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Conserved domains on  [gi|388490458|ref|NP_001253916|]
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transmembrane protein 168 [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TMEM168 cd21494
Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 ...
17-695 0e+00

Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 (TMEM168) and similar proteins. TMEM168 is a multi-pass membrane protein predicted to contain nine transmembrane helices. Its expression has been implicated in several diseases. It is upregulated in glioblastoma multiforme (GBM) and small interfering RNA (siRNA)-TMEM168 has been shown to prevent viability of human GBM cell lines, induce cell cycle arrest (G0/G1 phase), and promote apoptosis through the suppression of the Wnt/beta-catenin pathway. A TMEM168 point mutation has also been associated with arrhythmogenesis in familial Brugada syndrome.


:

Pssm-ID: 411069  Cd Length: 681  Bit Score: 1214.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458  17 MTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTANSLILVIFILGLFVLGIASILYYYFSMEAASLSLSN 96
Cdd:cd21494    1 MTRLMEVNREVNMHSSVRYLGYLSSLNLLVAICLGLYVRWEKTADSLILVIFILGLFVFAIASILYYYFSMEDASLSLSH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458  97 LWFGFLLGLLCFLDNSSFKNDVKEESTKYLLLTSIVLRILCSLVERISGYVRHRPTLLTTIEFLELVGFAIAsTTMLVEK 176
Cdd:cd21494   81 LWFGFLLGLLCFTDNSSFQSDVKEEVTNYLLLTSVVLRCFWALVERICGLVRYRPTLLTSVEFLELVGFAIA-TTMLVQK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 177 SLSVILLVVALAMLIIDLRMKSFLAIPNLVIFAV---LLFFSSLETPKNPIAFACFFICLITDPFLDIYFSGLSVTERWK 253
Cdd:cd21494  160 SLSVILLVLALAMLIIDLRLKSFLAIPNLIVFAVisaLLFFPALKIPPNPFALSCFAGRLIFDPLLDLYFSGLSVTERWK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 254 PFLYRGRICRRLSVVFAGMIELTFFILSAFKLRDTHLWYFVIPGFSIFGIFWMICHIIFLLTLWGFHTKLNDCHKVYFTH 333
Cdd:cd21494  240 PYLYRGRICRRLSVLLIGIIELTFFVLAAFKLRDHKEWYFVIPGFSIFGIFWLIFHIIFLITLWGFHTKLNECHKVYRTH 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 334 RTDYNSLDRIMASKGMRHFCLISEQLVFFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGNCLGGTSVG 413
Cdd:cd21494  320 RDDNNSLDRIMASKGMRHFCLISERLVFFSLLSTLILGAVSWQPTNGIFISLFLIVLPLESMAHGLFHELGNCLGGTCTG 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 414 YAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSKLKAFLELRTVDGP 493
Cdd:cd21494  400 YAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETFGCDYSTSGLSLDTLQSKLKAFFERRTPDGP 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 494 RHDTYILYYSGHTHGTGEWALAGGDTLRLDTLLEWWREKNGSFCSRLIIVLDSENSTPWVKEVRKINDQYIAVQGAELVK 573
Cdd:cd21494  480 RHDTYVLYYSGHVHGNGDWALAGGDTLRLDTLLEWWREKNGSSGSRLIIVLDTENSQPWVKEVRKINDQYIAVQGAELAK 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 574 TVDIEEADPPQLGDFTKDWVEYNCNSSNNICWTEKGRTVKAVYGVSKRWSDYTLHLPTGSDVAKHWMLHFPRITYPLVHL 653
Cdd:cd21494  560 TVDPEEGDPPQLGDFTKEWVEYNCNSENDINWTEKGRTVKAVYGVSRRWSDFTFHLPTGSDVAKHWMLHFPRITYPLVKL 639
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 388490458 654 ANWLCGLNLFWICKTCFRCLKRLKMSWFLPTVLDTGQGFKLV 695
Cdd:cd21494  640 ANWCCGLNLFWCCDWCFRCLKRLKMKWFPPAVLDTGHGFKLV 681
 
Name Accession Description Interval E-value
TMEM168 cd21494
Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 ...
17-695 0e+00

Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 (TMEM168) and similar proteins. TMEM168 is a multi-pass membrane protein predicted to contain nine transmembrane helices. Its expression has been implicated in several diseases. It is upregulated in glioblastoma multiforme (GBM) and small interfering RNA (siRNA)-TMEM168 has been shown to prevent viability of human GBM cell lines, induce cell cycle arrest (G0/G1 phase), and promote apoptosis through the suppression of the Wnt/beta-catenin pathway. A TMEM168 point mutation has also been associated with arrhythmogenesis in familial Brugada syndrome.


Pssm-ID: 411069  Cd Length: 681  Bit Score: 1214.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458  17 MTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTANSLILVIFILGLFVLGIASILYYYFSMEAASLSLSN 96
Cdd:cd21494    1 MTRLMEVNREVNMHSSVRYLGYLSSLNLLVAICLGLYVRWEKTADSLILVIFILGLFVFAIASILYYYFSMEDASLSLSH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458  97 LWFGFLLGLLCFLDNSSFKNDVKEESTKYLLLTSIVLRILCSLVERISGYVRHRPTLLTTIEFLELVGFAIAsTTMLVEK 176
Cdd:cd21494   81 LWFGFLLGLLCFTDNSSFQSDVKEEVTNYLLLTSVVLRCFWALVERICGLVRYRPTLLTSVEFLELVGFAIA-TTMLVQK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 177 SLSVILLVVALAMLIIDLRMKSFLAIPNLVIFAV---LLFFSSLETPKNPIAFACFFICLITDPFLDIYFSGLSVTERWK 253
Cdd:cd21494  160 SLSVILLVLALAMLIIDLRLKSFLAIPNLIVFAVisaLLFFPALKIPPNPFALSCFAGRLIFDPLLDLYFSGLSVTERWK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 254 PFLYRGRICRRLSVVFAGMIELTFFILSAFKLRDTHLWYFVIPGFSIFGIFWMICHIIFLLTLWGFHTKLNDCHKVYFTH 333
Cdd:cd21494  240 PYLYRGRICRRLSVLLIGIIELTFFVLAAFKLRDHKEWYFVIPGFSIFGIFWLIFHIIFLITLWGFHTKLNECHKVYRTH 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 334 RTDYNSLDRIMASKGMRHFCLISEQLVFFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGNCLGGTSVG 413
Cdd:cd21494  320 RDDNNSLDRIMASKGMRHFCLISERLVFFSLLSTLILGAVSWQPTNGIFISLFLIVLPLESMAHGLFHELGNCLGGTCTG 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 414 YAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSKLKAFLELRTVDGP 493
Cdd:cd21494  400 YAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETFGCDYSTSGLSLDTLQSKLKAFFERRTPDGP 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 494 RHDTYILYYSGHTHGTGEWALAGGDTLRLDTLLEWWREKNGSFCSRLIIVLDSENSTPWVKEVRKINDQYIAVQGAELVK 573
Cdd:cd21494  480 RHDTYVLYYSGHVHGNGDWALAGGDTLRLDTLLEWWREKNGSSGSRLIIVLDTENSQPWVKEVRKINDQYIAVQGAELAK 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 574 TVDIEEADPPQLGDFTKDWVEYNCNSSNNICWTEKGRTVKAVYGVSKRWSDYTLHLPTGSDVAKHWMLHFPRITYPLVHL 653
Cdd:cd21494  560 TVDPEEGDPPQLGDFTKEWVEYNCNSENDINWTEKGRTVKAVYGVSRRWSDFTFHLPTGSDVAKHWMLHFPRITYPLVKL 639
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 388490458 654 ANWLCGLNLFWICKTCFRCLKRLKMSWFLPTVLDTGQGFKLV 695
Cdd:cd21494  640 ANWCCGLNLFWCCDWCFRCLKRLKMKWFPPAVLDTGHGFKLV 681
 
Name Accession Description Interval E-value
TMEM168 cd21494
Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 ...
17-695 0e+00

Transmembrane (TMEM) protein family 168; This family includes transmembrane protein 168 (TMEM168) and similar proteins. TMEM168 is a multi-pass membrane protein predicted to contain nine transmembrane helices. Its expression has been implicated in several diseases. It is upregulated in glioblastoma multiforme (GBM) and small interfering RNA (siRNA)-TMEM168 has been shown to prevent viability of human GBM cell lines, induce cell cycle arrest (G0/G1 phase), and promote apoptosis through the suppression of the Wnt/beta-catenin pathway. A TMEM168 point mutation has also been associated with arrhythmogenesis in familial Brugada syndrome.


Pssm-ID: 411069  Cd Length: 681  Bit Score: 1214.47  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458  17 MTRLEEVNREVNMHSSVRYLGYLARINLLVAICLGLYVRWEKTANSLILVIFILGLFVLGIASILYYYFSMEAASLSLSN 96
Cdd:cd21494    1 MTRLMEVNREVNMHSSVRYLGYLSSLNLLVAICLGLYVRWEKTADSLILVIFILGLFVFAIASILYYYFSMEDASLSLSH 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458  97 LWFGFLLGLLCFLDNSSFKNDVKEESTKYLLLTSIVLRILCSLVERISGYVRHRPTLLTTIEFLELVGFAIAsTTMLVEK 176
Cdd:cd21494   81 LWFGFLLGLLCFTDNSSFQSDVKEEVTNYLLLTSVVLRCFWALVERICGLVRYRPTLLTSVEFLELVGFAIA-TTMLVQK 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 177 SLSVILLVVALAMLIIDLRMKSFLAIPNLVIFAV---LLFFSSLETPKNPIAFACFFICLITDPFLDIYFSGLSVTERWK 253
Cdd:cd21494  160 SLSVILLVLALAMLIIDLRLKSFLAIPNLIVFAVisaLLFFPALKIPPNPFALSCFAGRLIFDPLLDLYFSGLSVTERWK 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 254 PFLYRGRICRRLSVVFAGMIELTFFILSAFKLRDTHLWYFVIPGFSIFGIFWMICHIIFLLTLWGFHTKLNDCHKVYFTH 333
Cdd:cd21494  240 PYLYRGRICRRLSVLLIGIIELTFFVLAAFKLRDHKEWYFVIPGFSIFGIFWLIFHIIFLITLWGFHTKLNECHKVYRTH 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 334 RTDYNSLDRIMASKGMRHFCLISEQLVFFSLLATAILGAVSWQPTNGIFLSMFLIVLPLESMAHGLFHELGNCLGGTSVG 413
Cdd:cd21494  320 RDDNNSLDRIMASKGMRHFCLISERLVFFSLLSTLILGAVSWQPTNGIFISLFLIVLPLESMAHGLFHELGNCLGGTCTG 399
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 414 YAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETYGCDYSTSGLSFDTLHSKLKAFLELRTVDGP 493
Cdd:cd21494  400 YAIVIPTNFCSPDGQPTLLPPEHVQELNLRSTGMLNAIQRFFAYHMIETFGCDYSTSGLSLDTLQSKLKAFFERRTPDGP 479
                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 494 RHDTYILYYSGHTHGTGEWALAGGDTLRLDTLLEWWREKNGSFCSRLIIVLDSENSTPWVKEVRKINDQYIAVQGAELVK 573
Cdd:cd21494  480 RHDTYVLYYSGHVHGNGDWALAGGDTLRLDTLLEWWREKNGSSGSRLIIVLDTENSQPWVKEVRKINDQYIAVQGAELAK 559
                        570       580       590       600       610       620       630       640
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490458 574 TVDIEEADPPQLGDFTKDWVEYNCNSSNNICWTEKGRTVKAVYGVSKRWSDYTLHLPTGSDVAKHWMLHFPRITYPLVHL 653
Cdd:cd21494  560 TVDPEEGDPPQLGDFTKEWVEYNCNSENDINWTEKGRTVKAVYGVSRRWSDFTFHLPTGSDVAKHWMLHFPRITYPLVKL 639
                        650       660       670       680
                 ....*....|....*....|....*....|....*....|..
gi 388490458 654 ANWLCGLNLFWICKTCFRCLKRLKMSWFLPTVLDTGQGFKLV 695
Cdd:cd21494  640 ANWCCGLNLFWCCDWCFRCLKRLKMKWFPPAVLDTGHGFKLV 681
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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