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Conserved domains on  [gi|388452668|ref|NP_001253949|]
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WD repeat domain phosphoinositide-interacting protein 4 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-274 3.49e-09

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 167 GSLQLVDLASTKPgtssaPFTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAtlYCINFS 246
Cdd:COG2319  184 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGSV--RSVAFS 255

                         90       100
                 ....*....|....*....|....*...
gi 388452668 247 HDSSFLCASSDKGTVHIFALKDTRLNRR 274
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRT 283
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-264 1.56e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668   8 GVTSLRFNQDQS--CFCCAMETgVRIYNVEPLME----KGHLdheqvGSMGLVEMLHRSNLLALVGGGSSpkfseisVLI 81
Cdd:cd00200   11 GVTCVAFSPDGKllATGSGDGT-IKVWDLETGELlrtlKGHT-----GPVRDVAASADGTYLASGSSDKT-------IRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668  82 WDDaregkdSKEKLVLEFT-FTKPVLSVRMRHDkivivlkNRIYVYSFPDNPRKLFEFDT-------RDNPKGLCDLCPS 153
Cdd:cd00200   78 WDL------ETGECVRTLTgHTSYVSSVAFSPD-------GRILSSSSRDKTIKVWDVETgkclttlRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 154 LEKQLLVFpGHKCGSLQLVDLASTKPGTssapfTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRR 233
Cdd:cd00200  145 PDGTFVAS-SSQDGTIKLWDLRTGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRG 217

                        250       260       270
                 ....*....|....*....|....*....|.
gi 388452668 234 GTDPatLYCINFSHDSSFLCASSDKGTVHIF 264
Cdd:cd00200  218 HENG--VNSVAFSPDGYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-274 3.49e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 167 GSLQLVDLASTKPgtssaPFTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAtlYCINFS 246
Cdd:COG2319  184 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGSV--RSVAFS 255

                         90       100
                 ....*....|....*....|....*...
gi 388452668 247 HDSSFLCASSDKGTVHIFALKDTRLNRR 274
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRT 283
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-274 1.12e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 187 TINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFSHDSSFLCASSDKGTVHIFAL 266
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTLRGHTDWVN--SVAFSPDGTFVASSSQDGTIKLWDL 164


                 ....*...
gi 388452668 267 KDTRLNRR 274
Cdd:cd00200  165 RTGKCVAT 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-264 1.56e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668   8 GVTSLRFNQDQS--CFCCAMETgVRIYNVEPLME----KGHLdheqvGSMGLVEMLHRSNLLALVGGGSSpkfseisVLI 81
Cdd:cd00200   11 GVTCVAFSPDGKllATGSGDGT-IKVWDLETGELlrtlKGHT-----GPVRDVAASADGTYLASGSSDKT-------IRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668  82 WDDaregkdSKEKLVLEFT-FTKPVLSVRMRHDkivivlkNRIYVYSFPDNPRKLFEFDT-------RDNPKGLCDLCPS 153
Cdd:cd00200   78 WDL------ETGECVRTLTgHTSYVSSVAFSPD-------GRILSSSSRDKTIKVWDVETgkclttlRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 154 LEKQLLVFpGHKCGSLQLVDLASTKPGTssapfTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRR 233
Cdd:cd00200  145 PDGTFVAS-SSQDGTIKLWDLRTGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRG 217

                        250       260       270
                 ....*....|....*....|....*....|.
gi 388452668 234 GTDPatLYCINFSHDSSFLCASSDKGTVHIF 264
Cdd:cd00200  218 HENG--VNSVAFSPDGYLLASGSEDGTIRVW 246
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
167-274 3.49e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.00  E-value: 3.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 167 GSLQLVDLASTKPgtssaPFTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPAtlYCINFS 246
Cdd:COG2319  184 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKLLASGSADGT-VRLWDLATGKLLRTLTGHSGSV--RSVAFS 255

                         90       100
                 ....*....|....*....|....*...
gi 388452668 247 HDSSFLCASSDKGTVHIFALKDTRLNRR 274
Cdd:COG2319  256 PDGRLLASGSADGTVRLWDLATGELLRT 283
WD40 COG2319
WD40 repeat [General function prediction only];
167-271 3.55e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 3.55e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 167 GSLQLVDLASTKPGTssapfTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFS 246
Cdd:COG2319  226 GTVRLWDLATGKLLR-----TLTGHSGSVRSVAFSPDGRLLASGSADGT-VRLWDLATGELLRTLTGHSGGVN--SVAFS 297

                         90       100
                 ....*....|....*....|....*
gi 388452668 247 HDSSFLCASSDKGTVHIFALKDTRL 271
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDLATGKL 322
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 187-274 1.12e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 1.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 187 TINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFSHDSSFLCASSDKGTVHIFAL 266
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKT-IKVWDVETGKCLTTLRGHTDWVN--SVAFSPDGTFVASSSQDGTIKLWDL 164


                 ....*...
gi 388452668 267 KDTRLNRR 274
Cdd:cd00200  165 RTGKCVAT 172
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 8-264 1.56e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.03  E-value: 1.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668   8 GVTSLRFNQDQS--CFCCAMETgVRIYNVEPLME----KGHLdheqvGSMGLVEMLHRSNLLALVGGGSSpkfseisVLI 81
Cdd:cd00200   11 GVTCVAFSPDGKllATGSGDGT-IKVWDLETGELlrtlKGHT-----GPVRDVAASADGTYLASGSSDKT-------IRL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668  82 WDDaregkdSKEKLVLEFT-FTKPVLSVRMRHDkivivlkNRIYVYSFPDNPRKLFEFDT-------RDNPKGLCDLCPS 153
Cdd:cd00200   78 WDL------ETGECVRTLTgHTSYVSSVAFSPD-------GRILSSSSRDKTIKVWDVETgkclttlRGHTDWVNSVAFS 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 154 LEKQLLVFpGHKCGSLQLVDLASTKPGTssapfTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRR 233
Cdd:cd00200  145 PDGTFVAS-SSQDGTIKLWDLRTGKCVA-----TLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTLRG 217

                        250       260       270
                 ....*....|....*....|....*....|.
gi 388452668 234 GTDPatLYCINFSHDSSFLCASSDKGTVHIF 264
Cdd:cd00200  218 HENG--VNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
167-271 3.55e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 3.55e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 167 GSLQLVDLASTKPGTssapfTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFS 246
Cdd:COG2319  142 GTVRLWDLATGKLLR-----TLTGHSGAVTSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGA--VRSVAFS 213

                         90       100
                 ....*....|....*....|....*
gi 388452668 247 HDSSFLCASSDKGTVHIFALKDTRL 271
Cdd:COG2319  214 PDGKLLASGSADGTVRLWDLATGKL 238
WD40 COG2319
WD40 repeat [General function prediction only];
167-271 3.88e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 3.88e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 167 GSLQLVDLASTKPgtssaPFTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFS 246
Cdd:COG2319  100 GTVRLWDLATGLL-----LRTLTGHTGAVRSVAFSPDGKTLASGSADGT-VRLWDLATGKLLRTLTGHSGA--VTSVAFS 171

                         90       100
                 ....*....|....*....|....*
gi 388452668 247 HDSSFLCASSDKGTVHIFALKDTRL 271
Cdd:COG2319  172 PDGKLLASGSDDGTVRLWDLATGKL 196
WD40 COG2319
WD40 repeat [General function prediction only];
167-268 4.94e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 4.94e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 167 GSLQLVDLASTKPgtssaPFTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFS 246
Cdd:COG2319  310 GTVRLWDLATGKL-----LRTLTGHTGAVRSVAFSPDGKTLASGSDDGT-VRLWDLATGELLRTLTGHTGA--VTSVAFS 381

                         90       100
                 ....*....|....*....|..
gi 388452668 247 HDSSFLCASSDKGTVHIFALKD 268
Cdd:COG2319  382 PDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
167-271 5.12e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 5.12e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 167 GSLQLVDLASTKPGTssapfTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFS 246
Cdd:COG2319  268 GTVRLWDLATGELLR-----TLTGHSGGVNSVAFSPDGKLLASGSDDGT-VRLWDLATGKLLRTLTGHTGA--VRSVAFS 339

                         90       100
                 ....*....|....*....|....*
gi 388452668 247 HDSSFLCASSDKGTVHIFALKDTRL 271
Cdd:COG2319  340 PDGKTLASGSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-271 1.07e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 52.72  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 186 FTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSkEKLVELRRG-TDPatLYCINFSHDSSFLCASSDKGTVHIF 264
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGT-IKLWDLRT-GKCVATLTGhTGE--VNSVAFSPDGEKLLSSSSDGTIKLW 204


                 ....*..
gi 388452668 265 ALKDTRL 271
Cdd:cd00200  205 DLSTGKC 211
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-265 1.77e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.87  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668   3 QQPLRGVTSLRFnqDQSCFCCAMETGVRIYNVEplmeKGHLDHEQVGSMGLVE--MLHRSNLLALVGGGSSpkfseiSVL 80
Cdd:cd00200   51 TGPVRDVAASAD--GTYLASGSSDKTIRLWDLE----TGECVRTLTGHTSYVSsvAFSPDGRILSSSSRDK------TIK 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668  81 IWDdareGKDSKEKLVLEfTFTKPVLSVRMRHDKIVIV---LKNRIYVYSFPDN-PRKLFEFDTRDnpkgLCDLCPSLEK 156
Cdd:cd00200  119 VWD----VETGKCLTTLR-GHTDWVNSVAFSPDGTFVAsssQDGTIKLWDLRTGkCVATLTGHTGE----VNSVAFSPDG 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 157 QLLVFPGHKcGSLQLVDLASTKPGTssapfTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTD 236
Cdd:cd00200  190 EKLLSSSSD-GTIKLWDLSTGKCLG-----TLRGHENGVNSVAFSPDGYLLASGSEDGT-IRVWDLRTGECVQTLSGHTN 262

                        250       260
                 ....*....|....*....|....*....
gi 388452668 237 PATlyCINFSHDSSFLCASSDKGTVHIFA 265
Cdd:cd00200  263 SVT--SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
168-271 1.34e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.83  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 168 SLQLVDLASTKPGTSSAPFTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPATlyCINFSH 247
Cdd:COG2319   54 GAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGT-VRLWDLATGLLLRTLTGHTGAVR--SVAFSP 130

                         90       100
                 ....*....|....*....|....
gi 388452668 248 DSSFLCASSDKGTVHIFALKDTRL 271
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKL 154
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-274 6.43e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 6.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452668 186 FTINAHQSDIACVSLNQPGTVVASASQKGTlIRLFDTQSKEKLVELRRGTDPatLYCINFSHDSSFLCASSDKGTVHIFA 265
Cdd:cd00200    3 RTLKGHTGGVTCVAFSPDGKLLATGSGDGT-IKVWDLETGELLRTLKGHTGP--VRDVAASADGTYLASGSSDKTIRLWD 79


                 ....*....
gi 388452668 266 LKDTRLNRR 274
Cdd:cd00200   80 LETGECVRT 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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