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Conserved domains on  [gi|388454701|ref|NP_001253899|]
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protein SEC13 homolog [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 2.08e-35

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 2.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 104
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 105 SVNSVCWAPHdyGLILACGSSDGAISLlmYTGEGQWEVKKInNAHTIGCNAVSWApavvpgslidqPSGQkpnyikRFAS 184
Cdd:COG2319  206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFS-----------PDGR------LLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 185 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNTWSPKLLHKFN- 262
Cdd:COG2319  264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                        250       260
                 ....*....|....*....|....*....
gi 388454701 263 --DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319  329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 2.08e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 2.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 104
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 105 SVNSVCWAPHdyGLILACGSSDGAISLlmYTGEGQWEVKKInNAHTIGCNAVSWApavvpgslidqPSGQkpnyikRFAS 184
Cdd:COG2319  206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFS-----------PDGR------LLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 185 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNTWSPKLLHKFN- 262
Cdd:COG2319  264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                        250       260
                 ....*....|....*....|....*....
gi 388454701 263 --DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319  329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 9.13e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 9.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 89
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  90 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLlmytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 164
Cdd:cd00200   82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 165 gslidqpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:cd00200  147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 388454701 244 TCDDASgntwSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:cd00200  205 DLSTGK----CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-86 3.08e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.08e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 388454701    49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 11-90 1.62e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 83
Cdd:PTZ00420  72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                 ....*..
gi 388454701  84 IIWREEN 90
Cdd:PTZ00420 151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
202-243 5.26e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 388454701  202 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 2.08e-35

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 2.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGtwEKSHEHAGHDS 104
Cdd:COG2319  132 GKTLASGSADGTVRLWDLATGK--LLRTLTGHSGAVTSVAFSPD--GKLLASGSDDGTVRLWDLATG--KLLRTLTGHTG 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 105 SVNSVCWAPHdyGLILACGSSDGAISLlmYTGEGQWEVKKInNAHTIGCNAVSWApavvpgslidqPSGQkpnyikRFAS 184
Cdd:COG2319  206 AVRSVAFSPD--GKLLASGSADGTVRL--WDLATGKLLRTL-TGHSGSVRSVAFS-----------PDGR------LLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 185 GGCDNLIKLWkeeeDGQWKEE-QKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcddasgNTWSPKLLHKFN- 262
Cdd:COG2319  264 GSADGTVRLW----DLATGELlRTLTGHSGGVNSVAFSPD-G---KLLASGSDDGTVRLW-------DLATGKLLRTLTg 328

                        250       260
                 ....*....|....*....|....*....
gi 388454701 263 --DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319  329 htGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 4.91e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 128.49  E-value: 4.91e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEKSHEhaGHDS 104
Cdd:COG2319  174 GKLLASGSDDGTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPD--GKLLASGSADGTVRLWDLATGKLLRTLT--GHSG 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 105 SVNSVCWAPHdyGLILACGSSDGAISLlmytgegqWEVK-----KINNAHTIGCNAVSWApavvpgslidqPSGqkpnyi 179
Cdd:COG2319  248 SVRSVAFSPD--GRLLASGSADGTVRL--------WDLAtgellRTLTGHSGGVNSVAFS-----------PDG------ 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 180 KRFASGGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIWtcddasgNTWSPKLLH 259
Cdd:COG2319  301 KLLASGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD----GKTLASGSDDGTVRLW-------DLATGELLR 366

                        250       260       270
                 ....*....|....*....|....*....|...
gi 388454701 260 KFN---DVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319  367 TLTghtGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
10-289 3.93e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 126.18  E-value: 3.93e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREE 89
Cdd:COG2319   75 LGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGL--LLRTLTGHTGAVRSVAFSPD--GKTLASGSADGTVRLWDLA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  90 NGtwEKSHEHAGHDSSVNSVCWAPhDyGLILACGSSDGAISLL-MYTGEGQWEVKkinnAHTIGCNAVSWApavvpgsli 168
Cdd:COG2319  151 TG--KLLRTLTGHSGAVTSVAFSP-D-GKLLASGSDDGTVRLWdLATGKLLRTLT----GHTGAVRSVAFS--------- 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 169 dqPSGQkpnyikRFASGGCDNLIKLWKEEedgQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDA 248
Cdd:COG2319  214 --PDGK------LLASGSADGTVRLWDLA---TGKLLRTLTGHSGSVRSVAFSPD-G---RLLASGSADGTVRLW---DL 275

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 388454701 249 SGNTWsPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319  276 ATGEL-LRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-289 9.13e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 9.13e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGgqILIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIWREE 89
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG--ELLRTLKGHTGPVRDVAASA--DGTYLASGSSDKTIRLWDLE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  90 NGtwEKSHEHAGHDSSVNSVCWAPHDYglILACGSSDGAISLlmytgegqWEVKKIN-----NAHTIGCNAVSWAPAvvp 164
Cdd:cd00200   82 TG--ECVRTLTGHTSYVSSVAFSPDGR--ILSSSSRDKTIKV--------WDVETGKclttlRGHTDWVNSVAFSPD--- 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 165 gslidqpsgqkpnyiKRFASGGC-DNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:cd00200  147 ---------------GTFVASSSqDGTIKLW---DLRTGKCVATLTGHTGEVNSVAFSPD----GEKLLSSSSDGTIKLW 204

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 388454701 244 TCDDASgntwSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:cd00200  205 DLSTGK----CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVW 246
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 7-290 2.65e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.89  E-value: 2.65e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701   7 TVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWaHPMyGNILASCSYDRKVIIW 86
Cdd:cd00200   45 RTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE--CVRTLTGHTSYVSSVAF-SPD-GRILSSSSRDKTIKVW 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  87 REENGtwEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISLlmytgegqWEVKKIN-----NAHTIGCNAVSWApa 161
Cdd:cd00200  121 DVETG--KCLTTLRGHTDWVNSVAFSPD--GTFVASSSQDGTIKL--------WDLRTGKcvatlTGHTGEVNSVAFS-- 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 162 vvpgslidqPSGqkpnyiKRFASGGCDNLIKLWkEEEDGQWKEEqkLEAHSDWVRDVAWAPSIGLptstIASCSQDGRVF 241
Cdd:cd00200  187 ---------PDG------EKLLSSSSDGTIKLW-DLSTGKCLGT--LRGHENGVNSVAFSPDGYL----LASGSEDGTIR 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 388454701 242 IWtcddasgNTWSPKLLHKF---NDVVWHVSWSITANILAVSGGDNKVTLWK 290
Cdd:cd00200  245 VW-------DLRTGECVQTLsghTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
25-289 1.76e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 1.76e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  25 GTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWREENGTWEksHEHAGHDS 104
Cdd:COG2319   48 GARLAAGAGDLTLLLLDAAAGA--LLATLLGHTAAVLSVAFSPD--GRLLASASADGTVRLWDLATGLLL--RTLTGHTG 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 105 SVNSVCWAPHdyGLILACGSSDGAISLL-MYTGEGQWEVKkinnAHTIGCNAVSWApavvpgslidqPSGqkpnyiKRFA 183
Cdd:COG2319  122 AVRSVAFSPD--GKTLASGSADGTVRLWdLATGKLLRTLT----GHSGAVTSVAFS-----------PDG------KLLA 178

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701 184 SGGCDNLIKLWkeeEDGQWKEEQKLEAHSDWVRDVAWAPSiGlptSTIASCSQDGRVFIWtcdDASGNTWsPKLLHKFND 263
Cdd:COG2319  179 SGSDDGTVRLW---DLATGKLLRTLTGHTGAVRSVAFSPD-G---KLLASGSADGTVRLW---DLATGKL-LRTLTGHSG 247

                        250       260
                 ....*....|....*....|....*.
gi 388454701 264 VVWHVSWSITANILAVSGGDNKVTLW 289
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
10-87 1.20e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.85  E-value: 1.20e-10
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 388454701  10 TSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGqiLIADLRGHEGPVWQVAWAHPmyGNILASCSYDRKVIIWR 87
Cdd:COG2319  327 TGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGE--LLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWD 400
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-86 3.08e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.08e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 388454701    49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSP--DGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 201-243 1.41e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 1.41e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 388454701   201 QWKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD----GKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 11-90 1.62e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.40  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454701  11 SHEDMIHDAQMD-YYGTRLATCSSDRSVKIFDVRNGGQIL--IAD----LRGHEGPVWQVAWaHPMYGNILASCSYDRKV 83
Cdd:PTZ00420  72 GHTSSILDLQFNpCFSEILASGSEDLTIRVWEIPHNDESVkeIKDpqciLKGHKKKISIIDW-NPMNYYIMCSSGFDSFV 150


                 ....*..
gi 388454701  84 IIWREEN 90
Cdd:PTZ00420 151 NIWDIEN 157
WD40 pfam00400
WD domain, G-beta repeat;
202-243 5.26e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.26e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 388454701  202 WKEEQKLEAHSDWVRDVAWAPSiglpTSTIASCSQDGRVFIW 243
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPD----GKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
49-86 5.63e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 5.63e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 388454701   49 LIADLRGHEGPVWQVAWAHpmYGNILASCSYDRKVIIW 86
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSP--DGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 2.93e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 2.93e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454701    92 TWEKSHEHAGHDSSVNSVCWAPHdyGLILACGSSDGAISL 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPD--GKYLASGSDDGTIKL 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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