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Conserved domains on  [gi|392899864|ref|NP_001255352|]
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Ig-like and fibronectin type-III domain-containing protein C27B7.7 [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 530-628 2.31e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  530 DAPTQIQVLSVNALDALVVWHSPQFPNSPITSYIVLVSnddKEDKSTWLQYESNAKETqiNRMLLPtgNLEKSTEYFVCV 609
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR---EKGSGDWKEVEVTPGSE--TSYTLT--GLKPGTEYEFRV 74

                          90
                  ....*....|....*....
gi 392899864  610 RAKNAAGIGPTSSLISFIT 628
Cdd:cd00063    75 RAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 635-733 2.73e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  635 SPPDNLKVLINEANQVIVYWNTPNST-TEVTGYLIYYTRDlslsndDYKNWQFVEMNN-NSTRYKFDlsvGLKPKTFYRV 712
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREK------GSGDWKEVEVTPgSETSYTLT---GLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 392899864  713 RISGKNSHADGPASEVVEFET 733
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 133-224 7.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 7.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  133 PKAPLIVNTKILYNSSVLISF-VPADDVNAIENYTLMYKQMEAEEWKSLNFKSDFDGKVLLDGLIPNHTYEIKIFVTGGI 211
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 392899864  212 VQGTPSNLATFTT 224
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 954-1043 8.77e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 8.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  954 NPPENIILTAY-RNQINVTWQESTLPNGDIMKYIVYYSENENDDLSDWNKFETAELETYVETFGPHTKHFIRVQAVSDRG 1032
Cdd:cd00063     2 SPPTNLRVTDVtSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 392899864 1033 PGIISNVLSCI 1043
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
54-364 3.35e-05

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.46  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   54 SVTGYKLYYTNDSSQTNEEYekwmhqeALSNQNSYnfvIDANkheIVSGDVY--RVRAtVFFNNVESVPTGVISINTRQS 131
Cdd:COG3401   260 DATGYRVYRSNSGDGPFTKV-------ATVTTTSY---TDTG---LTNGTTYyyRVTA-VDAAGNESAPSNVVSVTTDLT 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  132 IPKAPLIVNTKILYNSSVLISFVPADDVNAIeNYTLMYKQMEAEEWKSLNfkSDFDGKVLLD-GLIPNHTYEIKIF-VTG 209
Cdd:COG3401   326 PPAAPSGLTATAVGSSSITLSWTASSDADVT-GYNVYRSTSGGGTYTKIA--ETVTTTSYTDtGLTPGTTYYYKVTaVDA 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  210 GIVQGTPSNLATFTTNSTALALVKTEPDEEYTADPQ--TNEPLSITCTVKSVSKASVLWKVNGIKVSVDSSFYTVVTSVH 287
Cdd:COG3401   403 AGNESAPSEEVSATTASAASGESLTASVDAVPLTDVagATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTT 482

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  288 E---DFIESTIRAKSRTRSAKFTCLATNDAGDSSKEVNVIIKGPGSPPSEITLVAEKRGYTISWKPPSHPNGKITKYVVY 364
Cdd:COG3401   483 DtttANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVS 562
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 868-949 4.84e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05730:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 95  Bit Score: 43.77  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  868 NLFEELSVTCTGMGSPAPIITWEWMNKSIENGTEGWnILNIQIDDTTVVsKITRNnirESGDLTCLANNNEGSSSASVEI 947
Cdd:cd05730    16 NLGQSVTLACDADGFPEPTMTWTKDGEPIESGEEKY-SFNEDGSEMTIL-DVDKL---DEAEYTCIAENKAGEQEAEIHL 90


                  ..
gi 392899864  948 RV 949
Cdd:cd05730    91 KV 92
fn3 pfam00041
Fibronectin type III domain;
330-414 5.52e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 5.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   330 SPPSEITLVAEKRGY-TISWKPPSHPNGKITKYVV-YHTLNREDPlsdWRKIDLDGSEKMVRIIMDTEESFY-GRVQAAT 406
Cdd:pfam00041    1 SAPSNLTVTDVTSTSlTVSWTPPPDGNGPITGYEVeYRPKNSGEP---WNEITVPGTTTSVTLTGLKPGTEYeVRVQAVN 77


                   ....*...
gi 392899864   407 ELGPGIIS 414
Cdd:pfam00041   78 GGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1249-1337 1.62e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864 1249 DSKVYIFWVEPRLPNGEIQNYTIYIQKENeseneehsiDKEWKKFIYG-SNITHVIIgvdDGLEENERYQMKMTATNQRH 1327
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKG---------SGDWKEVEVTpGSETSYTL---TGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|
gi 392899864 1328 EGPETKVYTF 1337
Cdd:cd00063    82 ESPPSESVTV 91
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 436-463 3.35e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05874:

Pssm-ID: 472250  Cd Length: 95  Bit Score: 38.43  E-value: 3.35e-03
                          10        20
                  ....*....|....*....|....*...
gi 392899864  436 SATTMVVNPRETLSIQCTARGKPRPSIS 463
Cdd:cd05874     7 SPKDYIVDPRENIVIQCEAKGKPPPSFS 34
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 530-628 2.31e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  530 DAPTQIQVLSVNALDALVVWHSPQFPNSPITSYIVLVSnddKEDKSTWLQYESNAKETqiNRMLLPtgNLEKSTEYFVCV 609
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR---EKGSGDWKEVEVTPGSE--TSYTLT--GLKPGTEYEFRV 74

                          90
                  ....*....|....*....
gi 392899864  610 RAKNAAGIGPTSSLISFIT 628
Cdd:cd00063    75 RAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 635-733 2.73e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  635 SPPDNLKVLINEANQVIVYWNTPNST-TEVTGYLIYYTRDlslsndDYKNWQFVEMNN-NSTRYKFDlsvGLKPKTFYRV 712
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREK------GSGDWKEVEVTPgSETSYTLT---GLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 392899864  713 RISGKNSHADGPASEVVEFET 733
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
530-621 1.27e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 1.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   530 DAPTQIQVLSVNALDALVVWHSPQFPNSPITSYIVLVSNDDKEDKSTWLQYESNAKETQINrmllptgNLEKSTEYFVCV 609
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLT-------GLKPGTEYEVRV 73

                           90
                   ....*....|..
gi 392899864   610 RAKNAAGIGPTS 621
Cdd:pfam00041   74 QAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 133-224 7.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 7.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  133 PKAPLIVNTKILYNSSVLISF-VPADDVNAIENYTLMYKQMEAEEWKSLNFKSDFDGKVLLDGLIPNHTYEIKIFVTGGI 211
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 392899864  212 VQGTPSNLATFTT 224
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
510-760 6.21e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.40  E-value: 6.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  510 AKNSAGSNYSTMELKVDKPgDAPTQIQVLSVNALDALVVWHSPqfPNSPITSYIVLVSNDDKEDkstwLQYESNAKETQI 589
Cdd:COG3401   215 GGESAPSNEVSVTTPTTPP-SAPTGLTATADTPGSVTLSWDPV--TESDATGYRVYRSNSGDGP----FTKVATVTTTSY 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  590 NRMllptgNLEKSTEYFVCVRAKNAAGIGPTSSLISFITLNGGPDSPPDNLKVLINEANQVIVYWNtPNSTTEVTGYLIY 669
Cdd:COG3401   288 TDT-----GLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWT-ASSDADVTGYNVY 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  670 YtrdlslSNDDYKNWQFVEMNNNSTRYKFDlsvGLKPKTFYRVRISGKNshADGPASEVVEFETAYSEVPIPTDLKTEVL 749
Cdd:COG3401   362 R------STSGGGTYTKIAETVTTTSYTDT---GLTPGTTYYYKVTAVD--AAGNESAPSEEVSATTASAASGESLTASV 430

                         250
                  ....*....|.
gi 392899864  750 DDNTIHIKFNA 760
Cdd:COG3401   431 DAVPLTDVAGA 441
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
596-765 2.73e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 2.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  596 TGNLEKSTEYFVCVRAKNAAGIGPTSSLISFITLNGGPdSPPDNLKVLINEANQVIVYWnTPNSTTEVTGYLIYYtrdls 675
Cdd:COG3401   196 GGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADTPGSVTLSW-DPVTESDATGYRVYR----- 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  676 lSNDDYKNWQFVEmNNNSTRYkfdLSVGLKPKTFYRVRISGKN-SHADGPASEVVEFETAYSEVPIPTDLKTEVLDDNTI 754
Cdd:COG3401   269 -SNSGDGPFTKVA-TVTTTSY---TDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSI 343

                         170
                  ....*....|.
gi 392899864  755 HIKFNAVRDPD 765
Cdd:COG3401   344 TLSWTASSDAD 354
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 635-720 3.19e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 3.19e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864    635 SPPDNLKVLINEANQVIVYWNTPNSTTeVTGYLIYYTRdlsLSNDDYKNWQFVEMNNNSTRYKFDlsvGLKPKTFYRVRI 714
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRV---EYREEGSEWKEVNVTPSSTSYTLT---GLKPGTEYEFRV 74


                    ....*.
gi 392899864    715 SGKNSH 720
Cdd:smart00060   75 RAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 954-1043 8.77e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 8.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  954 NPPENIILTAY-RNQINVTWQESTLPNGDIMKYIVYYSENENDDLSDWNKFETAELETYVETFGPHTKHFIRVQAVSDRG 1032
Cdd:cd00063     2 SPPTNLRVTDVtSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 392899864 1033 PGIISNVLSCI 1043
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 530-618 1.44e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 1.44e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864    530 DAPTQIQVLSVNALDALVVWHSPQFPNSpiTSYIVLVSNDDKEDKSTWLQYESNAKETQINrmllpTGNLEKSTEYFVCV 609
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYT-----LTGLKPGTEYEFRV 74


                    ....*....
gi 392899864    610 RAKNAAGIG 618
Cdd:smart00060   75 RAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 952-1034 3.37e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.37e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864    952 PGNPPENIILTAYRNQINVTWQESTLPNGDimKYIVYYSENENDDLSDWNKFETAELETYVETFG--PHTKHFIRVQAVS 1029
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGlkPGTEYEFRVRAVN 78


                    ....*
gi 392899864   1030 DRGPG 1034
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
955-1037 1.62e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   955 PPENIILTA-YRNQINVTWQESTLPNGDIMKYIVYYSenENDDLSDWNKFETAELETYVETFG--PHTKHFIRVQAVSDR 1031
Cdd:pfam00041    2 APSNLTVTDvTSTSLTVSWTPPPDGNGPITGYEVEYR--PKNSGEPWNEITVPGTTTSVTLTGlkPGTEYEVRVQAVNGG 79


                   ....*.
gi 392899864  1032 GPGIIS 1037
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
635-726 3.27e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 3.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   635 SPPDNLKVLINEANQVIVYWNTPNSTT-EVTGYLIYYTrdlSLSNDDYKNWQFVEmnNNSTRYKFDlsvGLKPKTFYRVR 713
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNgPITGYEVEYR---PKNSGEPWNEITVP--GTTTSVTLT---GLKPGTEYEVR 72

                           90
                   ....*....|...
gi 392899864   714 ISGKNSHADGPAS 726
Cdd:pfam00041   73 VQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
54-364 3.35e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.46  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   54 SVTGYKLYYTNDSSQTNEEYekwmhqeALSNQNSYnfvIDANkheIVSGDVY--RVRAtVFFNNVESVPTGVISINTRQS 131
Cdd:COG3401   260 DATGYRVYRSNSGDGPFTKV-------ATVTTTSY---TDTG---LTNGTTYyyRVTA-VDAAGNESAPSNVVSVTTDLT 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  132 IPKAPLIVNTKILYNSSVLISFVPADDVNAIeNYTLMYKQMEAEEWKSLNfkSDFDGKVLLD-GLIPNHTYEIKIF-VTG 209
Cdd:COG3401   326 PPAAPSGLTATAVGSSSITLSWTASSDADVT-GYNVYRSTSGGGTYTKIA--ETVTTTSYTDtGLTPGTTYYYKVTaVDA 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  210 GIVQGTPSNLATFTTNSTALALVKTEPDEEYTADPQ--TNEPLSITCTVKSVSKASVLWKVNGIKVSVDSSFYTVVTSVH 287
Cdd:COG3401   403 AGNESAPSEEVSATTASAASGESLTASVDAVPLTDVagATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTT 482

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  288 E---DFIESTIRAKSRTRSAKFTCLATNDAGDSSKEVNVIIKGPGSPPSEITLVAEKRGYTISWKPPSHPNGKITKYVVY 364
Cdd:COG3401   483 DtttANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVS 562
IgI_3_NCAM-1 cd05730
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of ...
 868-949 4.84e-05

Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.


Pssm-ID: 143207 [Multi-domain]  Cd Length: 95  Bit Score: 43.77  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  868 NLFEELSVTCTGMGSPAPIITWEWMNKSIENGTEGWnILNIQIDDTTVVsKITRNnirESGDLTCLANNNEGSSSASVEI 947
Cdd:cd05730    16 NLGQSVTLACDADGFPEPTMTWTKDGEPIESGEEKY-SFNEDGSEMTIL-DVDKL---DEAEYTCIAENKAGEQEAEIHL 90


                  ..
gi 392899864  948 RV 949
Cdd:cd05730    91 KV 92
fn3 pfam00041
Fibronectin type III domain;
330-414 5.52e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 5.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   330 SPPSEITLVAEKRGY-TISWKPPSHPNGKITKYVV-YHTLNREDPlsdWRKIDLDGSEKMVRIIMDTEESFY-GRVQAAT 406
Cdd:pfam00041    1 SAPSNLTVTDVTSTSlTVSWTPPPDGNGPITGYEVeYRPKNSGEP---WNEITVPGTTTSVTLTGLKPGTEYeVRVQAVN 77


                   ....*...
gi 392899864   407 ELGPGIIS 414
Cdd:pfam00041   78 GGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1249-1337 1.62e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864 1249 DSKVYIFWVEPRLPNGEIQNYTIYIQKENeseneehsiDKEWKKFIYG-SNITHVIIgvdDGLEENERYQMKMTATNQRH 1327
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKG---------SGDWKEVEVTpGSETSYTL---TGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|
gi 392899864 1328 EGPETKVYTF 1337
Cdd:cd00063    82 ESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 330-417 2.92e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  330 SPPSEITLVA-EKRGYTISWKPPSHPNGKITKYVVYHtlnREDPLSDWRKIDL-DGSEKMVRI---IMDTEESFygRVQA 404
Cdd:cd00063     2 SPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYVVEY---REKGSGDWKEVEVtPGSETSYTLtglKPGTEYEF--RVRA 76

                          90
                  ....*....|...
gi 392899864  405 ATELGPGIISDIV 417
Cdd:cd00063    77 VNGGGESPPSESV 89
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 330-411 4.22e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 4.22e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864    330 SPPSEITLVA-EKRGYTISWKPPSHPNGkiTKYVVYHTLNREDPLSDWRKIDLDGSEKMVRI---IMDTEESFygRVQAA 405
Cdd:smart00060    2 SPPSNLRVTDvTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLtglKPGTEYEF--RVRAV 77


                    ....*.
gi 392899864    406 TELGPG 411
Cdd:smart00060   78 NGAGEG 83
I-set pfam07679
Immunoglobulin I-set domain;
245-325 2.28e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.78  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   245 QTNEPLSITCTVKSVSKASVLWKVNGIKVSVDSSFytVVTSVHEDFiESTIRAKSRTRSAKFTCLATNDAGDSSKEVNVI 324
Cdd:pfam07679   13 QEGESARFTCTVTGTPDPEVSWFKDGQPLRSSDRF--KVTYEGGTY-TLTISNVQPDDSGKYTCVATNSAGEAEASAELT 89


                   .
gi 392899864   325 I 325
Cdd:pfam07679   90 V 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 248-325 2.73e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.73e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392899864    248 EPLSITCTVKSVSKASVLWKVNGIKVSVDSSFYTVVTSVHEDFIesTIRAKSRTRSAKFTCLATNDAGDSSKEVNVII 325
Cdd:smart00410   10 ESVTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTL--TISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
IgI_NrCAM cd05874
Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); ...
 436-463 3.35e-03

Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule). NrCAM belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region, and an intracellular domain. NrCAM is primarily expressed in the nervous system.


Pssm-ID: 409458  Cd Length: 95  Bit Score: 38.43  E-value: 3.35e-03
                          10        20
                  ....*....|....*....|....*...
gi 392899864  436 SATTMVVNPRETLSIQCTARGKPRPSIS 463
Cdd:cd05874     7 SPKDYIVDPRENIVIQCEAKGKPPPSFS 34
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 871-936 7.23e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.77  E-value: 7.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392899864   871 EELSVTCTGMGSPAPIITWEWMNKSIENGtegwNILNIQIDDTTVVSKITRNNIRESGDLTCLANN 936
Cdd:pfam13927   17 ETVTLTCEATGSPPPTITWYKNGEPISSG----STRSRSLSGSNSTLTISNVTRSDAGTYTCVASN 78
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 248-323 7.43e-03

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 36.99  E-value: 7.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392899864  248 EPLSITCTVKSVSKASVLWKVNGIKVSVDSSFYTVvtsvhEDFIeSTIRAKSRTRSAKFTCLATNDAGDSSKEVNV 323
Cdd:cd20978    17 QDVTLPCQVTGVPQPKITWLHNGKPLQGPMERATV-----EDGT-LTIINVQPEDTGYYGCVATNEIGDIYTETLL 86
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
934-1046 8.39e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.76  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  934 ANNNEGSSSASVEIRVLGPGNPPENII-LTA---YRNQINVTWQESTlpNGDIMKYIVYYSENENddlSDWNKFETAELE 1009
Cdd:COG3401   211 ATDTGGESAPSNEVSVTTPTTPPSAPTgLTAtadTPGSVTLSWDPVT--ESDATGYRVYRSNSGD---GPFTKVATVTTT 285

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 392899864 1010 TYVET-FGPHTKHFIRVQAVSDRG-PGIISNVLSCISDV 1046
Cdd:COG3401   286 SYTDTgLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDL 324
fn3 pfam00041
Fibronectin type III domain;
1248-1332 8.79e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.01  E-value: 8.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  1248 QDSKVYIFWVEPRLPNGEIQNYTIYIQKENESeneehsidKEWKKFIYGSNITHVIIgvdDGLEENERYQMKMTATNQRH 1327
Cdd:pfam00041   12 TSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG--------EPWNEITVPGTTTSVTL---TGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 392899864  1328 EGPET 1332
Cdd:pfam00041   81 EGPPS 85
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 530-628 2.31e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.31e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  530 DAPTQIQVLSVNALDALVVWHSPQFPNSPITSYIVLVSnddKEDKSTWLQYESNAKETqiNRMLLPtgNLEKSTEYFVCV 609
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGPITGYVVEYR---EKGSGDWKEVEVTPGSE--TSYTLT--GLKPGTEYEFRV 74

                          90
                  ....*....|....*....
gi 392899864  610 RAKNAAGIGPTSSLISFIT 628
Cdd:cd00063    75 RAVNGGGESPPSESVTVTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 635-733 2.73e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 61.36  E-value: 2.73e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  635 SPPDNLKVLINEANQVIVYWNTPNST-TEVTGYLIYYTRDlslsndDYKNWQFVEMNN-NSTRYKFDlsvGLKPKTFYRV 712
Cdd:cd00063     2 SPPTNLRVTDVTSTSVTLSWTPPEDDgGPITGYVVEYREK------GSGDWKEVEVTPgSETSYTLT---GLKPGTEYEF 72

                          90       100
                  ....*....|....*....|.
gi 392899864  713 RISGKNSHADGPASEVVEFET 733
Cdd:cd00063    73 RVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
530-621 1.27e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 1.27e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   530 DAPTQIQVLSVNALDALVVWHSPQFPNSPITSYIVLVSNDDKEDKSTWLQYESNAKETQINrmllptgNLEKSTEYFVCV 609
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLT-------GLKPGTEYEVRV 73

                           90
                   ....*....|..
gi 392899864   610 RAKNAAGIGPTS 621
Cdd:pfam00041   74 QAVNGGGEGPPS 85
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 133-224 7.02e-10

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 57.12  E-value: 7.02e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  133 PKAPLIVNTKILYNSSVLISF-VPADDVNAIENYTLMYKQMEAEEWKSLNFKSDFDGKVLLDGLIPNHTYEIKIFVTGGI 211
Cdd:cd00063     1 PSPPTNLRVTDVTSTSVTLSWtPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                          90
                  ....*....|...
gi 392899864  212 VQGTPSNLATFTT 224
Cdd:cd00063    81 GESPPSESVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
510-760 6.21e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 60.40  E-value: 6.21e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  510 AKNSAGSNYSTMELKVDKPgDAPTQIQVLSVNALDALVVWHSPqfPNSPITSYIVLVSNDDKEDkstwLQYESNAKETQI 589
Cdd:COG3401   215 GGESAPSNEVSVTTPTTPP-SAPTGLTATADTPGSVTLSWDPV--TESDATGYRVYRSNSGDGP----FTKVATVTTTSY 287

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  590 NRMllptgNLEKSTEYFVCVRAKNAAGIGPTSSLISFITLNGGPDSPPDNLKVLINEANQVIVYWNtPNSTTEVTGYLIY 669
Cdd:COG3401   288 TDT-----GLTNGTTYYYRVTAVDAAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSITLSWT-ASSDADVTGYNVY 361

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  670 YtrdlslSNDDYKNWQFVEMNNNSTRYKFDlsvGLKPKTFYRVRISGKNshADGPASEVVEFETAYSEVPIPTDLKTEVL 749
Cdd:COG3401   362 R------STSGGGTYTKIAETVTTTSYTDT---GLTPGTTYYYKVTAVD--AAGNESAPSEEVSATTASAASGESLTASV 430

                         250
                  ....*....|.
gi 392899864  750 DDNTIHIKFNA 760
Cdd:COG3401   431 DAVPLTDVAGA 441
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
596-765 2.73e-08

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 58.48  E-value: 2.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  596 TGNLEKSTEYFVCVRAKNAAGIGPTSSLISFITLNGGPdSPPDNLKVLINEANQVIVYWnTPNSTTEVTGYLIYYtrdls 675
Cdd:COG3401   196 GGDIEPGTTYYYRVAATDTGGESAPSNEVSVTTPTTPP-SAPTGLTATADTPGSVTLSW-DPVTESDATGYRVYR----- 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  676 lSNDDYKNWQFVEmNNNSTRYkfdLSVGLKPKTFYRVRISGKN-SHADGPASEVVEFETAYSEVPIPTDLKTEVLDDNTI 754
Cdd:COG3401   269 -SNSGDGPFTKVA-TVTTTSY---TDTGLTNGTTYYYRVTAVDaAGNESAPSNVVSVTTDLTPPAAPSGLTATAVGSSSI 343

                         170
                  ....*....|.
gi 392899864  755 HIKFNAVRDPD 765
Cdd:COG3401   344 TLSWTASSDAD 354
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 635-720 3.19e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 52.23  E-value: 3.19e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864    635 SPPDNLKVLINEANQVIVYWNTPNSTTeVTGYLIYYTRdlsLSNDDYKNWQFVEMNNNSTRYKFDlsvGLKPKTFYRVRI 714
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDG-ITGYIVGYRV---EYREEGSEWKEVNVTPSSTSYTLT---GLKPGTEYEFRV 74


                    ....*.
gi 392899864    715 SGKNSH 720
Cdd:smart00060   75 RAVNGA 80
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 954-1043 8.77e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 51.34  E-value: 8.77e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  954 NPPENIILTAY-RNQINVTWQESTLPNGDIMKYIVYYSENENDDLSDWNKFETAELETYVETFGPHTKHFIRVQAVSDRG 1032
Cdd:cd00063     2 SPPTNLRVTDVtSTSVTLSWTPPEDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|.
gi 392899864 1033 PGIISNVLSCI 1043
Cdd:cd00063    82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 530-618 1.44e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 50.31  E-value: 1.44e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864    530 DAPTQIQVLSVNALDALVVWHSPQFPNSpiTSYIVLVSNDDKEDKSTWLQYESNAKETQINrmllpTGNLEKSTEYFVCV 609
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYT-----LTGLKPGTEYEFRV 74


                    ....*....
gi 392899864    610 RAKNAAGIG 618
Cdd:smart00060   75 RAVNGAGEG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 952-1034 3.37e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.15  E-value: 3.37e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864    952 PGNPPENIILTAYRNQINVTWQESTLPNGDimKYIVYYSENENDDLSDWNKFETAELETYVETFG--PHTKHFIRVQAVS 1029
Cdd:smart00060    1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGIT--GYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGlkPGTEYEFRVRAVN 78


                    ....*
gi 392899864   1030 DRGPG 1034
Cdd:smart00060   79 GAGEG 83
fn3 pfam00041
Fibronectin type III domain;
955-1037 1.62e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.41  E-value: 1.62e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   955 PPENIILTA-YRNQINVTWQESTLPNGDIMKYIVYYSenENDDLSDWNKFETAELETYVETFG--PHTKHFIRVQAVSDR 1031
Cdd:pfam00041    2 APSNLTVTDvTSTSLTVSWTPPPDGNGPITGYEVEYR--PKNSGEPWNEITVPGTTTSVTLTGlkPGTEYEVRVQAVNGG 79


                   ....*.
gi 392899864  1032 GPGIIS 1037
Cdd:pfam00041   80 GEGPPS 85
fn3 pfam00041
Fibronectin type III domain;
635-726 3.27e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 46.64  E-value: 3.27e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   635 SPPDNLKVLINEANQVIVYWNTPNSTT-EVTGYLIYYTrdlSLSNDDYKNWQFVEmnNNSTRYKFDlsvGLKPKTFYRVR 713
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDGNgPITGYEVEYR---PKNSGEPWNEITVP--GTTTSVTLT---GLKPGTEYEVR 72

                           90
                   ....*....|...
gi 392899864   714 ISGKNSHADGPAS 726
Cdd:pfam00041   73 VQAVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
54-364 3.35e-05

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 48.46  E-value: 3.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   54 SVTGYKLYYTNDSSQTNEEYekwmhqeALSNQNSYnfvIDANkheIVSGDVY--RVRAtVFFNNVESVPTGVISINTRQS 131
Cdd:COG3401   260 DATGYRVYRSNSGDGPFTKV-------ATVTTTSY---TDTG---LTNGTTYyyRVTA-VDAAGNESAPSNVVSVTTDLT 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  132 IPKAPLIVNTKILYNSSVLISFVPADDVNAIeNYTLMYKQMEAEEWKSLNfkSDFDGKVLLD-GLIPNHTYEIKIF-VTG 209
Cdd:COG3401   326 PPAAPSGLTATAVGSSSITLSWTASSDADVT-GYNVYRSTSGGGTYTKIA--ETVTTTSYTDtGLTPGTTYYYKVTaVDA 402

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  210 GIVQGTPSNLATFTTNSTALALVKTEPDEEYTADPQ--TNEPLSITCTVKSVSKASVLWKVNGIKVSVDSSFYTVVTSVH 287
Cdd:COG3401   403 AGNESAPSEEVSATTASAASGESLTASVDAVPLTDVagATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTT 482

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  288 E---DFIESTIRAKSRTRSAKFTCLATNDAGDSSKEVNVIIKGPGSPPSEITLVAEKRGYTISWKPPSHPNGKITKYVVY 364
Cdd:COG3401   483 DtttANLSVTTGSLVGGSGASSVTNSVSVIGASAAAAVGGAPDGTPNVTGASPVTVGASTGDVLITDLVSLTTSASSSVS 562
IgI_3_NCAM-1 cd05730
Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of ...
 868-949 4.84e-05

Third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule 1 (NCAM-1); member of the I-set of IgSF domains; The members here are composed of the third immunoglobulin (Ig)-like domain of Neural Cell Adhesion Molecule (NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM), and heterophilic (NCAM-non-NCAM), interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions) through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain.


Pssm-ID: 143207 [Multi-domain]  Cd Length: 95  Bit Score: 43.77  E-value: 4.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  868 NLFEELSVTCTGMGSPAPIITWEWMNKSIENGTEGWnILNIQIDDTTVVsKITRNnirESGDLTCLANNNEGSSSASVEI 947
Cdd:cd05730    16 NLGQSVTLACDADGFPEPTMTWTKDGEPIESGEEKY-SFNEDGSEMTIL-DVDKL---DEAEYTCIAENKAGEQEAEIHL 90


                  ..
gi 392899864  948 RV 949
Cdd:cd05730    91 KV 92
fn3 pfam00041
Fibronectin type III domain;
330-414 5.52e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 43.17  E-value: 5.52e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   330 SPPSEITLVAEKRGY-TISWKPPSHPNGKITKYVV-YHTLNREDPlsdWRKIDLDGSEKMVRIIMDTEESFY-GRVQAAT 406
Cdd:pfam00041    1 SAPSNLTVTDVTSTSlTVSWTPPPDGNGPITGYEVeYRPKNSGEP---WNEITVPGTTTSVTLTGLKPGTEYeVRVQAVN 77


                   ....*...
gi 392899864   407 ELGPGIIS 414
Cdd:pfam00041   78 GGGEGPPS 85
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 532-628 8.46e-05

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 42.78  E-value: 8.46e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   532 PTQIQVLSVNALDALVV-WHSPQFPNSPITSYIVLVSNDDKEDKSTWLQYESNAKETQ-INRMLLptGNLEKSTEYFVCV 609
Cdd:pfam16656    1 PEQVHLSLTGDSTSMTVsWVTPSAVTSPVVQYGTSSSALTSTATATSSTYTTGDGGTGyIHRATL--TGLEPGTTYYYRV 78

                           90
                   ....*....|....*....
gi 392899864   610 RAKNaagiGPTSSLISFIT 628
Cdd:pfam16656   79 GDDN----GGWSEVYSFTT 93
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1249-1337 1.62e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 1.62e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864 1249 DSKVYIFWVEPRLPNGEIQNYTIYIQKENeseneehsiDKEWKKFIYG-SNITHVIIgvdDGLEENERYQMKMTATNQRH 1327
Cdd:cd00063    14 STSVTLSWTPPEDDGGPITGYVVEYREKG---------SGDWKEVEVTpGSETSYTL---TGLKPGTEYEFRVRAVNGGG 81

                          90
                  ....*....|
gi 392899864 1328 EGPETKVYTF 1337
Cdd:cd00063    82 ESPPSESVTV 91
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 330-417 2.92e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 41.33  E-value: 2.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  330 SPPSEITLVA-EKRGYTISWKPPSHPNGKITKYVVYHtlnREDPLSDWRKIDL-DGSEKMVRI---IMDTEESFygRVQA 404
Cdd:cd00063     2 SPPTNLRVTDvTSTSVTLSWTPPEDDGGPITGYVVEY---REKGSGDWKEVEVtPGSETSYTLtglKPGTEYEF--RVRA 76

                          90
                  ....*....|...
gi 392899864  405 ATELGPGIISDIV 417
Cdd:cd00063    77 VNGGGESPPSESV 89
Ig4_Contactin-2-like cd05728
Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains; The ...
 866-949 3.21e-04

Fourth Ig domain of the neural cell adhesion molecule contactin-2, and similar domains; The members here are composed of the fourth Ig domain of the neural cell adhesion molecule contactin-2. Contactins are comprised of six Ig domains followed by four fibronectin type III (FnIII) domains anchored to the membrane by glycosylphosphatidylinositol. Contactin-2 (also called TAG-1, axonin-1) facilitates cell adhesion by homophilic binding between molecules in apposed membranes. The first four Ig domains form the intermolecular binding fragment which arranges as a compact U-shaped module by contacts between Ig domains 1 and 4, and domains 2 and 3. It has been proposed that a linear zipper-like array forms, from contactin-2 molecules alternatively provided by the two apposed membranes.


Pssm-ID: 143205 [Multi-domain]  Cd Length: 85  Bit Score: 41.05  E-value: 3.21e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  866 EPNLFEELSVTCTGMGSPAPIITWewmnksIENGtegwNILN----IQIDDTTVvsKITRNNIRESGDLTCLANNNEGSS 941
Cdd:cd05728    10 EADIGSSLRWECKASGNPRPAYRW------LKNG----QPLAsenrIEVEAGDL--RITKLSLSDSGMYQCVAENKHGTI 77


                  ....*...
gi 392899864  942 SASVEIRV 949
Cdd:cd05728    78 YASAELAV 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 330-411 4.22e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 4.22e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864    330 SPPSEITLVA-EKRGYTISWKPPSHPNGkiTKYVVYHTLNREDPLSDWRKIDLDGSEKMVRI---IMDTEESFygRVQAA 405
Cdd:smart00060    2 SPPSNLRVTDvTSTSVTLSWEPPPDDGI--TGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLtglKPGTEYEF--RVRAV 77


                    ....*.
gi 392899864    406 TELGPG 411
Cdd:smart00060   78 NGAGEG 83
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 873-945 5.00e-04

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 40.01  E-value: 5.00e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392899864  873 LSVTCTGMGSPAPIITWEWMNKSIENGTegwnILNIQIDDTTVVSKITRNNIRESGDLTCLANN-NEGSSSASV 945
Cdd:cd00096     1 VTLTCSASGNPPPTITWYKNGKPLPPSS----RDSRRSELGNGTLTISNVTLEDSGTYTCVASNsAGGSASASV 70
IgI_4_MYLK-like cd20976
Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a ...
 877-949 6.68e-04

Fourth Ig-like domain from smooth muscle myosin light chain kinase and similar domains ; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain from smooth muscle myosin light chain kinase (MYLK) and similar domains. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of this group shows that the fourth Ig-like domain from myosin light chain kinase lacks this strand and thus belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409568 [Multi-domain]  Cd Length: 90  Bit Score: 40.31  E-value: 6.68e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392899864  877 CTGMGSPAPIITWewmnksIENGTEgwniLNIQIDDTTVVSKITRNNIRES-----GDLTCLANNNEGSSSASVEIRV 949
Cdd:cd20976    23 CSARGKPVPRITW------IRNAQP----LQYAADRSTCEAGVGELHIQDVlpedhGTYTCLAKNAAGQVSCSAWVTV 90
IgI_SALM5_like cd05764
Immunoglobulin domain of human Synaptic Adhesion-Like Molecule 5 (SALM5) and similar proteins; ...
 861-949 2.06e-03

Immunoglobulin domain of human Synaptic Adhesion-Like Molecule 5 (SALM5) and similar proteins; member of the I-set of IgSF domains; This group contains the immunoglobulin domain of human Synaptic Adhesion-Like Molecule 5 (SALM5) and similar proteins. The SALM (for synaptic adhesion-like molecules; also known as Lrfn for leucine-rich repeat and fibronectin type III domain containing) family of adhesion molecules consists of five known members: SALM1/Lrfn2, SALM2/Lrfn1, SALM3/Lrfn4, SALM4/Lrfn3, and SALM5/Lrfn5. SALMs share a similar domain structure, containing leucine-rich repeats (LRRs), an immunoglobulin (Ig) domain, and a fibronectin III (FNIII) domain, followed by a transmembrane domain and a C-terminal PDZ-binding motif. SALM5 is implicated in autism spectrum disorders (ASDs) and schizophrenia, induces presynaptic differentiation in contacting axons. SALM5 interacts with the Ig domains of LAR (Leukocyte common Antigen-Related) family receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPdelta, and PTPsigma). In addition, PTPdelta is implicated in ASDs, ADHD, bipolar disorder, and restless leg syndrome. Studies have shown that LAR-RPTPs are novel and splicing-dependent presynaptic ligands for SALM5, and that they mediate SALM5-dependent presynaptic differentiation. Furthermore, SALM5 maintains AMPA receptor (AMPAR)-mediated excitatory synaptic transmission through mechanisms involving the interaction of SALM5 with LAR-RPTPs. This group belongs to the I-set of immunoglobulin superfamily (IgSF) domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand.


Pssm-ID: 409421 [Multi-domain]  Cd Length: 88  Bit Score: 38.61  E-value: 2.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  861 PLIEK---EPNLFEELSVT--CTGMGSPAPIITWEWMN-KSIENGTEGWNILNIQIDdttvvskITRNNIRESGDLTCLA 934
Cdd:cd05764     1 PLITRhthELRVLEGQRATlrCKARGDPEPAIHWISPEgKLISNSSRTLVYDNGTLD-------ILITTVKDTGAFTCIA 73

                          90
                  ....*....|....*
gi 392899864  935 NNNEGSSSASVEIRV 949
Cdd:cd05764    74 SNPAGEATARVELHI 88
IgI_1_MuSK cd20970
agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of ...
 871-936 2.09e-03

agrin-responsive first immunoglobulin-like domains (Ig1) of the MuSK ectodomain; a member of the I-set of IgSF domains; The members here are composed of the first immunoglobulin-like domains (Ig1) of the Muscle-specific kinase (MuSK). MuSK is a receptor tyrosine kinase specifically expressed in skeletal muscle, where it plays a central role in the formation and maintenance of the neuromuscular junction (NMJ). MuSK is activated by agrin, a neuron-derived heparan sulfate proteoglycan. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the MuSK lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409562 [Multi-domain]  Cd Length: 92  Bit Score: 38.64  E-value: 2.09e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392899864  871 EELSVTCTGMGSPAPIITWEWMNKSIENGTEGWNIlnIQIDDTTVVSKITRNnirESGDLTCLANN 936
Cdd:cd20970    18 ENATFMCRAEGSPEPEISWTRNGNLIIEFNTRYIV--RENGTTLTIRNIRRS---DMGIYLCIASN 78
I-set pfam07679
Immunoglobulin I-set domain;
245-325 2.28e-03

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 38.78  E-value: 2.28e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   245 QTNEPLSITCTVKSVSKASVLWKVNGIKVSVDSSFytVVTSVHEDFiESTIRAKSRTRSAKFTCLATNDAGDSSKEVNVI 324
Cdd:pfam07679   13 QEGESARFTCTVTGTPDPEVSWFKDGQPLRSSDRF--KVTYEGGTY-TLTISNVQPDDSGKYTCVATNSAGEAEASAELT 89


                   .
gi 392899864   325 I 325
Cdd:pfam07679   90 V 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 248-325 2.73e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.73e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392899864    248 EPLSITCTVKSVSKASVLWKVNGIKVSVDSSFYTVVTSVHEDFIesTIRAKSRTRSAKFTCLATNDAGDSSKEVNVII 325
Cdd:smart00410   10 ESVTLSCEASGSPPPEVTWYKQGGKLLAESGRFSVSRSGSTSTL--TISNVTPEDSGTYTCAATNSSGSASSGTTLTV 85
IgI_NrCAM cd05874
Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); ...
 436-463 3.35e-03

Immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule); member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of NrCAM (Ng (neuronglia) CAM-related cell adhesion molecule). NrCAM belongs to the L1 subfamily of cell adhesion molecules (CAMs) and is comprised of an extracellular region having six Ig-like domains and five fibronectin type III domains, a transmembrane region, and an intracellular domain. NrCAM is primarily expressed in the nervous system.


Pssm-ID: 409458  Cd Length: 95  Bit Score: 38.43  E-value: 3.35e-03
                          10        20
                  ....*....|....*....|....*...
gi 392899864  436 SATTMVVNPRETLSIQCTARGKPRPSIS 463
Cdd:cd05874     7 SPKDYIVDPRENIVIQCEAKGKPPPSFS 34
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 637-733 4.41e-03

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 37.77  E-value: 4.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   637 PDNLKV-LINEANQVIVYWNTPNSTTevTGYLIYYTRDLSLSNDDYKNWQFVEMNNNSTRYKFDLSV-GLKPKTFYRVRI 714
Cdd:pfam16656    1 PEQVHLsLTGDSTSMTVSWVTPSAVT--SPVVQYGTSSSALTSTATATSSTYTTGDGGTGYIHRATLtGLEPGTTYYYRV 78

                           90
                   ....*....|....*....
gi 392899864   715 SGKNShadgPASEVVEFET 733
Cdd:pfam16656   79 GDDNG----GWSEVYSFTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
44-230 7.20e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.76  E-value: 7.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864   44 LVEKKPYFTGSVTGYKLYYTNDSSQTNEEYEKWMHQEALSNQNSYNFVIDANKHEIVSGDVYRVRATVFFNNVESVPTGV 123
Cdd:COG3401   144 GAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNE 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  124 ISINTRQSIPKAPLIVNTKILYNSSVLISFVPADDVNAiENYTLMYKQMEAEEWKSLnfkSDFDGKVLLD-GLIPNHTYE 202
Cdd:COG3401   224 VSVTTPTTPPSAPTGLTATADTPGSVTLSWDPVTESDA-TGYRVYRSNSGDGPFTKV---ATVTTTSYTDtGLTNGTTYY 299

                         170       180
                  ....*....|....*....|....*....
gi 392899864  203 IKIF-VTGGIVQGTPSNLATFTTNSTALA 230
Cdd:COG3401   300 YRVTaVDAAGNESAPSNVVSVTTDLTPPA 328
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 871-936 7.23e-03

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 36.77  E-value: 7.23e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392899864   871 EELSVTCTGMGSPAPIITWEWMNKSIENGtegwNILNIQIDDTTVVSKITRNNIRESGDLTCLANN 936
Cdd:pfam13927   17 ETVTLTCEATGSPPPTITWYKNGEPISSG----STRSRSLSGSNSTLTISNVTRSDAGTYTCVASN 78
IgI_4_hemolin-like cd20978
Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set ...
 248-323 7.43e-03

Fourth immunoglobulin (Ig)-like domain of hemolin, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the fourth immunoglobulin (Ig)-like domain of hemolin and similar proteins. Hemolin, an insect immunoglobulin superfamily (IgSF) member containing four Ig-like domains, is a lipopolysaccharide-binding immune protein induced during bacterial infection. Hemolin shares significant sequence similarity with the first four Ig-like domains of the transmembrane cell adhesion molecules (CAMs) of the L1 family. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The fourth Ig-like domain of hemolin is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409570 [Multi-domain]  Cd Length: 88  Bit Score: 36.99  E-value: 7.43e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392899864  248 EPLSITCTVKSVSKASVLWKVNGIKVSVDSSFYTVvtsvhEDFIeSTIRAKSRTRSAKFTCLATNDAGDSSKEVNV 323
Cdd:cd20978    17 QDVTLPCQVTGVPQPKITWLHNGKPLQGPMERATV-----EDGT-LTIINVQPEDTGYYGCVATNEIGDIYTETLL 86
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
934-1046 8.39e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 40.76  E-value: 8.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  934 ANNNEGSSSASVEIRVLGPGNPPENII-LTA---YRNQINVTWQESTlpNGDIMKYIVYYSENENddlSDWNKFETAELE 1009
Cdd:COG3401   211 ATDTGGESAPSNEVSVTTPTTPPSAPTgLTAtadTPGSVTLSWDPVT--ESDATGYRVYRSNSGD---GPFTKVATVTTT 285

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 392899864 1010 TYVET-FGPHTKHFIRVQAVSDRG-PGIISNVLSCISDV 1046
Cdd:COG3401   286 SYTDTgLTNGTTYYYRVTAVDAAGnESAPSNVVSVTTDL 324
IgI_Twitchin_like cd20949
C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, ...
 871-949 8.39e-03

C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin, and similar domains; member of the I-set IgSF domains; The members here are composed of the C-terminal immunoglobulin-like domain of the myosin-associated giant protein kinase Twitchin and similar proteins, including Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. In humans these proteins are called Titin. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig-like domain of the Twitchin is a member of the I-set IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins (titin, telokin, and twitchin), the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D.


Pssm-ID: 409541 [Multi-domain]  Cd Length: 89  Bit Score: 36.93  E-value: 8.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392899864  871 EELSVTCTGMGSPAPIITWEWMNKSIENGTEGWNILNIqIDDTTVVSKITRNnirESGDLTCLANNNEGSSSASVEIRV 949
Cdd:cd20949    15 QSATILCEVKGEPQPNVTWHFNGQPISASVADMSKYRI-LADGLLINKVTQD---DTGEYTCRAYQVNSIASDMQERTV 89
fn3 pfam00041
Fibronectin type III domain;
1248-1332 8.79e-03

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 37.01  E-value: 8.79e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  1248 QDSKVYIFWVEPRLPNGEIQNYTIYIQKENESeneehsidKEWKKFIYGSNITHVIIgvdDGLEENERYQMKMTATNQRH 1327
Cdd:pfam00041   12 TSTSLTVSWTPPPDGNGPITGYEVEYRPKNSG--------EPWNEITVPGTTTSVTL---TGLKPGTEYEVRVQAVNGGG 80


                   ....*
gi 392899864  1328 EGPET 1332
Cdd:pfam00041   81 EGPPS 85
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 871-947 9.12e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.79  E-value: 9.12e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392899864   871 EELSVTCTG-MGSPAPIITWEWMNKSIENGTEGWNILNIQIDDTTVVSKITRNNireSGDLTCLANNNEGSSSASVEI 947
Cdd:pfam00047   12 DSATLTCSAsTGSPGPDVTWSKEGGTLIESLKVKHDNGRTTQSSLLISNVTKED---AGTYTCVVNNPGGSATLSTSL 86
IgI_NCAM-1 cd05869
Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1); The members ...
 869-949 9.87e-03

Immunoglobulin (Ig)-like I-set domain of Neural Cell Adhesion Molecule 1 (NCAM-1); The members here are composed of the fourth Ig domain of Neural Cell Adhesion Molecule 1(NCAM-1). NCAM plays important roles in the development and regeneration of the central nervous system, in synaptogenesis and neural migration. NCAM mediates cell-cell and cell-substratum recognition and adhesion via homophilic (NCAM-NCAM) and heterophilic (NCAM-non-NCAM) interactions. NCAM is expressed as three major isoforms having different intracellular extensions. The extracellular portion of NCAM has five N-terminal Ig-like domains and two fibronectin type III domains. The double zipper adhesion complex model for NCAM homophilic binding involves Ig1, Ig2, and Ig3. By this model, Ig1 and Ig2 mediate dimerization of NCAM molecules situated on the same cell surface (cis interactions), and Ig3 domains mediate interactions between NCAM molecules expressed on the surface of opposing cells (trans interactions), through binding to the Ig1 and Ig2 domains. The adhesive ability of NCAM is modulated by the addition of polysialic acid chains to the fifth Ig-like domain. One of the unique features of I-set domains is the lack of a C" strand. The structures of this group show that the Ig domain lacks this strand and thus is a member of the I-set of Ig domains.


Pssm-ID: 143277 [Multi-domain]  Cd Length: 97  Bit Score: 37.27  E-value: 9.87e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392899864  869 LFEELSVTCTGMGSPAPIITWEWMNKSIENGTEGWNiLNIQIDDTTVVSKITRNNIR--ESGDLTCLANNNEGSSSASVE 946
Cdd:cd05869    16 LEEQITLTCEASGDPIPSITWRTSTRNISSEEKTLD-GHIVVRSHARVSSLTLKYIQytDAGEYLCTASNTIGQDSQSMY 94


                  ...
gi 392899864  947 IRV 949
Cdd:cd05869    95 LEV 97
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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