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Conserved domains on  [gi|392891199|ref|NP_001254211|]
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Major facilitator superfamily (MFS) profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 12-415 6.61e-38

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17318:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 389  Bit Score: 141.99  E-value: 6.61e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  12 DFVNSNKSLDEINWNDP--DLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVIT 89
Cdd:cd17318   24 AMVNSTATHDNNNTSTDkdTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLT 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  90 PIVITWSFPVFVILRVLQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYlh 169
Cdd:cd17318  104 PLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFY-- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 170 gaILGALTILWAVYYrdravkhpfvqrkewrkisfgkkldqtgkgsnetpirkIVSSIVIWGVWIAVIGNFLVSQFSISY 249
Cdd:cd17318  182 --IFGGLGLLWCLLW--------------------------------------FFLVLPVWAIVVAHFGHNWGFYTLLTE 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 250 APIYLRGVIGCTPTEAGLLTLIPMACLLVIKFSTGFFSDRIKS---ISDLTKMKMFNSCALLGSSIFFIILscSSPGGSK 326
Cdd:cd17318  222 LPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSrgiLSTTTVRKLFTSIGFLGPGVFLIAL--GYLGSNA 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 327 VLDVILLSIPMALLGFSSGGYSKCAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALTPSD-SFSEWQRVFMIYGAVLA 405
Cdd:cd17318  300 TLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVKNDqTIGQWRIVFFISAAIYI 379

                        410
                 ....*....|
gi 392891199 406 ITNTIFIVFA 415
Cdd:cd17318  380 LGAIFYLIFG 389
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 12-415 6.61e-38

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 141.99  E-value: 6.61e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  12 DFVNSNKSLDEINWNDP--DLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVIT 89
Cdd:cd17318   24 AMVNSTATHDNNNTSTDkdTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLT 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  90 PIVITWSFPVFVILRVLQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYlh 169
Cdd:cd17318  104 PLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFY-- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 170 gaILGALTILWAVYYrdravkhpfvqrkewrkisfgkkldqtgkgsnetpirkIVSSIVIWGVWIAVIGNFLVSQFSISY 249
Cdd:cd17318  182 --IFGGLGLLWCLLW--------------------------------------FFLVLPVWAIVVAHFGHNWGFYTLLTE 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 250 APIYLRGVIGCTPTEAGLLTLIPMACLLVIKFSTGFFSDRIKS---ISDLTKMKMFNSCALLGSSIFFIILscSSPGGSK 326
Cdd:cd17318  222 LPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSrgiLSTTTVRKLFTSIGFLGPGVFLIAL--GYLGSNA 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 327 VLDVILLSIPMALLGFSSGGYSKCAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALTPSD-SFSEWQRVFMIYGAVLA 405
Cdd:cd17318  300 TLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVKNDqTIGQWRIVFFISAAIYI 379

                        410
                 ....*....|
gi 392891199 406 ITNTIFIVFA 415
Cdd:cd17318  380 LGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 37-428 1.75e-34

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 134.10  E-value: 1.75e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199   37 FAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMtlsgILGTFLVVITPIVITWSFPVFVIL----RVLQGITLA 112
Cdd:TIGR00894  71 FKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSI----GIGMFLSSVISIVIPWAAGGGIALvvfcRVIQGLAQG 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  113 NLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATS-AGWPWVFYLHGAILGALTILWAVYYRDRAVKH 191
Cdd:TIGR00894 147 SVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIH 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  192 PFVQRKEwrKISFGKKLDQT-GKGSNETPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLTL 270
Cdd:TIGR00894 227 PCISKFE--KKYINSSLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSS 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  271 IPMACLLVIKFSTGFFSDRIKSISDLTKM---KMFNSCALLGSSIFFIILSCSSPGgsKVLDVILLSIPMALLGFSSGGY 347
Cdd:TIGR00894 305 LPYLFAWLCSIFAGYLADFLKSSKTLSLTaarKIFNGIGGLGPGIFAYALPYLSAA--FYLTIIILTLANAVSSGPLAGV 382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  348 SKCAVMVSGQYSPFVMSIVQIIAcsslMAGSFLVPALT----PSDSFSEWQRVFMIYGAVLAITNTIFIVFARAEPAKWA 423
Cdd:TIGR00894 383 LINSLDLAPRFLGFIKGITGLPG----FIGGLIASTLAgnilSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWA 458


                  ....*
gi 392891199  424 QQKGD 428
Cdd:TIGR00894 459 KEEKD 463
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
34-424 1.62e-26

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 110.36  E-value: 1.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  34 QRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVItwSFPVFVILRVLQGITLAN 113
Cdd:COG2223   32 AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV--SYWLLLLLGLLLGIGGGG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 114 LFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAVYYRDRAVKHPF 193
Cdd:COG2223  110 SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 194 VQRKEWRkisfgkkldqtgkgsnetPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLTLIPM 273
Cdd:COG2223  190 AAKASLR------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 274 ACLLVIKFSTGFFSDRIKSISDLTkmkmfnsCALLGSSIFFIILscSSPGGSKVLDVILLSIPMALLGFSSGGYSK-CAV 352
Cdd:COG2223  252 LLGALGRPLGGWLSDRIGGRRVLL-------IVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAVFAlVPD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392891199 353 MVSGQYSPFVMSIVQIIAcsslMAGSFLVPAL--TPSDSFSEWQRVFMIYGAVLAITnTIFIVFARAEPAKWAQ 424
Cdd:COG2223  323 IFPTKNAGAVYGLVGAAG----GLGGFLGPLLfgALLDATGSYTAAFLVFAVLALVA-LVLTLLLYRRPRRAAA 391
MFS_1 pfam07690
Major Facilitator Superfamily;
37-378 2.44e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 103.27  E-value: 2.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199   37 FAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILgtFLVVITPIVITWSFPVFVILRVLQGITLANLFT 116
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLL--FALGLLLLLFASSLWLLLVLRVLQGLGAGALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  117 TAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWaVYYRDRAVKHPFVQR 196
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL-LLPRPPPESKRPKPA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  197 KEWRKISFgkkldqtgkgsneTPIRKIVSSIVIWGVWIAVIGNFLVSQFSiSYAPIYLrGVIGCTPTEAGLLTLIPMACL 276
Cdd:pfam07690 184 EEARLSLI-------------VAWKALLRDPVLWLLLALLLFGFAFFGLL-TYLPLYQ-EVLGLSALLAGLLLGLGGLLG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  277 LVIKFSTGFFSDRIKSIsdlTKMKMFNSCALLGSSIFFIILSCSSPGgskVLDVILLSIPMALLGFSSGGYSKCAVMVSG 356
Cdd:pfam07690 249 AIGRLLLGRLSDRLGRR---RRLLLALLLLILAALGLLLLSLTLSSL---WLLLALLLLGFGFGLVFPALNALVSDLAPK 322

                         330       340
                  ....*....|....*....|..
gi 392891199  357 QYSPFVMSIVQIIACSSLMAGS 378
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 35-180 1.49e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 43.80  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  35 RRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVitWSFPVFVILRVLQGITLA-- 112
Cdd:PRK11551  43 QEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQA--WDFPSLLVARLLTGVGLGga 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392891199 113 --NLFTtagvVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGA---ILGALTILW 180
Cdd:PRK11551 121 lpNLIA----LTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgplLLVPLLMRW 189
 
Name Accession Description Interval E-value
MFS_SLC17 cd17318
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ...
 12-415 6.61e-38

Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340876 [Multi-domain]  Cd Length: 389  Bit Score: 141.99  E-value: 6.61e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  12 DFVNSNKSLDEINWNDP--DLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVIT 89
Cdd:cd17318   24 AMVNSTATHDNNNTSTDkdTLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLT 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  90 PIVITWSFPVFVILRVLQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYlh 169
Cdd:cd17318  104 PLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFY-- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 170 gaILGALTILWAVYYrdravkhpfvqrkewrkisfgkkldqtgkgsnetpirkIVSSIVIWGVWIAVIGNFLVSQFSISY 249
Cdd:cd17318  182 --IFGGLGLLWCLLW--------------------------------------FFLVLPVWAIVVAHFGHNWGFYTLLTE 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 250 APIYLRGVIGCTPTEAGLLTLIPMACLLVIKFSTGFFSDRIKS---ISDLTKMKMFNSCALLGSSIFFIILscSSPGGSK 326
Cdd:cd17318  222 LPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSrgiLSTTTVRKLFTSIGFLGPGVFLIAL--GYLGSNA 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 327 VLDVILLSIPMALLGFSSGGYSKCAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALTPSD-SFSEWQRVFMIYGAVLA 405
Cdd:cd17318  300 TLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVGAIVKNDqTIGQWRIVFFISAAIYI 379

                        410
                 ....*....|
gi 392891199 406 ITNTIFIVFA 415
Cdd:cd17318  380 LGAIFYLIFG 389
2A0114euk TIGR00894
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
 37-428 1.75e-34

Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]


Pssm-ID: 129972 [Multi-domain]  Cd Length: 465  Bit Score: 134.10  E-value: 1.75e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199   37 FAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMtlsgILGTFLVVITPIVITWSFPVFVIL----RVLQGITLA 112
Cdd:TIGR00894  71 FKWSGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSI----GIGMFLSSVISIVIPWAAGGGIALvvfcRVIQGLAQG 146

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  113 NLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATS-AGWPWVFYLHGAILGALTILWAVYYRDRAVKH 191
Cdd:TIGR00894 147 SVSPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESwGGWPMIFYVFGIVGCAWSLLWFVFPADDPSIH 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  192 PFVQRKEwrKISFGKKLDQT-GKGSNETPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLTL 270
Cdd:TIGR00894 227 PCISKFE--KKYINSSLQGQkGSTRQSLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSS 304

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  271 IPMACLLVIKFSTGFFSDRIKSISDLTKM---KMFNSCALLGSSIFFIILSCSSPGgsKVLDVILLSIPMALLGFSSGGY 347
Cdd:TIGR00894 305 LPYLFAWLCSIFAGYLADFLKSSKTLSLTaarKIFNGIGGLGPGIFAYALPYLSAA--FYLTIIILTLANAVSSGPLAGV 382

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  348 SKCAVMVSGQYSPFVMSIVQIIAcsslMAGSFLVPALT----PSDSFSEWQRVFMIYGAVLAITNTIFIVFARAEPAKWA 423
Cdd:TIGR00894 383 LINSLDLAPRFLGFIKGITGLPG----FIGGLIASTLAgnilSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWA 458


                  ....*
gi 392891199  424 QQKGD 428
Cdd:TIGR00894 459 KEEKD 463
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
34-424 1.62e-26

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 110.36  E-value: 1.62e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  34 QRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVItwSFPVFVILRVLQGITLAN 113
Cdd:COG2223   32 AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV--SYWLLLLLGLLLGIGGGG 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 114 LFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAVYYRDRAVKHPF 193
Cdd:COG2223  110 SFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 194 VQRKEWRkisfgkkldqtgkgsnetPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLTLIPM 273
Cdd:COG2223  190 AAKASLR------------------DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFA 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 274 ACLLVIKFSTGFFSDRIKSISDLTkmkmfnsCALLGSSIFFIILscSSPGGSKVLDVILLSIPMALLGFSSGGYSK-CAV 352
Cdd:COG2223  252 LLGALGRPLGGWLSDRIGGRRVLL-------IVFALMALGLLLL--ALALGSLWLFLVLFLLLGLALGGGNGAVFAlVPD 322

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392891199 353 MVSGQYSPFVMSIVQIIAcsslMAGSFLVPAL--TPSDSFSEWQRVFMIYGAVLAITnTIFIVFARAEPAKWAQ 424
Cdd:COG2223  323 IFPTKNAGAVYGLVGAAG----GLGGFLGPLLfgALLDATGSYTAAFLVFAVLALVA-LVLTLLLYRRPRRAAA 391
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
34-421 1.29e-24

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 104.57  E-value: 1.29e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  34 QRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVitWSFPVFVILRVLQGITLAN 113
Cdd:COG2271   37 QADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFA--TSFWQLLLLRFLLGLGEAG 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 114 LFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYlhgaILGALTILWAVyyrdravkhpf 193
Cdd:COG2271  115 FFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFL----ILGLPGLLLAL----------- 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 194 vqrkewrkisfgkkldqtgkgsnetpirkivssIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLTLIPM 273
Cdd:COG2271  180 ---------------------------------LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPF 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 274 ACLLVIKFSTGFFSDRIKSisdltKMKMFNSCALLGSSIFFIILSCSSPGGSKVLDVILLSIpmALLGFSSGGYSKCAVM 353
Cdd:COG2271  227 LAGIVGSLLGGWLSDRLGR-----RRKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGF--GLGGAFGLLWALAAEL 299

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392891199 354 VSGQYSPFVMSIVQIIACSSLMAGSFLVPALtpSDSFSeWQRVFMIYGAVLAITnTIFIVFARAEPAK 421
Cdd:COG2271  300 FPKKARGTASGLVNTFGFLGGALGPLLVGYL--LDATG-YQAAFLLLAALALLA-ALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
37-378 2.44e-24

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 103.27  E-value: 2.44e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199   37 FAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILgtFLVVITPIVITWSFPVFVILRVLQGITLANLFT 116
Cdd:pfam07690  27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLL--FALGLLLLLFASSLWLLLVLRVLQGLGAGALFP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  117 TAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWaVYYRDRAVKHPFVQR 196
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLL-LLPRPPPESKRPKPA 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  197 KEWRKISFgkkldqtgkgsneTPIRKIVSSIVIWGVWIAVIGNFLVSQFSiSYAPIYLrGVIGCTPTEAGLLTLIPMACL 276
Cdd:pfam07690 184 EEARLSLI-------------VAWKALLRDPVLWLLLALLLFGFAFFGLL-TYLPLYQ-EVLGLSALLAGLLLGLGGLLG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  277 LVIKFSTGFFSDRIKSIsdlTKMKMFNSCALLGSSIFFIILSCSSPGgskVLDVILLSIPMALLGFSSGGYSKCAVMVSG 356
Cdd:pfam07690 249 AIGRLLLGRLSDRLGRR---RRLLLALLLLILAALGLLLLSLTLSSL---WLLLALLLLGFGFGLVFPALNALVSDLAPK 322

                         330       340
                  ....*....|....*....|..
gi 392891199  357 QYSPFVMSIVQIIACSSLMAGS 378
Cdd:pfam07690 323 EERGTASGLYNTAGSLGGALGP 344
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 30-415 5.04e-23

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 99.94  E-value: 5.04e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRrFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVITWSFPVFVILRVLQGI 109
Cdd:cd17380   23 VPMAKE-FGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPLLAYSSLPLLILSRILLGL 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 110 TLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLhgaiLGALTILWAVYYRdrav 189
Cdd:cd17380  102 GEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF----FGLLGLLWALVWL---- 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 190 khpfvqrkewrkisfgkkldqtgkgsnetpirkivssIVIWGVWIAVIGNFLVS-QFSI--SYAPIYLRGVIGCTpTEAG 266
Cdd:cd17380  174 -------------------------------------IYLPPVWAIIVAHFCMNwGFYIllSWLPTYFHEVLVPL-AKGW 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 267 LLTLIPMACLLVIKFSTGFFSDRI--KSISDLTKMKMFNSCALLGSSIFFIILSCSSpggSKVLDVILLSIPMALLGFSS 344
Cdd:cd17380  216 VFNVVPWLVMFPSSNVAGWLADHLisRGWTVTSVRKLMQSIGFLGPALFLLLLSHTD---SFSLALLCMSVALGLSAFSS 292

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392891199 345 GGYSKCAVMVSGQYSPFVMSIvqiiacsSLMAGS---FLVPALTPS--DSFSEWQRVFMIYGAVLAITNTIFIVFA 415
Cdd:cd17380  293 SGVLVNHQDIAPNYAGIVFGI-------SNTAGTipgIVGVYLTGYilEATGSWSLVFVLAAVVNLVGAVVFLLFG 361
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 30-406 1.59e-22

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 98.41  E-value: 1.59e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVitWSFPVFVILRVLQGI 109
Cdd:cd17319   26 APTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFA--TSLTSLYVLRFLLGV 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 110 TLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYlhgaILGALTILWAVYYRdrav 189
Cdd:cd17319  104 AEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFI----IEGLLGLLLAVLWW---- 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 190 khpfvqrkewrkisfgkkldqtgkgsnetpirkivssIVIWGVWIAVIGNFLVS---QFSISYAPIYLRGVIGCTPTEAG 266
Cdd:cd17319  176 -------------------------------------FYLRQVWGLALGYFGINyalYGLLTWLPTYLKQARGFSLKQVG 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 267 LLTLIPMACLLVIKFSTGFFSDRIKSISdlTKMKMFNSCALLGSSIFFIILScsspgGSKVLDVILLSIPMALLGFSSGG 346
Cdd:cd17319  219 LLAAIPFLAGAIGMILGGRLSDRLLRGA--RRLVIIIGLLLAAVGLLLAYLT-----TSPVVAVILLSLAGFGIGAASPV 291

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392891199 347 -YSKCAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALTpsDSFSEWQRVFMIYGAVLAI 406
Cdd:cd17319  292 fWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLV--DATGSYTAAFLFLAAVALL 350
MFS_SLC17A5 cd17381
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ...
 1-415 3.73e-22

Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340939 [Multi-domain]  Cd Length: 397  Bit Score: 97.93  E-value: 3.73e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199   1 MVNPQSSPywEDFVNSNKSLDEINWNDPDLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGvHKVMTLSGI 80
Cdd:cd17381   26 MVNSNSTL--PSNNSSNACPEHSSSPSVEHNETGKKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIG-GKLLLGFGI 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  81 LGT-FLVVITPIVITWSFPVFVILRVLQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATS 159
Cdd:cd17381  103 LGTaVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYY 182

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 160 AGWPWVFYlhgaILGALTILWAVYYrdravkhpfvqrkewrkisfgkkldqtgkgsnetpirkivsSIVIWGVWIAVign 239
Cdd:cd17381  183 LDWTYVFY----IFGAVGLLWFFLW-----------------------------------------IWLVMPLWAIV--- 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 240 flVSQFSISYA--------PIYLRGVIGCTPTEAGLLTLIP-MACLLVIkFSTGFFSDRIKS---ISDLTKMKMFNSCAL 307
Cdd:cd17381  215 --VAHFSYNWTfytlltllPTYMKEILRFDIQENGFLSALPyLGCWLFM-ILSGQIADNLREkqnFSTVCVRKIFTLIGM 291

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 308 LGSSIFfiILSCSSPGGSKVLDVILLSIPMALLGFSSGGYSKCAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALTPS 387
Cdd:cd17381  292 IGPAVF--LLAAGFTGCNYSLAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTHN 369

                        410       420
                 ....*....|....*....|....*...
gi 392891199 388 DSFSEWQRVFMIYGAVLAITNTIFIVFA 415
Cdd:cd17381  370 NTVEEWQTVFYISAAINVFGAIFFTIFG 397
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
30-346 3.97e-20

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 91.19  E-value: 3.97e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVItpIVITWSFPVFVILRVLQGI 109
Cdd:COG2814   33 LPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL--CALAPSLWLLLAARFLQGL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 110 TLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLhGAILGALTILWAVYYRDRAV 189
Cdd:COG2814  111 GAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV-NAVLALLALLLLLRLLPESR 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 190 KHPfvqrkewrkisfgkkldqtgKGSNETPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLT 269
Cdd:COG2814  190 PAA--------------------RARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLL 249

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 392891199 270 LIPMACLLVIKFSTGFFSDRIKSISDLTkmkmfnsCALLGSSIFFIILSCSSPggskvldVILLSIPMALLGFSSGG 346
Cdd:COG2814  250 ALFGLGGVLGALLAGRLADRFGRRRLLL-------IGLLLLALGLLLLALAGS-------LWLLLLALFLLGFGFGL 312
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 28-415 1.20e-16

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 81.08  E-value: 1.20e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  28 PDLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMtlsgILGTFLVVITPIVITW--SFPVFVILRV 105
Cdd:cd17325   17 PILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLL----LLGLLLLAVSTLLFAFatSYWQLLLARF 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 106 LQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLhGAILGALTILWAVYYR 185
Cdd:cd17325   93 LQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLV-CAALALLALVLALLLL 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 186 DRAVKHPFVQRKEWRKIsfgkkldqtgkgsnETPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEA 265
Cdd:cd17325  172 PEPRPPPNKRAVSAARL--------------RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQI 237

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 266 GLLTLIPMACLLVIKFSTGFFSDRIKSIsdltkmKMFNSCALLGSSIFFIILSCSSpggskvldVILLSIPMALLGFSSG 345
Cdd:cd17325  238 GLLFGAQGLASALSQPPAGKLSDRIGRK------PLILIGLLLSAVALLLLPLATS--------FWLLLLLLALLGLGLG 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392891199 346 GYSK-----CAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALTPSDSFSEwqrVFMIYGAVLAITNTIFIVFA 415
Cdd:cd17325  304 LVFPatlalLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFAT---PFLAAAALLLLAAVLFLLLR 375
MFS_SLC17A6_7_8_VGluT cd17382
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ...
 39-415 1.28e-16

Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340940 [Multi-domain]  Cd Length: 380  Bit Score: 81.23  E-value: 1.28e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  39 FDTTQKSLGFAAG--FLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVITWSFPVFVILRVLQGITLANLFT 116
Cdd:cd17382   44 FNWTPETVGLIESsfFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYP 123

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 117 TAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAIlgalTILWAVYyrdravkhpfvqr 196
Cdd:cd17382  124 ACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVF----GIIWYMF------------- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 197 keWRKISFGkkldqtgkgsnetpirkivssiviwgVWIAVIGNF---------LVSQfsisyaPIYLRGVIGCTPTEAGL 267
Cdd:cd17382  187 --WMLVSMP--------------------------VYAIIVANFcrswtfyllLISQ------PAYFKEVFGFDISKVGI 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 268 LTLIPMACLLVIKFSTGFFSDRIKSISDLTKM---KMFNSCALLGSSIFFIILSCSSpggSKVLDVILLSIPMALLGFSS 344
Cdd:cd17382  233 LSALPHLVMTIIVPIGGQLADYLRSRGILSTTavrKIFNCGGFGMEATFLLVVAFSH---SPTVAISFLVLAVGFSGFAI 309

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392891199 345 GGYSKCAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALTPSDSFSEWQRVFMIYGAVLAITNTIFIVFA 415
Cdd:cd17382  310 SGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTREEWQYVFLIASLVHFFGVIFYAIFA 380
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 30-412 3.36e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 79.78  E-value: 3.36e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVitWSFPVFVILRVLQGI 109
Cdd:cd06174   19 LPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA--PSFWLLLLGRFLLGL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 110 TLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALAT--SAGWPWVFYLHGAILGALTILWAVYYRDR 187
Cdd:cd06174   97 GSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDP 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 188 AVKHPFVQRKEWRKISFgkkldqtgkgsneTPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGL 267
Cdd:cd06174  177 PESARAKNEEASSKSVL-------------KLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGL 243

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 268 LTLIPMACLLVIKFSTGFFSDRIKSISDLTKMkmfnscALLGSSIFFIILSCSSPGGSKVLDVILLSIPMAllGFSSGGY 347
Cdd:cd06174  244 LLSLFGLAGALGSLLLGLLSDRLIGRKPLLLI------GLLLMALGLALLLLAPSLLLLLLLLLLLGFGLG--GLLPLSF 315

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392891199 348 SKCAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALTpsDSFSEWQRVFMIYGAVLAITNTIFI 412
Cdd:cd06174  316 ALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL--AATFGLTGAFLVLAVLLLLAAILLL 378
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 30-286 4.61e-13

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 69.45  E-value: 4.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILgtFLVVITPIVITWSFPVFVILRVLQGI 109
Cdd:COG0477   37 LPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL--FGLASLLCGLAPSPELLIAARALQGI 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 110 TLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLhGAILGALTILWAVYYRDRAV 189
Cdd:COG0477  115 GAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLI-NAPLGLLALVLRLRLPESRG 193

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 190 KHPFVQRKEWRKISFGKKLDQTGKGSNETPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLT 269
Cdd:COG0477  194 LLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLA 273

                        250
                 ....*....|....*..
gi 392891199 270 LIPMACLLVIKFSTGFF 286
Cdd:COG0477  274 LLLALLLLLLLLLLLLL 290
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
26-421 2.11e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 65.26  E-value: 2.11e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  26 NDPDLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVItpIVITWSFPVFVILRV 105
Cdd:COG0738   27 WGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLL--FALAPSYPLLLLALF 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 106 LQGITLANLFTTAgvvvNEWAAVNEKGLFISVLS-AH-VEMGAVFTMPVSGALATSAG----WPWVFYLHGAILGALTIL 179
Cdd:COG0738  105 LLGLGLGLLDVAA----NPYVAALGPETAASRLNlLHaFFSLGALLGPLLGGLLILLGlslsWHLPYLILAVLLLLLALL 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 180 WAvyyrdravkhpFVQRKEWRKisfgkklDQTGKGSNETPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIG 259
Cdd:COG0738  181 FL-----------RSKLPEIEE-------EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLG 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 260 CTPTEAGLLTLIPMACLLVIKFSTGFFSDRIKSIsdltkmKMFNSCALLGssIFFIILSCSSPGGSkvldVILLSIPMAL 339
Cdd:COG0738  243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPV------RLLRLSALLA--AVGLLLALLAPGPW----LALIGLALVG 310

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 340 LGFS---SGGYSKcAVMVSGQYSPFVMSIVQIIACSSLMAGSFLVPALtpSDSFSewQRVFMIYGAVLAITNTIFIVFAR 416
Cdd:COG0738  311 LGLSlmfPTIFSL-ALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFL--ADAFG--LRAAFLVPLVCYLLILLLALALK 385


                 ....*
gi 392891199 417 AEPAK 421
Cdd:COG0738  386 RKRRK 390
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 31-407 1.37e-10

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 62.64  E-value: 1.37e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  31 PLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMtlsgILGTFLVVITPIVITW--SFPVFVILRVLQG 108
Cdd:cd17475   20 PFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVL----AVGLLLMGAAALLMALvgSYPVLLVLLFLVG 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 109 ITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAVYYRDRA 188
Cdd:cd17475   96 AGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPP 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 189 VK--HPFVQRKEWRKisfgkkldqtgkgsnetpIRKIVSSIVIWgvWIAVIGNFLVS-QFSIS-YAPIYLRGVIGCTPTE 264
Cdd:cd17475  176 AAsaATESASTLLRS------------------LKEVLRNRDVW--LIAIAGALLVApQFALLtFLLLFLHDHLGLSVVA 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 265 AGLLTLIPMACLLVIKFSTGFFSDRIKSISDLTKMKmfnsCALLGSSIFFIILSCSSPGGSKVLDVILlsipMALLGFSS 344
Cdd:cd17475  236 AGALLAVAQLGGALGRIGLGRVSDRVFGGRRRPVLV----ITAAIAAAALLVLSLLSPGTPLWLLVLL----LILLGLFA 307

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 345 GG-----YSKCAVMVSGQYSPFVMSIVQIIAcsslMAGSFLVPALTPS--DSFSEWQRVFMIYGAVLAIT 407
Cdd:cd17475  308 IGwnglyLTLVAESAGPEQAGTALGLANTIN----FIGIAIGPPLFGLlvDATHSYAPAWLALALLLVLA 373
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 34-187 2.78e-10

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 61.90  E-value: 2.78e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  34 QRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIViTWSFPVFVILRVLQGITLAN 113
Cdd:cd17355   30 IAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALA-TSLWQLYLLWGLLGGGGAGT 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392891199 114 LFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAVYYRDR 187
Cdd:cd17355  109 LAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRR 182
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 39-370 1.68e-09

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 59.57  E-value: 1.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  39 FDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVitWSFPVFVILRVLQGITLANLFTTA 118
Cdd:cd17327   38 LVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAV--KNFGGLIALRFFLGLFESGVFPGF 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 119 GVVVNEWAAVNEKGLFISVLSAHVEMG---------AVFTMPVSGALAtsaGWPWVFYLHGAILGALTILWAVYYRDRAV 189
Cdd:cd17327  116 ILYLGMWYKREEQAKRIAFFYAAAGLGsifggllayGVFKILGVGGLA---GWRWLFIIEGLITIIIGLVIFFWLPDNPS 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 190 KHPFVQRKEWRKISFGKKLDQTGKGSNETP---IRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGvIGCTPTEAG 266
Cdd:cd17327  193 KAWFLTEEEKELAVERLRANQTGKGDQKFKwkqIKEAFKDPRTWLLFLFFFCSQITNNGISNFLPLILKS-LGFYSLQTN 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 267 LLTLIPMACLLVIKFSTGFFSDRIKSISDLtkMKMFNSCALLGSSiffIILSCSSPGGSKVLDVILLSI--PMALLGFS- 343
Cdd:cd17327  272 LLSVPIGALGAVSLLIAALLSDRFKKRGLF--AIFACVLALVGSI---ILLAAPNPPGAYFAAYILGGGsyAGFPILLSw 346

                        330       340       350
                 ....*....|....*....|....*....|.
gi 392891199 344 ----SGGYSKCAVMVSGQYspFVMSIVQIIA 370
Cdd:cd17327  347 issnCAGYTKRATVLAIML--IFYNVGNIVA 375
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 81-346 2.63e-09

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 58.93  E-value: 2.63e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199   81 LGTFLVVITPIVITWS--FPVFVILRVLQGITLANLFTTAGVVVNEWAAVNEKGLFISVLS-AHVEMGAVFTMPVSGALA 157
Cdd:TIGR00881  65 IGLILCAIVNLFFGFStsLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNcSHNVGGGLLPPLVLFGIA 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  158 TSAGWPWVFYLHGAILGALTILWAVYYRDRAVKHPFVQRKEWRkiSFGKKLDQTGKGSNETP----IRKIVSSIVIWGVW 233
Cdd:TIGR00881 145 ELYSWHWVFIVPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMP--NEEPDGDAEKKEEELTKkqifLQYVLLNKVLWYIS 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  234 IAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLTLIPMACLLVIKFSTGFFSDRiksisDLTKMKMFNSCALLGSSIF 313
Cdd:TIGR00881 223 LGYVFVYVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDK-----LFNGRRGPLAVFFMALIIV 297

                         250       260       270
                  ....*....|....*....|....*....|...
gi 392891199  314 FIILSCSSPGGSKVLDVILLsipmALLGFSSGG 346
Cdd:TIGR00881 298 SLLVYWLNPAANPLMDLICL----FALGFLVYG 326
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 30-179 1.55e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 56.41  E-value: 1.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGvHKVMTLSGI----LGTFLVVITPivitwSFPVFVILRV 105
Cdd:cd17321   19 LPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFG-RKRVFLIGLalfgLASLLCALAP-----SLAFLIAARA 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 392891199 106 LQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTIL 179
Cdd:cd17321   93 LQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL 166
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 37-358 2.05e-08

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 55.69  E-value: 2.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  37 FAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGIL---GTFLvvitpIVITWSFPVFVILRVLQGITLAN 113
Cdd:cd17316   31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLfglATLL-----IGLLPTPILLLVLRFLQGIGIGG 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 114 LFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVF----TMPVSGALATSAGWPWVFylhgaILGALTILWAVYYRDRav 189
Cdd:cd17316  106 EYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLaalvASLLIPLLSGDWGWRILF-----LIGALPALLALLLRRR-- 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 190 khpfvqrkewrkisfgkkldqtgkgsnetpirkivssivIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLT 269
Cdd:cd17316  179 ---------------------------------------TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYL 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 270 LIPMACLLVIKFSTGFFSDRIksisdltKMKMFNSCALLGSSIFFIILSCSSPGGSKVLdvILLSIpmALLGFSSGGYSK 349
Cdd:cd17316  220 LLISLGALVGALIAGLLSDRI-------GRKKTLVIGLILSGILALPLFYLLSGSPTLL--LLLLF--ILSFFVGGVWGA 288


                 ....*....
gi 392891199 350 CAVMVSGQY 358
Cdd:cd17316  289 LYAYLAELF 297
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 37-179 4.31e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 54.90  E-value: 4.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  37 FAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIviTWSFPVFVILRVLQGITLANLFT 116
Cdd:cd17365   29 WGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF--AQSVLQLALLRFLTGLGLGAAMP 106

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392891199 117 TAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTIL 179
Cdd:cd17365  107 NAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILLPL 169
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 51-345 4.55e-08

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 54.89  E-value: 4.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  51 GFLGAIAAVVPMSR-LTARFGVHKVMTLSgiLGTFLVVITPIVITWSFPVFVILRVLQGITLANLFTTAGVVVNEWAAVN 129
Cdd:cd17503   39 SYLLALAIMIPLSGwLADRFGTRRLFLTA--LALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPE 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 130 EKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHgAILGALTILWAVYYRDRAVKHPFVqrkewrkisfgkkld 209
Cdd:cd17503  117 KRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYIN-LPIGILALLLAPLLDLRLFKDRNF--------------- 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 210 qtgkgsnetpirkIVSSIVIWGVWIAVIGNFLVsqfsisyAPIYLRGVIGCTPTEAGLLtLIPMACLLVI-KFSTGFFSD 288
Cdd:cd17503  181 -------------TLGLLLSFLLGLGLFGAMFL-------LPLYLQNVLGYSAFESGLV-LAPGGLASAIlSPLVGRLLD 239

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 392891199 289 RIksisDLTKMKMFNSCALLGSSIFFIILSCSSPggskvldVILLSIPMALLGFSSG 345
Cdd:cd17503  240 KF----GPRLLLLAGLLLLALGTLLLAFLTPDTS-------LWLIILPLFIRGLGMG 285
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
30-417 1.12e-07

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 53.72  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGIL---GTFLVVITPivitwSFPVFVILRVL 106
Cdd:COG2807   41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLlaaGLLLRSLAP-----SVALLLAGTAL 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 107 QGITLANLFTTAGVVVNEWAAvNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAVYYRD 186
Cdd:COG2807  116 IGAGIAVGNVLLPGLIKRWFP-DRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRR 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 187 RAVKHPfvqrkewrkisfgkkldqtgKGSNETPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGvIGCTPTEAG 266
Cdd:COG2807  195 RPAAAA--------------------AAPAAASLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAG 253

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 267 LLTLIPMACLLVIKFSTGFFSDRIKSISDLtkmkmfnscallgsSIFFIILSCSSPGGSKVLDVILLSIPMALLGFSSGG 346
Cdd:COG2807  254 LLLSLFQLAGIPGSLLVPLLADRLGDRRPL--------------LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGG 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 347 YSKCAVMVSGQYSP----------FVMSIVQIIACsslmAGSFLVPALtpSDSFSEWQRVFMIYGAVLAITNTIFIVFAR 416
Cdd:COG2807  320 LFPLALTLIGLRARtpaeaaalsgMAQSVGYLLAA----LGPLLVGAL--HDATGSWTAALLLLAALAVLMLVAGLLAGR 393


                 .
gi 392891199 417 A 417
Cdd:COG2807  394 P 394
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 30-192 1.41e-07

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 53.32  E-value: 1.41e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVitWSFPVFVILRVLQGI 109
Cdd:cd17324   22 LPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA--PSFALLLLARALAGL 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 110 TLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAIlgALTILWAVYYRDRAV 189
Cdd:cd17324  100 AHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVL--ALLAALLLWRLLPSL 177


                 ...
gi 392891199 190 KHP 192
Cdd:cd17324  178 PPK 180
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 30-381 2.76e-07

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 52.32  E-value: 2.76e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILgtFLVVITPIVITWSFPVFVILRVLQGI 109
Cdd:cd17333   19 GPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLL--ISLALALIFATPSIYLFVVLMFLAGL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 110 TLANLFTTAGVVVNEwAAVNEKGLFISVLSAHVEMGAVFTMPVSGAL-ATSAGWPWVFYLHGAI--LGALTILWAVYYRD 186
Cdd:cd17333   97 GAGILDTGANTFVGA-LFEESSATRLNVLHGFFGLGALIGPLIATSLlTSELSWSWAYLIIGLIylLLAILILLTLFPEL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 187 RAVKHPFVQRKEWRKISFGKKLdqtgkgsnetpirkivssivIWGVWIAVIGNFL--VSQFSI-SYAPIYLRGVIGCTPT 263
Cdd:cd17333  176 PSARNPQQSVGAFSASASRLLR--------------------NPSIILGALALFLyvGAETAFsSWVPSYLVEKKHVSDG 235

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 264 EAGLLTLIPMACLLVIKFSTGFFSDRIKSisdlTKMKMFNscaLLGSSIFFIILSCSSpggskvlDVILLSIPMALLGFS 343
Cdd:cd17333  236 LAGYLLSGFWVGITIGRLLGGPISRRIKP----HTLLVLS---GSGALLGLLILLLAP-------TLVVGLVATALLGLF 301

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 392891199 344 SGGYSKCA----VMVSGQYSPFVMSIVQIIACSSLMAGSFLV 381
Cdd:cd17333  302 MAALFPTIlslgISNLPYAKGKGTSVLLAAGSIGGAIIPFIM 343
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 27-284 3.24e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 52.19  E-value: 3.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  27 DPDLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSgiLGTFLVVITPIVITWSFPVFVILRVL 106
Cdd:cd17474   19 DPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPG--LLLFGIGGLLCGLSDSFALLLAGRAL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 107 QGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTmPVSGALATSAGWPWVFYLHGAILGALTILWAVYyrd 186
Cdd:cd17474   97 QGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFL--- 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 187 raVKHPFVQRKEWRKISFGKKldqtgkgsnetpiRKIVSSIVIWGV-WIAVIGNFLVSQFsISYAPIYLRGVIGCTPTEA 265
Cdd:cd17474  173 --LPEPKEKAKSSSATKLRDL-------------KKALRGRGLLTFlVSAFLYFFLYFAF-LTYLPFLLELLYGISPIII 236

                        250
                 ....*....|....*....
gi 392891199 266 GLLTLIPMACLLVIKFSTG 284
Cdd:cd17474  237 GLLFAGWSVLLALGSLFVG 255
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 28-179 1.28e-06

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 50.27  E-value: 1.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  28 PDLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIviTWSFPVFVILRVLQ 107
Cdd:cd17504   17 PALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAF--APNLPVLIAGRALQ 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 392891199 108 GITLAnLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTIL 179
Cdd:cd17504   95 GIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL 165
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 35-181 8.32e-06

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 47.95  E-value: 8.32e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  35 RRFAFDTTQKSLGFAA-GFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVItwSFPVFVILRVLQGITLAN 113
Cdd:cd17474  227 LLYGISPIIIGLLFAGwSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVP--SLALLLIAIVLFGLGLGL 304

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 392891199 114 LFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWA 181
Cdd:cd17474  305 NLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLA 372
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 30-202 9.49e-06

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 47.55  E-value: 9.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVItwSFPVFVILRVLQGI 109
Cdd:cd17477   19 LSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD--SPWVWFLLRFVMGI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 110 TLANLFTTAGVVVNEWAAVNEKGLFISVLSAhVEMGAVFTMPVSGALATSAGWPWvfYLHGAILGALTILWAVYYRDRAV 189
Cdd:cd17477   97 GLAGLFVVSESWLNALATNENRGRVLGLYST-VLGLGFALGPLLLALVGTAGALP--FLIAAVLLLLALVPLLLTRRAAP 173

                        170
                 ....*....|...
gi 392891199 190 KHPFVQRKEWRKI 202
Cdd:cd17477  174 EIEEAESISLRRL 186
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 32-182 1.05e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 47.61  E-value: 1.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  32 LSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVItpIVITWSFPVFVILRVLQGITL 111
Cdd:cd06173  234 LAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLV--LGLSPSLWLLLAALFLLGLAG 311

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392891199 112 ANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAV 182
Cdd:cd06173  312 GLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLL 382
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 49-279 3.93e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 45.63  E-value: 3.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  49 AAGFLGAIAAVVPM-SRLTARFGVhKVMTLSGI----LGTFLVVITPivitwSFPVFVILRVLQGITLANLFTTAGVVVN 123
Cdd:cd17502   36 GTAYLLTSTAFQPIyGKLSDLFGR-KWVLLIAIvifeLGSLLCGLAP-----NMTMLIVGRAIQGIGGGGLMSLAFIIIA 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 124 EWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHgAILGALTIlwavyyrdravkhpfvqrkewrkis 203
Cdd:cd17502  110 DLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYIN-LPIGGLAL------------------------- 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392891199 204 fgkkldqtgkgsnetpirkivssIVIWGVWIAVIGNFLVSQF---SISYAPIYLRGVIGCTPTEAGLLtLIPMACLLVI 279
Cdd:cd17502  164 -----------------------ALLRTILLSSIFGFLFGGAlfgLIYYLPLYFQLVLGDSATKSGVR-LLPLIIGLVI 218
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 30-180 4.11e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 45.63  E-value: 4.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVITWSFPVFVILRVLqGI 109
Cdd:cd17477  211 LPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLLFLW-GG 289

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 392891199 110 TLANLFTTAGVVVNEWAAVNE----KGLFISVLSAhvemGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILW 180
Cdd:cd17477  290 AAGPLYTLALALAGDRLPGDElvaaNAALLLLYGL----GSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
45-197 8.41e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 44.89  E-value: 8.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  45 SLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVITWSFPVFVILRVLQGITLANLFTTAGVVVNE 124
Cdd:COG2211  267 GLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLAD 346

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 125 WAAVNEK-------GLFISVLSAHVEMGAVFTMPVSGALATSAGWP--------------WVFYLHGAILGALTILWAVY 183
Cdd:COG2211  347 VVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFGYVagaaqspsaltgirLLFFLLPAVLLLLAALLLLF 426

                        170
                 ....*....|....
gi 392891199 184 YRDRAVKHPFVQRK 197
Cdd:COG2211  427 YPLTRERHAEIRAE 440
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 38-180 9.14e-05

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 44.56  E-value: 9.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  38 AFDTTQKSLG-FAAGF-LGAIAAVVPMSRLTARFGVHKVMtlsgILGTFLVVITPIV--ITWSFPVFVILRVLQGITLAN 113
Cdd:cd17476   27 SFGTSPNQLSwLAASYsLTVGTFILIFGRLGDIYGHKKMF----VIGSFWFAIWSLIagFSPNFIFFIICRALQGLGPAF 102

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392891199 114 LFTTA-GVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHG---AILGALTILW 180
Cdd:cd17476  103 LLPNAmALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLAilaAIVAVAAIFW 173
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 35-180 1.49e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 43.80  E-value: 1.49e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  35 RRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVitWSFPVFVILRVLQGITLA-- 112
Cdd:PRK11551  43 QEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQA--WDFPSLLVARLLTGVGLGga 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392891199 113 --NLFTtagvVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGA---ILGALTILW 180
Cdd:PRK11551 121 lpNLIA----LTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHIFYVGGVgplLLVPLLMRW 189
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 30-172 2.25e-04

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 43.50  E-value: 2.25e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199   30 LPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILgtFLVVITPIVITWSFPVFVILRVLQGI 109
Cdd:TIGR00895  40 APAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL--FSVFTLLCALATNVTQLLILRFLAGL 117

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 392891199  110 TLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAI 172
Cdd:TIGR00895 118 GLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIA 180
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
227-426 4.78e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.18  E-value: 4.78e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 227 IVIWGVWIAVIGNFLVsQFSISYAPIYLRGVIGCTPTEAGLLTLIPMACLLVIKFSTGFFSDRIKsisdlTKMKMFNSCA 306
Cdd:COG2223    5 RVLLLATLAFFLAFGV-WYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFG-----PRRVLLIGLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 307 LLGSSIFFIILscsspggskVLDVILLSIPMALLGFSSGG-YSKCAVMVSGQYSP----FVMSIVQIIACSSLMAGSFLV 381
Cdd:COG2223   79 LLGIGLLLLAL---------AVSYWLLLLLGLLLGIGGGGsFAVGIALVSKWFPPdrrgLALGLAAGGGNLGAAVAAFLA 149

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 392891199 382 PALTPSDSfseWQRVFMIYGAVLAITNTIFIVFARAEPAKWAQQK 426
Cdd:COG2223  150 PLLIAAFG---WRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAA 191
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 253-446 4.81e-04

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 42.36  E-value: 4.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  253 YLRGVIGCTPTEAGLLTLIPMACLLVIKFSTGFFSDRIKSisdltkmKMFNSCALLGSSIFFIILSCSSpggskvlDVIL 332
Cdd:TIGR00881  20 YLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNP-------RVFLPIGLILCAIVNLFFGFST-------SLWV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  333 LSIPMALLGFSSG-GYSKCAVMVSGQYSPFVM-SIVQIIACSSLMAGSFLVPALTPSDSFS-EWQRVFMIYGAVLAITNT 409
Cdd:TIGR00881  86 MAALWALNGIFQGmGWPPCGRTVTKWFSRSERgTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSL 165

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 392891199  410 IFIVFARAEPAKWAQQKGDLTLAEAVMGSEPKNTEVM 446
Cdd:TIGR00881 166 ICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKKEEEL 202
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 43-125 5.29e-04

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 41.80  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  43 QKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVitWSFPVFVILRVLQGITLANLFTTAGVVV 122
Cdd:cd17317   26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFS--PSYELFLVLRFLVGVTSAGIFTVGFVLG 103


                 ...
gi 392891199 123 NEW 125
Cdd:cd17317  104 MEI 106
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 40-346 6.30e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.83  E-value: 6.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  40 DTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVITwSFPVFVILRVLQGITLANLFTTAG 119
Cdd:cd17353   36 SLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAIS-LPLLFLGYGVLGGIGAGIGYITPV 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 120 VVVNEWAAvNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAVYYRDravkhpfvQRKEW 199
Cdd:cd17353  115 STAVKWFP-DKRGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRD--------PPKGW 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 200 RKISFGKKLDQTGKGSNETPIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEA----GLLTLIPMAC 275
Cdd:cd17353  186 VPPGVDPLANNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAalavSILSIFNGGG 265

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 392891199 276 LLVIkfstGFFSDRIKSisdltKMKMFNSCALLGSSIFFIILScsspGGSKVLDVILLsipmALLGFSSGG 346
Cdd:cd17353  266 RPFW----GWLSDKIGR-----KNTLSIAFLIQGVAMFLLPFI----GSVAVLFVLGV----ALIGFCYGG 319
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 28-345 9.50e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 41.41  E-value: 9.50e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  28 PDLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMtlsgILGTFLVVITPIVITW--SFPVFVILRV 105
Cdd:cd17320   20 PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVL----LAGLLLFILASLLCALasSIEQLLIARF 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 106 LQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGALATSAGWPWVFYLHgAILGALTILWAVYYR 185
Cdd:cd17320   96 LQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL-ALLGLLLLLLVLLFL 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 186 dravkhPFVQRKEWRKISFGKKLDQtgkgsnetpIRKIVSSIVIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEA 265
Cdd:cd17320  175 ------PETLPEEKRKPLLSSLLRA---------YKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQF 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 266 GLLTLIPMACLLVIKFSTGFFSDRIKSisdlTKMKMFNSCALLGSSIFFIILSCSSPGGskvldVILLSIPMALLGFSSG 345
Cdd:cd17320  240 GLLFALNAIALILGSLLNGRLVRRFGP----RRLLRLGLLLLLAAALVLLLAALLGGLS-----LWPLVAPLFLIFFGFG 310
MFS_NRT2_like cd17341
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ...
 37-345 1.07e-03

Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340899 [Multi-domain]  Cd Length: 384  Bit Score: 41.08  E-value: 1.07e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  37 FAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIVITwSFPVFVILRVLQGITLANlFT 116
Cdd:cd17341   29 LGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVS-SYWGLLVLGFLLGFAGAN-FA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 117 TAGVVVNEWAAVNEKGLFISVLSAHVEMGAV---FTMP-VSGALA---TSAGWPWVFYLHGAILGALTILWAVYYRDRAv 189
Cdd:cd17341  107 SGQPWASFWFPKEKIGGAAGGIAGAGNMGVAvsqLLAPlIAGAIVfdgGFVGWRNAFFVPGILLAIAAVLVLLFGDDLP- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 190 khpfvqrkewrkisfgkkldqTGKGSNETPIRKIVSSIVIWGVWIAVI------GNFLVsqFSiSYAPIYLRGVIGCTPT 263
Cdd:cd17341  186 ---------------------TGKASALEFLKVQLAVLKNYRTWILSLlygvtfGSFVG--FS-NVLPTYFKTRFGLPLV 241

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 264 EAGLLTLI-PMACLLVIKFStGFFSDRIksisDLTKMKMFNScALLGSSIFFIILSCSSPGGSKVLDVILLSIPMALLGF 342
Cdd:cd17341  242 TAGILAALfPLAGALARPAG-GWLSDRF----GGRRRLWWLF-IVMTIGAALLSLSLPTSGTNLVLFLALFVALGLGAGA 315


                 ...
gi 392891199 343 SSG 345
Cdd:cd17341  316 GNG 318
MFS_KgtP cd17367
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ...
 48-291 1.59e-03

Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340925 [Multi-domain]  Cd Length: 407  Bit Score: 40.74  E-value: 1.59e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  48 FAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGIL---GTFLVVITPIVIT---WSFPVFVILRVLQGITLANLFTTAGVV 121
Cdd:cd17367   46 FAVGFLMRPIGGWLFGRLADRIGRRAALTLSVSLmaaGSLVIAVTPTYATigiWAPIILLLARLLQGLSVGGEYGTSATY 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 122 VNEWAAVNEKGLFISVLSAHVEMGAVFTMPVSGAL------ATSAGWPW-VFYLHGAILGaltiLWAVYYRDRAVKHP-F 193
Cdd:cd17367  126 LSEVAPPGRRGFYSSFQYVTLIGGQLLALGVLLVLqhtlgeDQMAAWGWrIPFLLGGVLA----VVVLWLRRGLEETEsF 201

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 194 VQRKEwrkisfgkkldqtGKGSNETPIRKIVSSiviWGVWIAVIGnfLVSQFSI------SYAPIYLRGVIGCTPTEAGL 267
Cdd:cd17367  202 EAIAE-------------SNEASAGTLRELRRH---PRELLLVVG--LTAGGTLafytwtTYLQKFLVNTAGFSKGDATW 263

                        250       260
                 ....*....|....*....|....
gi 392891199 268 LTLIPMACLLVIKFSTGFFSDRIK 291
Cdd:cd17367  264 ITTAALLVFMLLQPLGGRLSDRIG 287
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 62-415 1.79e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.25  E-value: 1.79e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  62 MSRLTARFGVHKVMtLSGILGTFLVVITPIVITwSFPVFVILRVLQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAH 141
Cdd:cd17473   55 AGWLADRFGRKRLL-IAGLLLYGIGGVAGLFLD-SLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAA 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 142 VEMGAVFTMPVSGALATSaGWPWVFYLHG-AILGALTILWAVYYRDRAVKHPFVQRKEWRKisfgkkldqtgkgsnETPI 220
Cdd:cd17473  133 MSLGGVVFLLLGGALAEI-GWRAPFLVYLlALPVLILVLLFLPEPARKSKSAASPGAATAA---------------ALPW 196

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 221 RKivssivIWGVWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLTLIPMACLLVIKFSTGFFSDRIKSisdltkmK 300
Cdd:cd17473  197 KR------VLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGK-------R 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 301 MFNSCALLGSSIFFIILSCSSpggskvlDVILLSIPMALLGFSSG-----GYSKCAVMVSGQYSPFVMSIVQiiacSSLM 375
Cdd:cd17473  264 RLLAIGFALMALGFLLLALAS-------GLWVVLLGAILAGLGFGlllptLNSWAMSLVPPELRGRAMGIVT----SAFF 332

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 392891199 376 AGSFLVPAL--TPSDSFSEWQRVFMIYGAVLAITNTIFIVFA 415
Cdd:cd17473  333 LGQFLSPLVlgPLVNLTGGLSGAFLILGVLALVLAIVLLLLR 374
MFS_YjiJ cd06180
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ...
 28-194 3.49e-03

Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340869 [Multi-domain]  Cd Length: 371  Bit Score: 39.59  E-value: 3.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  28 PDLPLSQRRFAFDTTQKSLGFAAGFLGAIAAVVPMSRLTARFGVHKVMTLSGILGTFLVVITPIviTWSFPVFVILRVLQ 107
Cdd:cd06180   20 PLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAAMAL--TSGFAALLALRFLA 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 108 GITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMG-AVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAVYYRD 186
Cdd:cd06180   98 GAASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGiALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRR 177


                 ....*...
gi 392891199 187 RAVKHPFV 194
Cdd:cd06180  178 GPSAPTEA 185
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 68-187 3.62e-03

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 39.56  E-value: 3.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  68 RFGVHKVMtlsgILGTFLVVITPIVITWS--FPVFVILRVLQGITLANLFTTAGVVVNEWAAVNEKGLFISVLSAHVEMG 145
Cdd:cd17312   64 RSNIRRFM----SAGLLLSALANIFMGFStsLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFG 139

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 392891199 146 AVFTMPVSGALATSAGWPWVFYLHGAILGALTILWAVYYRDR 187
Cdd:cd17312  140 GILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDS 181
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 53-205 8.93e-03

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 38.38  E-value: 8.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  53 LGAIAAVVPMSRLTARFGVHKVMtlsgILGTFLVVITPIV--ITWSFPVFVILRVLQGITLANL----FTTAGVVVNEWa 126
Cdd:cd06179   43 LAQAVLGPIVGRLSDLFGRRWFF----IGGNLLGVVGSIVagTAKSVNMLIGGQALIGIGAGTQglgaAVASELVPNKY- 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199 127 avneKGLFISVLSAHVEMGAVFTMPVSGAL--ATSAGWPWVFYLHGAILGALTILWAVYYR--DRAVKHPFVQRKEWRKI 202
Cdd:cd06179  118 ----RGLVQGVVNLVASPGSALGPLIAGALveANAAGWRWIFYINAIFNALALILLFFFYHppPRPQLHGSSTRQKLKRL 193


                 ...
gi 392891199 203 SFG 205
Cdd:cd06179  194 DWV 196
MFS_1 pfam07690
Major Facilitator Superfamily;
232-424 9.23e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.17  E-value: 9.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  232 VWIAVIGNFLVSQFSISYAPIYLRGVIGCTPTEAGLLTLIPMACLLVIKFSTGFFSDRIKSisdltkmKMFNSCALLGSS 311
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGR-------RRVLLIGLLLFA 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392891199  312 IFFIILSCSSPggskvldVILLSIPMALLGFSSGGYSKCAVMVSGQYSP-----FVMSIVQIIACSSLMAGSFLVPALTp 386
Cdd:pfam07690  74 LGLLLLLFASS-------LWLLLVLRVLQGLGAGALFPAALALIADWFPpeergRALGLVSAGFGLGAALGPLLGGLLA- 145

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 392891199  387 sdSFSEWQRVFMIYGAVLAItNTIFIVFARAEPAKWAQ 424
Cdd:pfam07690 146 --SLFGWRAAFLILAILSLL-AAVLLLLPRPPPESKRP 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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