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Conserved domains on  [gi|400153675|ref|NP_001257809|]
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glucosamine-6-phosphate isomerase 2 isoform 2 [Homo sapiens]

Protein Classification

sugar phosphate isomerase family( domain architecture ID 368)

sugar phosphate isomerase family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SugarP_isomerase super family cl00339
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 1-219 2.42e-124

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


The actual alignment was detected with superfamily member PTZ00285:

Pssm-ID: 469729  Cd Length: 253  Bit Score: 352.91  E-value: 2.42e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   1 MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTG----------------------------------LPRN 46
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGstplptyqelirayregrvsfsnvvtfnmdeyvgLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  47 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 126
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 127 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 206
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 400153675 207 EDATLELRVKTVK 219
Cdd:PTZ00285 241 EDATLELKVKTTK 253
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-219 2.42e-124

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 352.91  E-value: 2.42e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   1 MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTG----------------------------------LPRN 46
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGstplptyqelirayregrvsfsnvvtfnmdeyvgLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  47 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 126
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 127 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 206
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 400153675 207 EDATLELRVKTVK 219
Cdd:PTZ00285 241 EDATLELKVKTTK 253
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-224 3.80e-112

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 322.53  E-value: 3.80e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675    1 MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTG----------------------------------LPRN 46
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGgtpigtykqlielhqagkisfqnvttfnmdeyagLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   47 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 126
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  127 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 206
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*...
gi 400153675  207 EDATLELRVKTVKYFKGL 224
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 12-213 6.34e-107

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 307.87  E-value: 6.34e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  12 ASEWAAKYICNRIIQFKPgqdryFTLGLPTG----------------------------------LPRNHPESYHSYMWN 57
Cdd:cd01399    3 MSEAAAELIAELIREKPP-----AVLGLATGstplgvyeelielhkegglsfsnvttfnldeyvgLPPDHPQSYHYFMRE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  58 NFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANA 137
Cdd:cd01399   78 NLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 400153675 138 KYFDGDlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLEL 213
Cdd:cd01399  158 RFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-213 6.04e-88

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 260.48  E-value: 6.04e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   1 MRLVILDNYDLASEWAAKYICNRI---IQFKPgqdrYFTLGLPTG----------------------------------L 43
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIaeaIAEKG----RAVLGLAGGstplglyeelarlhkeggldwsrvhvfnldeyvgL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  44 PRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRT 123
Cdd:COG0363   78 PPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 124 -RLKTLAMDTILANAKYFDgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTI 202
Cdd:COG0363  158 dRVVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVT 236

                        250
                 ....*....|.
gi 400153675 203 FVCDEDATLEL 213
Cdd:COG0363  237 WFLDEAAASLL 247
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
43-189 6.32e-16

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 73.81  E-value: 6.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   43 LPRNHPES-YHSYMwNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGG------IDLFVGGIGPDGHIA--Fn 113
Cdd:pfam01182  67 VPPDDPDSnYGMAR-EALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHTAslF- 144

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 400153675  114 ePGSSLVSRTRLKTLAMDtilanakyfdgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHM 189
Cdd:pfam01182 145 -PGSPALEETDRLVVAVT-----------DSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
 
Name Accession Description Interval E-value
PTZ00285 PTZ00285
glucosamine-6-phosphate isomerase; Provisional
 1-219 2.42e-124

glucosamine-6-phosphate isomerase; Provisional


Pssm-ID: 140308  Cd Length: 253  Bit Score: 352.91  E-value: 2.42e-124
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   1 MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTG----------------------------------LPRN 46
Cdd:PTZ00285   1 MRIVISEDADAVADYTSNYIIKRINDFKPTSDRPFVLGLPTGstplptyqelirayregrvsfsnvvtfnmdeyvgLPRD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  47 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 126
Cdd:PTZ00285  81 HPQSYHYFMKENFFDHVDIKEENRHILNGTAPDLEEECRRYEEKIRAVGGIDLFLAGIGTDGHIAFNEPGSSLDSRTRVK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 127 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 206
Cdd:PTZ00285 161 SLNQETIDANARFFGNDISKVPTMALTVGIRTIMEAREVLLLATGASKAIAVARCVEGGVTHMCPASALQMHPAAVLCLD 240

                        250
                 ....*....|...
gi 400153675 207 EDATLELRVKTVK 219
Cdd:PTZ00285 241 EDATLELKVKTTK 253
nagB PRK00443
glucosamine-6-phosphate deaminase; Provisional
 1-224 2.85e-120

glucosamine-6-phosphate deaminase; Provisional


Pssm-ID: 179028 [Multi-domain]  Cd Length: 261  Bit Score: 342.96  E-value: 2.85e-120
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   1 MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPT----------------------------------GLPRN 46
Cdd:PRK00443   1 MRLIILKTAEEVGKWAARHIANRINAFLPTKERPFVLGLATgsspletykalielhkagkvdfsrvttfnldeyvGLPAD 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  47 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 126
Cdd:PRK00443  81 HPESYRYFMRENFFDHVDIPPENINLLNGNAPDPEAECRRYEEKIKSAGGIDLQILGIGENGHIAFNEPGSSFASRTRIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 127 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 206
Cdd:PRK00443 161 TLTEDTRIANSRFFDGDIEQVPKYALTVGVGTILDAKEIMLLAPGHNKAEAVKAAVEGPVNHMWPASILQLHPKATLVLD 240

                        250
                 ....*....|....*...
gi 400153675 207 EDATLELRVKTVKYFKGL 224
Cdd:PRK00443 241 EAAASELKVKTVKYFTEL 258
nagB TIGR00502
glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a ...
 1-224 3.80e-112

glucosamine-6-phosphate isomerase; The set of proteins recognized by this model includes a closely related pair from Bacillus subtilis, one of which is uncharacterized but included as a member of the orthologous set. [Central intermediary metabolism, Amino sugars]


Pssm-ID: 129593  Cd Length: 259  Bit Score: 322.53  E-value: 3.80e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675    1 MRLVILDNYDLASEWAAKYICNRIIQFKPGQDRYFTLGLPTG----------------------------------LPRN 46
Cdd:TIGR00502   1 MRLIILQTYEELSKWAARHIANRINEFKPTAARPFVLGLPTGgtpigtykqlielhqagkisfqnvttfnmdeyagLSEE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   47 HPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLK 126
Cdd:TIGR00502  81 HPESYHSFMHNNFFQHIDIKPENINILNGNAPDLEAECRRYEEKIRSYGGIDLFMGGIGPDGHIAFNEPGSSLTSRTRIK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  127 TLAMDTILANAKYFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCD 206
Cdd:TIGR00502 161 TLTEDTIQANSRFFEGDVNQVPKYALTVGIGTILDSKEVLILVSGHQKALALQKAVEGGVNHMWTISALQLHKHAIVVCD 240

                         250
                  ....*....|....*...
gi 400153675  207 EDATLELRVKTVKYFKGL 224
Cdd:TIGR00502 241 ENATQELKVKTVEYFNEL 258
GlcN6P_deaminase cd01399
GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase ...
 12-213 6.34e-107

GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or deamination. It is the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate (GlcNAc6P). GlcN6P deaminase is a hexameric enzyme that is allosterically activated by GlcNAc6P.


Pssm-ID: 238693 [Multi-domain]  Cd Length: 232  Bit Score: 307.87  E-value: 6.34e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  12 ASEWAAKYICNRIIQFKPgqdryFTLGLPTG----------------------------------LPRNHPESYHSYMWN 57
Cdd:cd01399    3 MSEAAAELIAELIREKPP-----AVLGLATGstplgvyeelielhkegglsfsnvttfnldeyvgLPPDHPQSYHYFMRE 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  58 NFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTILANA 137
Cdd:cd01399   78 NLFDHIDIKPENIHIPDGNAADLEAECRRYEALIAEAGGIDLQLLGIGENGHIGFNEPGSSLDSRTRVVTLDESTRQANA 157

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 400153675 138 KYFDGDlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLEL 213
Cdd:cd01399  158 RFFDGD-EDVPTQAITMGIGTIMKAKEILLLATGEGKAEAVKKALEGPVTEECPASILQLHPNVTVILDEAAASEL 232
NagB COG0363
6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport ...
 1-213 6.04e-88

6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase is part of the Pathway/BioSystem: Pentose phosphate pathway


Pssm-ID: 440132 [Multi-domain]  Cd Length: 248  Bit Score: 260.48  E-value: 6.04e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   1 MRLVILDNYDLASEWAAKYICNRI---IQFKPgqdrYFTLGLPTG----------------------------------L 43
Cdd:COG0363    2 MRVIIFPDAEELAAAAAERAAERIaeaIAEKG----RAVLGLAGGstplglyeelarlhkeggldwsrvhvfnldeyvgL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  44 PRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRT 123
Cdd:COG0363   78 PPDHPQSNRRFMREALLDHVDIPPENIHIPDGEAEDPEAAAARYEALIAEAGGIDLQLLGIGEDGHIAFNFPGSPFLSET 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 124 -RLKTLAMDTILANAKYFDgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTI 202
Cdd:COG0363  158 dRVVTLDESTRQANARFFG-SIPKVPPQAITLGIPTIMKAREILLLATGENKAEAVAAALEGPVTEEVPASILQGHPNVT 236

                        250
                 ....*....|.
gi 400153675 203 FVCDEDATLEL 213
Cdd:COG0363  237 WFLDEAAASLL 247
PRK02122 PRK02122
glucosamine-6-phosphate deaminase-like protein; Validated
 13-217 5.30e-56

glucosamine-6-phosphate deaminase-like protein; Validated


Pssm-ID: 235005 [Multi-domain]  Cd Length: 652  Bit Score: 189.08  E-value: 5.30e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  13 SEWAAKYICNRI---IQFKPGQDRYFTLGLPTG---------LPRNHPE-------------------------SYHSYM 55
Cdd:PRK02122  36 SEEASRAVAQEIatlIRERQAEGKPCVLGLATGsspigvyaeLIRMHREeglsfknvitfnldeyypmqpdslqSYHRFM 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  56 WNNFFKHIDIDPNNAHILDG--NAADLQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSLVSRTRLKTLAMDTI 133
Cdd:PRK02122 116 KENLFDHVDIPPENIHIPDGtiPKEEIDEYCRDYEEKIEAAGGIDFQLLGIGRTGHIGFNEPGSGRNSRTRLVTLDHITR 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 134 LANAKYFdGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVCDEDATLEL 213
Cdd:PRK02122 196 RDAASDF-FGEENVPRKAITMGVGTILKARRIVLLAWGEHKAPIIKRAVEGEISDEVPASYLQEHPNATFVLDLAAASEL 274


                 ....*
gi 400153675 214 -RVKT 217
Cdd:PRK02122 275 tRIKT 279
PRK12358 PRK12358
glucosamine-6-phosphate deaminase;
1-213 1.69e-21

glucosamine-6-phosphate deaminase;


Pssm-ID: 183470  Cd Length: 239  Bit Score: 89.43  E-value: 1.69e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   1 MRLVILDNYDLASEWAAKYICNRIIQfkpgqDRYFTLGLPTGlprNHPESYHSYM--------------WNNF------- 59
Cdd:PRK12358   1 MKIIITKDYEEMSRVAAHHLLGYMSK-----TKRVNLAITAG---STPKGMYEYLitlvkgkawydnvhYYNFdeipfrg 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  60 ----------FKHIDIDPnnAHILDGNAADLQAECDA-FENKIKEAGGIDLFVGGIGPDGHIAFNEPG-SSLVSRTRLKT 127
Cdd:PRK12358  73 kegegvtitnLRNLFFTP--AGIKEENIHKLTIDNYReHDQKLARDGGLDLVVLGLGADGHFCGNLPGtTHFHDETVEVP 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 128 LA--MDTILANAKyFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVC 205
Cdd:PRK12358 151 IQgeMVDIVAHGE-LGGDFSLVPDSYVTMGPKSIMAAKNLLLIVNGKGKAQILKKVLQGPVTEDVPASILQLHPNLTVIL 229


                 ....*...
gi 400153675 206 DEDATLEL 213
Cdd:PRK12358 230 DEAAAAEL 237
SugarP_isomerase cd00458
SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate ...
 14-205 3.76e-20

SugarP_isomerase: Sugar Phosphate Isomerase family; includes type A ribose 5-phosphate isomerase (RPI_A), glucosamine-6-phosphate (GlcN6P) deaminase, and 6-phosphogluconolactonase (6PGL). RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium, the last step of the metabolic pathway of N-acetyl-D-glucosamine-6-phosphate. 6PGL converts 6-phosphoglucono-1,5-lactone to 6-phosphogluconate, the second step of the oxidative phase of the pentose phosphate pathway.


Pssm-ID: 238258  Cd Length: 169  Bit Score: 84.33  E-value: 3.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  14 EWAAKYICNRIIQFkPGQDRYFTLGLPTG-------------------------------LPRNHPESYHSYMWNNFFKH 62
Cdd:cd00458    2 KEALKFIEDK*EKL-LEEKDDMVIGLGTGstpayfykllgeklkrgeisdivgfptderyVPLDSDQSNFRQAKLLAFEH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  63 IDIDPNNAHILDGNAADLQAECDAFENKIKEAGGIDLFVGGIGpdghiafnepgsslvsrtrlktlamdtilanakyfdg 142
Cdd:cd00458   81 DIIPASNVHYVDTSLPIEKACEKYEREILDQVDAIDLAVDGAG------------------------------------- 123

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 400153675 143 dlskvptmaltvgvgtvMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQQHPRTIFVC 205
Cdd:cd00458  124 -----------------YRAGTVIVLVDGRKKVDYLCQNTEPGVIENGIFADIRGKEKDIVIV 169
PRK09762 PRK09762
galactosamine-6-phosphate isomerase; Provisional
 42-202 6.51e-20

galactosamine-6-phosphate isomerase; Provisional


Pssm-ID: 182064  Cd Length: 232  Bit Score: 84.88  E-value: 6.51e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  42 GLPRNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADlQAECDAFENKIKEAGGIDLFVGGIGPDGHIAFNEPGSSL-- 119
Cdd:PRK09762  71 DLPLTMPGTCETFLQQHIVQPLGLREDQLISFRSEEIN-ETECERVTNLIARKGGLDLCVLGLGKNGHLGLNEPGESLqp 149

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 120 ---VSRTRLKTLAMDTILANakyfdgdlSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHMWTVSAFQ 196
Cdd:PRK09762 150 achISQLDARTQQHEMLKTA--------GRPVTRGITLGLKDILNAREVLLLVTGEGKQDATERFLTAKVSTAIPASFLW 221


                 ....*.
gi 400153675 197 QHPRTI 202
Cdd:PRK09762 222 LHSNFI 227
Glucosamine_iso pfam01182
Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;
43-189 6.32e-16

Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase;


Pssm-ID: 460101 [Multi-domain]  Cd Length: 222  Bit Score: 73.81  E-value: 6.32e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   43 LPRNHPES-YHSYMwNNFFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEAGG------IDLFVGGIGPDGHIA--Fn 113
Cdd:pfam01182  67 VPPDDPDSnYGMAR-EALLSHVPIPASNVHPIPASAADPEEAAAAYEAELRELLPdlelpvFDLVLLGMGPDGHTAslF- 144

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 400153675  114 ePGSSLVSRTRLKTLAMDtilanakyfdgDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEGVNHM 189
Cdd:pfam01182 145 -PGSPALEETDRLVVAVT-----------DSPKPPPERITLTLPVLNAARRVWFLVTGAGKADALRRALAGDPDPL 208
6PGL cd01400
6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the ...
 43-205 6.35e-15

6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard against the accumulation of the delta form of the lactone, which may be toxic through its reaction with endogenous cellular nucleophiles.


Pssm-ID: 238694 [Multi-domain]  Cd Length: 219  Bit Score: 71.05  E-value: 6.35e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  43 LPRNHPES-YHSYMwNNFFKHIDIDPNNAHILDGnAADLQAECDAFENKIKEAGG----IDLFVGGIGPDGHIA--FneP 115
Cdd:cd01400   63 VPPDDPDSnYRLAR-EALLSHVAIPAANIHPIPT-ELGPEDAAAAYEKELRALFGgvppFDLVLLGMGPDGHTAslF--P 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675 116 GSSLVSRTRLKT-LAMDtilanakyfdgDLSKVPT--MALTVGVgtVMDAREVMILITGAHKAFALYKAIEEGVNHMWTV 192
Cdd:cd01400  139 GHPALLEETDRLvVAVT-----------DSPKPPPerITLTLPV--LNNARRVVFLVTGAEKAEALKRALAGPDPEELPA 205

                        170
                 ....*....|...
gi 400153675 193 SAFQQHPRTIFVC 205
Cdd:cd01400  206 ARVLPRPGEVLWF 218
pgl TIGR01198
6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a ...
 43-213 9.57e-12

6-phosphogluconolactonase; This enzyme of the pentose phosphate pathway is often found as a part of a multifunctional protein with [Energy metabolism, Pentose phosphate pathway]


Pssm-ID: 273494 [Multi-domain]  Cd Length: 233  Bit Score: 62.78  E-value: 9.57e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675   43 LPRNHPES----YHSYMwnnfFKHIDIDPNNAHILDGNAADLQAECDAFENKIKEA------GGIDLFVGGIGPDGHIAF 112
Cdd:TIGR01198  67 VPLDHADSntglAREAL----LDRVAIPASNIHPMPTELSDIEEAAELYEQELAAAfqpivfPVFDLLLLGMGPDGHTAS 142

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  113 NEPGSSLV-SRTRLKTLAMDTIlanakyfdgdlsKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIE-EGVNHMW 190
Cdd:TIGR01198 143 LFPHTPALqETERLVTVLTKSP------------KPPHERITLTLPAINAARKVFLLIAGEEKRNALAEALAvEAEPYPL 210

                         170       180
                  ....*....|....*....|...
gi 400153675  191 TVSAFQQHPRTIFVCDEDATLEL 213
Cdd:TIGR01198 211 PAAGVLHSGKTLWLLDYAAARKL 233
PLN02360 PLN02360
probable 6-phosphogluconolactonase
 45-185 2.58e-03

probable 6-phosphogluconolactonase


Pssm-ID: 166001 [Multi-domain]  Cd Length: 268  Bit Score: 38.30  E-value: 2.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 400153675  45 RNHPESYHSYMWNNFFKHIDIDPNNAHILDGNAADLQAECDaFE--------------NKIKEAGGIDLFVGGIGPDGHI 110
Cdd:PLN02360  86 KNHADSNYKLAKDGLLSKVPVVPSHVYSINDTVTAEEAATD-YEfairqlvktrtigvSDISDCPKFDLILLGMGSDGHV 164

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 400153675 111 AfnepgsSLVSRTRLKTLAMDTILanakyFDGDLSKVPTMALTVGVGTVMDAREVMILITGAHKAFALYKAIEEG 185
Cdd:PLN02360 165 A------SLFPNHPALEEKDDWVT-----FITDSPKPPPERITFTLPVINSASNVAVVATGESKANAVHLAIDDV 228
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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