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Conserved domains on  [gi|392902053|ref|NP_001255881|]
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Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-330 9.39e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.46  E-value: 9.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  240 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 319
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 392902053  320 QDGLGHPSMSS 330
Cdd:cd00063    79 GGGESPPSESV 89
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
132-403 1.70e-15

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.20  E-value: 1.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  132 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 210
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  211 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 290
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  291 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 370
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 392902053  371 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 403
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 455-546 1.71e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  455 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 533
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 392902053  534 SGCSQPSPPSDFV 546
Cdd:cd00063    80 GGESPPSESVTVT 92
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-688 2.29e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 2.29e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392902053   649 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 688
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
PLN03200 super family cl33659
cellulose synthase-interactive protein; Provisional
 618-825 4.31e-07

cellulose synthase-interactive protein; Provisional


The actual alignment was detected with superfamily member PLN03200:

Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.72  E-value: 4.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  618 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 697
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  698 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 772
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 392902053  773 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 825
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 891-926 3.91e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 3.91e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 392902053   891 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 926
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-330 9.39e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.46  E-value: 9.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  240 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 319
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 392902053  320 QDGLGHPSMSS 330
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
132-403 1.70e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.20  E-value: 1.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  132 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 210
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  211 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 290
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  291 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 370
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 392902053  371 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 403
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 240-324 7.73e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 68.02  E-value: 7.73e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053    240 PLAPGRPTVIAVDGQGVLLEWTPPVADVHSSPPQGYQVEYRVyGSRDWIVANEQlVQENVFTVESLRPNGVYEFRVRGKN 319
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYRE-EGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 392902053    320 QDGLG 324
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 132-221 1.71e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  132 PSAPGVPDVVDAGIGEVTVVWSAPlQSNGGEVRGYQIEMREFPDGEWESMGVDHlLKDTTCRVTNLT-SHEVQFRVSAYG 210
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTP-GSETSYTLTGLKpGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 392902053  211 RTGFGPASNPS 221
Cdd:cd00063    79 GGGESPPSESV 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 455-546 1.71e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  455 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 533
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 392902053  534 SGCSQPSPPSDFV 546
Cdd:cd00063    80 GGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
242-327 2.37e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 2.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053   242 APGRPTVIAVDGQGVLLEWTPPvaDVHSSPPQGYQVEYR-VYGSRDWivaNEQLV--QENVFTVESLRPNGVYEFRVRGK 318
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRpKNSGEPW---NEITVpgTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 392902053   319 NQDGLGHPS 327
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 132-215 8.01e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 8.01e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053    132 PSAPGVPDVVDAGIGEVTVVWSAPLQSNG-GEVRGYQIEMREfPDGEWESMGVDHllKDTTCRVTNLT-SHEVQFRVSAY 209
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYRE-EGSEWKEVNVTP--SSTSYTLTGLKpGTEYEFRVRAV 77


                    ....*.
gi 392902053    210 GRTGFG 215
Cdd:smart00060   78 NGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-688 2.29e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 2.29e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392902053   649 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 688
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 3.45e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.81  E-value: 3.45e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 392902053    649 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSF 689
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 618-825 4.31e-07

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.72  E-value: 4.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  618 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 697
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  698 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 772
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 392902053  773 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 825
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
fn3 pfam00041
Fibronectin type III domain;
355-434 6.84e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 6.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053   355 PPGQPQMVEVGDDVVKLEWAPSVQN----ARYIVEYREVGDPE-WHTANyDPIVQNGIQVEGLHRNSTYEFCVISIVDNI 429
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEpWNEIT-VPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 392902053   430 ASQPS 434
Cdd:pfam00041   81 EGPPS 85
fn3 pfam00041
Fibronectin type III domain;
453-540 1.45e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053   453 PAPNILEapeFLEVDGDKITICWL-PAQSQLPVMGYDVEFRDL--QQDDRWYKVNDQPVFackMTVGDLIMDHDYQFRVL 529
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTpPPDGNGPITGYEVEYRPKnsGEPWNEITVPGTTTS---VTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 392902053   530 AHNASGCSQPS 540
Cdd:pfam00041   75 AVNGGGEGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 461-537 1.97e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.97e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392902053    461 PEFLEVDGDKITICWLPAQSQlPVMGYDVEFR--DLQQDDRWYKVNDQPVfACKMTVGDLIMDHDYQFRVLAHNASGCS 537
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDD-GITGYIVGYRveYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAVNGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 693-734 5.36e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 5.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392902053   693 NDANKLAVMEADGVRLIAEVLRTThDASVKEEAAAALWNLSS 734
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
660-758 2.01e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 42.18  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  660 GGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANklAVMEADGVRLIAEVLrTTHDASVKEEAAAALWNLSSADMLK 739
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQ--AVIDANLIPPLIHLL-SSAEYKIKKEACWAISNATSGGLNR 403

                          90
                  ....*....|....*....
gi 392902053  740 PVILESateILSQQVIAPV 758
Cdd:COG5064   404 PDIIRY---LVSQGFIKPL 419
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 891-926 3.91e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 3.91e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 392902053   891 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 926
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 693-734 4.66e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.87  E-value: 4.66e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 392902053    693 NDANKLAVMEADGVRLIAEVLRTTHDaSVKEEAAAALWNLSS 734
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDE-EVVKEAAWALSNLSS 41
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 240-330 9.39e-18

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 79.46  E-value: 9.39e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  240 PLAPGRPTVIAVDGQGVLLEWTPPVADvhSSPPQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKN 319
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPPEDD--GGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 392902053  320 QDGLGHPSMSS 330
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
132-403 1.70e-15

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 81.20  E-value: 1.70e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  132 PSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGVdhlLKDTTCRVTNLTS-HEVQFRVSAYg 210
Cdd:COG3401   233 PSAPTGLTATADTPGSVTLSWDP---VTESDATGYRVYRSNSGDGPFTKVAT---VTTTSYTDTGLTNgTTYYYRVTAV- 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  211 rTGFGPASNPSLPVKIpisetdlATSAGAPLAPGRPTVIAVDGQGVLLEWTPpvadVHSSPPQGYQVEYRVYGSRDWIVA 290
Cdd:COG3401   306 -DAAGNESAPSNVVSV-------TTDLTPPAAPSGLTATAVGSSSITLSWTA----SSDADVTGYNVYRSTSGGGTYTKI 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  291 NEqLVQENVFTVESLRPNGVYEFRVRGKNQDGLGhpSMSSGGVAIRPAApqrhVPARKVSESVQPPGQPQMVEVGDDVVK 370
Cdd:COG3401   374 AE-TVTTTSYTDTGLTPGTTYYYKVTAVDAAGNE--SAPSEEVSATTAS----AASGESLTASVDAVPLTDVAGATAAAS 446

                         250       260       270
                  ....*....|....*....|....*....|...
gi 392902053  371 LEWAPSVQNARYIVEYREVGDPEWHTANYDPIV 403
Cdd:COG3401   447 AASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA 479
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 240-324 7.73e-14

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 68.02  E-value: 7.73e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053    240 PLAPGRPTVIAVDGQGVLLEWTPPVADVHSSPPQGYQVEYRVyGSRDWIVANEQlVQENVFTVESLRPNGVYEFRVRGKN 319
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYRE-EGSEWKEVNVT-PSSTSYTLTGLKPGTEYEFRVRAVN 78


                    ....*
gi 392902053    320 QDGLG 324
Cdd:smart00060   79 GAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 132-221 1.71e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.44  E-value: 1.71e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  132 PSAPGVPDVVDAGIGEVTVVWSAPlQSNGGEVRGYQIEMREFPDGEWESMGVDHlLKDTTCRVTNLT-SHEVQFRVSAYG 210
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWTPP-EDDGGPITGYVVEYREKGSGDWKEVEVTP-GSETSYTLTGLKpGTEYEFRVRAVN 78

                          90
                  ....*....|.
gi 392902053  211 RTGFGPASNPS 221
Cdd:cd00063    79 GGGESPPSESV 89
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
203-440 1.85e-12

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 71.57  E-value: 1.85e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  203 QFRVSAYGRTGFGPASNPslpvkipISETDLATsagAPLAPGRPTVIAVDGQGVLLEWTP-PVADVhssppQGYQVEYRV 281
Cdd:COG3401   206 YYRVAATDTGGESAPSNE-------VSVTTPTT---PPSAPTGLTATADTPGSVTLSWDPvTESDA-----TGYRVYRSN 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  282 YGSRDW-IVANeqlVQENVFTVESLRPNGVYEFRVRGKNQDGLghPSMSSGGVairpaapqrhvparKVSESVQPPGQPQ 360
Cdd:COG3401   271 SGDGPFtKVAT---VTTTSYTDTGLTNGTTYYYRVTAVDAAGN--ESAPSNVV--------------SVTTDLTPPAAPS 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  361 MVEV---GDDVVKLEWAPSVQN--ARYIVEYREVGDPEWHTANyDPIVQNGIQVEGLHRNSTYEFCVISI-VDNIASQPS 434
Cdd:COG3401   332 GLTAtavGSSSITLSWTASSDAdvTGYNVYRSTSGGGTYTKIA-ETVTTTSYTDTGLTPGTTYYYKVTAVdAAGNESAPS 410


                  ....*.
gi 392902053  435 ETSDII 440
Cdd:COG3401   411 EEVSAT 416
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 355-440 1.21e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 62.13  E-value: 1.21e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  355 PPGQPQMVEVGDDVVKLEWAPSVQNAR----YIVEYREVGDPEWHTANYDPIVQNGIQVEGLHRNSTYEFCVISIVDNIA 430
Cdd:cd00063     3 PPTNLRVTDVTSTSVTLSWTPPEDDGGpitgYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGE 82

                          90
                  ....*....|
gi 392902053  431 SQPSETSDII 440
Cdd:cd00063    83 SPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 455-546 1.71e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.74  E-value: 1.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  455 PNILEAPEFLEVDGDKITICW-LPAQSQLPVMGYDVEFRDLQqDDRWYKVNDQPVFACKMTVGDLIMDHDYQFRVLAHNA 533
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKG-SGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNG 79

                          90
                  ....*....|...
gi 392902053  534 SGCSQPSPPSDFV 546
Cdd:cd00063    80 GGESPPSESVTVT 92
fn3 pfam00041
Fibronectin type III domain;
242-327 2.37e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 60.89  E-value: 2.37e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053   242 APGRPTVIAVDGQGVLLEWTPPvaDVHSSPPQGYQVEYR-VYGSRDWivaNEQLV--QENVFTVESLRPNGVYEFRVRGK 318
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRpKNSGEPW---NEITVpgTTTSVTLTGLKPGTEYEVRVQAV 76


                   ....*....
gi 392902053   319 NQDGLGHPS 327
Cdd:pfam00041   77 NGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
141-563 2.90e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.72  E-value: 2.90e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  141 VDAGIGEVTVVWSAPLQSNGGEVRGYQIEMREFPDGEWESMGVDHLLKDTTCRVTNLTSHEVQFRVSAYGRTGFGPASNP 220
Cdd:COG3401    34 KTILVYLAVVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  221 SLPVKIPISETDLATSAGAPLAPGRPTVIAVDG-QGVLLEWTPPVADVHSSPPQGYQVEYRVYGSRDWIVANEQLVQENV 299
Cdd:COG3401   114 SDEVPSPAVGTATTATAVAGGAATAGTYALGAGlYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLV 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  300 FTVESLRPNGVYEFRVRGKNQDGLGHPSmssggvairpaapqrhvPARKVSESVQPPGQPQMVEV---GDDVVKLEWAPS 376
Cdd:COG3401   194 DGGGDIEPGTTYYYRVAATDTGGESAPS-----------------NEVSVTTPTTPPSAPTGLTAtadTPGSVTLSWDPV 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  377 VQN--ARYIVEYREVGDPEW------HTANY-DPIVQNGiqveglhrnSTYEFCVISI-VDNIASQPSETSdiihlrpTC 446
Cdd:COG3401   257 TESdaTGYRVYRSNSGDGPFtkvatvTTTSYtDTGLTNG---------TTYYYRVTAVdAAGNESAPSNVV-------SV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  447 NTSALRPApnileAPEFLEV---DGDKITICWLPAqSQLPVMGYDVEfRDLQQDDRWYKVN---DQPVFackmTVGDLIM 520
Cdd:COG3401   321 TTDLTPPA-----APSGLTAtavGSSSITLSWTAS-SDADVTGYNVY-RSTSGGGTYTKIAetvTTTSY----TDTGLTP 389

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 392902053  521 DHDYQFRVLAHNASGCSqpSPPSDFVHIEPSTNRFSSDTMESP 563
Cdd:COG3401   390 GTTYYYKVTAVDAAGNE--SAPSEEVSATTASAASGESLTASV 430
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
105-322 7.41e-08

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 56.88  E-value: 7.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  105 ASDHDSEDRSAPPPAPASRFLHEdsgipsapgVPDVVDAGIGEVTVV--WSAPLQSNGgevrgYQIEMREfPDGEWESMG 182
Cdd:COG4733   518 AIDAGAFDDVPPQWPPVNVTTSE---------SLSVVAQGTAVTTLTvsWDAPAGAVA-----YEVEWRR-DDGNWVSVP 582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  183 VDHllkDTTCRVTNLTSHEVQFRVSAYGRtgFGPASNPSLPvkipiSETDLATSAGAPLAPGRPTVIAVDGqGVLLEWTP 262
Cdd:COG4733   583 RTS---GTSFEVPGIYAGDYEVRVRAINA--LGVSSAWAAS-----SETTVTGKTAPPPAPTGLTATGGLG-GITLSWSF 651

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392902053  263 PV-ADVhssppQGYQVEYRVYGSRDWIVANEQLVQENVFTVESLRPNGVYEFRVRGKNQDG 322
Cdd:COG4733   652 PVdADT-----LRTEIRYSTTGDWASATVAQALYPGNTYTLAGLKAGQTYYYRARAVDRSG 707
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 132-215 8.01e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.69  E-value: 8.01e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053    132 PSAPGVPDVVDAGIGEVTVVWSAPLQSNG-GEVRGYQIEMREfPDGEWESMGVDHllKDTTCRVTNLT-SHEVQFRVSAY 209
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGItGYIVGYRVEYRE-EGSEWKEVNVTP--SSTSYTLTGLKpGTEYEFRVRAV 77


                    ....*.
gi 392902053    210 GRTGFG 215
Cdd:smart00060   78 NGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-688 2.29e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 48.22  E-value: 2.29e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392902053   649 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLS 688
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 649-689 3.45e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 47.81  E-value: 3.45e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 392902053    649 DNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSF 689
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 618-825 4.31e-07

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 54.72  E-value: 4.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  618 PSLKEVIEYLSSADKDKQLNASGYLQHLTYTDNQIKEETREYGGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANK 697
Cdd:PLN03200  147 PSLWDQLQPGNKQDKVVEGLLTGALRNLCGSTDGFWSATLEAGGVDILVKLLSSGNSDAQANAASLLARLMMAFESSISK 226

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  698 laVMEADGVRLIAEVLRTTHDASVKEEAAAALWNLSSADMlkpvilESATEILSQQVIaPVLAVGTSDPTRHF-----GS 772
Cdd:PLN03200  227 --VLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSK------EAKQAIADAGGI-PALINATVAPSKEFmqgefAQ 297

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 392902053  773 TLFKNSTGVLRNVSAAsqqarrrlrdipnlIEALVHFLTHAIQKSQVDSPTVE 825
Cdd:PLN03200  298 ALQENAMGALANICGG--------------MSALILYLGELSESPRSPAPIAD 336
fn3 pfam00041
Fibronectin type III domain;
355-434 6.84e-07

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 48.18  E-value: 6.84e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053   355 PPGQPQMVEVGDDVVKLEWAPSVQN----ARYIVEYREVGDPE-WHTANyDPIVQNGIQVEGLHRNSTYEFCVISIVDNI 429
Cdd:pfam00041    2 APSNLTVTDVTSTSLTVSWTPPPDGngpiTGYEVEYRPKNSGEpWNEIT-VPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 392902053   430 ASQPS 434
Cdd:pfam00041   81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 355-425 3.22e-06

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 46.45  E-value: 3.22e-06
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392902053    355 PPGQPQMVEVGDDVVKLEWAPSVQNA--RYIVEYREVG---DPEWHTANYDPIvQNGIQVEGLHRNSTYEFCVISI 425
Cdd:smart00060    3 PPSNLRVTDVTSTSVTLSWEPPPDDGitGYIVGYRVEYreeGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAV 77
fn3 pfam00041
Fibronectin type III domain;
453-540 1.45e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.33  E-value: 1.45e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053   453 PAPNILEapeFLEVDGDKITICWL-PAQSQLPVMGYDVEFRDL--QQDDRWYKVNDQPVFackMTVGDLIMDHDYQFRVL 529
Cdd:pfam00041    1 SAPSNLT---VTDVTSTSLTVSWTpPPDGNGPITGYEVEYRPKnsGEPWNEITVPGTTTS---VTLTGLKPGTEYEVRVQ 74

                           90
                   ....*....|.
gi 392902053   530 AHNASGCSQPS 540
Cdd:pfam00041   75 AVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
128-266 1.76e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.85  E-value: 1.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  128 DSGIPSAPGVPDVVDAGIGEVTVVWSAplqSNGGEVRGYQIEMREFPDGEWESMGvdHLLKDTTCRVTNLTS-HEVQFRV 206
Cdd:COG3401   323 DLTPPAAPSGLTATAVGSSSITLSWTA---SSDADVTGYNVYRSTSGGGTYTKIA--ETVTTTSYTDTGLTPgTTYYYKV 397

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  207 SAYGRTgfGPASNPSLPVKIPISETDLATSAGAPLAPGRPTVIAVDGQGVLLEWTPPVAD 266
Cdd:COG3401   398 TAVDAA--GNESAPSEEVSATTASAASGESLTASVDAVPLTDVAGATAAASAASNPGVSA 455
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 461-537 1.97e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 44.14  E-value: 1.97e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392902053    461 PEFLEVDGDKITICWLPAQSQlPVMGYDVEFR--DLQQDDRWYKVNDQPVfACKMTVGDLIMDHDYQFRVLAHNASGCS 537
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDD-GITGYIVGYRveYREEGSEWKEVNVTPS-STSYTLTGLKPGTEYEFRVRAVNGAGEG 83
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 693-734 5.36e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 5.36e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392902053   693 NDANKLAVMEADGVRLIAEVLRTThDASVKEEAAAALWNLSS 734
Cdd:pfam00514    1 SPENKQAVIEAGAVPPLVRLLSSP-DEEVQEEAAWALSNLAA 41
Tissue_fac pfam01108
Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type ...
 233-318 1.37e-03

Tissue factor; This family is found in metazoa, and is very similar to the fibronectin type III domain. The family is found in cytokine receptors, interleukin and interferon receptors and coagulation factor III proteins. It occurs multiple times, as does fn3, family pfam00041.


Pssm-ID: 460067  Cd Length: 107  Bit Score: 39.67  E-value: 1.37e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053   233 LATSAGAPLAPGRPTVIAVDGQGVLlEWTPpvaDVHSSPPQGYQVEYRVYGSRDWI-VANEQLVQENV--FTVESLRPNG 309
Cdd:pfam01108   15 SAAGGPSLPAPQNVTFQSTNFKNIL-TWEP---GPNSPPDVVYTVQYKIYGSGDWKnVPNCTNITRTEcdLTDETSDLTE 90


                   ....*....
gi 392902053   310 VYEFRVRGK 318
Cdd:pfam01108   91 TYYARVRAV 99
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
660-758 2.01e-03

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 42.18  E-value: 2.01e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392902053  660 GGIPKLIALLRSDTPRIQKNACACLKNLSFGKENDANklAVMEADGVRLIAEVLrTTHDASVKEEAAAALWNLSSADMLK 739
Cdd:COG5064   327 GALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQ--AVIDANLIPPLIHLL-SSAEYKIKKEACWAISNATSGGLNR 403

                          90
                  ....*....|....*....
gi 392902053  740 PVILESateILSQQVIAPV 758
Cdd:COG5064   404 PDIIRY---LVSQGFIKPL 419
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 891-926 3.91e-03

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 36.28  E-value: 3.91e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 392902053   891 VLWQPHVVKLYLKLLQdSSNIETLEASAGAIQNLAA 926
Cdd:pfam00514    7 AVIEAGAVPPLVRLLS-SPDEEVQEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 693-734 4.66e-03

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 35.87  E-value: 4.66e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 392902053    693 NDANKLAVMEADGVRLIAEVLRTTHDaSVKEEAAAALWNLSS 734
Cdd:smart00185    1 DDENKQAVVDAGGLPALVELLKSEDE-EVVKEAAWALSNLSS 41
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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