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Conserved domains on  [gi|396578170|ref|NP_001257546|]
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solute carrier family 12 member 1 isoform 1 [Rattus norvegicus]

Protein Classification

solute carrier family 12 protein( domain architecture ID 11489985)

solute carrier family 12 protein similar to Arabidopsis thaliana cation-chloride cotransporter 1, which mediates both potassium-chloride and sodium-chloride cotransports and is involved in plant development and Cl(-) homeostasis

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
100-1095 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


:

Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1534.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   100 NTMDAVPKIEYYRNTGSVSGPKVNRPSLQEIHEQLAKNVAVAPGSADRVANGDGMPGDEQAEN----KEEDVTGVVKFGW 175
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   176 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGS 255
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   256 IGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAI 334
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   335 ANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTEGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTML 413
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   414 AIFITTVAYIGVAICVAACVVRDATGSMNDTVVSgmnCNGSAACglgydFSRCQHEPCQYGLMNNFQVMSMVSGFGPLIT 493
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   494 AGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLA 573
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   574 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQA 653
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   654 LSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 733
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   734 WLMKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQ 813
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   814 GFDISpVLQVQDELEkleqerlaleaaikdNDCEEgkggirglfkkagklnitKPAPKKDSNISTIQSMHvgefnqklVE 893
Cdd:TIGR00930  712 GLPIS-VLQVQEELE---------------NDCSE------------------DSIELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   894 ASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHII 972
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   973 GDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1051
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 396578170  1052 SLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1095
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
100-1095 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1534.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   100 NTMDAVPKIEYYRNTGSVSGPKVNRPSLQEIHEQLAKNVAVAPGSADRVANGDGMPGDEQAEN----KEEDVTGVVKFGW 175
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   176 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGS 255
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   256 IGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAI 334
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   335 ANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTEGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTML 413
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   414 AIFITTVAYIGVAICVAACVVRDATGSMNDTVVSgmnCNGSAACglgydFSRCQHEPCQYGLMNNFQVMSMVSGFGPLIT 493
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   494 AGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLA 573
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   574 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQA 653
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   654 LSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 733
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   734 WLMKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQ 813
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   814 GFDISpVLQVQDELEkleqerlaleaaikdNDCEEgkggirglfkkagklnitKPAPKKDSNISTIQSMHvgefnqklVE 893
Cdd:TIGR00930  712 GLPIS-VLQVQEELE---------------NDCSE------------------DSIELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   894 ASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHII 972
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   973 GDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1051
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 396578170  1052 SLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1095
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
690-1095 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 605.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   690 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLMKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 769
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   770 PNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELEkleqERLALEAAIKDNDCEEG 849
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEE----LGLGDETNSSYAEQSSE 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   850 KGGIRGLFKKAGKLNItkpaPKKDSNIS-------TIQSMHVGEFNQKLV------------------EASAQFKKKQGK 904
Cdd:pfam03522  155 EQSTSNSKQDDDKSKL----SKKDSNLSlspdkstKNPSGKDSSKSDKLKkkspsiilrtasnekeilNNITQFQKKQKK 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   905 GTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKES 983
Cdd:pfam03522  231 GTIDVWWLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKET 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   984 WKVFEEMIEPYRLHESHKDLttaeklkrESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISD 1063
Cdd:pfam03522  311 KKFFDELIEPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSA 382
                          410       420       430
                   ....*....|....*....|....*....|..
gi 396578170  1064 LLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1095
Cdd:pfam03522  383 PLYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
186-645 2.17e-38

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 149.28  E-value: 2.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  186 NIWGVMLFIRLSWIVGEAGiGLGVLIILLSTMVTSITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGSIGLIFAFANA 265
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  266 VAVAMYVVGFAETVVDLLkesdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGtvips 345
Cdd:COG0531   103 LAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV----- 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  346 nnekksrGFFNYQASIFAeNFGPSFTEGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGV 425
Cdd:COG0531   169 -------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  426 AICVAACVVRDATGSMNDTVvsgmncngsaacglgydfsrcqhepcqyglmnnFQVMSMVSG--FGPLITAGIFSATLSS 503
Cdd:COG0531   241 SLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGA 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  504 ALASLVSAPKVFQALCKDNIFkgLQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNVIAPIISNFFLASYALINFS 581
Cdd:COG0531   288 LNASILGASRLLYAMARDGLL--PKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALA 365
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 396578170  582 CFHASYaKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWA---AVITYVIELFLYIYVTYKKPDV 645
Cdd:COG0531   366 VIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
 
Name Accession Description Interval E-value
2a30 TIGR00930
K-Cl cotransporter; [Transport and binding proteins, Other]
100-1095 0e+00

K-Cl cotransporter; [Transport and binding proteins, Other]


Pssm-ID: 273347 [Multi-domain]  Cd Length: 953  Bit Score: 1534.66  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   100 NTMDAVPKIEYYRNTGSVSGPKVNRPSLQEIHEQLAKNVAVAPGSADRVANGDGMPGDEQAEN----KEEDVTGVVKFGW 175
Cdd:TIGR00930    1 NTVDAVPRIEHYRNSEGQGGPKRNRPSLEELHDLLDKVVSLLGPLADYTNNGQGMKEHEEAEDaegtKEKPPAGAVKFGW 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   176 VKGVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGS 255
Cdd:TIGR00930   81 VMGVLVPCLLNIWGVILFLRLSWIVGQAGIGLSLLIILLCCCVTTITGLSMSAIATNGVVKGGGAYYLISRSLGPEFGGS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   256 IGLIFAFANAVAVAMYVVGFAETVVDLLKESDS-MMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAI 334
Cdd:TIGR00930  161 IGLIFAFANAVAVAMYVVGFAETVLDLLRENGSkIMVDPINDIRIYGTVTVVVLLGISFAGMEWENKAQVLFLVIVLLSI 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   335 ANFFIGTVIPSNNeKKSRGFFNYQASIFAENFGPSFTEGEG-FFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTML 413
Cdd:TIGR00930  241 LNIFVGTIIPAFD-KPAKGFFGLGNEIFSENFIPGIPGPEGgFFSLFGIFFPSVTGILAGANISGDLKDPQKAIPKGTLL 319
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   414 AIFITTVAYIGVAICVAACVVRDATGSMNDTVVSgmnCNGSAACglgydFSRCQHEPCQYGLMNNFQVMSMVSGFGPLIT 493
Cdd:TIGR00930  320 AILTTTVVYLGSVVLFGACVVRDATGDKNDTLVT---NCTSAAC-----FSECAHNTCSYGLMNNLQVMSLVSPFPPLIT 391
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   494 AGIFSATLSSALASLVSAPKVFQALCKDNIFKGLQFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNVIAPIISNFFLA 573
Cdd:TIGR00930  392 AGIFSATLSSALASLVSAPRLFQALCKDNIYPFLQFFGKGYGKNGEPLRAYLLTAFIAEGFILIAELNTIAPIISNFFLA 471
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   574 SYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGSSTQA 653
Cdd:TIGR00930  472 SYALINFSCFHASLLRSPGWRPRFKYYHWWLSLLGASLCCAIMFLISWWAALVAMVIALFLYKYVTYKKPDVNWGSSTQA 551
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   654 LSYVSALDNALELTTVEDHVKNFRPQCIVLTGGPMTRPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNSGMAKKQA 733
Cdd:TIGR00930  552 LSYSLALYSLLRLEEVEDHVKNWRPQCLVLTGPPVCRPALLDFASQFTKGKGLMICGSVIQGPRLECVKEAQAAEAKIQT 631
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   734 WLMKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMKPNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQ 813
Cdd:TIGR00930  632 WLEKNKVKAFYAVVVADDLREGVRHLIQASGLGRMKPNTLVMGYKKDWRQAEPRAWETYIGIIHDAFDAHLAVVVVRNSE 711
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   814 GFDISpVLQVQDELEkleqerlaleaaikdNDCEEgkggirglfkkagklnitKPAPKKDSNISTIQSMHvgefnqklVE 893
Cdd:TIGR00930  712 GLPIS-VLQVQEELE---------------NDCSE------------------DSIELNDGKISTQPDMH--------LE 749
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   894 ASAQFKKKQGKGTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHII 972
Cdd:TIGR00930  750 ASTQFQKKQGKGTIDVWWLVDDGGLTLLLPYLLTTKKVWKKCKIRIFVGAqKDDRSEQEKKDMATLLYKFRIDAEVIVVL 829
                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   973 GDINIKPNKESWKVFEEMIEPYRLHESHKDLTTAE-KLKRESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVL 1051
Cdd:TIGR00930  830 MDINAKPQTESMEAFEEMIRPFRLHKTEKDREAKDpKMTWTKPWKITDAELQSNVRKSYRQVRLNELLLEYSRDAALVVL 909
                          970       980       990      1000
                   ....*....|....*....|....*....|....*....|....
gi 396578170  1052 SLPVARKGSISDLLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1095
Cdd:TIGR00930  910 SLPVPRKGSIPDELYMAWLEVLSEDLPPVLLVRGNHRNVLTFYS 953
SLC12 pfam03522
Solute carrier family 12;
690-1095 0e+00

Solute carrier family 12;


Pssm-ID: 460955  Cd Length: 414  Bit Score: 605.38  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   690 RPALLDITHAFTKNSGLCICCEVFVGPRKLCVKEMNsgMAKKQAWLMKNKIKAFYAAVAADCFRDGVRSLLQASGLGRMK 769
Cdd:pfam03522    1 RPALVDFAHLITKNVSLMICGHVVKGRLSQKLRSEL--QKKAYRWLRKRKIKAFYALVDGDNLREGAQALLQASGLGKLK 78
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   770 PNTLVIGYKKNWRKAPLSELENYVGIIHDAFDFEIGVVIVRISQGFDISPVLQVQDELEkleqERLALEAAIKDNDCEEG 849
Cdd:pfam03522   79 PNILLMGYKSDWRTCDKEELEEYFNVIHDAFDLQYAVAILRLPEGLDVSHLLQDQDTEE----LGLGDETNSSYAEQSSE 154
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   850 KGGIRGLFKKAGKLNItkpaPKKDSNIS-------TIQSMHVGEFNQKLV------------------EASAQFKKKQGK 904
Cdd:pfam03522  155 EQSTSNSKQDDDKSKL----SKKDSNLSlspdkstKNPSGKDSSKSDKLKkkspsiilrtasnekeilNNITQFQKKQKK 230
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   905 GTIDVWWLFDDGGLTLLIPYILTLRKKWKDCKLRIYVGG-KINRIEEEKISMASLLSKFRIKFADIHIIGDINIKPNKES 983
Cdd:pfam03522  231 GTIDVWWLYDDGGLTLLLPYILSTRSKWSDCKLRVFALGnRKDELEEEQRNMASLLSKFRIDYSDLTVIPDITKKPKKET 310
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   984 WKVFEEMIEPYRLHESHKDLttaeklkrESPWKITDAELEAVKEKSYRQVRLNELLQEHSRAANLIVLSLPVARKGSISD 1063
Cdd:pfam03522  311 KKFFDELIEPFRLHEDDKEE--------ESAEKITDSELEALKEKTNRQLRLRELLLEHSSDANLIVMTLPMPRKGTVSA 382
                          410       420       430
                   ....*....|....*....|....*....|..
gi 396578170  1064 LLYMAWLEILTKNLPPVLLVRGNHKNVLTFYS 1095
Cdd:pfam03522  383 PLYMAWLETLTKDLPPFLLVRGNQTSVLTFYS 414
AA_permease pfam00324
Amino acid permease;
178-681 6.47e-127

Amino acid permease;


Pssm-ID: 366028 [Multi-domain]  Cd Length: 467  Bit Score: 395.54  E-value: 6.47e-127
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   178 GVLVRCMLNIWGVMLFIRLSWIVGEAGIGLGVLIILLSTMVTSITGLSTSAIATNGFVrGGGAYYLISRSLGPEFGGSIG 257
Cdd:pfam00324    1 HVQMIALGGVIGTGLFVGSGSVLGQAGPAGALLGYLISGVVIFLVMLSLGEISTNGPV-SGGFYTYASRFLGPSLGFATG 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   258 L------IFAFANAVAVAMYVVGFAETVVDLLKESdsmmvdptndirIIGSITVVILLGISVAGMEWEAKAQVILLVILL 331
Cdd:pfam00324   80 WnywlswITVLALELTAASILIQFWELVPDIPYLW------------VWGAVFLVLLTIINLVGVKWYGEAEFWFALIKI 147
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   332 IAIANFFIGTVIPSNNEKKSRG--FFNYQASIFAENFGPSFteGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPR 409
Cdd:pfam00324  148 IAIIGFIIVGIILLSGGNPNDGaiFRYLGDNGGKNNFPPGF--GKGFISVFVIAFFAFTGIELVGIAAGEVKNPEKSIPK 225
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   410 GTMLAIFITTVAYIGVAICVAACVVRDATGSMNDTVVSgmncngsaacglgydfsrcqhepcqYGLMNNFQVMSMVSGFG 489
Cdd:pfam00324  226 AILQVIWRITIFYILSLLAIGLLVPWNDPGLLNDSASA-------------------------ASPFVIFFKFLGISGLA 280
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   490 PLITAGIFSATLSSALASLVSAPKVFQALCKDNIFKglqFFAKGYGKNNEPLRGYFLTFVIAMAFILIAELNviAPIISN 569
Cdd:pfam00324  281 PLINAVILTAALSAANSSLYSGSRMLYSLARDGLAP---KFLKKVDKRGVPLRAILVSMVISLLALLLASLN--PAIVFN 355
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   570 FFLASYALINFSCFHASYAKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWAAVITYVIELFLYIYVTYKKPDVNWGS 649
Cdd:pfam00324  356 FLLAISGLSGLIVWGLISLSHLRFRKAFKYQGRSIDELPFKAPLGPLGVILGLAAIIIILIIQFLYAFLPVPGGPKNWGA 435
                          490       500       510
                   ....*....|....*....|....*....|..
gi 396578170   650 STQALSYVSALDNALELTTVEDHVKNFRPQCI 681
Cdd:pfam00324  436 GSFAAAYLIVLLFLIILIGVKLHVKNWKPQLL 467
PotE COG0531
Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];
186-645 2.17e-38

Serine transporter YbeC, amino acid:H+ symporter family [Amino acid transport and metabolism];


Pssm-ID: 440297 [Multi-domain]  Cd Length: 438  Bit Score: 149.28  E-value: 2.17e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  186 NIWGVMLFIRLSWIVGEAGiGLGVLIILLSTMVTSITGLSTSAIATNgFVRGGGAYYLISRSLGPEFGGSIGLIFAFANA 265
Cdd:COG0531    25 AIIGAGIFVLPGLAAGLAG-PAAILAWLIAGLLALLVALSYAELASA-FPRAGGAYTYARRALGPLLGFLAGWALLLSYV 102
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  266 VAVAMYVVGFAETVVDLLkesdsmmvdPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGtvips 345
Cdd:COG0531   103 LAVAAVAVAFGGYLSSLF---------PAGGSVLIALVLILLLTLLNLRGVKESAKVNNILTVLKLLVLLLFIVV----- 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  346 nnekksrGFFNYQASIFAeNFGPSFTEGEGFFSVFAIFFPAATGILAGANISGDLEDPQDAIPRGTMLAIFITTVAYIGV 425
Cdd:COG0531   169 -------GLFAFDPANFT-PFLPAGGGLSGVLAALALAFFAFTGFEAIANLAEEAKNPKRNIPRAIILSLLIVGVLYILV 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  426 AICVAACVVRDATGSMNDTVvsgmncngsaacglgydfsrcqhepcqyglmnnFQVMSMVSG--FGPLITAGIFSATLSS 503
Cdd:COG0531   241 SLALTGVVPYDELAASGAPL---------------------------------ADAAEAVFGpwGAILIALGALLSLLGA 287
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170  504 ALASLVSAPKVFQALCKDNIFkgLQFFAKGYGKNNEPLRGYFLTFVIAMAFILI--AELNVIAPIISNFFLASYALINFS 581
Cdd:COG0531   288 LNASILGASRLLYAMARDGLL--PKVFAKVHPRFGTPVNAILLTGVIALLLLLLgaASFTALASLASVGVLLAYLLVALA 365
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 396578170  582 CFHASYaKSPGWRPAYGIYNMWVSLFGAILCCAVMFVINWWA---AVITYVIELFLYIYVTYKKPDV 645
Cdd:COG0531   366 VIVLRR-RRPDLPRPFRVPLPLIPILGILLCLFLLYLLGPGAlliGLVLLAIGLLLYLLYRRRHPKL 431
AA_permease_N pfam08403
Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid ...
86-153 1.88e-37

Amino acid permease N-terminal; This domain is found to the N-terminus of the amino acid permease domain (pfam00324) in metazoan Na-K-Cl cotransporters.


Pssm-ID: 429977  Cd Length: 70  Bit Score: 134.49  E-value: 1.88e-37
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170    86 DSHTNTYYLQTFGHNTMDAVPKIEYYRNTGSVSGPKVNRPSLQEIHEQLAKNV--AVAPGSADRVANGDG 153
Cdd:pfam08403    1 DTHGSTYYLQTFGHNTLDAVPRIDFYRNTGSVSGVKKSRPSLAELHSQLKKNSalAVAEGSVDGVENGDG 70
AA_permease_2 pfam13520
Amino acid permease;
203-625 1.40e-16

Amino acid permease;


Pssm-ID: 404414 [Multi-domain]  Cd Length: 427  Bit Score: 83.51  E-value: 1.40e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   203 AGIGLGVLIILLSTMVTSITGLSTSAIATNGFVRGGGAYYLISRSLGPEFGGSIGLIFAFANAVAVAMYVVGFAETVVDL 282
Cdd:pfam13520   27 SGGPALIVWGWIAAIIFSLAVGLVYAELSSALPRSGGIYVYLENAFGKFVAFLAGWSNWFAYVLGLASSASVAASYLLSA 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   283 LKESdsmMVDPTNDIRIIGSITVVILLGISVAGMEWEAKAQVILLVILLIAIANFFIGTVIPsnneKKSRGFFNYqASIF 362
Cdd:pfam13520  107 LGPD---LVPTTWLTYGIAIAILIIFAIINIRGVRESAKIQNILGILKLLLPLILIIILGLV----TADGGGFNL-LSGE 178
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   363 AENFGPSFTEGegFFSVFAIFFPAATGILAGANISGdlEDPQDAIPRGTMLAIFITTVAYIGVAICVAACVVRDATGSMN 442
Cdd:pfam13520  179 WHTFFPDGWPG--VFAGFLGVLWSFTGFESAANVSE--EVKKRNVPKAIFIGVIIVGVLYILVNIAFFGVVPDDEIALSS 254
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   443 DTVVSGmncngsaacglgydfsrcqhepcqyGLMNNFQVMSMVSGFgplITAGIFSATLSSALASLVSAPKVFQALCKDN 522
Cdd:pfam13520  255 GLGQVA-------------------------ALLFQAVGGKWGAII---VVILLALSLLGAVNTAIVGASRLLYALARDG 306
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 396578170   523 IFKGLQFFAKgYGKNNEPLRGYFLTFVIAMAFILI-----AELNVIAPIISNFFLASYALINFSCFHASYAKSPGWRpay 597
Cdd:pfam13520  307 VLPFSRFFAK-VNKFGSPIRAIILTAILSLILLLLfllspAAYNALLSLSAYGYLLSYLLPIIGLLILRKKRPDLGR--- 382
                          410       420
                   ....*....|....*....|....*...
gi 396578170   598 gIYNMWVSLFGAILCCAVMFVINWWAAV 625
Cdd:pfam13520  383 -IPGRWPVAIFGILFSLFLIVALFFPPV 409
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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