
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
4-249 1.33e-81

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 245.73  E-value: 1.33e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:COG0656    5 IPALGLGTWQLPGEEAAAAVRTALEAGYRHIDTAAMYGNEEGVGEAIA----ASGVPREELFVTTKVWNDNHGYDDTLAA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMgfkpphpewimscselsfclshprvqdlpldesnmvipsDTDFLDTWEAMEDLVITGL 163
Cdd:COG0656   81 FEESLERLGLDYLDLYLIHWPG---------------------------------------PGPYVETWRALEELYEEGL 121
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGLrfKPLTNQIL----------------------------------------------- 196
Cdd:COG0656  122 IRAIGVSNFDPEHLEELLAETGV--KPAVNQVElhpylqqrellafcrehgivveaysplgrgkllddpvlaeiaekhgk 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 402244307 197 ------IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFP 249
Cdd:COG0656  200 tpaqvvLRWHLQRGVVVIPKSVTPERIRENLDAFDFELSDEDMAAIDALDRGERLGPDP 258
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
4-245 1.77e-76

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 233.84  E-value: 1.77e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19123   12 IPALGLGTWKSKPGEVGQAVKQALEAGYRHIDCAAIYGNEAEIGAALAEVFKEGKVKREDLWITSKLWNNSHAPEDVLPA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKPphpewimscselsfclshprvqDLPLDESN--MVIPSDTDFLDTWEAMEDLVIT 161
Cdd:cd19123   92 LEKTLADLQLDYLDLYLMHWPVALKK----------------------GVGFPESGedLLSLSPIPLEDTWRAMEELVDK 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 162 GLVKNIGVSNFNHEQLERLLNKPglRFKPLTNQ----------------------------------------------- 194
Cdd:cd19123  150 GLCRHIGVSNFSVKKLEDLLATA--RIKPAVNQvelhpylqqpellafcrdngihltaysplgsgdrpaamkaegepvll 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402244307 195 ------------------ILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 245
Cdd:cd19123  228 edpvinkiaekhgaspaqVLIAWAIQRGTVVIPKSVNPERIQQNLEAAEVELDASDMATIAALDRHHRY 296
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
4-248 6.86e-76

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 232.69  E-value: 6.86e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19154   12 MPLIGLGTWQSKGAEGITAVRTALKAGYRLIDTAFLYQNEEAIGEALAELLEEGVVKREDLFITTKLWTHEHAPEDVEEA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMscselsfclshprvqdlplDESNMVIPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19154   92 LRESLKKLQLEYVDLYLIHAPAAFKDDEGESGT-------------------MENGMSIHDAVDVEDVWRGMEKVYDEGL 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLN----KP------------------------------------------------------- 184
Cdd:cd19154  153 TKAIGVSNFNNDQIQRILDnarvKPhnnqvechlyfpqkelvefckkhnisvtsyatlgspgranftkstgvspapnllq 232
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 402244307 185 -------GLRFKPLTNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 248
Cdd:cd19154  233 dpivkaiAEKHGKTPAQVLLRYLLQRGIAVIPKSATPSRIKENFNIFDFSLSEEDMATLEEIEKSLRLFLF 303
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
4-245 1.35e-72

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 223.76  E-value: 1.35e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19125   11 IPAVGLGTWQADPGVVGNAVKTAIKEGYRHIDCAAIYGNEKEIGKALKKLFEDGVVKREDLFITSKLWCTDHAPEDVPPA 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKpphpewimscselsfclshprvQDLPLDESNMVIPsdTDFLDTWEAMEDLVITGL 163
Cdd:cd19125   91 LEKTLKDLQLDYLDLYLIHWPVRLK----------------------KGAHMPEPEEVLP--PDIPSTWKAMEKLVDSGK 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNK-------------PGLR-----------------FKPLTN-------------------- 193
Cdd:cd19125  147 VRAIGVSNFSVKKLEDLLAVarvppavnqvechPGWQqdklhefckskgihlsaYSPLGSpgttwvkknvlkdpivtkva 226
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 194 --------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 245
Cdd:cd19125  227 eklgktpaQVALRWGLQRGTSVLPKSTNEERIKENIDVFDWSIPEEDFAKFSSIEQQRRV 286
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
4-248 7.30e-64

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 201.99  E-value: 7.30e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19155   12 MPVVGLGTWQSSPEEIETAVDTALEAGYRHIDTAYVYRNEAAIGNVLKKWIDSGKVKREELFIVTKLPPGGNRREKVEKF 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFkpphpewiMSCSELSFCLShprvqdlplDESNMVIPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19155   92 LLKSLEKLQLDYVDLYLIHFPVGS--------LSKEDDSGKLD---------PTGEHKQDYTTDLLDIWKAMEAQVDQGL 154
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLN----------------------------------------KPGL-------------RFKP 190
Cdd:cd19155  155 TRSIGLSNFNREQMARILKnarikpanlqvelhvylqqkdlvdfcsthsitvtayaplgSPGAahfspgtgspsgsSPDL 234
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 402244307 191 LTN---------------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 248
Cdd:cd19155  235 LQDpvvkaiaerhgkspaQVLLRWLMQRGVVVIPKSTNAARIKENFQVFDFELTEADMAKLSSLDKNIRGRTF 307
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
4-225 1.12e-63

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 200.71  E-value: 1.12e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKE-GAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19118    7 IPAIGLGTWQAEPGEVGAAVKIALKAGYRHLDLAKVYQNQHEVGQALKELLKEePGVKREDLFITSKLWNNSHRPEYVEP 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWIMscselsfclsHPRvqdlPLDESNMVIPSDTDFLDTWEAMEDLVITG 162
Cdd:cd19118   87 ALDDTLKELGLDYLDLYLIHWPVAFKPTGDLNPL----------TAV----PTNGGEVDLDLSVSLVDTWKAMVELKKTG 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLERLLNKPGLR------------------------------FKPLTN------------------- 193
Cdd:cd19118  153 KVKSIGVSNFSIDHLQAIIEETGVVpavnqieahplllqdelvdycksknihitaYSPLGNnlaglpllvqhpevkaiaa 232
                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 402244307 194 -------QILIRFQIQRNVIVIPGSITPSHIKENIQVFD 225
Cdd:cd19118  233 klgktpaQVLIAWGIQRGHSVIPKSVTPSRIRSNFEQVE 271
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
4-244 1.53e-62

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 198.86  E-value: 1.53e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHkkSLVETA 83
Cdd:cd19112   11 MPVIGLGVWRMEPGEIKELILNAIKIGYRHFDCAADYKNEKEVGEALAEAFKTGLVKREDLFITTKLWNSDH--GHVIEA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKppH-----PEWIMScselsfclshprvqdlplDESNMVIPSDTDFLDTWEAMEDL 158
Cdd:cd19112   89 CKDSLKKLQLDYLDLYLVHFPVATK--HtgvgtTGSALG------------------EDGVLDIDVTISLETTWHAMEKL 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 159 VITGLVKNIGVSNFN----------------------HEQLER------------------------------------- 179
Cdd:cd19112  149 VSAGLVRSIGISNYDifltrdclayskikpavnqietHPYFQRdslvkfcqkhgisvtahtplggaaanaewfgsvspld 228
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 402244307 180 --LLNKPGLRFKPLTNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 244
Cdd:cd19112  229 dpVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMKLIKSLDRKYR 295
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
4-241 5.02e-61

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 193.87  E-value: 5.02e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKslVETA 83
Cdd:cd19117   14 IPAVGLGTWQSKPNEVAKAVEAALKAGYRHIDTAAIYGNEEEVGQG----IKDSGVPREEIFITTKLWCTWHRR--VEEA 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKPphpewimscselsfclshPRVQDLPL-DESNMVIPSDTDFLDTWEAMEDLVITG 162
Cdd:cd19117   88 LDQSLKKLGLDYVDLYLMHWPVPLDP------------------DGNDFLFKkDDGTKDHEPDWDFIKTWELMQKLPATG 149
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQI----------------------------------------------- 195
Cdd:cd19117  150 KVKAIGVSNFSIKNLEKLLASPSAKIVPAVNQIelhpllpqpklvdfckskgihataysplgstnapllkepviikiakk 229
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 402244307 196 --------LIRFQIQRNVIVIPGSITPSHIKENIQVfdFELTQHDMDNILSLNR 241
Cdd:cd19117  230 hgktpaqvIISWGLQRGYSVLPKSVTPSRIESNFKL--FTLSDEEFKEIDELHK 281
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
4-248 1.73e-60

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 192.71  E-value: 1.73e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19111    4 MPVIGLGTYQSPPEEVRAAVDYALFVGYRHIDTALSYQNEKAIGEALKWWLKNGKLKREEVFITTKLPPVYLEFKDTEKS 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKPPhpewimscselsfclshprvqdlplDESNMVIPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19111   84 LEKSLENLKLPYVDLYLIHHPCGFVNK-------------------------KDKGERELASSDVTSVWRAMEALVSEGK 138
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLL------------------------------------------------NKPGLRFKPLTN-- 193
Cdd:cd19111  139 VKSIGLSNFNPRQINKILayakvkpsnlqlechaylqqrelrkfcnkknivvtayaplgspgranqSLWPDQPDLLEDpt 218
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 402244307 194 -------------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMF 248
Cdd:cd19111  219 vlaiakeldktpaQVLLRFVLQRGTGVLPKSTNKERIEENFEVFDFELTEEHFKKLKTLDRNMKYFDF 286
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
3-240 1.33e-59

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 189.51  E-value: 1.33e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19131    9 TIPQLGLGVWQVSNDEAASAVREALEVGYRSIDTAAIYGNEEGVGKAIR----ASGVPREELFITTKLWNSDQGYDSTLR 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAMEDLVITG 162
Cdd:cd19131   85 AFDESLRKLGLDYVDLYLIHWPV-------------------------------------PAQDKYVETWKALIELKKEG 127
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLERLLNKPGL-----------RFK-------------------PLTN------------------- 193
Cdd:cd19131  128 RVKSIGVSNFTIEHLQRLIDETGVvpvvnqielhpRFQqrelrafhakhgiqteswsPLGQggllsdpvigeiaekhgkt 207
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 402244307 194 --QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 240
Cdd:cd19131  208 paQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAIAGLD 256
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
4-239 1.87e-58

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 187.35  E-value: 1.87e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIkEGAVRREDLFIATKLWCTCHKKslVETA 83
Cdd:cd19121   12 IPAVGLGTWQAKAGEVKAAVAHALKIGYRHIDGALCYQNEDEVGEGIKEAI-AGGVKREDLFVTTKLWSTYHRR--VELC 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMGFKPPHpewimscselsfclSHPRVQDLPlDESNMVIPsDTDFLDTWEAMEDLVITGL 163
Cdd:cd19121   89 LDRSLKSLGLDYVDLYLVHWPVLLNPNG--------------NHDLFPTLP-DGSRDLDW-DWNHVDTWKQMEKVLKTGK 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLL-------------NKPGL-----------------RFKPL---------------------- 191
Cdd:cd19121  153 TKAIGVSNYSIPYLEELLkhatvvpavnqveNHPYLpqqelvdfckekgilieAYSPLgstgsplisdepvveiakkhnv 232
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 402244307 192 -TNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFelTQHDMDNILSL 239
Cdd:cd19121  233 gPGTVLISYQVARGAVVLPKSVTPDRIKSNLEIIDL--DDEDMNKLNDI 279
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
5-239 2.95e-57

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 184.26  E-value: 2.95e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   5 PAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVETAC 84
Cdd:cd19128    2 PRLGFGTYKITESESKEAVKNAIKAGYRHIDCAYYYGNEAFIGIAFSEIFKDGGVKREDLFITSKLWPTMHQPENVKEQL 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  85 RKSLKALKLNYLDLYLIHWPMGFKpphpewimscselsfclsHPRVQDLPLDESNMVIpSDTDFLDTWEAMEDLVITGLV 164
Cdd:cd19128   82 LITLQDLQLEYLDLFLIHWPLAFD------------------MDTDGDPRDDNQIQSL-SKKPLEDTWRAMEQCVDEKLT 142
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 165 KNIGVSNFNHEQLERLLNKpgLRFKPLTNQI----------LIRFQIQRNVIV--------------------------- 207
Cdd:cd19128  143 KNIGVSNYSTKLLTDLLNY--CKIKPFMNQIechpyfqndkLIKFCIENNIHVtayrplggsygdgnltflndselkala 220
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 402244307 208 -------------------------IPGSITPSHIKENIQVFDFELTQHDMDNILSL 239
Cdd:cd19128  221 tkynttppqviiawhlqkwpknysvIPKSANKSRCQQNFDINDLALTKEDMDAINTL 277
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
4-240 6.10e-56

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 180.08  E-value: 6.10e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTC-----HKK 77
Cdd:cd19133    9 MPILGFGVFQIPDPEECErAVLEAIKAGYRLIDTAAAYGNEEAVGRA----IKKSGIPREELFITTKLWIQDagyekAKK 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  78 SLvetacRKSLKALKLNYLDLYLIHWPMGfkpphpewimscselsfclshprvqdlpldesnmvipsdtDFLDTWEAMED 157
Cdd:cd19133   85 AF-----ERSLKRLGLDYLDLYLIHQPFG----------------------------------------DVYGAWRAMEE 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 158 LVITGLVKNIGVSNFNHEQLERLLN----KPGL----------------------------------RFKPLTN------ 193
Cdd:cd19133  120 LYKEGKIRAIGVSNFYPDRLVDLILhnevKPAVnqiethpfnqqieaveflkkygvqieawgpfaegRNNLFENpvltei 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 402244307 194 ---------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 240
Cdd:cd19133  200 aekygksvaQVILRWLIQRGIVVIPKSVRPERIAENFDIFDFELSDEDMEAIAALD 255
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
2-244 5.14e-55

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 179.54  E-value: 5.14e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19115   11 YDMPLVGFGLWKVNNDTCADQVYNAIKAGYRLFDGACDYGNEVEAGQGVARAIKEGIVKREDLFIVSKLWNTFHDGERVE 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  82 TACRKSLKALKLNYLDLYLIHWPMGFK--------PphPEWimscselsfclshprvqdlpLDESNMVIPSDTDFLDTWE 153
Cdd:cd19115   91 PICRKQLADWGIDYFDLFLIHFPIALKyvdpavryP--PGW--------------------FYDGKKVEFSNAPIQETWT 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 154 AMEDLVITGLVKNIGVSNFN----------------------HEQL--ERLL---NKPGL------RFKPLT-------- 192
Cdd:cd19115  149 AMEKLVDKGLARSIGVSNFSaqllmdllryarirpatlqiehHPYLtqPRLVkyaQKEGIavtaysSFGPQSfleldlpg 228
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 402244307 193 ------------------------NQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 244
Cdd:cd19115  229 akdtpplfehdviksiaekhgktpAQVLLRWATQRGIAVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLR 304
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
3-244 5.36e-55

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 179.18  E-value: 5.36e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19113   10 KMPSVGFGCWKLDNATAADQIYQAIKAGYRLFDGAEDYGNEKEVGEGVNRAIDEGLVKREELFLTSKLWNNFHDPKNVET 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMGFKPphpewimscselsfclshprvqdLPLDES----------NMVIPSDTDFLDTW 152
Cdd:cd19113   90 ALNKTLSDLKLDYVDLFLIHFPIAFKF-----------------------VPIEEKyppgfycgdgDNFVYEDVPILDTW 146
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 153 EAMEDLVITGLVKNIGVSNFNHEQLERLLNkpGLRFKPLTNQI------------------------------------- 195
Cdd:cd19113  147 KALEKLVDAGKIKSIGVSNFPGALILDLLR--GATIKPAVLQIehhpylqqpklieyaqkagititayssfgpqsfveln 224
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402244307 196 ------------------------------LIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 244
Cdd:cd19113  225 qgralntptlfehdtiksiaakhnktpaqvLLRWATQRGIAVIPKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLR 303
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
4-236 1.05e-54

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 176.31  E-value: 1.05e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19073    1 IPALGLGTWQLRGDDCANAVKEALELGYRHIDTAEIYNNEAEVGEAI----AESGVPREDLFITTKVWRDHLRPEDLKKS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19073   77 VDRSLEKLGTDYVDLLLIHWP--------------------------------------NPTVPLEETLGALKELKEAGK 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGL-------RFKPLTN------------------------------------------- 193
Cdd:cd19073  119 VKSIGVSNFTIELLEEALDISPLpiavnqvEFHPFLYqaelleycrendivitaysplargevlrdpviqeiaekydktp 198
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 402244307 194 -QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 236
Cdd:cd19073  199 aQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKI 242
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
4-240 9.12e-54

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 174.55  E-value: 9.12e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19126    9 MPWLGLGVFQTPDGDETErAVQTALENGYRSIDTAAIYKNEEGVGEAIR----ESGVPREELFVTTKLWNDDQRARRTED 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMGFKpphpewimscselsfclshprvqdlpldesnmvipsdtdFLDTWEAMEDLVITG 162
Cdd:cd19126   85 AFQESLDRLGLDYVDLYLIHWPGKDK---------------------------------------FIDTWKALEKLYASG 125
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLERL------------------LNKPGLR------------FKPLTN------------------- 193
Cdd:cd19126  126 KVKAIGVSNFQEHHLEELlahadvvpavnqvefhpyLTQKELRgyckskgivveaWSPLGQggllsnpvlaaigekygks 205
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 402244307 194 --QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 240
Cdd:cd19126  206 aaQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
2-244 9.25e-53

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 173.51  E-value: 9.25e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   2 GD-IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19114    1 GDkMPLVGFGTAKIKANETEEVIYNAIKVGYRLIDGALLYGNEAEVGRGIRKAIQEGLVKREDLFIVTKLWNNFHGKDHV 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEwimscSELSFCLSHPRVQDLPLDESNMvipsdtdfLDTWEAMEDLVI 160
Cdd:cd19114   81 REAFDRQLKDYGLDYIDLYLIHFPIPAAYVDPA-----ENYPFLWKDKELKKFPLEQSPM--------QECWREMEKLVD 147
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 161 TGLVKNIGVSNFN------------------------HEQLERL------------------------LNKPGLRFKPL- 191
Cdd:cd19114  148 AGLVRNIGIANFNvqlildlltyakikpavlqiehhpYLQQKRLidwakkqgiqitayssfgnavytkVTKHLKHFTNLl 227
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 402244307 192 ---------------TNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 244
Cdd:cd19114  228 ehpvvkkladkhkrdTGQVLLRWAVQRNITVIPKSVNVERMKTNLDITSYKLDEEDMEALYELEANAR 295
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
2-244 1.43e-52

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 172.64  E-value: 1.43e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19129    4 GAIPALGFGTLIPDPSATRNAVKAALEAGFRHFDCAERYRNEAEVGEAMQEVFKAGKIRREDLFVTTKLWNTNHRPERVK 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  82 TACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvQDlPLDESNMVIPSD-TDFLDTWEAMEDLVI 160
Cdd:cd19129   84 PAFEASLKRLQLDYLDLYLIHTPFAFQPGDE------------------QD-PRDANGNVIYDDgVTLLDTWRAMERLVD 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 161 TGLVKNIGVSNFNHEQLERLLN----KPG--------------------------LRFKPLTN----------------- 193
Cdd:cd19129  145 EGRCKAIGLSDVSLEKLREIFEaariKPAvvqveshpylpewelldfcknhgivlQAFAPLGHgmepklledpvitaiar 224
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 402244307 194 -------QILIRFQIQRNVIVIPGSITPSHIKENiqvfdFELTQHDMDNILSLNRNLR 244
Cdd:cd19129  225 rvnktpaQVLLAWAIQRGTALLTTSKTPSRIREN-----FDISTLPEDAMREINEGIK 277
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
4-239 1.60e-52

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 171.28  E-value: 1.60e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19136    1 MPILGLGTFRLRGEEEVRqAVDAALKAGYRLIDTASVYRNEADIGKALRDLLPKYGLSREDIFITSKLAPKDQGYEKARA 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPmGfkpphpewimscselsfclshprVQDLPldesnmviPSDTDF----LDTWEAMEDL 158
Cdd:cd19136   81 ACLGSLERLGTDYLDLYLIHWP-G-----------------------VQGLK--------PSDPRNaelrRESWRALEDL 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 159 VITGLVKNIGVSNFNHEQLERLL---------------------------NKPGLRF-----------KPLTN------- 193
Cdd:cd19136  129 YKEGKLRAIGVSNYTVRHLEELLkycevppavnqvefhphlvqkellkfcKDHGIHLqaysslgsgdlRLLEDptvlaia 208
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 402244307 194 --------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSL 239
Cdd:cd19136  209 kkygrtpaQVLLRWALQQGIGVIPKSTNPERIAENIKVFDFELSEEDMAELNAL 262
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
4-245 1.26e-51

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 169.48  E-value: 1.26e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKslVETA 83
Cdd:PRK11565  15 MPQLGLGVWQASNEEVITAIHKALEVGYRSIDTAAIYKNEEGVGKA----LKEASVAREELFITTKLWNDDHKR--PREA 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAMEDLVITGL 163
Cdd:PRK11565  89 LEESLKKLQLDYVDLYLMHWPV-------------------------------------PAIDHYVEAWKGMIELQKEGL 131
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGL------------------------------RFKPLTN-------------------- 193
Cdd:PRK11565 132 IKSIGVCNFQIHHLQRLIDETGVtpvinqielhplmqqrqlhawnathkiqteSWSPLAQggkgvfdqkvirdladkygk 211
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 402244307 194 ---QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 245
Cdd:PRK11565 212 tpaQIVIRWHLDSGLVVIPKSVTPSRIAENFDVFDFRLDKDELGEIAKLDQGKRL 266
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
4-244 2.50e-51

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 168.34  E-value: 2.50e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGK-VTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19157   10 MPWLGLGVFKVEEGSeVVNAVKTALKNGYRSIDTAAIYGNEEGVGKG----IKESGIPREELFITSKVWNADQGYDSTLK 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMGFKpphpewimscselsfclshprvqdlpldesnmvipsdtdFLDTWEAMEDLVITG 162
Cdd:cd19157   86 AFEASLERLGLDYLDLYLIHWPVKGK---------------------------------------YKETWKALEKLYKDG 126
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLERLL---------------------------NKPGLRFK---PL--------------------- 191
Cdd:cd19157  127 RVRAIGVSNFQVHHLEDLLadaeivpmvnqvefhprltqkelrdycKKQGIQLEawsPLmqgqlldnpvlkeiaekynks 206
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 402244307 192 TNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLR 244
Cdd:cd19157  207 VAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLR 259
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
3-239 5.60e-51

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 167.05  E-value: 5.60e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19140    7 RIPALGLGTYPLTGEECTRAVEHALELGYRHIDTAQMYGNEAQVGEA----IAASGVPRDELFLTTKVWPDNYSPDDFLA 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAMEDLVITG 162
Cdd:cd19140   83 SVEESLRKLRTDYVDLLLLHWP--------------------------------------NKDVPLAETLGALNEAQEAG 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLE------------------------RLLNK------------PGLRFKPLTN------------- 193
Cdd:cd19140  125 LARHIGVSNFTVALLReavelseaplftnqveyhpyldqrKLLDAarehgialtaysPLARGEVLKDpvlqeigrkhgkt 204
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 402244307 194 --QILIRFQIQR-NVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSL 239
Cdd:cd19140  205 paQVALRWLLQQeGVAAIPKATNPERLEENLDIFDFTLSDEEMARIAAL 253
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
4-249 1.77e-49

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 163.84  E-value: 1.77e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTE-AVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19156    9 MPRLGLGVWRVQDGAEAEnAVKWAIEAGYRHIDTAAIYKNEEGVGQGIR----ESGVPREEVFVTTKLWNSDQGYESTLA 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMGFKpphpewimscselsfclshprvqdlpldesnmvipsdtdFLDTWEAMEDLVITG 162
Cdd:cd19156   85 AFEESLEKLGLDYVDLYLIHWPVKGK---------------------------------------FKDTWKAFEKLYKEK 125
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLERLL------------------NKPGLR------------FKPLTN------------------- 193
Cdd:cd19156  126 KVRAIGVSNFHEHHLEELLksckvapmvnqielhpllTQEPLRkfckekniaveaWSPLGQgkllsnpvlkaigkkygks 205
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 402244307 194 --QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLAMFP 249
Cdd:cd19156  206 aaQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRYGPDP 263
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
4-236 1.59e-48

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 161.67  E-value: 1.59e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGL--SSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVR-REDLFIATKLWCTCHKKSLV 80
Cdd:cd19124    5 MPVIGMgtASDPPSPEDIKAAVLEAIEVGYRHFDTAAAYGTEEALGEALAEALRLGLVKsRDELFVTSKLWCSDAHPDLV 84
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPphpewimscselsfclshprvqdlpldESNMVIPSDTDFLD-----TWEAM 155
Cdd:cd19124   85 LPALKKSLRNLQLEYVDLYLIHWPVSLKP---------------------------GKFSFPIEEEDFLPfdikgVWEAM 137
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 156 EDLVITGLVKNIGVSNFNHEQLERLL---------NK----PG-----LR------------FKPL-------------- 191
Cdd:cd19124  138 EECQRLGLTKAIGVSNFSCKKLQELLsfatippavNQvemnPAwqqkkLRefckangihvtaYSPLgapgtkwgsnavme 217
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 402244307 192 --------------TNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 236
Cdd:cd19124  218 sdvlkeiaaakgktVAQVSLRWVYEQGVSLVVKSFNKERMKQNLDIFDWELTEEDLEKI 276
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
4-233 5.52e-48

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 159.80  E-value: 5.52e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKaSPGKVTEAVKEAI-DAGYRHFDCAYFYHNEREVGAGIrckiKEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19135   13 MPILGLGTSH-SGGYSHEAVVYALkECGYRHIDTAKRYGCEELLGKAI----KESGVPREDLFLTTKLWPSDYGYESTKQ 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMGfkpphPEWIMSCSELSfclshprvqdlpldesnmvipsdtdfLDTWEAMEDLVITG 162
Cdd:cd19135   88 AFEASLKRLGVDYLDLYLLHWPDC-----PSSGKNVKETR--------------------------AETWRALEELYDEG 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 163 LVKNIGVSNFNHEQLERLL-----------------NKP----------GLRF---------KPLTN------------- 193
Cdd:cd19135  137 LCRAIGVSNFLIEHLEQLLedcsvvphvnqvefhpfQNPvelieycrdnNIVFegycplakgKALEEptvtelakkyqkt 216
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 402244307 194 --QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDM 233
Cdd:cd19135  217 paQILIRWSIQNGVVTIPKSTKEERIKENCQVFDFSLSEEDM 258
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
4-236 2.92e-47

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 158.16  E-value: 2.92e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGL---SSWKASPG-----KVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGirckIKEGAVRREDLFIATKLWCtch 75
Cdd:cd19120    4 IPAIAFgtgTAWYKSGDddiqrDLVDSVKLALKAGFRHIDTAEMYGNEKEVGEA----LKESGVPREDLFITTKVSP--- 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  76 KKSLVETACRKSLKALKLNYLDLYLIHWPMGFKpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAM 155
Cdd:cd19120   77 GIKDPREALRKSLAKLGVDYVDLYLIHSPFFAK----------------------------------EGGPTLAEAWAEL 122
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 156 EDLVITGLVKNIGVSNFNHEQLERLLNKPglRFKPLTNQI---------------------------------------- 195
Cdd:cd19120  123 EALKDAGLVRSIGVSNFRIEDLEELLDTA--KIKPAVNQIefhpylypqqpalleycrehgivvsaysplspltrdaggp 200
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 196 -------------------LIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 236
Cdd:cd19120  201 ldpvlekiaekygvtpaqvLLRWALQKGIVVVTTSSKEERMKEYLEAFDFELTEEEVEEI 260
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
2-241 1.10e-46

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 156.28  E-value: 1.10e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   2 GDIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19132    5 TQIPAIGFGTYPLKGDEGVEAVVAALQAGYRLLDTAFNYENEGAVGEAVR----RSGVPREELFVTTKLPGRHHGYEEAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  82 TACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclsHPRvQDLpldesnmvipsdtdFLDTWEAMEDLVIT 161
Cdd:cd19132   81 RTIEESLYRLGLDYVDLYLIHWP----------------------NPS-RDL--------------YVEAWQALIEAREE 123
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 162 GLVKNIGVSNFNHEQLERLLNKPGLrfKPLTNQI---------------------------------------------- 195
Cdd:cd19132  124 GLVRSIGVSNFLPEHLDRLIDETGV--TPAVNQIelhpyfpqaeqrayhrehgivtqswsplgrgsglldepvikaiaek 201
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....
gi 402244307 196 --------LIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNR 241
Cdd:cd19132  202 hgktpaqvVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALDR 255
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
4-195 5.52e-44

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 150.34  E-value: 5.52e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWkaSP----GKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKLWCTCHKKsl 79
Cdd:cd19119   12 IPALGLGTA--SPhedrAEVKEAVEAAIKEGYRHIDTAYAYETEDFVGEAIKRAIDDGSIKREELFITTKVWPTFYDE-- 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  80 VETACRKSLKALKLNYLDLYLIHWPMGFK-----PPHPEWimscselsfclshprvqdlPLDESNMVIPSDT-DFLDTWE 153
Cdd:cd19119   88 VERSLDESLKALGLDYVDLLLVHWPVCFEkdsddSGKPFT-------------------PVNDDGKTRYAASgDHITTYK 148
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 402244307 154 AMEDLVITGLVKNIGVSNFNHEQLERLLNKpgLRFKPLTNQI 195
Cdd:cd19119  149 QLEKIYLDGRAKAIGVSNYSIVYLERLIKE--CKVVPAVNQV 188
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
3-240 3.97e-43

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 147.55  E-value: 3.97e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   3 DIPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVET 82
Cdd:cd19127    8 EMPALGLGVFQTPPEETADAVATALADGYRLIDTAAAYGNEREVGEGIR----RSGVDRSDIFVTTKLWISDYGYDKALR 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  83 ACRKSLKALKLNYLDLYLIHWPMgfkpPHpewimscselsfclshprvqdlpldesnmvipsdtDFLDT---WEAMEDLV 159
Cdd:cd19127   84 GFDASLRRLGLDYVDLYLLHWPV----PN-----------------------------------DFDRTiqaYKALEKLL 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 160 ITGLVKNIGVSNFNHEQLERLLNK------------------------------------------------PGLRFKPL 191
Cdd:cd19127  125 AEGRVRAIGVSNFTPEHLERLIDAttvvpavnqvelhpyfsqkdlrafhrrlgivtqawspiggvmrygasgPTGPGDVL 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 402244307 192 TN---------------QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 240
Cdd:cd19127  205 QDptitglaekygktpaQIVLRWHLQNGVSAIPKSVHPERIAENIDIFDFALSAEDMAAIDALD 268
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
4-245 2.32e-42

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 145.38  E-value: 2.32e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19134   11 MPVIGLGVGELSDDEAERSVSAALEAGYRLIDTAAAYGNEAAVGRAIA----ASGIPRGELFVTTKLATPDQGFTASQAA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19134   87 CRASLERLGLDYVDLYLIHWPA-------------------------------------GREGKYVDSWGGLMKLREEGL 129
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPG-------LRFKPLTN------------------------------------------- 193
Cdd:cd19134  130 ARSIGVSNFTAEHLENLIDLTFftpavnqIELHPLLNqaelrkvnaqhgivtqaysplgvgrlldnpavtaiaaahgrtp 209
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 402244307 194 -QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRL 245
Cdd:cd19134  210 aQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDGTRF 262
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
4-236 3.78e-42

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 144.68  E-value: 3.78e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWK---------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKLW 71
Cdd:cd19072    4 VPVLGLGTWGigggmskdySDDKKAIEALRYAIELGINLIDTAEMYgggHAEELVGKAIK------GFDREDLFITTKVS 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  72 CTCHKKSLVETACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlpldesNMVIPsdtdFLDT 151
Cdd:cd19072   78 PDHLKYDDVIKAAKESLKRLGTDYIDLYLIHWP----------------------------------NPSIP----IEET 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 152 WEAMEDLVITGLVKNIGVSNFNHEQLERL-------------------------------------------LNKPGLRF 188
Cdd:cd19072  120 LRAMEELVEEGKIRYIGVSNFSLEELEEAqsylkkgpivanqveynlfdreeesgllpycqkngiaiiayspLEKGKLSN 199
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 402244307 189 KPLT--------------NQILIRFQIQR-NVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 236
Cdd:cd19072  200 AKGSplldeiakkygktpAQIALNWLISKpNVIAIPKASNIEHLEENAGALGWELSEEDLQRL 262
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
4-240 8.65e-41

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 141.20  E-value: 8.65e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKikegAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19130   10 IPQLGYGVFKVPPADTQRAVATALEVGYRHIDTAAIYGNEEGVGAAIAAS----GIPRDELFVTTKLWNDRHDGDEPAAA 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPMgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19130   86 FAESLAKLGLDQVDLYLVHWPT-------------------------------------PAAGNYVHTWEAMIELRAAGR 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGL-----------RFK-------------------PLTN-------------------- 193
Cdd:cd19130  129 TRSIGVSNFLPPHLERIVAATGVvpavnqielhpAYQqrtirdwaqahdvkieawsPLGQgkllgdppvgaiaaahgktp 208
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 402244307 194 -QILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLN 240
Cdd:cd19130  209 aQIVLRWHLQKGHVVFPKSVRRERMEDNLDVFDFDLTDTEIAAIDALD 256
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
4-197 2.41e-38

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 135.83  E-value: 2.41e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSW--KASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEG-AVRREDLFIATKLWCTCHKKSLV 80
Cdd:cd19122    9 IPAVGFGTFanEGAKGETYAAVTKALDVGYRHLDCAWFYLNEDEVGDAVRDFLKENpSVKREDLFICTKVWNHLHEPEDV 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  81 ETACRKSLKALKLNYLDLYLIHWPMGFKPphpewimscselsfclSHPRVQDLPLDESNMVIPSDTDFLD-TWEAMEDLV 159
Cdd:cd19122   89 KWSIDNSLKNLKLDYIDLFLVHWPIAAEK----------------NDQRSPKLGPDGKYVILKDLTENPEpTWRAMEEIY 152
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 402244307 160 ITGLVKNIGVSNFNHEQLERLLNKPglRFKPLTNQILI 197
Cdd:cd19122  153 ESGKAKAIGVSNWTIPGLKKLLSFA--KVKPHVNQIEI 188
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
6-255 1.65e-36

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 130.89  E-value: 1.65e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307    6 AVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYH---NEREVGAGIrckiKEGAVRREDLFIATKL------WCTCHK 76
Cdd:pfam00248   7 QLGGGWGPISKEEALEALRAALEAGINFIDTAEVYGdgkSEELLGEAL----KDYPVKRDKVVIATKVpdgdgpWPSGGS 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   77 KSLVETACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAME 156
Cdd:pfam00248  83 KENIRKSLEESLKRLGTDYIDLYYLHWP--------------------------------------DPDTPIEETWDALE 124
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  157 DLVITGLVKNIGVSNFNHEQLERLLNKPGLRF----------KPLTNQILIRFQIQRNVIVIP------GSITPShIKEN 220
Cdd:pfam00248 125 ELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIvavqveynllRRRQEEELLEYCKKNGIPLIAysplggGLLTGK-YTRD 203
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 402244307  221 IQVFDFELTqHDMDNILSLNRNLRLAMFPITKNHK 255
Cdd:pfam00248 204 PDKGPGERR-RLLKKGTPLNLEALEALEEIAKEHG 237
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
4-239 4.05e-32

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 118.22  E-value: 4.05e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:cd19139    1 IPAFGLGTFRLKDDVVIDSVRTALELGYRHIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKIWIDNLSKDKLLPS 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPmgfkPPhpewimscselsfclshprvqdlpldesNMVIPSDtdflDTWEAMEDLVITGL 163
Cdd:cd19139   77 LEESLEKLRTDYVDLTLIHWP----SP----------------------------NDEVPVE----EYIGALAEAKEQGL 120
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFNHEQLERLLNKPGLRfKPLTNQI--------------------------------------LIR------- 198
Cdd:cd19139  121 TRHIGVSNFTIALLDEAIAVVGAG-AIATNQIelspylqnrklvahckqhgihvtsymtlaygkvlddpvLAAiaerhga 199
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 402244307 199 --------FQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSL 239
Cdd:cd19139  200 tpaqialaWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
4-234 3.13e-29

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 111.12  E-value: 3.13e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWK---------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKLW 71
Cdd:cd19137    4 IPALGLGTWGiggfltpdySRDEEMVELLKTAIELGYTHIDTAEMYgggHTEELVGKAIK------DFPREDLFIVTKVW 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  72 CTCHKKSLVETACRKSLKALKLNYLDLYLIHWPmgfkppHPEwimscselsfclshprvqdLPLDEsnmvipsdtdfldT 151
Cdd:cd19137   78 PTNLRYDDLLRSLQNSLRRLDTDYIDLYLIHWP------NPN-------------------IPLEE-------------T 119
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 152 WEAMEDLVITGLVKNIGVSNFNHEQLER---------------------------------------------------- 179
Cdd:cd19137  120 LSAMAEGVRQGLIRYIGVSNFNRRLLEEaisksqtpivcnqvkynledrdperdglleycqkngitvvaysplrrglekt 199
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 402244307 180 --LLNKPGLRFKPLTNQILIRFQIQR-NVIVIPGSITPSHIKENIQVFDFELTQHDMD 234
Cdd:cd19137  200 nrTLEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMK 257
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
4-236 1.47e-28

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 109.26  E-value: 1.47e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSW-----KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRCkikegavRREDLFIATKLWCTCH 75
Cdd:cd19138   11 VPALGQGTWymgedPAKRAQEIEALRAGIDLGMTLIDTAEMYGDggsEELVGEAIRG-------RRDKVFLVSKVLPSNA 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  76 KKSLVETACRKSLKALKLNYLDLYLIHWPMGfkpphpewimscselsfclshprvqdLPLDEsnmvipsdtdfldTWEAM 155
Cdd:cd19138   84 SRQGTVRACERSLRRLGTDYLDLYLLHWRGG--------------------------VPLAE-------------TVAAM 124
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 156 EDLVITGLVKNIGVSNFNHEQLERLLNKPG--------------------------------------------LRFKPL 191
Cdd:cd19138  125 EELKKEGKIRAWGVSNFDTDDMEELWAVPGggncaanqvlynlgsrgieydllpwcrehgvpvmaysplaqgglLRRGLL 204
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 402244307 192 TN---------------QILIRFQI-QRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 236
Cdd:cd19138  205 ENptlkeiaarhgatpaQVALAWVLrDGNVIAIPKSGSPEHARENAAAADLELTEEDLAEL 265
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
4-181 2.74e-26

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 103.82  E-value: 2.74e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTE---------AVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikEGavRREDLFIATKLW 71
Cdd:cd19085    1 VSRLGLGCWQFGGGYWWGdqddeesiaTIHAALDAGINFFDTAEAYgdgHSEEVLGKAL-----KG--RRDDVVIATKVS 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  72 cTCH-KKSLVETACRKSLKALKLNYLDLYLIHWPMGFKPPHPewimscselsfclshprvqdlpldesnmvipsdtdfld 150
Cdd:cd19085   74 -PDNlTPEDVRKSCERSLKRLGTDYIDLYQIHWPSSDVPLEE-------------------------------------- 114
                        170       180       190
                 ....*....|....*....|....*....|.
gi 402244307 151 TWEAMEDLVITGLVKNIGVSNFNHEQLERLL 181
Cdd:cd19085  115 TMEALEKLKEEGKIRAIGVSNFGPAQLEEAL 145
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
4-246 4.92e-26

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 102.79  E-value: 4.92e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRckikEGAVRREDLFIATKLWCTCHKKSLVETA 83
Cdd:PRK11172   3 IPAFGLGTFRLKDQVVIDSVKTALELGYRAIDTAQIYDNEAAVGQAIA----ESGVPRDELFITTKIWIDNLAKDKLIPS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPmgfkPPHPEwimscselsfclshprvqdLPLDEsnmvipsdtdFLdtwEAMEDLVITGL 163
Cdd:PRK11172  79 LKESLQKLRTDYVDLTLIHWP----SPNDE-------------------VSVEE----------FM---QALLEAKKQGL 122
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 164 VKNIGVSNFN-----------------HEQLE------------------------------RLLNKPGL-----RFKPL 191
Cdd:PRK11172 123 TREIGISNFTialmkqaiaavgaeniaTNQIElspylqnrkvvafakehgihvtsymtlaygKVLKDPVIariaaKHNAT 202
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 402244307 192 TNQILIRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNILSLNRNLRLA 246
Cdd:PRK11172 203 PAQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAALDRNGRLV 257
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
8-195 8.33e-25

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 100.25  E-value: 8.33e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKL--------WCTCHK 76
Cdd:COG0667   24 GGPWGGVDEAEAIAILDAALDAGINFFDTADVYgpgRSEELLGEALK------GRPRDDVVIATKVgrrmgpgpNGRGLS 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  77 KSLVETACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlpldesnmviPSDTDFLDTWEAME 156
Cdd:COG0667   98 REHIRRAVEASLRRLGTDYIDLYQLHRP--------------------------------------DPDTPIEETLGALD 139
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 402244307 157 DLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPLTNQI 195
Cdd:COG0667  140 ELVREGKIRYIGVSNYSAEQLRRALAIAEGLPPIVAVQN 178
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
21-222 9.90e-25

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 98.36  E-value: 9.90e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  21 EAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikeGAVRREDLFIATKLWCT---------CHKKSLVEtACRKSL 88
Cdd:cd06660   21 ALLDAALEAGGNFFDTADVYgdgRSERLLGRWLK-----GRGNRDDVVIATKGGHPpggdpsrsrLSPEHIRR-DLEESL 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  89 KALKLNYLDLYLIHWPmgfkPPhpewimscselsfclshprvqDLPLDEsnmvipsdtdfldTWEAMEDLVITGLVKNIG 168
Cdd:cd06660   95 RRLGTDYIDLYYLHRD----DP---------------------STPVEE-------------TLEALNELVREGKIRYIG 136
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 169 VSNFNHEQLERLL------NKPGLR-------------------------------FKPL---TNQILIRFQIQR--NVI 206
Cdd:cd06660  137 VSNWSAERLAEALayakahGLPGFAavqpqyslldrspmeeelldwaeenglpllaYSPLargPAQLALAWLLSQpfVTV 216
                        250
                 ....*....|....*.
gi 402244307 207 VIPGSITPSHIKENIQ 222
Cdd:cd06660  217 PIVGARSPEQLEENLA 232
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
4-195 3.49e-23

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 95.37  E-value: 3.49e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKA-----------SPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckiKEGAVRrEDLFIATK 69
Cdd:cd19093    2 VSPLGLGTWQWgdrlwwgygeyGDEDLQAAFDAALEAGVNLFDTAEVYgtgRSERLLGRFL----KELGDR-DEVVIATK 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  70 LWCTCHKKSL--VETACRKSLKALKLNYLDLYLIHWPMGFKPPHPEWimscselsfclshprvqdlpldesnmvipsdtd 147
Cdd:cd19093   77 FAPLPWRLTRrsVVKALKASLERLGLDSIDLYQLHWPGPWYSQIEAL--------------------------------- 123
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 402244307 148 fldtWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPGLRFKPL-TNQI 195
Cdd:cd19093  124 ----MDGLADAVEEGLVRAVGVSNYSADQLRRAHKALKERGVPLaSNQV 168
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
4-182 2.36e-21

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 90.66  E-value: 2.36e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASP---GKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATK--- 69
Cdd:cd19084    4 VSRIGLGTWAIGGtwwGEVDDqesieAIKAAIDLGINFFDTAPVYgfgHSEEILGKAL-------KGRRDDVVIATKcgl 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  70 LW------CTCHKKSLVETACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlplDEsnmvip 143
Cdd:cd19084   77 RWdggkgvTKDLSPESIRKEVEQSLRRLQTDYIDLYQIHWP-------------------------------DP------ 119
                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 402244307 144 sDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLN 182
Cdd:cd19084  120 -NTPIEETAEALEKLKKEGKIRYIGVSNFSVEQLEEARK 157
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
6-179 1.55e-19

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 85.80  E-value: 1.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   6 AVGLSSWKASPGKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATK---LW--- 71
Cdd:cd19102   10 AIGGGGWGGGWGPQDDrdsiaAIRAALDLGINWIDTAAVYglgHSEEVVGRALK-------GLRDRPIVATKcglLWdee 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  72 ---CTCHKKSLVETACRKSLKALKLNYLDLYLIHWPMGfkpphpewimscselsfclshprvqdlpldesnmvipsDTDF 148
Cdd:cd19102   83 griRRSLKPASIRAECEASLRRLGVDVIDLYQIHWPDP--------------------------------------DEPI 124
                        170       180       190
                 ....*....|....*....|....*....|.
gi 402244307 149 LDTWEAMEDLVITGLVKNIGVSNFNHEQLER 179
Cdd:cd19102  125 EEAWGALAELKEEGKVRAIGVSNFSVDQMKR 155
AKR_AKR11C1 cd19086
AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase ...
4-223 8.02e-19

AKR11C family of aldo-keto reductase (AKR); Bacillus subtilis uncharacterized oxidoreductase YqkF is a founding member of aldo-keto reductase family 11 member C1 (AKR11C1). It may function as oxidoreductase. This family also includes Bacillus halodurans AKR11C1, an NADPH-dependent 4-hydroxy-2,3-trans-nonenal reductase.


Pssm-ID: 381312 [Multi-domain]  Cd Length: 238  Bit Score: 82.53  E-value: 8.02e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSW--------KASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGagircKIKEGavRREDLFIATKLWC 72
Cdd:cd19086    3 VSEIGFGTWglggdwwgDVDDAEAIRALRAALDLGINFFDTADVYgdgHSERLLG-----KALKG--RRDKVVIATKFGN 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  73 TCHK---------KSLVETACRKSLKALKLNYLDLYLIH-WPMgfkpphpewimscselsfclshprvqdlpldesnmvi 142
Cdd:cd19086   76 RFDGgperpqdfsPEYIREAVEASLKRLGTDYIDLYQLHnPPD------------------------------------- 118
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 143 pSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLLNKPG----------LRFKP---------------------- 190
Cdd:cd19086  119 -EVLDNDELFEALEKLKQEGKIRAYGVSVGDPEEALAALRRGGidvvqviynlLDQRPeeelfplaeehgvgviarvpla 197
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 402244307 191 ---LTN---QILIRFQIQRNVI--VIPGSITPSHIKENIQV 223
Cdd:cd19086  198 sglLTGklaQAALRFILSHPAVstVIPGARSPEQVEENAAA 238
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
8-195 2.40e-18

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 82.22  E-value: 2.40e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIrckiKEGAVRREDLFIATK----------LWCTC 74
Cdd:cd19092   15 RLADWGESAEELLSLIEAALELGITTFDHADIYGGgkcEELFGEAL----ALNPGLREKIEIQTKcgirlgddprPGRIK 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  75 H---KKSLVETACRKSLKALKLNYLDLYLIHwpmgfkppHPEWIMSCSELSfclshprvqdlpldesnmvipsdtdfldt 151
Cdd:cd19092   91 HydtSKEHILASVEGSLKRLGTDYLDLLLLH--------RPDPLMDPEEVA----------------------------- 133
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 402244307 152 wEAMEDLVITGLVKNIGVSNFNHEQLErLLNKpGLRFKPLTNQI 195
Cdd:cd19092  134 -EAFDELVKSGKVRYFGVSNFTPSQIE-LLQS-YLDQPLVTNQI 174
YdhF COG4989
Predicted oxidoreductase YdhF [General function prediction only];
8-195 3.12e-15

Predicted oxidoreductase YdhF [General function prediction only];


Pssm-ID: 444013 [Multi-domain]  Cd Length: 299  Bit Score: 73.65  E-value: 3.12e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCA--Y-FYHNEREVGAGIrckiKEGAVRREDLFIATK----LWCTCHKKSL- 79
Cdd:COG4989   22 RLGEWDLSPAEAAALIEAALELGITTFDHAdiYgGYTCEALFGEAL----KLSPSLREKIELQTKcgirLPSEARDNRVk 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  80 --------VETACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqDlPLdesnmvipsdTDFLDT 151
Cdd:COG4989   98 hydtskehIIASVEGSLRRLGTDYLDLLLLHRP---------------------------D-PL----------MDPEEV 139
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 402244307 152 WEAMEDLVITGLVKNIGVSNFNHEQLErLLNKpGLRFKPLTNQI 195
Cdd:COG4989  140 AEAFDELKASGKVRHFGVSNFTPSQFE-LLQS-ALDQPLVTNQI 181
AKR_unchar cd19105
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
14-102 7.05e-15

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381331 [Multi-domain]  Cd Length: 250  Bit Score: 71.85  E-value: 7.05e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  14 ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKLWCTCHKKS---LVETAcRKS 87
Cdd:cd19105   22 GLPRESPELLRRALDLGINYFDTAEGYgngNSEEIIGEALK------GLRRDKVFLATKASPRLDKKDkaeLLKSV-EES 94
                         90
                 ....*....|....*
gi 402244307  88 LKALKLNYLDLYLIH 102
Cdd:cd19105   95 LKRLQTDYIDIYQLH 109
COG1453 COG1453
Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];
18-178 1.91e-14

Predicted oxidoreductase of the aldo/keto reductase family [General function prediction only];


Pssm-ID: 441062 [Multi-domain]  Cd Length: 365  Bit Score: 72.16  E-value: 1.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  18 KVTEAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRCkikegavRREDLFIATKLWCTCHKKSLVETACRKSLKALKLNYL 96
Cdd:COG1453   30 EAEALIRRAIDNGINYIDTARGYGDsEEFLGKALKG-------PRDKVILATKLPPWVRDPEDMRKDLEESLKRLQTDYI 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  97 DLYLIHwpmgfkpphpewimscselsfCLSHPRVQDLPLDESNMvipsdtdfldtWEAMEDLVITGLVKNIGVSnfNHEQ 176
Cdd:COG1453  103 DLYLIH---------------------GLNTEEDLEKVLKPGGA-----------LEALEKAKAEGKIRHIGFS--THGS 148

                 ..
gi 402244307 177 LE 178
Cdd:COG1453  149 LE 150
AKR_PA4992-like cd19095
Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the ...
5-181 2.13e-14

Pseudomona aeruginosa PA4992 and similar proteins; Pseudomona aeruginosa PA4992 is the prototype of this family. It is a putative aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381321 [Multi-domain]  Cd Length: 253  Bit Score: 70.73  E-value: 2.13e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   5 PAVGLSSWK--ASPGKVTEA-----VKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikegAVRREDLFIATKLWCTC-- 74
Cdd:cd19095    1 SVLGLGTSGigRVWGVPSEAeaarlLNTALDLGINLIDTAPAYGRsEERLGRALA------GLRRDDLFIATKVGTHGeg 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  75 ------HKKSLVETACRKSLKALKLNYLDLYLIHwpmgfkpphpewimSCSElsfclshprvqDLPLDEsnmVIpsdtdf 148
Cdd:cd19095   75 grdrkdFSPAAIRASIERSLRRLGTDYIDLLQLH--------------GPSD-----------DELTGE---VL------ 120
                        170       180       190
                 ....*....|....*....|....*....|...
gi 402244307 149 ldtwEAMEDLVITGLVKNIGVSNFNHEqLERLL 181
Cdd:cd19095  121 ----ETLEDLKAAGKVRYIGVSGDGEE-LEAAI 148
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
12-182 2.47e-14

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 71.46  E-value: 2.47e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  12 WKASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikeGAVRREDLFIATKLwctCHKKSL--------- 79
Cdd:cd19079   30 WVLDEEESRPIIKRALDLGINFFDTANVYSGgasEEILGRALK-----EFAPRDEVVIATKV---YFPMGDgpngrglsr 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  80 --VETACRKSLKALKLNYLDLYLIHWpmgfkpphpewimscselsfclshprvqdlpLDEsnmvipsDTDFLDTWEAMED 157
Cdd:cd19079  102 khIMAEVDASLKRLGTDYIDLYQIHR-------------------------------WDY-------ETPIEETLEALHD 143
                        170       180
                 ....*....|....*....|....*
gi 402244307 158 LVITGLVKNIGVSNFNHEQLERLLN 182
Cdd:cd19079  144 VVKSGKVRYIGASSMYAWQFAKALH 168
AKR_unchar cd19100
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
8-184 1.56e-13

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381326 [Multi-domain]  Cd Length: 238  Bit Score: 67.89  E-value: 1.56e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   8 GLSSWKASPGKVTEAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikeGavRREDLFIATKlwcTCHKKSlvETACR- 85
Cdd:cd19100   18 GGPLGRLSQEEAAAIIRRALDLGINYFDTAPSYGDsEEKIGKALK-----G--RRDKVFLATK---TGARDY--EGAKRd 85
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  86 --KSLKALKLNYLDLYLIHwpmgfkpphpewimscselsfCLSHPRVQDLPLDESNMvipsdtdfldtWEAMEDLVITGL 163
Cdd:cd19100   86 leRSLKRLGTDYIDLYQLH---------------------AVDTEEDLDQVFGPGGA-----------LEALLEAKEEGK 133
                        170       180
                 ....*....|....*....|.
gi 402244307 164 VKNIGVSNFNHEQLERLLNKP 184
Cdd:cd19100  134 IRFIGISGHSPEVLLRALETG 154
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
23-178 2.59e-13

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 68.21  E-value: 2.59e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  23 VKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKlwcTCHKKS-----------LVETACRKSL 88
Cdd:cd19083   39 VREALDNGVNLLDTAFIYglgRSEELVGEVLK------EYNRNEVVIATK---GAHKFGgdgsvlnnspeFLRSAVEKSL 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  89 KALKLNYLDLYLIHWPMGfkpphpewimscselsfclshprvqDLPLDESnmvipsdtdfldtWEAMEDLVITGLVKNIG 168
Cdd:cd19083  110 KRLNTDYIDLYYIHFPDG-------------------------ETPKAEA-------------VGALQELKDEGKIRAIG 151
                        170
                 ....*....|
gi 402244307 169 VSNFNHEQLE 178
Cdd:cd19083  152 VSNFSLEQLK 161
Aldo_ket_red_shaker-like cd19074
Shaker potassium channel beta subunit family and similar proteins; This family includes ...
7-179 3.86e-13

Shaker potassium channel beta subunit family and similar proteins; This family includes voltage-gated potassium channel subunits, beta-1 (KCAB1B), beta-2 (KCAB2B) and beta-3 (KCAB3B). KCAB1B and KCAB2B are cytoplasmic potassium channel subunits that modulate the characteristics of the channel-forming alpha-subunits. KCAB3B is an accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit. The family also includes Drosophila melanogaster Hk protein, a founding member of aldo-keto reductase family 6 member B1 (AKR6B1), as well as voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa, founding members of AKR6C1and AKR6C2, respectively. Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381300 [Multi-domain]  Cd Length: 297  Bit Score: 67.62  E-value: 3.86e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   7 VGLSSWKASPGKVT-----EAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATKL-WCT---- 73
Cdd:cd19074    7 LSLGTWLTFGGQVDdedakACVRKAYDLGINFFDTADVYAAgqaEEVLGKALK------GWPRESYVISTKVfWPTgpgp 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  74 ----CHKKSLVEtACRKSLKALKLNYLDLYLIHwpmGFKPphpewimscselsfclshprvqDLPLDEsnmvipsdtdfl 149
Cdd:cd19074   81 ndrgLSRKHIFE-SIHASLKRLQLDYVDIYYCH---RYDP----------------------ETPLEE------------ 122
                        170       180       190
                 ....*....|....*....|....*....|
gi 402244307 150 dTWEAMEDLVITGLVKNIGVSNFNHEQLER 179
Cdd:cd19074  123 -TVRAMDDLIRQGKILYWGTSEWSAEQIAE 151
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
24-172 1.42e-12

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 66.06  E-value: 1.42e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  24 KEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATKL------WCTCHKKSL--VETACRKSLKALK 92
Cdd:cd19087   37 DRALDAGINFFDTADVYgggRSEEIIGRWI-------AGRRDDIVLATKVfgpmgdDPNDRGLSRrhIRRAVEASLRRLQ 109
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  93 LNYLDLYLIHwpmgfkpphpewimscselsfclsHPRVqDLPLDEsnmvipsdtdfldTWEAMEDLVITGLVKNIGVSNF 172
Cdd:cd19087  110 TDYIDLYQMH------------------------HFDR-DTPLEE-------------TLRALDDLVRQGKIRYIGVSNF 151
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
13-170 1.55e-12

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 65.66  E-value: 1.55e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  13 KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATKL-WCTCHKKSLVETACRKSL 88
Cdd:cd19096   17 SIDEEKAIEMIRYAIDAGINYFDTAYGYGGgksEEILGEALK------EGPREKFYLATKLpPWSVKSAEDFRRILEESL 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  89 KALKLNYLDLYLIHWPMgfKPPHPEWIMScselsfclshprvqdlpldesnmvipsdtdfLDTWEAMEDLVITGLVKNIG 168
Cdd:cd19096   91 KRLGVDYIDFYLLHGLN--SPEWLEKARK-------------------------------GGLLEFLEKAKKEGLIRHIG 137

                 ..
gi 402244307 169 VS 170
Cdd:cd19096  138 FS 139
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
12-181 1.80e-12

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 66.10  E-value: 1.80e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  12 WKASPGKVTEA-----VKEAIDAGYRHFDCAYFYHN---EREVGAGIRCkikegavRREDLFIATKLWCT---------C 74
Cdd:cd19091   29 FFGAWGGVDQEeadrlVDIALDAGINFFDTADVYSEgesEEILGKALKG-------RRDDVLIATKVRGRmgegpndvgL 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  75 HKKSLVEtACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqDL--PLDEsnmvipsdtdfldTW 152
Cdd:cd19091  102 SRHHIIR-AVEASLKRLGTDYIDLYQLHGF---------------------------DAltPLEE-------------TL 140
                        170       180
                 ....*....|....*....|....*....
gi 402244307 153 EAMEDLVITGLVKNIGVSNFNHEQLERLL 181
Cdd:cd19091  141 RALDDLVRQGKVRYIGVSNFSAWQIMKAL 169
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
26-171 2.85e-12

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 65.28  E-value: 2.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  26 AIDAGYRHFDCAYFY----------HNEREVGAGIRCKikegaVRREDLFIATKL--------WC----TCHKKSLVETA 83
Cdd:cd19094   27 AFDEGVNFIDTAEMYpvppspetqgRTEEIIGSWLKKK-----GNRDKVVLATKVagpgegitWPrgggTRLDRENIREA 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  84 CRKSLKALKLNYLDLYLIHWPmgfkpphPEWIMSCSELSFCLSHPRvqdlpldesnmviPSDTDFLDTWEAMEDLVITGL 163
Cdd:cd19094  102 VEGSLKRLGTDYIDLYQLHWP-------DRYTPLFGGGYYTEPSEE-------------EDSVSFEEQLEALGELVKAGK 161

                 ....*...
gi 402244307 164 VKNIGVSN 171
Cdd:cd19094  162 IRHIGLSN 169
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
14-195 4.19e-12

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 64.92  E-value: 4.19e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  14 ASPGKVTEAVKEAIDAGYRHFDCAYFYHNEREVGAGIRCKIKEGAVRREDLFIATKlWCT-----CHKKSLVETACRKSL 88
Cdd:cd19101   20 RDEDAAVRAMAAYVDAGLTTFDCADIYGPAEELIGEFRKRLRRERDAADDVQIHTK-WVPdpgelTMTRAYVEAAIDRSL 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  89 KALKLNYLDLYLIHWpmgfkpphpeWimscselsfclshprvqDlpldesnmviPSDTDFLDTWEAMEDLVITGLVKNIG 168
Cdd:cd19101   99 KRLGVDRLDLVQFHW----------W-----------------D----------YSDPGYLDAAKHLAELQEEGKIRHLG 141
                        170       180
                 ....*....|....*....|....*..
gi 402244307 169 VSNFNHEQLERLLNKPglrFKPLTNQI 195
Cdd:cd19101  142 LTNFDTERLREILDAG---VPIVSNQV 165
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
3-194 5.05e-12

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 64.64  E-value: 5.05e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   3 DIPA--VGLSSWK--------ASPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikEGAVRREDLFIATK 69
Cdd:cd19148    1 DLPVsrIALGTWAiggwmwggTDEKEAIETIHKALDLGINLIDTAPVYgfgLSEEIVGKAL-----KEYGKRDRVVIATK 75
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  70 L---WCTCHKKSLVETACR------KSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlplDEsnm 140
Cdd:cd19148   76 VgleWDEGGEVVRNSSPARirkeveDSLRRLQTDYIDLYQVHWP-------------------------------DP--- 121
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 402244307 141 vipsDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLERLlnkpgLRFKPL-TNQ 194
Cdd:cd19148  122 ----LVPIEETAEALKELLDEGKIRAIGVSNFSPEQMETF-----RKVAPLhTVQ 167
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
3-178 3.13e-11

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 62.29  E-value: 3.13e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   3 DIPAVGLSSWKA----SPGKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRCkikegavRREDLFIATKl 70
Cdd:cd19149   10 EASVIGLGTWAIgggpWWGGSDDnesirTIHAALDLGINLIDTAPAYgfgHSEEIVGKAIKG-------RRDKVVLATK- 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  71 wC------------------TCHK----KSLVETaCRKSLKALKLNYLDLYLIHWPmgfkpphpewimsCSElsfclshp 128
Cdd:cd19149   82 -CglrwdreggsfffvrdgvTVYKnlspESIREE-VEQSLKRLGTDYIDLYQTHWQ-------------DVE-------- 138
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 402244307 129 rvqdLPLDEsnmvipsdtdfldTWEAMEDLVITGLVKNIGVSNFNHEQLE 178
Cdd:cd19149  139 ----TPIEE-------------TMEALEELKRQGKIRAIGASNVSVEQIK 171
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
24-179 5.53e-11

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 61.46  E-value: 5.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  24 KEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATK---LWCTCHKK-------SLVETACRKSLKA 90
Cdd:cd19076   39 HRALELGVTFLDTADMYgpgTNEELLGKALK-------DRRDEVVIATKfgiVRDPGSGFrgvdgrpEYVRAACEASLKR 111
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  91 LKLNYLDLYLIHwpmgfkpphpewimscselsfclshpRVqdlpldesnmviPSDTDFLDTWEAMEDLVITGLVKNIGVS 170
Cdd:cd19076  112 LGTDVIDLYYQH--------------------------RV------------DPNVPIEETVGAMAELVEEGKVRYIGLS 153

                 ....*....
gi 402244307 171 NFNHEQLER 179
Cdd:cd19076  154 EASADTIRR 162
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
17-184 7.19e-10

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 57.92  E-value: 7.19e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  17 GKVTEA-----VKEAIDAGYRHFDCAYFYHN-EREVGagirckikEGAVRREDLFIATKL----WCTCHKKSLVETACRK 86
Cdd:cd19097   21 GKPSEKeakkiLEYALKAGINTLDTAPAYGDsEKVLG--------KFLKRLDKFKIITKLpplkEDKKEDEAAIEASVEA 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  87 SLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvQDLPLDESNMvipsdtdfldtWEAMEDLVITGLVKN 166
Cdd:cd19097   93 SLKRLKVDSLDGLLLHNP--------------------------DDLLKHGGKL-----------VEALLELKKEGLIRK 135
                        170
                 ....*....|....*...
gi 402244307 167 IGVSNFNHEQLERLLNKP 184
Cdd:cd19097  136 IGVSVYSPEELEKALESF 153
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
23-229 7.29e-10

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 58.00  E-value: 7.29e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  23 VKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegaVRREDLFIATKL---------WCTCHKKSLVETACRKSLKA 90
Cdd:cd19088   30 LRRALELGVNFIDTADSYgpdVNERLIAEALH-------PYPDDVVIATKGglvrtgpgwWGPDGSPEYLRQAVEASLRR 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  91 LKLNYLDLYLIHWPMgfkpphpewimscselsfclshPRVqdlPLDESnmvipsdtdfldtWEAMEDLVITGLVKNIGVS 170
Cdd:cd19088  103 LGLDRIDLYQLHRID----------------------PKV---PFEEQ-------------LGALAELQDEGLIRHIGLS 144
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307 171 NFNHEQLER------------LLN--------------------------------KPGLRFKPLTN-------QILIRF 199
Cdd:cd19088  145 NVTVAQIEEaraivrivsvqnRYNlanrddegvldyceaagiafipwfplgggdlaQPGGLLAEVAArlgatpaQVALAW 224
                        250       260       270
                 ....*....|....*....|....*....|..
gi 402244307 200 QIQR--NVIVIPGSITPSHIKENIQVFDFELT 229
Cdd:cd19088  225 LLARspVMLPIPGTSSVEHLEENLAAAGLRLS 256
AKR_AKR15A-like cd19090
AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes ...
5-182 1.11e-09

AKR15A family of aldo-keto reductase and similar proteins; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH) and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose and, to a much lesser degree, D-arabinose. The family also includes L-galactose dehydrogenase (L-galDH) and D-arabinose 1-dehydrogenase (ARA2). L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381316 [Multi-domain]  Cd Length: 278  Bit Score: 57.56  E-value: 1.11e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   5 PAVGL--SSWKASPGKVT-----EAVKEAIDAGYRHFDCAYFYHN-EREVGAGIRckikegAVRREDLFIATKLwCTCHK 76
Cdd:cd19090    1 SALGLgtAGLGGVFGGVDddeavATIRAALDLGINYIDTAPAYGDsEERLGLALA------ELPREPLVLSTKV-GRLPE 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  77 KSLVETACR------KSLKALKLNYLDLYLIHwpmgfkppHPEWImscselsfclshprvqdlPLDES---NMVIpsdtd 147
Cdd:cd19090   74 DTADYSADRvrrsveESLERLGRDRIDLLMIH--------DPERV------------------PWVDIlapGGAL----- 122
                        170       180       190
                 ....*....|....*....|....*....|....*
gi 402244307 148 fldtwEAMEDLVITGLVKNIGVSNFNHEQLERLLN 182
Cdd:cd19090  123 -----EALLELKEEGLIKHIGLGGGPPDLLRRAIE 152
AKR_unchar cd19099
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
21-170 5.03e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381325 [Multi-domain]  Cd Length: 316  Bit Score: 55.79  E-value: 5.03e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  21 EAVKEAIDAGYRHFDCA--YFY-HNEREVGAGIRCKIKEGAVRREDLFIATK---------------------------- 69
Cdd:cd19099   25 EALKAALDSGINVIDTAinYRGgRSERLIGKALRELIEKGGIKRDEVVIVTKagyipgdgdeplrplkyleeklgrglid 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  70 ------LWCTCHKKSLVEtACRKSLKALKLNYLDLYLIHwpmgfkppHPEWimscselsfclshprvQDLPLDESNMvip 143
Cdd:cd19099  105 vadsagLRHCISPAYLED-QIERSLKRLGLDTIDLYLLH--------NPEE----------------QLLELGEEEF--- 156
                        170       180
                 ....*....|....*....|....*..
gi 402244307 144 sDTDFLDTWEAMEDLVITGLVKNIGVS 170
Cdd:cd19099  157 -YDRLEEAFEALEEAVAEGKIRYYGIS 182
AKR_AKR6C1_2 cd19143
AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) ...
19-104 1.55e-08

AKR6C family of aldo-keto reductase (AKR); Voltage-gated potassium channel subunit beta (KCAB) from Arabidopsis thaliana and Egeria densa are founding members of aldo-keto reductase family 6 member C1 (AKR6C1) and C2 (AKR6C2), respectively. KCAB, also called Shaker channel b-subunit, or K(+) channel subunit beta, or potassium voltage beta 1, or KV-beta1, or KAB1, is a probable accessory potassium channel protein which modulates the activity of the pore-forming alpha subunit.


Pssm-ID: 381369 [Multi-domain]  Cd Length: 319  Bit Score: 54.52  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  19 VTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIrckiKEGAVRREDLFIATKL-W---------CTCHKKSLVEtACR 85
Cdd:cd19143   33 AKECMKAAYDAGVNFFDNAEVYANgqsEEIMGQAI----KELGWPRSDYVVSTKIfWggggpppndRGLSRKHIVE-GTK 107
                         90
                 ....*....|....*....
gi 402244307  86 KSLKALKLNYLDLYLIHWP 104
Cdd:cd19143  108 ASLKRLQLDYVDLVFCHRP 126
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
15-193 6.69e-08

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 52.34  E-value: 6.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  15 SPGKVTEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKLWCTCHKKSL--VETACRKSLK 89
Cdd:cd19103   30 DEDTLKAVFDKAMAAGLNLWDTAAVYgmgASEKILGEFLK------RYPREDYIISTKFTPQIAGQSAdpVADMLEGSLA 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  90 ALKLNYLDLYLIHWPMGFKPPHPEWImscselsfclshprvqdlpldesnmvipsdtdfldtweameDLVITGLVKNIGV 169
Cdd:cd19103  104 RLGTDYIDIYWIHNPADVERWTPELI-----------------------------------------PLLKSGKVKHVGV 142
                        170       180
                 ....*....|....*....|....*..
gi 402244307 170 SNFNHEQLER---LLNKPGLRFKPLTN 193
Cdd:cd19103  143 SNHNLAEIKRaneILAKAGVSLSAVQN 169
AKR_unchar cd19104
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
22-181 7.45e-08

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381330 [Multi-domain]  Cd Length: 321  Bit Score: 52.27  E-value: 7.45e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  22 AVKEAIDAGYRHFDCAYFY---HNER-------EVGAGIR--CKIKEGAVRREDLfiatklwctchkKSLVETACRKSLK 89
Cdd:cd19104   37 AVRRALDLGINFFDTAPSYgdgKSEEnlgralkGLPAGPYitTKVRLDPDDLGDI------------GGQIERSVEKSLK 104
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  90 ALKLNYLDLYLIHwpmgfkpphpewimscselsfclSHPRVQDLPLDESNMVIPSDTDFLDTWEAMEDLVITGLVKNIGV 169
Cdd:cd19104  105 RLKRDSVDLLQLH-----------------------NRIGDERDKPVGGTLSTTDVLGLGGVADAFERLRSEGKIRFIGI 161
                        170
                 ....*....|..
gi 402244307 170 SNFNHEQLERLL 181
Cdd:cd19104  162 TGLGNPPAIREL 173
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
60-181 1.23e-07

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 51.83  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  60 RREDLFIATKL--WCTCHKKSL----VETACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclsHPRVqdl 133
Cdd:cd19081   74 KRDRVVIATKVgfPMGPNGPGLsrkhIRRAVEASLRRLQTDYIDLYQAHWD----------------------DPAT--- 128
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 402244307 134 PLDEsnmvipsdtdfldTWEAMEDLVITGLVKNIGVSNFNHEQLERLL 181
Cdd:cd19081  129 PLEE-------------TLGALNDLIRQGKVRYIGASNYSAWRLQEAL 163
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
4-195 3.48e-07

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 50.33  E-value: 3.48e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWK-----ASPGKVTEAVKEAIDAGYRHFDCAYFY-----HNEREVGAGIRckiKEGAVRREDLFIATKLWCT 73
Cdd:cd19089   11 LPAISLGLWHnfgdyTSPEEARELLRTAFDLGITHFDLANNYgpppgSAEENFGRILK---RDLRPYRDELVISTKAGYG 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  74 CH---------KKSLVETaCRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclsHPRVqdlPLDEsnmvips 144
Cdd:cd19089   88 MWpgpygdggsRKYLLAS-LDQSLKRMGLDYVDIFYHHRY----------------------DPDT---PLEE------- 134
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 402244307 145 dtdfldTWEAMEDLVITGLVKNIGVSNFNHEQLER---LLNKPGLRFkpLTNQI 195
Cdd:cd19089  135 ------TMTALADAVRSGKALYVGISNYPGAKARRaiaLLRELGVPL--IIHQP 180
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
60-179 2.71e-06

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 47.71  E-value: 2.71e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  60 RREDLFIATKL---------WCTCH---KKSLVETACRKSLKALKLNYLDLYLIHwpmgfkpphpewimscselsfclsh 127
Cdd:cd19752   65 NRDDVVIATKVgagprdpdgGPESPeglSAETIEQEIDKSLRRLGTDYIDLYYAH------------------------- 119
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 402244307 128 prVQDlpldesnmvipSDTDFLDTWEAMEDLVITGLVKNIGVSNFNHEQLER 179
Cdd:cd19752  120 --VDD-----------RDTPLEETLEAFNELVKAGKVRAIGASNFAAWRLER 158
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
20-102 2.74e-06

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 47.61  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  20 TEAVKEAIDAGYRHFDCAYFY---HNEREVGAGIrckikegAVRREDLFIATKLWCTCHKKSLVET-----------ACR 85
Cdd:cd19078   28 IELIRKAVELGITFFDTAEVYgpyTNEELVGEAL-------KPFRDQVVIATKFGFKIDGGKPGPLgldsrpehirkAVE 100
                         90
                 ....*....|....*..
gi 402244307  86 KSLKALKLNYLDLYLIH 102
Cdd:cd19078  101 GSLKRLQTDYIDLYYQH 117
AKR_AKR6B1 cd19142
AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding ...
4-102 3.29e-06

AKR6B family of aldo-keto reductase (AKR); Drosophila melanogaster Hk protein is a founding member of aldo-keto reductase family 6 member B1 (AKR6B1). Hk protein, also called hyperkinetic, is a beta subunit of Shaker (Sh) K+ channels and shows high sequence homology to aldoketoreductase.


Pssm-ID: 381368 [Multi-domain]  Cd Length: 325  Bit Score: 47.46  E-value: 3.29e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   4 IPAVGLSSWKASPGKVTEAVKEAI-----DAGYRHFDCAYFYHNER-EVGAG-IrckIKEGAVRREDLFIATKL-W---- 71
Cdd:cd19142   13 VSNVGLGTWSTFSTAISEEQAEEIvtlayENGINYFDTSDAFTSGQaETELGrI---LKKKGWKRSSYIVSTKIyWsygs 89
                         90       100       110
                 ....*....|....*....|....*....|...
gi 402244307  72 --CTCHKKSLVEtACRKSLKALKLNYLDLYLIH 102
Cdd:cd19142   90 eeRGLSRKHIIE-SVRASLRRLQLDYIDIVIIH 121
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
8-102 3.38e-06

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 47.43  E-value: 3.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   8 GLSSWKASPGKVTEA---VKEAIDAGYRHFDCAYFY---HNEREVGAGIrckiKEGavRREDLFIATKLWCTCHKKSLVE 81
Cdd:cd19145   21 GLSGDYGAPKPEEEGialIHHAFNSGVTFLDTSDIYgpnTNEVLLGKAL----KDG--PREKVQLATKFGIHEIGGSGVE 94
                         90       100       110
                 ....*....|....*....|....*....|
gi 402244307  82 ---------TACRKSLKALKLNYLDLYLIH 102
Cdd:cd19145   95 vrgdpayvrAACEASLKRLDVDYIDLYYQH 124
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
8-182 5.43e-06

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 46.78  E-value: 5.43e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   8 GLSSWKASPGKVT-EAVKEAIDA----GYRHFDCAYFYHN---ER---EVGAGIRckikegavrreDLFIATK---LWCT 73
Cdd:cd19075    6 GTMTFGSQGRFTTaEAAAELLDAflerGHTEIDTARVYPDgtsEEllgELGLGER-----------GFKIDTKanpGVGG 74
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  74 CHKKSLVETACRKSLKALKLNYLDLYLIHWPmgfkpphpewimscselsfclshprvqdlplDESnmvipsdTDFLDTWE 153
Cdd:cd19075   75 GLSPENVRKQLETSLKRLKVDKVDVFYLHAP-------------------------------DRS-------TPLEETLA 116
                        170       180
                 ....*....|....*....|....*....
gi 402244307 154 AMEDLVITGLVKNIGVSNFNHEQLERLLN 182
Cdd:cd19075  117 AIDELYKEGKFKEFGLSNYSAWEVAEIVE 145
AKR_AKR10A1_2 cd19082
AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) ...
27-178 5.57e-06

AKR10A family of aldo-keto reductase (AKR); Streptomyces bluensis aldo-keto reductase (BlmT) and Streptomyces glaucescens aldo-keto reductase (StrT) are founding members of aldo-keto reductase family 10 member A1 (AKR10A1) and A2 (AKR10A2). BlmT is bluensomycin aldo-keto reductase (AKR) and StrT is streptomycin AKR.


Pssm-ID: 381308 [Multi-domain]  Cd Length: 291  Bit Score: 46.39  E-value: 5.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  27 IDAGYRHFDCAYFY-------HNEREVGAGIRCKIKegavrREDLFIATK-----LWCT----CHKKSLVEtACRKSLKA 90
Cdd:cd19082   27 VELGGNFIDTARVYgdwvergASERVIGEWLKSRGN-----RDKVVIATKgghpdLEDMsrsrLSPEDIRA-DLEESLER 100
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  91 LKLNYLDLYLIHwpmgfkpphpewimscselsfclshpR-VQDLPLDEsnmvipsdtdFLDTweaMEDLVITGLVKNIGV 169
Cdd:cd19082  101 LGTDYIDLYFLH--------------------------RdDPSVPVGE----------IVDT---LNELVRAGKIRAFGA 141

                 ....*....
gi 402244307 170 SNFNHEQLE 178
Cdd:cd19082  142 SNWSTERIA 150
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
27-172 3.09e-05

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 44.52  E-value: 3.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  27 IDAGYRHFDCAYFYHN---EREVGAGIrckikegAVRREDLFIATKL----------WCTCHKKSLVEtACRKSLKALKL 93
Cdd:cd19080   41 VEAGGNFIDTANNYTNgtsERLLGEFI-------AGNRDRIVLATKYtmnrrpgdpnAGGNHRKNLRR-SVEASLRRLQT 112
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 402244307  94 NYLDLYLIHWPMGFKPphPEWIMScselsfclshprvqdlpldesnmvipsdtdfldtweAMEDLVITGLVKNIGVSNF 172
Cdd:cd19080  113 DYIDLLYVHAWDFTTP--VEEVMR------------------------------------ALDDLVRAGKVLYVGISDT 153
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
6-102 4.50e-05

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 43.97  E-value: 4.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   6 AVGLSSWKASPGKVTEAVK---EAIDAGYRHFDCAYFY-HNEREVGAGIrckiKEGAVRREDLFIATKLWCTCHKKS--- 78
Cdd:cd19144   20 AMGLSAFYGPPKPDEERFAvldAAFELGCTFWDTADIYgDSEELIGRWF----KQNPGKREKIFLATKFGIEKNVETgey 95
                         90       100       110
                 ....*....|....*....|....*....|.
gi 402244307  79 -------LVETACRKSLKALKLNYLDLYLIH 102
Cdd:cd19144   96 svdgspeYVKKACETSLKRLGVDYIDLYYQH 126
AKR_ARA2 cd19164
D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+) ...
18-102 1.23e-04

D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381390 [Multi-domain]  Cd Length: 298  Bit Score: 42.65  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  18 KVTEAVKEAIDAGYRHFDCAYFYHnEREVGAGIRCKIKEGAVRREDLFIATKlwctCHKKSL---------VETACRKSL 88
Cdd:cd19164   35 PPVDIVRRALELGIRAFDTSPYYG-PSEIILGRALKALRDEFPRDTYFIITK----VGRYGPddfdyspewIRASVERSL 109
                         90
                 ....*....|....
gi 402244307  89 KALKLNYLDLYLIH 102
Cdd:cd19164  110 RRLHTDYLDLVYLH 123
AKR_AKR15A cd19152
AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum ...
7-70 1.52e-04

AKR15A family of aldo-keto reductase; The AKR15 family includes Microbacterium luteolum pyridoxal 4-dehydrogenase (PLD), Pseudomonas sp. D-threo-aldose 1-dehydrogenase (FDH), and similar proteins. PLD (EC1.1.1.107) catalyzes irreversible oxidation of pyridoxal. FDH(EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose. FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381378 [Multi-domain]  Cd Length: 308  Bit Score: 42.21  E-value: 1.52e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 402244307   7 VGLSSW-----KASPGKVTEAVKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikegAVRREDLFIATKL 70
Cdd:cd19152    5 FGTAPLgnlyeAVSDEEAKATLVAAWDLGIRYFDTAPWYGAglsEERLGAALR------ELGREDYVISTKV 70
AKR_galDH cd19163
L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called ...
8-102 1.62e-04

L-galactose dehydrogenase (L-galDH) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+).


Pssm-ID: 381389 [Multi-domain]  Cd Length: 293  Bit Score: 42.15  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   8 GLSSWKASPGKVTE-----AVKEAIDAGYRHFDCAYFY---HNEREVGAGIRckikegAVRREDLFIATKL--WCTCHKK 77
Cdd:cd19163   19 GASPLGGVFGPVDEeeairTVHEALDSGINYIDTAPWYgqgRSETVLGKALK------GIPRDSYYLATKVgrYGLDPDK 92
                         90       100       110
                 ....*....|....*....|....*....|.
gi 402244307  78 SLVETACR------KSLKALKLNYLDLYLIH 102
Cdd:cd19163   93 MFDFSAERitksveESLKRLGLDYIDIIQVH 123
AKR_galDH-like cd19153
L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; ...
6-102 3.55e-04

L-galactose dehydrogenase (L-galDH), D-arabinose 1-dehydrogenase (ARA2) and similar proteins; L-galDH (EC 1.1.1.316), also called L-galactose 1-dehydrogenase, catalyzes the oxidation of L-galactose to L-galactono-1,4-lactone in the presence of NAD(+). It uses NAD(+) as a hydrogen acceptor much more efficiently than NADP(+). ARA2 (EC1.1.1.116), also called NAD(+)-specific D-arabinose dehydrogenase, catalyzes the the oxidation of D-arabinose to D-arabinono-1,4-lactone in the presence of NAD(+).


Pssm-ID: 381379 [Multi-domain]  Cd Length: 294  Bit Score: 40.98  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307   6 AVGLSSWKASPGKVTEA---VKEAIDAGYRHFDCAYFYHN---EREVGAGIRckikEGAVRREDLFIATKLwctCHKKS- 78
Cdd:cd19153   19 TAALGGVYGDGLEQDEAvaiVAEAFAAGINHFDTSPYYGAessEAVLGKALA----ALQVPRSSYTVATKV---GRYRDs 91
                         90       100       110
                 ....*....|....*....|....*....|.
gi 402244307  79 -------LVETACRKSLKALKLNYLDLYLIH 102
Cdd:cd19153   92 efdysaeRVRASVATSLERLHTTYLDVVYLH 122
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
171-236 3.98e-04

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 41.07  E-value: 3.98e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 402244307 171 NFNH-----EQLERLLNKPGLrfkPLTNQIL--IRFQIQRNVIVIPGSITPSHIKENIQVFDFELTQHDMDNI 236
Cdd:cd19077  232 NFEKnlklvDALQELAEKKGC---TPAQLALawILAQSGPKIIPIPGSTTLERVEENLKAANVELTDEELKEI 301
PLN02587 PLN02587
L-galactose dehydrogenase
21-102 5.29e-03

L-galactose dehydrogenase


Pssm-ID: 178198 [Multi-domain]  Cd Length: 314  Bit Score: 37.45  E-value: 5.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 402244307  21 EAVKEAIDAGYRHFDCAYFYHN---EREVGAGirckIKEGAVRREDLFIATKlwCTCHKKSLVETACR------KSLKAL 91
Cdd:PLN02587  35 ASVREAFRLGINFFDTSPYYGGtlsEKVLGKA----LKALGIPREKYVVSTK--CGRYGEGFDFSAERvtksvdESLARL 108
                         90
                 ....*....|.
gi 402244307  92 KLNYLDLYLIH 102
Cdd:PLN02587 109 QLDYVDILHCH 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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