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Conserved domains on  [gi|392899919|ref|NP_001255360|]
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NR LBD domain-containing protein [Caenorhabditis elegans]

Protein Classification

nuclear hormone receptor family protein( domain architecture ID 10648245)

nuclear hormone receptor family protein is a ligand-regulated transcriptional modulator that may play a role in many developmental processes; similar to Caenorhabditis elegans nuclear hormone receptor family members

CATH:  1.10.565.10
Gene Ontology:  GO:0004879
SCOP:  4001384

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
HOLI smart00430
Ligand binding domain of hormone receptors;
65-244 1.09e-19

Ligand binding domain of hormone receptors;


:

Pssm-ID: 214658  Cd Length: 163  Bit Score: 83.57  E-value: 1.09e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919    65 LRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLGQAHrqMVLTNGEYLNMDPLpmsgneidarr 144
Cdd:smart00430   1 AERQLLLTVEWAKSFPGFRELSLEDQIVLLKSFWFELLLLELAYRSVKLKKEL--LLAPDGTYIRPDAV----------- 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919   145 yfdcdedFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYFKLTENGREKCRRQRNIIIGFLSKMC-H 223
Cdd:smart00430  68 -------LELRKLFSPFLDRILSELVKPLRELKLDDEEYALLKAIVLFNPAVPGLSEEGKEIVEKLQEKYANALHDYYlK 140
                          170       180
                   ....*....|....*....|.
gi 392899919   224 SPGGGGEHRVGELLMSMNYLR 244
Cdd:smart00430 141 NYPMNYPGRFAKLLLILPELR 161
 
Name Accession Description Interval E-value
HOLI smart00430
Ligand binding domain of hormone receptors;
65-244 1.09e-19

Ligand binding domain of hormone receptors;


Pssm-ID: 214658  Cd Length: 163  Bit Score: 83.57  E-value: 1.09e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919    65 LRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLGQAHrqMVLTNGEYLNMDPLpmsgneidarr 144
Cdd:smart00430   1 AERQLLLTVEWAKSFPGFRELSLEDQIVLLKSFWFELLLLELAYRSVKLKKEL--LLAPDGTYIRPDAV----------- 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919   145 yfdcdedFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYFKLTENGREKCRRQRNIIIGFLSKMC-H 223
Cdd:smart00430  68 -------LELRKLFSPFLDRILSELVKPLRELKLDDEEYALLKAIVLFNPAVPGLSEEGKEIVEKLQEKYANALHDYYlK 140
                          170       180
                   ....*....|....*....|.
gi 392899919   224 SPGGGGEHRVGELLMSMNYLR 244
Cdd:smart00430 141 NYPMNYPGRFAKLLLILPELR 161
Hormone_recep pfam00104
Ligand-binding domain of nuclear hormone receptor; This all helical domain is involved in ...
50-245 4.74e-13

Ligand-binding domain of nuclear hormone receptor; This all helical domain is involved in binding the hormone in these receptors.


Pssm-ID: 459675 [Multi-domain]  Cd Length: 194  Bit Score: 66.22  E-value: 4.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919   50 VNDLRPHDYRNFRGMLRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLgqaHRQMVLTNGEYLN 129
Cdd:pfam00104   5 LKKLRKATKEELCELWERDLLLVAEWAKHFPEFQELPLEDQMALLKSFWLEWLRLEKAARSAKL---RRKKILGEDVLMI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919  130 MDPLPMSGNEIDARryFDCDEDFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYFKLTENGREKCRR 209
Cdd:pfam00104  82 SDDDAMKFVEDDSS--WCTNYDLEQLLFFLPFFNSYFFELVKPLRELNPDDEELAYLLAQLLFDYAGDGLSGEILEIVEK 159
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 392899919  210 QRNIIIGFLSKMCHSpggGGEHRVGELLMSMNYLRE 245
Cdd:pfam00104 160 LQEKLANELHDYYVN---KYSGRLAKLLKILPSLRK 192
NR_LBD cd06157
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription ...
60-245 8.95e-13

The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Ligand-binding domain (LBD) of nuclear receptor (NR): Nuclear receptors form a superfamily of ligand-activated transcription regulators, which regulate various physiological functions in metazoans, from development, reproduction, to homeostasis and metabolism. The superfamily contains not only receptors for known ligands but also orphan receptors for which ligands do not exist or have not been identified. The members of the family include receptors of steroids, thyroid hormone, retinoids, cholesterol by-products, lipids and heme. With few exceptions, NRs share a common structural organization with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).


Pssm-ID: 132726  Cd Length: 168  Bit Score: 64.63  E-value: 8.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919  60 NFRGMLRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLGqahrqmvltngeylnmdplpMSGNE 139
Cdd:cd06157    2 LLCELATRDLLLIVEWAKSIPGFRELPLEDQIVLLKSFWLELLVLDLAYRSYKNG--------------------LSLLL 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919 140 IDARRYFDCDEDFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYfKLTENGREKCRRQRNIIIGFLS 219
Cdd:cd06157   62 APNGGHTDDDKEDEMKLLLKGELIRLLFEFVNPLRALKLDDEEYALLKAIVLFSPDR-KESLEDRKIVEELQERLLEALQ 140
                        170       180
                 ....*....|....*....|....*..
gi 392899919 220 KMCHS-PGGGGEHRVGELLMSMNYLRE 245
Cdd:cd06157  141 DYLRKnYPEEAPSRFAKLLLLLPSLRK 167
 
Name Accession Description Interval E-value
HOLI smart00430
Ligand binding domain of hormone receptors;
65-244 1.09e-19

Ligand binding domain of hormone receptors;


Pssm-ID: 214658  Cd Length: 163  Bit Score: 83.57  E-value: 1.09e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919    65 LRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLGQAHrqMVLTNGEYLNMDPLpmsgneidarr 144
Cdd:smart00430   1 AERQLLLTVEWAKSFPGFRELSLEDQIVLLKSFWFELLLLELAYRSVKLKKEL--LLAPDGTYIRPDAV----------- 67
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919   145 yfdcdedFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYFKLTENGREKCRRQRNIIIGFLSKMC-H 223
Cdd:smart00430  68 -------LELRKLFSPFLDRILSELVKPLRELKLDDEEYALLKAIVLFNPAVPGLSEEGKEIVEKLQEKYANALHDYYlK 140
                          170       180
                   ....*....|....*....|.
gi 392899919   224 SPGGGGEHRVGELLMSMNYLR 244
Cdd:smart00430 141 NYPMNYPGRFAKLLLILPELR 161
Hormone_recep pfam00104
Ligand-binding domain of nuclear hormone receptor; This all helical domain is involved in ...
50-245 4.74e-13

Ligand-binding domain of nuclear hormone receptor; This all helical domain is involved in binding the hormone in these receptors.


Pssm-ID: 459675 [Multi-domain]  Cd Length: 194  Bit Score: 66.22  E-value: 4.74e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919   50 VNDLRPHDYRNFRGMLRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLgqaHRQMVLTNGEYLN 129
Cdd:pfam00104   5 LKKLRKATKEELCELWERDLLLVAEWAKHFPEFQELPLEDQMALLKSFWLEWLRLEKAARSAKL---RRKKILGEDVLMI 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919  130 MDPLPMSGNEIDARryFDCDEDFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYFKLTENGREKCRR 209
Cdd:pfam00104  82 SDDDAMKFVEDDSS--WCTNYDLEQLLFFLPFFNSYFFELVKPLRELNPDDEELAYLLAQLLFDYAGDGLSGEILEIVEK 159
                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 392899919  210 QRNIIIGFLSKMCHSpggGGEHRVGELLMSMNYLRE 245
Cdd:pfam00104 160 LQEKLANELHDYYVN---KYSGRLAKLLKILPSLRK 192
NR_LBD cd06157
The ligand binding domain of nuclear receptors, a family of ligand-activated transcription ...
60-245 8.95e-13

The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators; Ligand-binding domain (LBD) of nuclear receptor (NR): Nuclear receptors form a superfamily of ligand-activated transcription regulators, which regulate various physiological functions in metazoans, from development, reproduction, to homeostasis and metabolism. The superfamily contains not only receptors for known ligands but also orphan receptors for which ligands do not exist or have not been identified. The members of the family include receptors of steroids, thyroid hormone, retinoids, cholesterol by-products, lipids and heme. With few exceptions, NRs share a common structural organization with a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a non-conserved hinge and a C-terminal ligand binding domain (LBD).


Pssm-ID: 132726  Cd Length: 168  Bit Score: 64.63  E-value: 8.95e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919  60 NFRGMLRHDFVMLFDYATRFPEFNSFTSHEKNMFYRQIVAVDFILSSAYYTAKLGqahrqmvltngeylnmdplpMSGNE 139
Cdd:cd06157    2 LLCELATRDLLLIVEWAKSIPGFRELPLEDQIVLLKSFWLELLVLDLAYRSYKNG--------------------LSLLL 61
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899919 140 IDARRYFDCDEDFSKYRALMPMHIAIWEESIVPFSKLNVTFEEFCLLKALTVWQATYfKLTENGREKCRRQRNIIIGFLS 219
Cdd:cd06157   62 APNGGHTDDDKEDEMKLLLKGELIRLLFEFVNPLRALKLDDEEYALLKAIVLFSPDR-KESLEDRKIVEELQERLLEALQ 140
                        170       180
                 ....*....|....*....|....*..
gi 392899919 220 KMCHS-PGGGGEHRVGELLMSMNYLRE 245
Cdd:cd06157  141 DYLRKnYPEEAPSRFAKLLLLLPSLRK 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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