DUF4150 domain-containing protein [Caenorhabditis elegans]
Protein Classification
transthyretin-like family protein( domain architecture ID 2821)
transthyretin-like family protein similar to Caenorhabditis elegans transthyretin-like protein 52 (TTR-52) that functions as a bridging molecule that mediates recognition and engulfment of apoptotic cells by cross-linking the surface-exposed phosphatidylserine with the extracellular domain of the phagocyte receptor ced-1
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| DUF6795 super family | cl03084 | Domain of unknown function (DUF6795); This domain, mainly found in bacteria and eukaryotes, is ... |
1-49 | 6.53e-15 | ||
Domain of unknown function (DUF6795); This domain, mainly found in bacteria and eukaryotes, is functionally uncharacterized. This domain is approximately 100 amino acids in length and, based on structure prediction and overlaps with other families, belongs to the transthyretin superfamily. It is likely to have a seven stranded beta sandwich fold. The actual alignment was detected with superfamily member pfam01060: Pssm-ID: 470730 Cd Length: 79 Bit Score: 62.98 E-value: 6.53e-15
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| Name | Accession | Description | Interval | E-value | ||
| TTR-52 | pfam01060 | Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to ... |
1-49 | 6.53e-15 | ||
Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure. Pssm-ID: 460046 Cd Length: 79 Bit Score: 62.98 E-value: 6.53e-15
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| Name | Accession | Description | Interval | E-value | ||
| TTR-52 | pfam01060 | Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to ... |
1-49 | 6.53e-15 | ||
Transthyretin-like family; TTR-52 was called family 2 in, and has weak similarity to transthyretin (formerly called pre-albumin) which transports thyroid hormones. The specific function of this protein is as a bridging molecule in apoptosis cross-linking dying cells to phagocytes. TTR-52 bridges by cross-linking surface-exposed phosphatidylserine (PtdSer) on apoptotic cells to the CED-1 receptor, a transmembrane receptor, on phagocytes. TTR-52 has an open beta-barrel-like structure. Pssm-ID: 460046 Cd Length: 79 Bit Score: 62.98 E-value: 6.53e-15
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