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Conserved domains on  [gi|388452700|ref|NP_001253440|]
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transmembrane protein 70, mitochondrial [Macaca mulatta]

Protein Classification

TMEM70/TMEM186/TMEM223 family protein( domain architecture ID 10536696)

TMEM70/TMEM186/TMEM223 family protein, such as human transmembrane protein 70 (TMEM70), a scaffold protein that participates in the c-ring assembly of mitochondrial ATP synthase (F(1)F(0) ATP synthase or complex V) by facilitating the membrane insertion and oligomer formation of the subunit c/ATP5MC1

Gene Ontology:  GO:0065003|GO:0031966
PubMed:  32275929|32320651

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM70 pfam06979
TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 ...
 91-238 7.24e-50

TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 protein family. TMEM70 is a family of proteins essential for assembly of the mitochondrial proton-transporting ATP synthase complex within the inner mitochondrial membrane. TMEM70 functions in the assembly of complexes I and V.


:

Pssm-ID: 462058  Cd Length: 151  Bit Score: 160.85  E-value: 7.24e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452700   91 DGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYFVTQNNaffESVSLPVQIIFYGIIGSFTLITPVLLHFITKGYVIRL 170
Cdd:pfam06979   1 KDVLLYTGDLTRFFRGLKIFSLSQSIFWLYLAPFAYTKLI---NLGSNKLRVGLTGICGFFGFVTPGLLHLFTKRYVTRL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 388452700  171 YHEATTDTYKAITYNALLAETSTLFHQDDVKIPDATHV----FTTFYAKTK-SLLVNP-VLFPNREDFIHLMGY 238
Cdd:pfam06979  78 YLDKGGDTVTATTYNPFGREKKTEFPLEDVSCPEVRGAapsmFTLKVKGKKfYYLLDPrGLFPNPKLYDHTMGY 151
 
Name Accession Description Interval E-value
TMEM70 pfam06979
TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 ...
 91-238 7.24e-50

TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 protein family. TMEM70 is a family of proteins essential for assembly of the mitochondrial proton-transporting ATP synthase complex within the inner mitochondrial membrane. TMEM70 functions in the assembly of complexes I and V.


Pssm-ID: 462058  Cd Length: 151  Bit Score: 160.85  E-value: 7.24e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452700   91 DGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYFVTQNNaffESVSLPVQIIFYGIIGSFTLITPVLLHFITKGYVIRL 170
Cdd:pfam06979   1 KDVLLYTGDLTRFFRGLKIFSLSQSIFWLYLAPFAYTKLI---NLGSNKLRVGLTGICGFFGFVTPGLLHLFTKRYVTRL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 388452700  171 YHEATTDTYKAITYNALLAETSTLFHQDDVKIPDATHV----FTTFYAKTK-SLLVNP-VLFPNREDFIHLMGY 238
Cdd:pfam06979  78 YLDKGGDTVTATTYNPFGREKKTEFPLEDVSCPEVRGAapsmFTLKVKGKKfYYLLDPrGLFPNPKLYDHTMGY 151
 
Name Accession Description Interval E-value
TMEM70 pfam06979
TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 ...
 91-238 7.24e-50

TMEM70/TMEM186/TMEM223 protein family; This entry represents the TMEM70/TMEM186/TMEM223 protein family. TMEM70 is a family of proteins essential for assembly of the mitochondrial proton-transporting ATP synthase complex within the inner mitochondrial membrane. TMEM70 functions in the assembly of complexes I and V.


Pssm-ID: 462058  Cd Length: 151  Bit Score: 160.85  E-value: 7.24e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388452700   91 DGRLIYTGNMARAVFGVKCFSYSTSLIGLTFLPYFVTQNNaffESVSLPVQIIFYGIIGSFTLITPVLLHFITKGYVIRL 170
Cdd:pfam06979   1 KDVLLYTGDLTRFFRGLKIFSLSQSIFWLYLAPFAYTKLI---NLGSNKLRVGLTGICGFFGFVTPGLLHLFTKRYVTRL 77

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 388452700  171 YHEATTDTYKAITYNALLAETSTLFHQDDVKIPDATHV----FTTFYAKTK-SLLVNP-VLFPNREDFIHLMGY 238
Cdd:pfam06979  78 YLDKGGDTVTATTYNPFGREKKTEFPLEDVSCPEVRGAapsmFTLKVKGKKfYYLLDPrGLFPNPKLYDHTMGY 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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