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Conserved domains on  [gi|388453287|ref|NP_001253758|]
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WD repeat-containing protein 11 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
487-820 5.78e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 5.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 565
Cdd:COG2319    92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  566 ndesPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKNFPAITALEWSPSHnlkslrkKQLATreAMARQTV-- 643
Cdd:COG2319   164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  644 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDNDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 717
Cdd:COG2319   231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  718 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 793
Cdd:COG2319   296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373

                         330       340
                  ....*....|....*....|....*...
gi 388453287  794 vtfRILDVDWCTSDKVIL-ASDDGCIRV 820
Cdd:COG2319   374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
8-168 1.04e-06

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287    8 FKVSARTLTGALNAHNKA--AVDWGWQG--LIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWAREnyhhniGSpyc 83
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAvrSVAFSPDGktLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD------GK--- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   84 lRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWlwnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADN 160
Cdd:COG2319   176 -LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF------SPDgkLLASGSADGTVRLWDLATGKLLRTlTGHSGS 248


                  ....*...
gi 388453287  161 ILSFSFDP 168
Cdd:COG2319   249 VRSVAFSP 256
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
487-820 5.78e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 5.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 565
Cdd:COG2319    92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  566 ndesPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKNFPAITALEWSPSHnlkslrkKQLATreAMARQTV-- 643
Cdd:COG2319   164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  644 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDNDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 717
Cdd:COG2319   231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  718 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 793
Cdd:COG2319   296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373

                         330       340
                  ....*....|....*....|....*...
gi 388453287  794 vtfRILDVDWCTSDKVIL-ASDDGCIRV 820
Cdd:COG2319   374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-820 8.62e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 8.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  485 QPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNMglvrneLQLVDLPTGRSIA-FRGe 563
Cdd:cd00200    21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL--ASGSSDKT------IRLWDLETGECVRtLTG- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  564 rgnDESPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKNFPAITALEWSPShnlkslrkKQLATreamarqTV 643
Cdd:cd00200    92 ---HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--------GTFVA-------SS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  644 VSDTELSIVESSVISLLQeaeskselsqnisarehfVFTDNDGQVYHLTVEGNsvkdsarippdgsmgsitciawkGDTL 723
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVA------------------TLTGHTGEVNSVAFSPD-----------------------GEKL 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  724 VLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkgNQKLIAMYN-DGA-EVWDTKEVQMVSSLRSGRNvtfRILD 800
Cdd:cd00200   193 LSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSP---DGYLLASGSeDGTiRVWDLRTGECVQTLSGHTN---SVTS 266

                         330       340
                  ....*....|....*....|.
gi 388453287  801 VDWCTSDKVIL-ASDDGCIRV 820
Cdd:cd00200   267 LAWSPDGKRLAsGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
8-168 1.04e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287    8 FKVSARTLTGALNAHNKA--AVDWGWQG--LIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWAREnyhhniGSpyc 83
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAvrSVAFSPDGktLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD------GK--- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   84 lRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWlwnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADN 160
Cdd:COG2319   176 -LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF------SPDgkLLASGSADGTVRLWDLATGKLLRTlTGHSGS 248


                  ....*...
gi 388453287  161 ILSFSFDP 168
Cdd:COG2319   249 VRSVAFSP 256
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-179 2.69e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   54 LQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLwnqdASRDLLL 133
Cdd:cd00200     2 RRTLKGHTGGVTCVAF----------SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS----ADGTYLA 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 388453287  134 AIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDPfdpsHLTLLTS 179
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTlTGHTSYVSSVAFSP----DGRILSS 110
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
487-820 5.78e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 5.78e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 565
Cdd:COG2319    92 LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTL--ASGSADG------TVRLWDLATGKLLRtLTGHSG 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  566 ndesPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKNFPAITALEWSPSHnlkslrkKQLATreAMARQTV-- 643
Cdd:COG2319   164 ----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDG-------KLLAS--GSADGTVrl 230

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  644 --VSDTELSIV----ESSVISLlqeaesksELSQNisaREHFVFTDNDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIA 717
Cdd:COG2319   231 wdLATGKLLRTltghSGSVRSV--------AFSPD---GRLLASGSADGTVRLWDLATGEL----LRTLTGHSGGVNSVA 295

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  718 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRN 793
Cdd:COG2319   296 FspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKTLASGSDDGtVRLWDLATGELLRTLTGHTG 373

                         330       340
                  ....*....|....*....|....*...
gi 388453287  794 vtfRILDVDWCTSDKVIL-ASDDGCIRV 820
Cdd:COG2319   374 ---AVTSVAFSPDGRTLAsGSADGTVRL 398
WD40 COG2319
WD40 repeat [General function prediction only];
487-780 3.76e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 66.47  E-value: 3.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNmglvrnELQLVDLPTGRSIA-FRGERG 565
Cdd:COG2319   134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLL--ASGSDDG------TVRLWDLATGKLLRtLTGHTG 205

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  566 ndesPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKNFPAITALEWSPSHNL-------KSLRKKQLATREAM 638
Cdd:COG2319   206 ----AVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLlasgsadGTVRLWDLATGELL 281

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  639 ARQTVVSDTELSIVessvisllqeaeskselsqnISA-REHFVFTDNDGQVYHLTVEGNSVKDSaripPDGSMGSITCIA 717
Cdd:COG2319   282 RTLTGHSGGVNSVA--------------------FSPdGKLLASGSDDGTVRLWDLATGKLLRT----LTGHTGAVRSVA 337

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 388453287  718 W--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTK 780
Cdd:COG2319   338 FspDGKTLASGSDDGTVRLWDLAtGELLRTLTGHTGAVTSVAFSP--DGRTLASGSADGtVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 485-820 8.62e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 8.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  485 QPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLsfATSTPNNMglvrneLQLVDLPTGRSIA-FRGe 563
Cdd:cd00200    21 GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYL--ASGSSDKT------IRLWDLETGECVRtLTG- 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  564 rgnDESPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKNFPAITALEWSPShnlkslrkKQLATreamarqTV 643
Cdd:cd00200    92 ---HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD--------GTFVA-------SS 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  644 VSDTELSIVESSVISLLQeaeskselsqnisarehfVFTDNDGQVYHLTVEGNsvkdsarippdgsmgsitciawkGDTL 723
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVA------------------TLTGHTGEVNSVAFSPD-----------------------GEKL 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  724 VLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkgNQKLIAMYN-DGA-EVWDTKEVQMVSSLRSGRNvtfRILD 800
Cdd:cd00200   193 LSSSSDGTIKLWDLStGKCLGTLRGHENGVNSVAFSP---DGYLLASGSeDGTiRVWDLRTGECVQTLSGHTN---SVTS 266

                         330       340
                  ....*....|....*....|.
gi 388453287  801 VDWCTSDKVIL-ASDDGCIRV 820
Cdd:cd00200   267 LAWSPDGKRLAsGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
487-824 1.44e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.44e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  487 LLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSFATSTpnnmglvrNELQLVDLPTGRSIAFRGERgn 566
Cdd:COG2319    50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASAD--------GTVRLWDLATGLLLRTLTGH-- 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  567 dESPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKNFPAITALEWSPShnlkslrKKQLATreamarqtvvsd 646
Cdd:COG2319   120 -TGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD-------GKLLAS------------ 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  647 telsivessvisllqeaeskselsqnisarehfvfTDNDGQVYHLTVEGNSVkdsaRIPPDGSMGSITCIAW--KGDTLV 724
Cdd:COG2319   180 -----------------------------------GSDDGTVRLWDLATGKL----LRTLTGHTGAVRSVAFspDGKLLA 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  725 LGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWDTKEVQMVSSLRSGRNvtfRILDVD 802
Cdd:COG2319   221 SGSADGTVRLWDLAtGKLLRTLTGHSGSVRSVAFSP--DGRLLASGSADGtVRLWDLATGELLRTLTGHSG---GVNSVA 295

                         330       340
                  ....*....|....*....|...
gi 388453287  803 WCTSDKVIL-ASDDGCIRVLEMS 824
Cdd:COG2319   296 FSPDGKLLAsGSDDGTVRLWDLA 318
WD40 COG2319
WD40 repeat [General function prediction only];
530-820 2.37e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.53  E-value: 2.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  530 LSFATSTPNNMGLVRNELQLVDLPTGRSIAFRGERGNDESPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKN 609
Cdd:COG2319    40 ASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGH 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  610 FPAITALEWSPSHnlkslrkKQLATreAMARQTVVsdtelsivessvisllqeaeskselsqnisarehfVFTDNDGQVY 689
Cdd:COG2319   120 TGAVRSVAFSPDG-------KTLAS--GSADGTVR-----------------------------------LWDLATGKLL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  690 HlTVEGNSvkdsarippdgsmGSITCIAW--KGDTLVLGDMDGNLNFWDLK-GRVSRGIPTHRSWVRKIRFAPgkGNQKL 766
Cdd:COG2319   156 R-TLTGHS-------------GAVTSVAFspDGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTGAVRSVAFSP--DGKLL 219

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 388453287  767 IAMYNDG-AEVWDTKEVQMVSSLRSGrnvTFRILDVDWCTSDKVIL-ASDDGCIRV 820
Cdd:COG2319   220 ASGSADGtVRLWDLATGKLLRTLTGH---SGSVRSVAFSPDGRLLAsGSADGTVRL 272
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 484-778 3.00e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 53.49  E-value: 3.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  484 YQPLLAVGTSNGSVLVYHLTSGLLHKELSIHSCEVKGIEWTSLTSFLSfaTSTPNNmglvrnELQLVDLPTGRSI-AFRG 562
Cdd:cd00200    62 DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILS--SSSRDK------TIKVWDVETGKCLtTLRG 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  563 ERGndesPIEMIKVSHLKQYLAVVFKDKPLELWDVRTCTLLREMSKNFPAITALEWSPShnlkslrKKQLAtreamarqT 642
Cdd:cd00200   134 HTD----WVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-------GEKLL--------S 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  643 VVSDTELSIVESSVISLLQEAESKSElsqnisarehfvftdndgqvyhltvegnsvkdsarippdgsmgSITCIAW--KG 720
Cdd:cd00200   195 SSSDGTIKLWDLSTGKCLGTLRGHEN-------------------------------------------GVNSVAFspDG 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  721 DTLVLGDMDGNLNFWDL-KGRVSRGIPTHRSWVRKIRFAPgkGNQKLIAMYNDG-AEVWD 778
Cdd:cd00200   232 YLLASGSEDGTIRVWDLrTGECVQTLSGHTNSVTSLAWSP--DGKRLASGSADGtIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
8-168 1.04e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 52.61  E-value: 1.04e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287    8 FKVSARTLTGALNAHNKA--AVDWGWQG--LIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWAREnyhhniGSpyc 83
Cdd:COG2319   105 WDLATGLLLRTLTGHTGAvrSVAFSPDGktLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPD------GK--- 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   84 lRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWlwnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADN 160
Cdd:COG2319   176 -LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF------SPDgkLLASGSADGTVRLWDLATGKLLRTlTGHSGS 248


                  ....*...
gi 388453287  161 ILSFSFDP 168
Cdd:COG2319   249 VRSVAFSP 256
WD40 COG2319
WD40 repeat [General function prediction only];
12-168 2.07e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 51.45  E-value: 2.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   12 ARTLTGALNAHNKAAVDWGWQGLIAYGCHSLVVVIDSITAQTLQVLEKHKADVVKVKWAREnyhhniGSpyclRLASADV 91
Cdd:COG2319    71 LATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPD------GK----TLASGSA 140

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   92 NGKIIVWDVAAGVAQCEIQEHAKPIQDVQWlwnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDP 168
Cdd:COG2319   141 DGTVRLWDLATGKLLRTLTGHSGAVTSVAF------SPDgkLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSP 214
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 54-179 2.69e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 50.41  E-value: 2.69e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   54 LQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLwnqdASRDLLL 133
Cdd:cd00200     2 RRTLKGHTGGVTCVAF----------SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS----ADGTYLA 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 388453287  134 AIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDPfdpsHLTLLTS 179
Cdd:cd00200    68 SGSSDKTIRLWDLETGECVRTlTGHTSYVSSVAFSP----DGRILSS 110
WD40 COG2319
WD40 repeat [General function prediction only];
43-168 2.84e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 47.98  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   43 VVVIDSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWl 122
Cdd:COG2319   228 VRLWDLATGKLLRTLTGHSGSVRSVAF----------SPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF- 296

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 388453287  123 wnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDP 168
Cdd:COG2319   297 -----SPDgkLLASGSDDGTVRLWDLATGKLLRTlTGHTGAVRSVAFSP 340
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-218 3.49e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.33  E-value: 3.49e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   47 DSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWLWNQD 126
Cdd:cd00200    79 DLETGECVRTLTGHTSYVSSVAF----------SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  127 ----ASRDlllaihppNYIVLWNADTGTKLWK-KSYADNILSFSFDPfDPSHLTLLTSEGIVFISDFSPSKPP-SGPGKK 200
Cdd:cd00200   149 fvasSSQD--------GTIKLWDLRTGKCVATlTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLgTLRGHE 219

                         170
                  ....*....|....*...
gi 388453287  201 VYISSPHSSPaHNKLATA 218
Cdd:cd00200   220 NGVNSVAFSP-DGYLLAS 236
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 50-121 2.70e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 44.25  E-value: 2.70e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 388453287   50 TAQTLQVLEKHKADVVKVKWARENYHhnigspyclrLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQW 121
Cdd:cd00200   208 TGKCLGTLRGHENGVNSVAFSPDGYL----------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAW 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 711-848 6.96e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 6.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287  711 GSITCIAWKGDTLVL--GDMDGNLNFWDL-KGRVSRGIPTHRSWVRKIRFAPgkgNQKLIA--MYNDGAEVWDtkevqmv 785
Cdd:cd00200    94 SYVSSVAFSPDGRILssSSRDKTIKVWDVeTGKCLTTLRGHTDWVNSVAFSP---DGTFVAssSQDGTIKLWD------- 163

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 388453287  786 ssLRSGRNV-TFR-----ILDVDWC-TSDKVILASDDGCIRVLEMSMKS--ACFRMDEQELTEPVWCP--YLLV 848
Cdd:cd00200   164 --LRTGKCVaTLTghtgeVNSVAFSpDGEKLLSSSSDGTIKLWDLSTGKclGTLRGHENGVNSVAFSPdgYLLA 235
WD40 COG2319
WD40 repeat [General function prediction only];
43-168 7.96e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.36  E-value: 7.96e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   43 VVVIDSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWl 122
Cdd:COG2319   270 VRLWDLATGELLRTLTGHSGGVNSVAF----------SPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF- 338

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 388453287  123 wnqdaSRD--LLLAIHPPNYIVLWNADTGTKLWK-KSYADNILSFSFDP 168
Cdd:COG2319   339 -----SPDgkTLASGSDDGTVRLWDLATGELLRTlTGHTGAVTSVAFSP 382
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-99 4.04e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 40.78  E-value: 4.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   10 VSARTLTGALNAHNKA--AVDWGWQGLIAYGCH--SLVVVIDSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLR 85
Cdd:cd00200   206 LSTGKCLGTLRGHENGvnSVAFSPDGYLLASGSedGTIRVWDLRTGECVQTLSGHTNSVTSLAW----------SPDGKR 275

                          90
                  ....*....|....
gi 388453287   86 LASADVNGKIIVWD 99
Cdd:cd00200   276 LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
43-148 4.68e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 4.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388453287   43 VVVIDSITAQTLQVLEKHKADVVKVKWarenyhhnigSPYCLRLASADVNGKIIVWDVAAGVAQCEIQEHAKPIQDVQWl 122
Cdd:COG2319   312 VRLWDLATGKLLRTLTGHTGAVRSVAF----------SPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF- 380

                          90       100
                  ....*....|....*....|....*...
gi 388453287  123 wnqdaSRD--LLLAIHPPNYIVLWNADT 148
Cdd:COG2319   381 -----SPDgrTLASGSADGTVRLWDLAT 403
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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