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Conserved domains on  [gi|388453895|ref|NP_001253827|]
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lambda-crystallin homolog [Macaca mulatta]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK06129 super family cl35428
3-hydroxyacyl-CoA dehydrogenase; Validated
 9-314 7.35e-108

3-hydroxyacyl-CoA dehydrogenase; Validated


The actual alignment was detected with superfamily member PRK06129:

Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 316.60  E-value: 7.35e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGA 88
Cdd:PRK06129   5 VAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTT 168
Cdd:PRK06129  84 DYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPAT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 169 VDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EG 247
Cdd:PRK06129 164 LARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGG 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 388453895 248 MLSYCDRYSEGMKHVLKTFGPIPEFSRATAEKVNQDMCVKVPDDpeHLAARRQWRDECLMRLAKLKS 314
Cdd:PRK06129 244 VADYAQRYGPMYRRMAAERGQPVPWDGELVARVEAERRAALPLD--QLAARQAWRDRRLMALAAHRR 308
 
Name Accession Description Interval E-value
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 9-314 7.35e-108

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 316.60  E-value: 7.35e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGA 88
Cdd:PRK06129   5 VAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTT 168
Cdd:PRK06129  84 DYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPAT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 169 VDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EG 247
Cdd:PRK06129 164 LARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGG 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 388453895 248 MLSYCDRYSEGMKHVLKTFGPIPEFSRATAEKVNQDMCVKVPDDpeHLAARRQWRDECLMRLAKLKS 314
Cdd:PRK06129 244 VADYAQRYGPMYRRMAAERGQPVPWDGELVARVEAERRAALPLD--QLAARQAWRDRRLMALAAHRR 308
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 9-243 1.18e-80

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 246.18  E-value: 1.18e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIqEAVEGA 88
Cdd:COG1250    5 VAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEE-EADAALARITPTTDL-AALADA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTT 168
Cdd:COG1250   83 DLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDET 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 388453895 169 VDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLETMHL 243
Cdd:COG1250  163 VATAVAFARRLGKTPVVV-KDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFP---MGPFELADL 233
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 9-186 8.92e-64

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 199.30  E-value: 8.92e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895    9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVeGA 88
Cdd:pfam02737   2 VAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEE-EVDAALARISFTTDLAAAV-DA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTT 168
Cdd:pfam02737  80 DLVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPET 159

                         170
                  ....*....|....*...
gi 388453895  169 VDRTHALMKKIGQCPMRV 186
Cdd:pfam02737 160 VATTVELAKKIGKTPVVV 177
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 9-221 2.95e-15

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 76.41  E-value: 2.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895    9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIE-------QQQIRNALENIRKEMKLleqagalkGSLSAEEQLSLISGCPNI 81
Cdd:TIGR02441 338 LAVLGAGLMGAGIAQVSVDKGLKTVLKDATpagldrgQQQVFKGLNKKVKRKKI--------TSLERDSILSNLTPTLDY 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   82 QeAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPH 161
Cdd:TIGR02441 410 S-GFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITH 488

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  162 PETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGiVSPSDLD 221
Cdd:TIGR02441 489 DGTSKDTLASAVAVGLKQGKVVIVV-KDGPGFYTTRCLGPMLAEVIRLLQEG-VDPKKLD 546
 
Name Accession Description Interval E-value
PRK06129 PRK06129
3-hydroxyacyl-CoA dehydrogenase; Validated
 9-314 7.35e-108

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 235706 [Multi-domain]  Cd Length: 308  Bit Score: 316.60  E-value: 7.35e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVEGA 88
Cdd:PRK06129   5 VAIIGAGLIGRAWAIVFARAGHEVRLWDADPAAAAAAPAYIAGRLEDLAAFDLLDGE-APDAVLARIRVTDSLADAVADA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTT 168
Cdd:PRK06129  84 DYVQESAPENLELKRALFAELDALAPPHAILASSTSALLASAFTEHLAGRERCLVAHPINPPYLIPVVEVVPAPWTAPAT 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 169 VDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNA-EG 247
Cdd:PRK06129 164 LARAEALYRAAGQSPVRLRREIDGFVLNRLQGALLREAFRLVADGVASVDDIDAVIRDGLGLRWSFMGPFETIDLNApGG 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 388453895 248 MLSYCDRYSEGMKHVLKTFGPIPEFSRATAEKVNQDMCVKVPDDpeHLAARRQWRDECLMRLAKLKS 314
Cdd:PRK06129 244 VADYAQRYGPMYRRMAAERGQPVPWDGELVARVEAERRAALPLD--QLAARQAWRDRRLMALAAHRR 308
FadB COG1250
3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA ...
 9-243 1.18e-80

3-hydroxyacyl-CoA dehydrogenase [Lipid transport and metabolism]; 3-hydroxyacyl-CoA dehydrogenase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440862 [Multi-domain]  Cd Length: 281  Bit Score: 246.18  E-value: 1.18e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIqEAVEGA 88
Cdd:COG1250    5 VAVIGAGTMGAGIAAVFANAGYEVVLLDISPEALERARARIAKLLDKLVKKGKLTEE-EADAALARITPTTDL-AALADA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTT 168
Cdd:COG1250   83 DLVIEAVPEDLDLKQEVFAELDAVAPPDAILASNTSSLSITELAAATKRPERFIGLHFFNPVPLMPLVEVIRGPATSDET 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 388453895 169 VDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLETMHL 243
Cdd:COG1250  163 VATAVAFARRLGKTPVVV-KDTPGFIVNRILVPYLNEAIRLLEEGVASPEDIDAAMRLGFGFP---MGPFELADL 233
3HCDH_N pfam02737
3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda ...
 9-186 8.92e-64

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; This family also includes lambda crystallin.


Pssm-ID: 397037 [Multi-domain]  Cd Length: 180  Bit Score: 199.30  E-value: 8.92e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895    9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQEAVeGA 88
Cdd:pfam02737   2 VAVIGAGTMGAGIAQVFALAGLEVVLVDISEEALEKALERIESSLERLVEKGRITEE-EVDAALARISFTTDLAAAV-DA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTT 168
Cdd:pfam02737  80 DLVIEAVPENLELKRKLFAELDAIAPPDAILATNTSSLSITELAAATKRPERFIGLHFFNPPPLMPLVEVVRGEKTSPET 159

                         170
                  ....*....|....*...
gi 388453895  169 VDRTHALMKKIGQCPMRV 186
Cdd:pfam02737 160 VATTVELAKKIGKTPVVV 177
PRK06130 PRK06130
3-hydroxybutyryl-CoA dehydrogenase; Validated
 11-244 2.59e-59

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 235707 [Multi-domain]  Cd Length: 311  Bit Score: 192.68  E-value: 2.59e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  11 IVGSGVIGRSWAMLFASGGFQVKLYDIEQqqirNALENIRKemKLLEQAGALKGSLSAEEQLSLISGCPNIQEAVEGAMH 90
Cdd:PRK06130   9 IIGAGTMGSGIAALFARKGLQVVLIDVME----GALERARG--VIERALGVYAPLGIASAGMGRIRMEAGLAAAVSGADL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  91 IQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTTVD 170
Cdd:PRK06130  83 VIEAVPEKLELKRDVFARLDGLCDPDTIFATNTSGLPITAIAQAVTRPERFVGTHFFTPADVIPLVEVVRGDKTSPQTVA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 388453895 171 RTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLN 244
Cdd:PRK06130 163 TTMALLRSIGKRPVLVKKDIPGFIANRIQHALAREAISLLEKGVASAEDIDEVVKWSLGIRLALTGPLEQRDMN 236
PRK07531 PRK07531
carnitine 3-dehydrogenase;
11-280 2.96e-58

carnitine 3-dehydrogenase;


Pssm-ID: 236044 [Multi-domain]  Cd Length: 495  Bit Score: 194.96  E-value: 2.96e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  11 IVGSGVIGRSWAMLFASGGFQVKLYDIE---QQQIRNALENIRKEMKLLEQAgalkgSLSAEEQLSLisgCPNIQEAVEG 87
Cdd:PRK07531   9 CIGGGVIGGGWAARFLLAGIDVAVFDPHpeaERIIGEVLANAERAYAMLTDA-----PLPPEGRLTF---CASLAEAVAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  88 AMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPT 167
Cdd:PRK07531  81 ADWIQESVPERLDLKRRVLAEIDAAARPDALIGSSTSGFLPSDLQEGMTHPERLFVAHPYNPVYLLPLVELVGGGKTSPE 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 168 TVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLnAEG 247
Cdd:PRK07531 161 TIRRAKEILREIGMKPVHIAKEIDAFVGDRLLEALWREALWLVKDGIATTEEIDDVIRYSFGLRWAQMGLFETYRI-AGG 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 388453895 248 mlsycdrySEGMKHVLKTFGP-----------IPEFSRATAEKV 280
Cdd:PRK07531 240 --------EAGMRHFLAQFGPclkwpwtklmdVPDLDDALVDKI 275
PRK07066 PRK07066
L-carnitine dehydrogenase;
12-307 1.81e-49

L-carnitine dehydrogenase;


Pssm-ID: 168796 [Multi-domain]  Cd Length: 321  Bit Score: 167.32  E-value: 1.81e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  12 VGSGVIGRSWAMLFASGGFQVKLYDIE---QQQIRNALENirkEMKLLEQAGALKGSlsAEEQLSLIsgcPNIQEAVEGA 88
Cdd:PRK07066  13 IGSGVIGSGWVARALAHGLDVVAWDPApgaEAALRANVAN---AWPALERQGLAPGA--SPARLRFV---ATIEACVADA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPTT 168
Cdd:PRK07066  85 DFIQESAPEREALKLELHERISRAAKPDAIIASSTSGLLPTDFYARATHPERCVVGHPFNPVYLLPLVEVLGGERTAPEA 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 169 VDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLnAEGm 248
Cdd:PRK07066 165 VDAAMGIYRALGMRPLHVRKEVPGFIADRLLEALWREALHLVNEGVATTGEIDDAIRFGAGIRWSFMGTFLTYTL-AGG- 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 388453895 249 lsycdrySEGMKHVLKTFGPIPE--FSRATAEKVNQDMCVKVPD------DPEHLAARRQWRDECLM 307
Cdd:PRK07066 243 -------DAGMRHFMQQFGPALElpWTKLVAPELTDALIDRVVEgtaeqqGPRSIKALERYRDECIT 302
PRK08269 PRK08269
3-hydroxybutyryl-CoA dehydrogenase; Validated
 17-258 9.56e-38

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181340 [Multi-domain]  Cd Length: 314  Bit Score: 136.34  E-value: 9.56e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  17 IGRSWAMLFASGGFQVKLYDIEQQQI-------RNALENIRKEMKLLEQAGALKGSlSAEEQLSLISGCPNIQ--EAVEG 87
Cdd:PRK08269   1 MGQGIALAFAFAGHDVTLIDFKPRDAagwraldAEARAEIERTLAALVALGRIDAA-QADAVLARIAVVARDGaaDALAD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  88 AMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETAPT 167
Cdd:PRK08269  80 ADLVFEAVPEVLDAKREALRWLGRHVDADAIIASTTSTFLVTDLQRHVAHPERFLNAHWLNPAYLMPLVEVSPSDATDPA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 168 TVDRTHALMKKIGQCPMrVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAEG 247
Cdd:PRK08269 160 VVDRLAALLERIGKVPV-VCGPSPGYIVPRIQALAMNEAARMVEEGVASAEDIDKAIRTGFGLRFAVLGLLEFIDWGGCD 238

                        250
                 ....*....|.
gi 388453895 248 MLSYCDRYSEG 258
Cdd:PRK08269 239 ILYYASRYLAG 249
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 8-243 1.27e-36

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 137.29  E-value: 1.27e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   8 CVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEM-KLLEqagalKGSLSAEE---QLSLISGCPNIQE 83
Cdd:PRK08268   9 TVAVIGAGAMGAGIAQVAAQAGHTVLLYDARAGAAAAARDGIAARLaKLVE-----KGKLTAEQadaALARLRPVEALAD 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  84 AVEGAMHIqECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQciVA--HPVNPPYYIPLVELVPH 161
Cdd:PRK08268  84 LADCDLVV-EAIVERLDVKQALFAQLEAIVSPDCILATNTSSLSITAIAAALKHPER--VAglHFFNPVPLMKLVEVVSG 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 162 PETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLETM 241
Cdd:PRK08268 161 LATDPAVADALYALARAWGKTPVRA-KDTPGFIVNRAARPYYTEALRVLEEGVADPATIDAILREAAGFR---MGPFELM 236


                 ..
gi 388453895 242 HL 243
Cdd:PRK08268 237 DL 238
PRK05808 PRK05808
3-hydroxybutyryl-CoA dehydrogenase; Validated
 9-238 1.86e-36

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 180269 [Multi-domain]  Cd Length: 282  Bit Score: 132.01  E-value: 1.86e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQagalKGSLSAEEQ---LSLISGCPNIQEAV 85
Cdd:PRK05808   6 IGVIGAGTMGNGIAQVCAVAGYDVVMVDISDAAVDRGLATITKSLDRLVK----KGKMTEADKeaaLARITGTTDLDDLK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  86 EGAMHIqECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETA 165
Cdd:PRK05808  82 DADLVI-EAATENMDLKKKIFAQLDEIAKPEAILATNTSSLSITELAAATKRPDKVIGMHFFNPVPVMKLVEIIRGLATS 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 388453895 166 PTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSegLGMRYAfIGPL 238
Cdd:PRK05808 161 DATHEAVEALAKKIGKTPVEV-KNAPGFVVNRILIPMINEAIFVLAEGVATAEDIDEGMK--LGCNHP-IGPL 229
PRK09260 PRK09260
3-hydroxyacyl-CoA dehydrogenase;
9-239 5.17e-36

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 236434 [Multi-domain]  Cd Length: 288  Bit Score: 131.07  E-value: 5.17e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQirnaLENIRKEMKLLEQAGALKGSLSAEEQLSLISGCP---NIQEAV 85
Cdd:PRK09260   4 LVVVGAGVMGRGIAYVFAVSGFQTTLVDIKQEQ----LESAQQEIASIFEQGVARGKLTEAARQAALARLSyslDLKAAV 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  86 EGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETA 165
Cdd:PRK09260  80 ADADLVIEAVPEKLELKKAVFETADAHAPAECYIATNTSTMSPTEIASFTKRPERVIAMHFFNPVHKMKLVELIRGLETS 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 388453895 166 PTTVDRTHALMKKIGQCPMRVQkEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSegLGMRYAfIGPLE 239
Cdd:PRK09260 160 DETVQVAKEVAEQMGKETVVVN-EFPGFVTSRISALVGNEAFYMLQEGVATAEDIDKAIR--LGLNFP-MGPLE 229
PRK08293 PRK08293
3-hydroxyacyl-CoA dehydrogenase;
9-241 1.16e-34

3-hydroxyacyl-CoA dehydrogenase;


Pssm-ID: 181359 [Multi-domain]  Cd Length: 287  Bit Score: 127.75  E-value: 1.16e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLEQAGALKGSLSAEEQLSLISGCPNIQEAVEGA 88
Cdd:PRK08293   6 VTVAGAGVLGSQIAFQTAFHGFDVTIYDISDEALEKAKERIAKLADRYVRDLEATKEAPAEAALNRITLTTDLAEAVKDA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  89 MHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKL---------FAGLvhvkqcivaHPVNPPYYIPLVELV 159
Cdd:PRK08293  86 DLVIEAVPEDPEIKGDFYEELAKVAPEKTIFATNSSTLLPSQFaeatgrpekFLAL---------HFANEIWKNNTAEIM 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 160 PHPETAPTTVDRTHALMKKIGQCPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGPLE 239
Cdd:PRK08293 157 GHPGTDPEVFDTVVAFAKAIGMVPIVLKKEQPGYILNSLLVPFLSAALALWAKGVADPETIDKTWMIATGAP---MGPFG 233


                 ..
gi 388453895 240 TM 241
Cdd:PRK08293 234 IL 235
PLN02545 PLN02545
3-hydroxybutyryl-CoA dehydrogenase
 1-239 8.35e-32

3-hydroxybutyryl-CoA dehydrogenase


Pssm-ID: 215300 [Multi-domain]  Cd Length: 295  Bit Score: 120.22  E-value: 8.35e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   1 MASSAAgcVVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKLLeqagALKGSLS---AEEQLSLISG 77
Cdd:PLN02545   1 MAEIKK--VGVVGAGQMGSGIAQLAAAAGMDVWLLDSDPAALSRGLDSISSSLARL----VKKGKMSqeeADATLGRIRC 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  78 CPNIQEaVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVE 157
Cdd:PLN02545  75 TTNLEE-LRDADFIIEAIVESEDLKKKLFSELDRICKPSAILASNTSSISITRLASATQRPQQVIGMHFMNPPPIMKLVE 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 158 LVPHPETAPTTVDRTHALMKKIGQCPMRVQkEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRyafIGP 237
Cdd:PLN02545 154 IIRGADTSDEVFDATKALAERFGKTVVCSQ-DYPGFIVNRILMPMINEAFYALYTGVASKEDIDTGMKLGTNHP---MGP 229


                 ..
gi 388453895 238 LE 239
Cdd:PLN02545 230 LH 231
PRK06035 PRK06035
3-hydroxyacyl-CoA dehydrogenase; Validated
 11-243 3.59e-31

3-hydroxyacyl-CoA dehydrogenase; Validated


Pssm-ID: 180361 [Multi-domain]  Cd Length: 291  Bit Score: 118.44  E-value: 3.59e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  11 IVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKE----MKLLEqagalKGSLSAEEQLSLIS--GCPNIQEA 84
Cdd:PRK06035   8 VVGSGVMGQGIAQVFARTGYDVTIVDVSEEILKNAMELIESGpyglRNLVE-----KGKMSEDEAKAIMAriRTSTSYES 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  85 VEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPET 164
Cdd:PRK06035  83 LSDADFIVEAVPEKLDLKRKVFAELERNVSPETIIASNTSGIMIAEIATALERKDRFIGMHWFNPAPVMKLIEVVRAALT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 165 APTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDlVMSEglgMRYAF-IGPLETMHL 243
Cdd:PRK06035 163 SEETFNTTVELSKKIGKIPIEV-ADVPGFFTTRFIEGWLLEAIRSFEIGIATIKDID-EMCK---LAFGFpMGPFELMDI 237
PRK07530 PRK07530
3-hydroxybutyryl-CoA dehydrogenase; Validated
 9-239 8.80e-22

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181018 [Multi-domain]  Cd Length: 292  Bit Score: 93.15  E-value: 8.80e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEMKllEQAGalKGSLSAEEQ---LSLISGCPNIQEAV 85
Cdd:PRK07530   7 VGVIGAGQMGNGIAHVCALAGYDVLLNDVSADRLEAGLATINGNLA--RQVA--KGKISEEARaaaLARISTATDLEDLA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  86 EGAMHIqECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPETA 165
Cdd:PRK07530  83 DCDLVI-EAATEDETVKRKIFAQLCPVLKPEAILATNTSSISITRLASATDRPERFIGIHFMNPVPVMKLVELIRGIATD 161

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 388453895 166 PTTVDRTHALMKKIGQCPMrVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSegLGMRYAfIGPLE 239
Cdd:PRK07530 162 EATFEAAKEFVTKLGKTIT-VAEDFPAFIVNRILLPMINEAIYTLYEGVGSVEAIDTAMK--LGANHP-MGPLE 231
PRK07819 PRK07819
3-hydroxybutyryl-CoA dehydrogenase; Validated
 9-248 9.59e-21

3-hydroxybutyryl-CoA dehydrogenase; Validated


Pssm-ID: 181133 [Multi-domain]  Cd Length: 286  Bit Score: 90.05  E-value: 9.59e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIEQQQIRNALENIRKEmklLEQAGAlKGSLSAEEQ---LSLISGCPNIQEAV 85
Cdd:PRK07819   8 VGVVGAGQMGAGIAEVCARAGVDVLVFETTEELATAGRNRIEKS---LERAVS-RGKLTERERdaaLARLRFTTDLGDFA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  86 EGAMHIqECVPEDLELKKKIFAQLDSIV-DDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPHPET 164
Cdd:PRK07819  84 DRQLVI-EAVVEDEAVKTEIFAELDKVVtDPDAVLASNTSSIPIMKLAAATKRPGRVLGLHFFNPVPVLPLVELVPTLVT 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 165 APTTVDRTHALMKKI-GQCPMRVQKEvAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLG-----MRYA-FIGp 237
Cdd:PRK07819 163 SEATVARAEEFASDVlGKQVVRAQDR-SGFVVNALLVPYLLSAIRMVESGFATAEDIDKAMVLGCAhpmgpLRLSdLVG- 240

                        250
                 ....*....|.
gi 388453895 238 LETMHLNAEGM 248
Cdd:PRK07819 241 LDTVKAIADSM 251
3HCDH pfam00725
3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda ...
 192-280 3.02e-19

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; This family also includes lambda crystallin. Some proteins include two copies of this domain.


Pssm-ID: 395588 [Multi-domain]  Cd Length: 97  Bit Score: 81.11  E-value: 3.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  192 GFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGMRYAFIGPLETMHLNAE--GMLSYCDRYSEGMKH---VLKTF 266
Cdd:pfam00725   1 GFVVNRLLAPYLNEAIRLVEEGVATPEDIDAAMRLGLGLPMGPFELSDLVGLDVGyhILEVLAEEFGDRAYRpppLLEKL 80

                          90
                  ....*....|....
gi 388453895  267 GPIPEFSRATAEKV 280
Cdd:pfam00725  81 VEAGRLGRKTGKGF 94
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
9-213 1.82e-16

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 79.94  E-value: 1.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   9 VVIVGSGVIGRSWAMLFAS-GGFQVKLYDIEQQQIRNALENI---------RKEMKLLEQagalkgslsaEEQLSLISGC 78
Cdd:PRK11154 312 VGVLGGGLMGGGIAYVTATkAGLPVRIKDINPQGINHALKYSwdlldkkvkRRHLKPSER----------DKQMALISGT 381

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  79 PNIQeAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVEL 158
Cdd:PRK11154 382 TDYR-GFKHADVVIEAVFEDLALKQQMVAEVEQNCAPHTIFASNTSSLPIGQIAAAAARPEQVIGLHYFSPVEKMPLVEV 460

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 388453895 159 VPHPETAPTTVDRTHALMKKIGQCPMrVQKEVAGFVLNRLQYAIISEAWRLVEEG 213
Cdd:PRK11154 461 IPHAKTSAETIATTVALAKKQGKTPI-VVRDGAGFYVNRILAPYINEAARLLLEG 514
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
 9-221 2.95e-15

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 76.41  E-value: 2.95e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895    9 VVIVGSGVIGRSWAMLFASGGFQVKLYDIE-------QQQIRNALENIRKEMKLleqagalkGSLSAEEQLSLISGCPNI 81
Cdd:TIGR02441 338 LAVLGAGLMGAGIAQVSVDKGLKTVLKDATpagldrgQQQVFKGLNKKVKRKKI--------TSLERDSILSNLTPTLDY 409

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895   82 QeAVEGAMHIQECVPEDLELKKKIFAQLDSIVDDRVILSSSTSCLMPSKLFAGLVHVKQCIVAHPVNPPYYIPLVELVPH 161
Cdd:TIGR02441 410 S-GFKNADMVIEAVFEDLSLKHKVIKEVEAVVPPHCIIASNTSALPIKDIAAVSSRPEKVIGMHYFSPVDKMQLLEIITH 488

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895  162 PETAPTTVDRTHALMKKIGQCPMRVqKEVAGFVLNRLQYAIISEAWRLVEEGiVSPSDLD 221
Cdd:TIGR02441 489 DGTSKDTLASAVAVGLKQGKVVIVV-KDGPGFYTTRCLGPMLAEVIRLLQEG-VDPKKLD 546
PRK08268 PRK08268
3-hydroxy-acyl-CoA dehydrogenase; Validated
 154-239 2.13e-05

3-hydroxy-acyl-CoA dehydrogenase; Validated


Pssm-ID: 236211 [Multi-domain]  Cd Length: 507  Bit Score: 45.99  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453895 154 PLVELVPHPETAPTTVDRTHALMKKIGQcPMRVQKEVAGFVLNRLQYAIISEAWRLVEEGIVSPSDLDLVMSEGLGmrYA 233
Cdd:PRK08268 379 KRRTLMAAPATSPAARDAAHALFQQDGK-AVSVIRDSPGFVAQRTVAMIVNEAADIAQQGIASPADIDLAMRLGLN--YP 455


                 ....*.
gi 388453895 234 FiGPLE 239
Cdd:PRK08268 456 L-GPLA 460
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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