|
Name |
Accession |
Description |
Interval |
E-value |
| SIX1_SD |
pfam16878 |
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic ... |
87-196 |
2.59e-60 |
|
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic proteins, and it is found N-terminal to the Homeobox domain. As a transcription factor it lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. It is the SD domain that is necessary for this protein-protein interaction, binding to the C-terminal region of EYA - Eyes absent homolog proteins.
:
Pssm-ID: 465293 Cd Length: 110 Bit Score: 198.15 E-value: 2.59e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 87 FSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYL 166
Cdd:pfam16878 1 FSLEQVACICEALQQAGDIERLARFLWSLPSYELLRNNESVLKARALVAFHRGNFKELYQLLESHPFSPSNHPELQELWY 80
|
90 100 110
....*....|....*....|....*....|
gi 388490110 167 RARYHEAERARGRALGAVDKYRLRKKFPLP 196
Cdd:pfam16878 81 EAHYKEAEKLRGRPLGAVDKYRLRKKFPLP 110
|
|
| homeodomain |
cd00086 |
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
207-258 |
1.43e-14 |
|
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
:
Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 68.42 E-value: 1.43e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 388490110 207 YCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDR 258
Cdd:cd00086 5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
|
|
| PHA03247 super family |
cl33720 |
large tegument protein UL36; Provisional |
417-668 |
1.53e-07 |
|
large tegument protein UL36; Provisional
The actual alignment was detected with superfamily member PHA03247:
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.33 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 417 APGEEVQGPLAQVVPGPPPAATFPLPPGPVPAVAAPQVVPLSPPPGYPA---GLSPTSPLLNLPQVVPTSQVVTLPQAVG 493
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarQASPALPAAPAPPAVPAGPATPGGPARP 2757
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 494 PLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNfLLANPVSGSPIVTGVAVQQGKIILTATFPTSML 573
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD-PADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 574 VSQVLPPAPgLALPLKPETAIsVPEGGL-------PVAPSPALPEAHALGTLSAQQPPPaaattSGTSLPFSPDSPGLLP 646
Cdd:PHA03247 2837 TAPPPPPGP-PPPSLPLGGSV-APGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSR-----STESFALPPDQPERPP 2909
|
250 260
....*....|....*....|..
gi 388490110 647 NfPAPPPEGLMLSPAAVPVWPA 668
Cdd:PHA03247 2910 Q-PQAPPPPQPQPQPPPPPQPQ 2930
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SIX1_SD |
pfam16878 |
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic ... |
87-196 |
2.59e-60 |
|
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic proteins, and it is found N-terminal to the Homeobox domain. As a transcription factor it lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. It is the SD domain that is necessary for this protein-protein interaction, binding to the C-terminal region of EYA - Eyes absent homolog proteins.
Pssm-ID: 465293 Cd Length: 110 Bit Score: 198.15 E-value: 2.59e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 87 FSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYL 166
Cdd:pfam16878 1 FSLEQVACICEALQQAGDIERLARFLWSLPSYELLRNNESVLKARALVAFHRGNFKELYQLLESHPFSPSNHPELQELWY 80
|
90 100 110
....*....|....*....|....*....|
gi 388490110 167 RARYHEAERARGRALGAVDKYRLRKKFPLP 196
Cdd:pfam16878 81 EAHYKEAEKLRGRPLGAVDKYRLRKKFPLP 110
|
|
| homeodomain |
cd00086 |
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
207-258 |
1.43e-14 |
|
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 68.42 E-value: 1.43e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 388490110 207 YCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDR 258
Cdd:cd00086 5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
|
|
| HOX |
smart00389 |
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
209-258 |
5.47e-14 |
|
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes
Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 66.89 E-value: 5.47e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 388490110 209 FKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDR 258
Cdd:smart00389 8 FTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
|
|
| Homeodomain |
pfam00046 |
Homeodomain; |
208-258 |
1.42e-12 |
|
Homeodomain;
Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 62.90 E-value: 1.42e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 388490110 208 CFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDR 258
Cdd:pfam00046 6 TFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
417-668 |
1.53e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.33 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 417 APGEEVQGPLAQVVPGPPPAATFPLPPGPVPAVAAPQVVPLSPPPGYPA---GLSPTSPLLNLPQVVPTSQVVTLPQAVG 493
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarQASPALPAAPAPPAVPAGPATPGGPARP 2757
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 494 PLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNfLLANPVSGSPIVTGVAVQQGKIILTATFPTSML 573
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD-PADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 574 VSQVLPPAPgLALPLKPETAIsVPEGGL-------PVAPSPALPEAHALGTLSAQQPPPaaattSGTSLPFSPDSPGLLP 646
Cdd:PHA03247 2837 TAPPPPPGP-PPPSLPLGGSV-APGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSR-----STESFALPPDQPERPP 2909
|
250 260
....*....|....*....|..
gi 388490110 647 NfPAPPPEGLMLSPAAVPVWPA 668
Cdd:PHA03247 2910 Q-PQAPPPPQPQPQPPPPPQPQ 2930
|
|
| COG5576 |
COG5576 |
Homeodomain-containing transcription factor [Transcription]; |
195-300 |
7.99e-05 |
|
Homeodomain-containing transcription factor [Transcription];
Pssm-ID: 227863 [Multi-domain] Cd Length: 156 Bit Score: 43.58 E-value: 7.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 195 LPKTIWDGEETVYCFKERSRAA------LKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAgggapCK 268
Cdd:COG5576 38 EMKLERKQDGSSPPKSKRRRTTdeqlmvLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR-----SG 112
|
90 100 110
....*....|....*....|....*....|..
gi 388490110 269 SESDGNPTTEDESSRSPenlERGVAPVSAEAA 300
Cdd:COG5576 113 KVEQRPGEEEADLAKIG---SLSTGQISIIET 141
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
403-665 |
2.81e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 41.06 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 403 APETKGAQVAVPGLAPGEEVQGPLAQVVPGPPPAATFPLP--PGPVPAVAAPQVVPLSPPPGypaGLSPTSPLLN-LPQV 479
Cdd:pfam05109 479 AGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPnaTSPTPAVTTPTPNATSPTLG---KTSPTSAVTTpTPNA 555
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 480 VPTSQVVTLPQAVGPLQLLaaGPGSPVKVAAAAGPanvHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGV-AVQ 558
Cdd:pfam05109 556 TSPTPAVTTPTPNATIPTL--GKTSPTSAVTTPTP---NATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATsAVT 630
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 559 QGKIILTATFPTSMlvsqVLPPApGLALPLKPETAISvpegglPVAPSPALPEAHALGTLSAQQPPPAAATTSGTSLPFS 638
Cdd:pfam05109 631 TGQHNITSSSTSSM----SLRPS-SISETLSPSTSDN------STSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSP 699
|
250 260
....*....|....*....|....*..
gi 388490110 639 PDSPGLLPNFPAPPPEGLMLSPAAVPV 665
Cdd:pfam05109 700 APRPGTTSQASGPGNSSTSTKPGEVNV 726
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| SIX1_SD |
pfam16878 |
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic ... |
87-196 |
2.59e-60 |
|
Transcriptional regulator, SIX1, N-terminal SD domain; SIX1_SD is a family of eukaryotic proteins, and it is found N-terminal to the Homeobox domain. As a transcription factor it lacks intrinsic activation domains and thus needs to bind to the EYA family of co-factors in order to mediate transcriptional activation. It is the SD domain that is necessary for this protein-protein interaction, binding to the C-terminal region of EYA - Eyes absent homolog proteins.
Pssm-ID: 465293 Cd Length: 110 Bit Score: 198.15 E-value: 2.59e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 87 FSPEQVACVCEALLQAGHAGRLSRFLGALPPAERLRGSDPVLRARALVAFQRGEYAELYRLLESRPFPAAHHAFLQDLYL 166
Cdd:pfam16878 1 FSLEQVACICEALQQAGDIERLARFLWSLPSYELLRNNESVLKARALVAFHRGNFKELYQLLESHPFSPSNHPELQELWY 80
|
90 100 110
....*....|....*....|....*....|
gi 388490110 167 RARYHEAERARGRALGAVDKYRLRKKFPLP 196
Cdd:pfam16878 81 EAHYKEAEKLRGRPLGAVDKYRLRKKFPLP 110
|
|
| homeodomain |
cd00086 |
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
207-258 |
1.43e-14 |
|
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 68.42 E-value: 1.43e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 388490110 207 YCFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDR 258
Cdd:cd00086 5 TRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLK 56
|
|
| HOX |
smart00389 |
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
209-258 |
5.47e-14 |
|
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes
Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 66.89 E-value: 5.47e-14
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 388490110 209 FKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDR 258
Cdd:smart00389 8 FTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
|
|
| Homeodomain |
pfam00046 |
Homeodomain; |
208-258 |
1.42e-12 |
|
Homeodomain;
Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 62.90 E-value: 1.42e-12
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 388490110 208 CFKERSRAALKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDR 258
Cdd:pfam00046 6 TFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWK 56
|
|
| Homeobox_KN |
pfam05920 |
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to ... |
222-256 |
3.23e-11 |
|
Homeobox KN domain; This is a homeobox transcription factor KN domain conserved from fungi to human and plants. They were first identified as TALE homeobox genes in eukaryotes, (including KNOX and MEIS genes). They have been recently classified.
Pssm-ID: 428673 Cd Length: 39 Bit Score: 58.30 E-value: 3.23e-11
10 20 30
....*....|....*....|....*....|....*
gi 388490110 222 RGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQR 256
Cdd:pfam05920 5 LHNPYPSEEEKAELAKETGLSRKQISNWFINARRR 39
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
417-668 |
1.53e-07 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 55.33 E-value: 1.53e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 417 APGEEVQGPLAQVVPGPPPAATFPLPPGPVPAVAAPQVVPLSPPPGYPA---GLSPTSPLLNLPQVVPTSQVVTLPQAVG 493
Cdd:PHA03247 2678 SPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPPGPAaarQASPALPAAPAPPAVPAGPATPGGPARP 2757
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 494 PLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNfLLANPVSGSPIVTGVAVQQGKIILTATFPTSML 573
Cdd:PHA03247 2758 ARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD-PADPPAAVLAPAAALPPAASPAGPLPPPTSAQP 2836
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 574 VSQVLPPAPgLALPLKPETAIsVPEGGL-------PVAPSPALPEAHALGTLSAQQPPPaaattSGTSLPFSPDSPGLLP 646
Cdd:PHA03247 2837 TAPPPPPGP-PPPSLPLGGSV-APGGDVrrrppsrSPAAKPAAPARPPVRRLARPAVSR-----STESFALPPDQPERPP 2909
|
250 260
....*....|....*....|..
gi 388490110 647 NfPAPPPEGLMLSPAAVPVWPA 668
Cdd:PHA03247 2910 Q-PQAPPPPQPQPQPPPPPQPQ 2930
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
389-678 |
7.06e-05 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 46.47 E-value: 7.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 389 PQTGEVRLEEAQPEAPetkgAQVAVPGlAPGEEVQGPLAQVVPGPPPAATFPLPPGPvpavAAPQVVPLSPPPGYPAgls 468
Cdd:PHA03247 2577 PSEPAVTSRARRPDAP----PQSARPR-APVDDRGDPRGPAPPSPLPPDTHAPDPPP----PSPSPAANEPDPHPPP--- 2644
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 469 pTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALQLPSATAPGNFLLANPVSG 548
Cdd:PHA03247 2645 -TVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPAPHALVSATPLPP 2723
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 549 SPIVTGVAVQQGKIILTATFPTSMLVSQVLPPAPGL-ALPLKPE--TAISVPEGGLPVAPSPALPEAHALGTLSAQQPPP 625
Cdd:PHA03247 2724 GPAAARQASPALPAAPAPPAVPAGPATPGGPARPARpPTTAGPPapAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWD 2803
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 388490110 626 AAATTSGTSLPFSPDSPGLLPNFPAPPPEGLMlsPAAVPVWPAGLELSTGTEG 678
Cdd:PHA03247 2804 PADPPAAVLAPAAALPPAASPAGPLPPPTSAQ--PTAPPPPPGPPPPSLPLGG 2854
|
|
| COG5576 |
COG5576 |
Homeodomain-containing transcription factor [Transcription]; |
195-300 |
7.99e-05 |
|
Homeodomain-containing transcription factor [Transcription];
Pssm-ID: 227863 [Multi-domain] Cd Length: 156 Bit Score: 43.58 E-value: 7.99e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 195 LPKTIWDGEETVYCFKERSRAA------LKACYRGNRYPTPDEKRRLATLTGLSLTQVSNWFKNRRQRDRTGAgggapCK 268
Cdd:COG5576 38 EMKLERKQDGSSPPKSKRRRTTdeqlmvLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKEKKKR-----SG 112
|
90 100 110
....*....|....*....|....*....|..
gi 388490110 269 SESDGNPTTEDESSRSPenlERGVAPVSAEAA 300
Cdd:COG5576 113 KVEQRPGEEEADLAKIG---SLSTGQISIIET 141
|
|
| PRK12323 |
PRK12323 |
DNA polymerase III subunit gamma/tau; |
432-649 |
1.36e-04 |
|
DNA polymerase III subunit gamma/tau;
Pssm-ID: 237057 [Multi-domain] Cd Length: 700 Bit Score: 45.25 E-value: 1.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 432 GPPPAATFPLPPGPVPAVAAPQVVPLSPPPGYPAGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAA 511
Cdd:PRK12323 373 GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQASARGPGGAPAPAP 452
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 512 AGPAnvhlinSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGVAVQQGKII---LTATFPTSMLVsQVLPPAPGLALPL 588
Cdd:PRK12323 453 APAA------APAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPPweeLPPEFASPAPA-QPDAAPAGWVAES 525
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 388490110 589 KPETAISVPEGG---LPVAPSPALPEAHALGTLSAQQPPPAAATTSGTSLPFSPDSPGLLPNFP 649
Cdd:PRK12323 526 IPDPATADPDDAfetLAPAPAAAPAPRAAAATEPVVAPRPPRASASGLPDMFDGDWPALAARLP 589
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
294-639 |
5.96e-04 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 43.39 E-value: 5.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 294 PVSAEAAAQGSIFLAGTSPPAPCPASSSILVNGSFLAASSSPAVLLNGGPVIINGLALGEASSLGPLLLTGGGGAPPPQP 373
Cdd:PHA03247 2720 PLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP 2799
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 374 SPQGASEAKTSLVLDPQTGEVRLEEAQPEAPETKGAQVAVP--------------GLAPGeevqGPLAQVVPGPPPAATF 439
Cdd:PHA03247 2800 SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPpppgppppslplggSVAPG----GDVRRRPPSRSPAAKP 2875
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 440 PLPPGP-VPAVAAPQV-----------VPLSPPPGYPAGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVK 507
Cdd:PHA03247 2876 AAPARPpVRRLARPAVsrstesfalppDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQPPLAPTTDPAGAGEP 2955
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 508 VAAAAGPANVHLINSGVGVTALQL----PSATAPGNFLLANPVSGSPIVTGVAVQQGKIILTATFPTSMLvsQVLPPAPG 583
Cdd:PHA03247 2956 SGAVPQPWLGALVPGRVAVPRFRVpqpaPSREAPASSTPPLTGHSLSRVSSWASSLALHEETDPPPVSLK--QTLWPPDD 3033
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 388490110 584 LALPLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSGTSLPFSP 639
Cdd:PHA03247 3034 TEDSDADSLFDSDSERSDLEALDPLPPEPHDPFAHEPDPATPEAGARESPSSQFGP 3089
|
|
| PRK14951 |
PRK14951 |
DNA polymerase III subunits gamma and tau; Provisional |
399-515 |
1.37e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 237865 [Multi-domain] Cd Length: 618 Bit Score: 42.01 E-value: 1.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 399 AQPEAPETKGAQVAVPGLAPGEEVQGPLAQVVPGPPPAAtfplpPGPVPAVAAPQVVPLSPPPGYPAGLSPTSPllnlPQ 478
Cdd:PRK14951 382 ARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAPPAA-----APPAPVAAPAAAAPAAAPAAAPAAVALAPA----PP 452
|
90 100 110
....*....|....*....|....*....|....*....
gi 388490110 479 VVPTSQVVTLPQAV--GPLQLLAAGPGSPVKVAAAAGPA 515
Cdd:PRK14951 453 AQAAPETVAIPVRVapEPAVASAAPAPAAAPAAARLTPT 491
|
|
| PHA03247 |
PHA03247 |
large tegument protein UL36; Provisional |
433-679 |
2.29e-03 |
|
large tegument protein UL36; Provisional
Pssm-ID: 223021 [Multi-domain] Cd Length: 3151 Bit Score: 41.46 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 433 PPPAATFPLPPGPVPAVAAPQVVPLSPPPGYPA-----GLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLAAGPGSPVK 507
Cdd:PHA03247 2552 PPPLPPAAPPAAPDRSVPPPRPAPRPSEPAVTSrarrpDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSP 2631
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 508 VAAAAGPANVHlinSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGV-AVQQGKIILTATFPTSMLVSQVLPPAPglal 586
Cdd:PHA03247 2632 SPAANEPDPHP---PPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQAsSPPQRPRRRAARPTVGSLTSLADPPPP---- 2704
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 587 PLKPETAISVPEGGLPVAPSPALPEAHALGTLSAQQPPPAAATTSGTSLPFSPDSPGLLPNFPAP-PPEGLMLSPAAVPV 665
Cdd:PHA03247 2705 PPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPaPPAAPAAGPPRRLT 2784
|
250
....*....|....
gi 388490110 666 WPAGLELSTGTEGL 679
Cdd:PHA03247 2785 RPAVASLSESRESL 2798
|
|
| Herpes_BLLF1 |
pfam05109 |
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ... |
403-665 |
2.81e-03 |
|
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.
Pssm-ID: 282904 [Multi-domain] Cd Length: 886 Bit Score: 41.06 E-value: 2.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 403 APETKGAQVAVPGLAPGEEVQGPLAQVVPGPPPAATFPLP--PGPVPAVAAPQVVPLSPPPGypaGLSPTSPLLN-LPQV 479
Cdd:pfam05109 479 AGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPnaTSPTPAVTTPTPNATSPTLG---KTSPTSAVTTpTPNA 555
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 480 VPTSQVVTLPQAVGPLQLLaaGPGSPVKVAAAAGPanvHLINSGVGVTALQLPSATAPGNFLLANPVSGSPIVTGV-AVQ 558
Cdd:pfam05109 556 TSPTPAVTTPTPNATIPTL--GKTSPTSAVTTPTP---NATSPTVGETSPQANTTNHTLGGTSSTPVVTSPPKNATsAVT 630
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 559 QGKIILTATFPTSMlvsqVLPPApGLALPLKPETAISvpegglPVAPSPALPEAHALGTLSAQQPPPAAATTSGTSLPFS 638
Cdd:pfam05109 631 TGQHNITSSSTSSM----SLRPS-SISETLSPSTSDN------STSHMPLLTSAHPTGGENITQVTPASTSTHHVSTSSP 699
|
250 260
....*....|....*....|....*..
gi 388490110 639 PDSPGLLPNFPAPPPEGLMLSPAAVPV 665
Cdd:pfam05109 700 APRPGTTSQASGPGNSSTSTKPGEVNV 726
|
|
| Atrophin-1 |
pfam03154 |
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ... |
422-655 |
3.91e-03 |
|
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.
Pssm-ID: 460830 [Multi-domain] Cd Length: 991 Bit Score: 40.91 E-value: 3.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 422 VQGPLAQVVPGPPPAATFPLPPGPVPAVAAPQVVPLSPPPGY--PAGLSPTSPLLNLPQVVPTSQVVTLPQAVGPLQLLA 499
Cdd:pfam03154 174 LQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSqpPNQTQSTAAPHTLIQQTPTLHPQRLPSPHPPLQPMT 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 500 AgPGSPVKVAAAAGPANVHLINSGVGVTALQ-----LPSATAPGNFLLANPVS---GSPIVTGVAVQQGKIILTATFPTS 571
Cdd:pfam03154 254 Q-PPPPSQVSPQPLPQPSLHGQMPPMPHSLQtgpshMQHPVPPQPFPLTPQSSqsqVPPGPSPAAPGQSQQRIHTPPSQS 332
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 572 MLVS------QVLPPAPGLALPLKPETAISVPEGGLP---------VAPSP-----ALPEAHALGTLS--------AQQP 623
Cdd:pfam03154 333 QLQSqqppreQPLPPAPLSMPHIKPPPTTPIPQLPNPqshkhpphlSGPSPfqmnsNLPPPPALKPLSslsthhppSAHP 412
|
250 260 270
....*....|....*....|....*....|..
gi 388490110 624 PPAAATTSGTSLPFSPDSPGLLPNFPAPPPEG 655
Cdd:pfam03154 413 PPLQLMPQSQQLPPPPAQPPVLTQSQSLPPPA 444
|
|
| Med15 |
pfam09606 |
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of ... |
386-664 |
6.88e-03 |
|
ARC105 or Med15 subunit of Mediator complex non-fungal; The approx. 70 residue Med15 domain of the ARC-Mediator co-activator is a three-helix bundle with marked similarity to the KIX domain. The sterol regulatory element binding protein (SREBP) family of transcription activators use the ARC105 subunit to activate target genes in the regulation of cholesterol and fatty acid homeostasis. In addition, Med15 is a critical transducer of gene activation signals that control early metazoan development.
Pssm-ID: 312941 [Multi-domain] Cd Length: 732 Bit Score: 39.99 E-value: 6.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 386 VLDPQTGEVRLEEAQPEAPETKGAQVAVPGLAPGEevQGPLAQvvpGPPPAATFPLPPGP-VPAVAAPQVVPLS--PPPG 462
Cdd:pfam09606 158 MMQPSSGQPGSGTPNQMGPNGGPGQGQAGGMNGGQ--QGPMGG---QMPPQMGVPGMPGPaDAGAQMGQQAQANggMNPQ 232
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 463 YPAGLSPTSPLLNLPQvVPTSQVVTLPQAVGPLQLLAAGPGSPVKVAAAAGPANVHLINSGVGVTALqlpSATAPGNF-- 540
Cdd:pfam09606 233 QMGGAPNQVAMQQQQP-QQQGQQSQLGMGINQMQQMPQGVGGGAGQGGPGQPMGPPGQQPGAMPNVM---SIGDQNNYqq 308
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388490110 541 LLANPVSGSPIVTGVAVQQGKIILtatfptSMLVSQVLPPAPGLALplkPETAISVPEGGLPVAPSPALPEAHalgtLSA 620
Cdd:pfam09606 309 QQTRQQQQQQGGNHPAAHQQQMNQ------SVGQGGQVVALGGLNH---LETWNPGNFGGLGANPMQRGQPGM----MSS 375
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 388490110 621 QQPPPAAATTSGTSLPFSPDSPGLLPNFPAPP--------PEGLMLSPAAVP 664
Cdd:pfam09606 376 PSPVPGQQVRQVTPNQFMRQSPQPSVPSPQGPgsqppqshPGGMIPSPALIP 427
|
|
| |
