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Conserved domains on  [gi|399154116|ref|NP_001257731|]
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importin subunit alpha-1 [Rattus norvegicus]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
12-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 526.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  12 ARLNRFKNKGKDST-EMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVEDIVKGINS 87
Cdd:COG5064    9 ARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQLFS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  88 NNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAF 167
Cdd:COG5064   83 DDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 168 ISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKHGAIDPLLALL--AVPDLSslacgYLRNLTWTLSNLCRNKNPAPP 245
Cdd:COG5064  163 IQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHIS-----MLRNATWTLSNLCRGKNPPPD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 246 LDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTD 325
Cdd:COG5064  238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 326 EQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYT 405
Cdd:COG5064  318 DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNAT 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 406 SGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEALQS 478
Cdd:COG5064  398 SGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHGLQD 477

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 399154116 479 HENESVYKASLNLIEKYFSvEEEEDQNVVPETTSEGFAFQVQDGAPGTFN 528
Cdd:COG5064  478 SVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
12-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 526.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  12 ARLNRFKNKGKDST-EMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVEDIVKGINS 87
Cdd:COG5064    9 ARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQLFS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  88 NNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAF 167
Cdd:COG5064   83 DDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 168 ISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKHGAIDPLLALL--AVPDLSslacgYLRNLTWTLSNLCRNKNPAPP 245
Cdd:COG5064  163 IQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHIS-----MLRNATWTLSNLCRGKNPPPD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 246 LDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTD 325
Cdd:COG5064  238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 326 EQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYT 405
Cdd:COG5064  318 DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNAT 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 406 SGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEALQS 478
Cdd:COG5064  398 SGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHGLQD 477

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 399154116 479 HENESVYKASLNLIEKYFSvEEEEDQNVVPETTSEGFAFQVQDGAPGTFN 528
Cdd:COG5064  478 SVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-98 6.43e-38

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 133.82  E-value: 6.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116   13 RLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATsplqenrNNQGTVNWSVEDIVKGINSNNLES 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSS-------SAESQLLESLPEMVQGVNSDDPEL 73


                  ....*.
gi 399154116   93 QLQATQ 98
Cdd:pfam01749  74 QLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 1.52e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.51  E-value: 1.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 399154116   151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 158-448 1.19e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 45.09  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  158 VVDGGAIPAFISLL--ASPHAHI-SEQAVWALGNIAGDGSVFRDLVIKHGAIDPLLALLAV-PDLSSLACGYLrnlTWTL 233
Cdd:PLN03200   95 VLLGGCIPPLLSLLksGSAEAQKaAAEAIYAVSSGGLSDHVGSKIFSTEGVVPSLWDQLQPgNKQDKVVEGLL---TGAL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  234 SNLCRNKNP--APPLDA--VEqilpTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLG-ATELP 308
Cdd:PLN03200  172 RNLCGSTDGfwSATLEAggVD----ILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGqGNEVS 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  309 IVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNP-KTNIQKE--------ATWTMSNITAGrqdqiqqvvnhglV 379
Cdd:PLN03200  248 VRAEAAGALEALSSQSKEAKQAIADAGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGG-------------M 314

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 399154116  380 PFLVGVLSKADFKTQKEA---------AWAITNYTSGGTVEQIVYLVHcgIIEPLMNLLSAKDTKIIQV-ILDAISNIF 448
Cdd:PLN03200  315 SALILYLGELSESPRSPApiadtlgalAYALMVFDSSAESTRAFDPTV--IEQILVKLLKPRDTKLVQErIIEALASLY 391
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
12-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 526.38  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  12 ARLNRFKNKGKDST-EMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVEDIVKGINS 87
Cdd:COG5064    9 ARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQLFS 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  88 NNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAF 167
Cdd:COG5064   83 DDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAVPLF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 168 ISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKHGAIDPLLALL--AVPDLSslacgYLRNLTWTLSNLCRNKNPAPP 245
Cdd:COG5064  163 IQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHIS-----MLRNATWTLSNLCRGKNPPPD 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 246 LDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVTGTD 325
Cdd:COG5064  238 WSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVTGSD 317

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 326 EQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYT 405
Cdd:COG5064  318 DQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAISNAT 397

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 406 SGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEALQS 478
Cdd:COG5064  398 SGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHGLQD 477

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|
gi 399154116 479 HENESVYKASLNLIEKYFSvEEEEDQNVVPETTSEGFAFQVQDGAPGTFN 528
Cdd:COG5064  478 SVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-98 6.43e-38

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 133.82  E-value: 6.43e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116   13 RLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATsplqenrNNQGTVNWSVEDIVKGINSNNLES 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSS-------SAESQLLESLPEMVQGVNSDDPEL 73


                  ....*.
gi 399154116   93 QLQATQ 98
Cdd:pfam01749  74 QLEATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 462-509 7.10e-21

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 85.72  E-value: 7.10e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 399154116  462 IMIEECGGLDKIEALQSHENESVYKASLNLIEKYFSVEEE-EDQNVVPE 509
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEeDDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 324-364 6.13e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 51.69  E-value: 6.13e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 399154116  324 TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 9.72e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 50.92  E-value: 9.72e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 399154116  151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 1.52e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.51  E-value: 1.52e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 399154116   151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 135-189 9.74e-08

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 48.52  E-value: 9.74e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 399154116  135 PIQFESAWALTNIASGTSEQTKAVVDGgAIPAFISLLASPHAHISEQAVWALGNI 189
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-406 1.62e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.45  E-value: 1.62e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 399154116  367 QDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTS 406
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
163-320 2.73e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.63  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 163 AIPAFISLLASPHAHISEQAVWALGNIaGDGSvfrdlvikhgAIDPLLALLAVPDlsslacGYLR-NLTWTLSNLcrnkn 241
Cdd:COG1413   17 AVPALIAALADEDPDVRAAAARALGRL-GDPR----------AVPALLEALKDPD------PEVRaAAAEALGRI----- 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 399154116 242 pappldAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDgpneriemvvkKGVVPQLVKLLGATELPIVTPALRAIGNI 320
Cdd:COG1413   75 ------GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 409-447 5.66e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 5.66e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 399154116  409 TVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNI 447
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 366-406 7.73e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.50  E-value: 7.73e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 399154116   366 RQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTS 406
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 324-364 1.35e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.11  E-value: 1.35e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 399154116   324 TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 109-149 2.59e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 43.98  E-value: 2.59e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 399154116  109 QPPIDNIIRAGLIPKFVSFLGKTDCSpIQFESAWALTNIAS 149
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEE-VQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 252-280 1.62e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.06  E-value: 1.62e-05
                          10        20
                  ....*....|....*....|....*....
gi 399154116  252 ILPTLVRLLHHNDPEVLADSCWAISYLTD 280
Cdd:pfam00514  13 AVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 282-322 2.38e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 2.38e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 399154116  282 PNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT 322
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 282-321 7.65e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.11  E-value: 7.65e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 399154116   282 PNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV 321
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 197-238 1.16e-04

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 39.36  E-value: 1.16e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 399154116  197 RDLVIKHGAIDPLLALLAVPDLSSlacgyLRNLTWTLSNLCR 238
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEV-----QEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 108-149 1.17e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.17e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 399154116   108 KQPPIDNIIRAGLIPKFVSFLGKTDcSPIQFESAWALTNIAS 149
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 158-448 1.19e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 45.09  E-value: 1.19e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  158 VVDGGAIPAFISLL--ASPHAHI-SEQAVWALGNIAGDGSVFRDLVIKHGAIDPLLALLAV-PDLSSLACGYLrnlTWTL 233
Cdd:PLN03200   95 VLLGGCIPPLLSLLksGSAEAQKaAAEAIYAVSSGGLSDHVGSKIFSTEGVVPSLWDQLQPgNKQDKVVEGLL---TGAL 171

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  234 SNLCRNKNP--APPLDA--VEqilpTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLG-ATELP 308
Cdd:PLN03200  172 RNLCGSTDGfwSATLEAggVD----ILVKLLSSGNSDAQANAASLLARLMMAFESSISKVLDAGAVKQLLKLLGqGNEVS 247

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116  309 IVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNP-KTNIQKE--------ATWTMSNITAGrqdqiqqvvnhglV 379
Cdd:PLN03200  248 VRAEAAGALEALSSQSKEAKQAIADAGGIPALINATVAPsKEFMQGEfaqalqenAMGALANICGG-------------M 314

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 399154116  380 PFLVGVLSKADFKTQKEA---------AWAITNYTSGGTVEQIVYLVHcgIIEPLMNLLSAKDTKIIQV-ILDAISNIF 448
Cdd:PLN03200  315 SALILYLGELSESPRSPApiadtlgalAYALMVFDSSAESTRAFDPTV--IEQILVKLLKPRDTKLVQErIIEALASLY 391
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 411-447 1.25e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.25e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 399154116   411 EQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNI 447
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 250-280 1.29e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.29e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 399154116   250 EQILPTLVRLLHHNDPEVLADSCWAISYLTD 280
Cdd:smart00185  11 AGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
121-267 1.29e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 1.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 121 IPKFVSFLGKTDcSPIQFESAWALTNIAsgtseqtkavvDGGAIPAFISLLASPHAHISEQAVWALGNIAGDgsvfrdlv 200
Cdd:COG1413   18 VPALIAALADED-PDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDP-------- 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 399154116 201 ikhGAIDPLLALLAVPDLS--SLACGYLRNLtwtlsnlcrnknpappldAVEQILPTLVRLLHHNDPEV 267
Cdd:COG1413   78 ---EAVPALIAALKDEDPEvrRAAAEALGRL------------------GDPAAVPALLEALKDPDWEV 125
HEAT COG1413
HEAT repeat [General function prediction only];
250-401 1.57e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.92  E-value: 1.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116 250 EQILPTLVRLLHHNDPEVLADSCWAISYLTDgpneriemvvkKGVVPQLVKLLGATELPIVTPALRAIGNIvtGTDEQTQ 329
Cdd:COG1413   15 PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--GDPEAVP 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 399154116 330 KVIDAgalavfpslLTNPKTNIQKEATWTMSNITAGRqdqiqqvvnhgLVPFLVGVLSKADFKTQKEAAWAI 401
Cdd:COG1413   82 ALIAA---------LKDEDPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARAL 133
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 231-278 2.00e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 39.27  E-value: 2.00e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 399154116  231 WTLSNLCrNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYL 278
Cdd:pfam13513   9 LALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 78-191 6.07e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.78  E-value: 6.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 399154116   78 VEDIVKGINSNNLESQLQATQAARKLLsREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKA 157
Cdd:PLN03200  191 VDILVKLLSSGNSDAQANAASLLARLM-MAFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSKEAKQA 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 399154116  158 VVDGGAIPAFISLLASP--------HAH-ISEQAVWALGNIAG 191
Cdd:PLN03200  270 IADAGGIPALINATVAPskefmqgeFAQaLQENAMGALANICG 312
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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