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Conserved domains on  [gi|392513656|ref|NP_001254734|]
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proteasomal ATPase-associated factor 1 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
74-374 4.23e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 4.23e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  74 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 153
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 154 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 233
Cdd:COG2319  199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 234 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 311
Cdd:COG2319  258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392513656 312 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 374
Cdd:COG2319  337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
74-374 4.23e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 4.23e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  74 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 153
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 154 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 233
Cdd:COG2319  199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 234 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 311
Cdd:COG2319  258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392513656 312 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 374
Cdd:COG2319  337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-321 1.36e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 1.36e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  72 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 151
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 152 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 222
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 223 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 285
Cdd:cd00200  166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 392513656 286 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 321
Cdd:cd00200  243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 106-145 1.16e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.16e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392513656   106 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 145
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
150-187 3.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.77e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392513656  150 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 187
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 74-192 2.33e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  74 HTKSITCLDISSRG-GLGVSSSTDGTMKIWQASNGelrrVLEGHV-FDVN-CCRFFPS--GLVVLSGGMDAQLKIWSAED 148
Cdd:PLN00181 574 HEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG----VSIGTIkTKANiCCVQFPSesGRSLAFGSADHKVYYYDLRN 649

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 392513656 149 ASC-VVTFKGHKGGILDTAIVDRGrNVVSASRDGTARLWDCGRSA 192
Cdd:PLN00181 650 PKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDLSMSI 693
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
74-374 4.23e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 138.51  E-value: 4.23e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  74 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 153
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLR 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 154 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAVgaadnsinlgSPeqmpserevgtE 233
Cdd:COG2319  199 TLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAF----------SP-----------D 257

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 234 AKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSL 311
Cdd:COG2319  258 GRLLASGSADGTVRLWDLATGELLRTLTGhSGGVNSVAFSpDGKLLASGSDDGTVRLWDLATGK-LLRTLTGHTGAVRSV 336

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392513656 312 LSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVATW--EKQIYTCCRDGLVRRYQLSD 374
Cdd:COG2319  337 AFSPDGkTLASGSdDGTVRLWDlATGELLRTLTGHT-GAVTSVAFSpdGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-321 1.36e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 131.69  E-value: 1.36e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  72 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 151
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGEC 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 152 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSINLGSPE 222
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFspdgtfvasSSQDGTIKLWDLR 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 223 qmpSEREVGT---------------EAKMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFL-SGFLLLAGTQDGN 285
Cdd:cd00200  166 ---TGKCVATltghtgevnsvafspDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSpDGYLLASGSEDGT 242

                        250       260       270
                 ....*....|....*....|....*....|....*..
gi 392513656 286 IYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIAS 321
Cdd:cd00200  243 IRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGkRLAS 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 74-187 5.53e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 5.53e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  74 HTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVV 153
Cdd:cd00200  176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQ 255

                         90       100       110
                 ....*....|....*....|....*....|....
gi 392513656 154 TFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 187
Cdd:cd00200  256 TLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 109-329 1.68e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 1.68e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 109 LRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDC 188
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 189 GRSACLGVLADCGSSINGVAVgaadnsinlgspeqMPSERevgteakMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFN 267
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAF--------------SPDGR-------ILSSSSRDKTIKVWDVETGKCLTTLRGhTDWVN 139

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392513656 268 CCTFL-SGFLLLAGTQDGNIYQLDVRSPRaPVQVIHRSGAPVLSLLSVRDG--FIASQGDGSCFI 329
Cdd:cd00200  140 SVAFSpDGTFVASSSQDGTIKLWDLRTGK-CVATLTGHTGEVNSVAFSPDGekLLSSSSDGTIKL 203
WD40 COG2319
WD40 repeat [General function prediction only];
72-374 2.25e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 97.29  E-value: 2.25e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  72 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASC 151
Cdd:COG2319   33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 152 VVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVA---------VGAADNSI---NLG 219
Cdd:COG2319  113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAfspdgkllaSGSDDGTVrlwDLA 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 220 SPEQMPS----EREVGTEA-----KMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFLS-GFLLLAGTQDGNIYQ 288
Cdd:COG2319  193 TGKLLRTltghTGAVRSVAfspdgKLLASGSADGTVRLWDLATGKLLRTLTGhSGSVRSVAFSPdGRLLASGSADGTVRL 272

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 289 LDVRSPRaPVQVIHRSGAPVLSLLSVRDG-FIASQG-DGSCFIVQ-QDLDYVTELTGADcDPVYKVA--TWEKQIYTCCR 363
Cdd:COG2319  273 WDLATGE-LLRTLTGHSGGVNSVAFSPDGkLLASGSdDGTVRLWDlATGKLLRTLTGHT-GAVRSVAfsPDGKTLASGSD 350

                        330
                 ....*....|.
gi 392513656 364 DGLVRRYQLSD 374
Cdd:COG2319  351 DGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
84-374 8.66e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.95  E-value: 8.66e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  84 SSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWSAEDASCVVTFKGHKGGIL 163
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 164 DTAIVDRGRNVVSASRDGTARLWDCGRSACLGVLADCGSSINGVAV---------GAADNSI---NLGSPEQMPSEREVG 231
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspdgktlasGSADGTVrlwDLATGKLLRTLTGHS 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 232 TEA---------KMLLLAREDKKLQCLGLQSRQLVFLFIG-SDAFNCCTFLS-GFLLLAGTQDGNIYQLDVRSPRaPVQV 300
Cdd:COG2319  163 GAVtsvafspdgKLLASGSDDGTVRLWDLATGKLLRTLTGhTGAVRSVAFSPdGKLLASGSADGTVRLWDLATGK-LLRT 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656 301 IHRSGAPVLSLLSVRDG-FIAS-QGDGSCFIVQ-QDLDYVTELTGADcDPVYKVAtW---EKQIYTCCRDGLVRRYQLSD 374
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGrLLASgSADGTVRLWDlATGELLRTLTGHS-GGVNSVA-FspdGKLLASGSDDGTVRLWDLAT 319
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 72-145 6.87e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 6.87e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392513656  72 RIHTKSITCLDISSRGGLGVSSSTDGTMKIWQASNGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 145
Cdd:cd00200  216 RGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 106-145 1.16e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.16e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 392513656   106 NGELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 145
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 150-187 1.37e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.37e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 392513656   150 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 187
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
150-187 3.77e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.10  E-value: 3.77e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392513656  150 SCVVTFKGHKGGILDTAIVDRGRNVVSASRDGTARLWD 187
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
107-145 8.35e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.33  E-value: 8.35e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 392513656  107 GELRRVLEGHVFDVNCCRFFPSGLVVLSGGMDAQLKIWS 145
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 74-192 2.33e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 43.15  E-value: 2.33e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392513656  74 HTKSITCLDISSRG-GLGVSSSTDGTMKIWQASNGelrrVLEGHV-FDVN-CCRFFPS--GLVVLSGGMDAQLKIWSAED 148
Cdd:PLN00181 574 HEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQG----VSIGTIkTKANiCCVQFPSesGRSLAFGSADHKVYYYDLRN 649

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 392513656 149 ASC-VVTFKGHKGGILDTAIVDRGrNVVSASRDGTARLWDCGRSA 192
Cdd:PLN00181 650 PKLpLCTMIGHSKTVSYVRFVDSS-TLVSSSTDNTLKLWDLSMSI 693
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 74-102 3.58e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 3.58e-04
                           10        20
                   ....*....|....*....|....*....
gi 392513656    74 HTKSITCLDISSRGGLGVSSSTDGTMKIW 102
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
74-102 4.13e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 4.13e-04
                          10        20
                  ....*....|....*....|....*....
gi 392513656   74 HTKSITCLDISSRGGLGVSSSTDGTMKIW 102
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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