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Conserved domains on  [gi|388454184|ref|NP_001252572|]
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WD repeat-containing protein 3 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455513)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-703 3.86e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 231.84  E-value: 3.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTM---TCEYALCSFfVPGDRQVVIGTKTGKLQLYD 482
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTLkghTGPVRDVAA-SADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 483 LASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFElvkdenstqkrlSVKQTRTLQL-DEDVLCVSYSPNQ 561
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------------TGKCLTTLRGhTDWVNSVAFSPDG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 562 KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQF 641
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 388454184 642 VPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
49-621 1.53e-46

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.53e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKD 128
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 129 TDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLVSEEKRLIT 208
Cdd:COG2319  142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 209 GASDSELRVWDIAylqeiedleepdpkkikgsspgvqdtleaedgtfemdeapedrilscrkagsimregrdrvvnlave 288
Cdd:COG2319  222 GSADGTVRLWDLA------------------------------------------------------------------- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 289 kTGRILAchgtdsvlelfcilskeeikkkmdkkmkkarkkaklhsckgeeedpevnvemslqdeiqrvtniktsakiksf 368
Cdd:COG2319  235 -TGKLLR------------------------------------------------------------------------- 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 369 dlihspqgelkavfllqnnlvelyslnpslptpqpvrtsriTIGGHRSDVRTLSFSSDNIAVLSAAADsikiwnrstlqc 448
Cdd:COG2319  241 -----------------------------------------TLTGHSGSVRSVAFSPDGRLLASGSAD------------ 267

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 449 irtmtceyalcsffvpgdrqvvigtktGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFElv 528
Cdd:COG2319  268 ---------------------------GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 529 kdenstqkrlSVKQTRTLQ-LDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIA 607
Cdd:COG2319  319 ----------TGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                        570
                 ....*....|....
gi 388454184 608 TGSADRNVKIWGLD 621
Cdd:COG2319  389 SGSADGTVRLWDLA 402
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 804-907 6.47e-29

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


:

Pssm-ID: 461125  Cd Length: 106  Bit Score: 111.49  E-value: 6.47e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  804 PSAYVLE-IFKGIRSSELEESLLVLPFSYVPDILKLFNEFIQLGSD-VELICRCLFFLLRIHFGQITSNQMLVPVIEKLR 881
Cdd:pfam04003   1 NDEYLLEsVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPhLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 388454184  882 ETTISKVSQVRDVIGFNMAGLDYLKR 907
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-703 3.86e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 231.84  E-value: 3.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTM---TCEYALCSFfVPGDRQVVIGTKTGKLQLYD 482
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTLkghTGPVRDVAA-SADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 483 LASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFElvkdenstqkrlSVKQTRTLQL-DEDVLCVSYSPNQ 561
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------------TGKCLTTLRGhTDWVNSVAFSPDG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 562 KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQF 641
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 388454184 642 VPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
370-710 2.44e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.78  E-value: 2.44e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 370 LIHSPQGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQC 448
Cdd:COG2319   33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADgTVRLWDLATGLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 449 IRTMTCE----YALCsfFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Cdd:COG2319  113 LRTLTGHtgavRSVA--FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 525 FElvkdenstqkrlSVKQTRTLQLDED-VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDG 603
Cdd:COG2319  191 LA------------TGKLLRTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 604 ALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                        330       340
                 ....*....|....*....|....*..
gi 388454184 684 SPSGDYVVSSSHDKSLRLWERTREPLI 710
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
49-621 1.53e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.53e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKD 128
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 129 TDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLVSEEKRLIT 208
Cdd:COG2319  142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 209 GASDSELRVWDIAylqeiedleepdpkkikgsspgvqdtleaedgtfemdeapedrilscrkagsimregrdrvvnlave 288
Cdd:COG2319  222 GSADGTVRLWDLA------------------------------------------------------------------- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 289 kTGRILAchgtdsvlelfcilskeeikkkmdkkmkkarkkaklhsckgeeedpevnvemslqdeiqrvtniktsakiksf 368
Cdd:COG2319  235 -TGKLLR------------------------------------------------------------------------- 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 369 dlihspqgelkavfllqnnlvelyslnpslptpqpvrtsriTIGGHRSDVRTLSFSSDNIAVLSAAADsikiwnrstlqc 448
Cdd:COG2319  241 -----------------------------------------TLTGHSGSVRSVAFSPDGRLLASGSAD------------ 267

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 449 irtmtceyalcsffvpgdrqvvigtktGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFElv 528
Cdd:COG2319  268 ---------------------------GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 529 kdenstqkrlSVKQTRTLQ-LDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIA 607
Cdd:COG2319  319 ----------TGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                        570
                 ....*....|....
gi 388454184 608 TGSADRNVKIWGLD 621
Cdd:COG2319  389 SGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-230 3.09e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 3.09e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGS 126
Cdd:cd00200   33 IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 127 KDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLVSEEKRL 206
Cdd:cd00200  113 RDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192

                        170       180
                 ....*....|....*....|....
gi 388454184 207 ITGASDSELRVWDIAYLQEIEDLE 230
Cdd:cd00200  193 LSSSSDGTIKLWDLSTGKCLGTLR 216
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 804-907 6.47e-29

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 111.49  E-value: 6.47e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  804 PSAYVLE-IFKGIRSSELEESLLVLPFSYVPDILKLFNEFIQLGSD-VELICRCLFFLLRIHFGQITSNQMLVPVIEKLR 881
Cdd:pfam04003   1 NDEYLLEsVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPhLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 388454184  882 ETTISKVSQVRDVIGFNMAGLDYLKR 907
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 664-703 5.92e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.92e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454184   664 KFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
665-703 7.97e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 7.97e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 388454184  665 FEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 482-703 4.49e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 4.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 482 DLASGNLLETidahDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEdvLCV-SYSPN 560
Cdd:PLN00181 473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSG--ICWnSYIKS 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 561 QklLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISY-DGALIATGSADRNVKIWGLDFGDCHKSLfAHDDSVMYL 639
Cdd:PLN00181 547 Q--VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI-KTKANICCV 623

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 388454184 640 QFVPKSHLFFTAGK-DHKIKQWDADKFE-HIQTLEGHHQEIWCLAVSPSGDyVVSSSHDKSLRLWE 703
Cdd:PLN00181 624 QFPSESGRSLAFGSaDHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 54-113 7.52e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.04  E-value: 7.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 388454184   54 KGEKI--LILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTL 113
Cdd:pfam12894  25 NWQRVwtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 47-222 9.51e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 9.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  47 VFIWDLRKGEKILILQGLKQEVTCL-CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGhKAAITTLKYDQLGGR-LAS 124
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRsLAF 635

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 125 GSKDTDVIVWDVINES-GLYRLKGHKDAITQALFLrEKNLLVTSGKDTMVKWWDLD------TQHCFKTMVGHrTEVWGL 197
Cdd:PLN00181 636 GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH-TNVKNF 713

                        170       180
                 ....*....|....*....|....*.
gi 388454184 198 VLVS-EEKRLITGASDSELRVWDIAY 222
Cdd:PLN00181 714 VGLSvSDGYIATGSETNEVFVYHKAF 739
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 2.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454184    54 KGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFS 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 407-703 3.86e-69

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 231.84  E-value: 3.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTM---TCEYALCSFfVPGDRQVVIGTKTGKLQLYD 482
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDgTIKVWDLETGELLRTLkghTGPVRDVAA-SADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 483 LASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFElvkdenstqkrlSVKQTRTLQL-DEDVLCVSYSPNQ 561
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE------------TGKCLTTLRGhTDWVNSVAFSPDG 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 562 KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQF 641
Cdd:cd00200  148 TFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAF 227

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 388454184 642 VPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Cdd:cd00200  228 SPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
370-710 2.44e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.78  E-value: 2.44e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 370 LIHSPQGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQC 448
Cdd:COG2319   33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADgTVRLWDLATGLL 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 449 IRTMTCE----YALCsfFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Cdd:COG2319  113 LRTLTGHtgavRSVA--FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWD 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 525 FElvkdenstqkrlSVKQTRTLQLDED-VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDG 603
Cdd:COG2319  191 LA------------TGKLLRTLTGHTGaVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDG 258

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 604 ALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683
Cdd:COG2319  259 RLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAF 338

                        330       340
                 ....*....|....*....|....*..
gi 388454184 684 SPSGDYVVSSSHDKSLRLWERTREPLI 710
Cdd:COG2319  339 SPDGKTLASGSDDGTVRLWDLATGELL 365
WD40 COG2319
WD40 repeat [General function prediction only];
397-702 3.35e-63

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 219.40  E-value: 3.35e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 397 SLPTPQPVRTSRitigGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCE----YALCsfFVPGDRQVVI 471
Cdd:COG2319  106 DLATGLLLRTLT----GHTGAVRSVAFSPDGKTLASGSADgTVRLWDLATGKLLRTLTGHsgavTSVA--FSPDGKLLAS 179

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 472 GTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFElvkdenstqkrlSVKQTRTLQLDED 551
Cdd:COG2319  180 GSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLA------------TGKLLRTLTGHSG 247

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 552 -VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIATGSADRNVKIWGLDFGDCHKSLF 630
Cdd:COG2319  248 sVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 388454184 631 AHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
Cdd:COG2319  328 GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
49-621 1.53e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 172.02  E-value: 1.53e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKD 128
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAD 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 129 TDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLVSEEKRLIT 208
Cdd:COG2319  142 GTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 209 GASDSELRVWDIAylqeiedleepdpkkikgsspgvqdtleaedgtfemdeapedrilscrkagsimregrdrvvnlave 288
Cdd:COG2319  222 GSADGTVRLWDLA------------------------------------------------------------------- 234

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 289 kTGRILAchgtdsvlelfcilskeeikkkmdkkmkkarkkaklhsckgeeedpevnvemslqdeiqrvtniktsakiksf 368
Cdd:COG2319  235 -TGKLLR------------------------------------------------------------------------- 240

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 369 dlihspqgelkavfllqnnlvelyslnpslptpqpvrtsriTIGGHRSDVRTLSFSSDNIAVLSAAADsikiwnrstlqc 448
Cdd:COG2319  241 -----------------------------------------TLTGHSGSVRSVAFSPDGRLLASGSAD------------ 267

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 449 irtmtceyalcsffvpgdrqvvigtktGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFElv 528
Cdd:COG2319  268 ---------------------------GTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLA-- 318

                        490       500       510       520       530       540       550       560
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 529 kdenstqkrlSVKQTRTLQ-LDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIA 607
Cdd:COG2319  319 ----------TGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLA 388

                        570
                 ....*....|....
gi 388454184 608 TGSADRNVKIWGLD 621
Cdd:COG2319  389 SGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
429-709 2.29e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 171.63  E-value: 2.29e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 429 AVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQ 508
Cdd:COG2319   11 AASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDG 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 509 RGFVTGGADKSVKFWDFelvkdenSTQKRLSVKQTRTlqldEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLY 588
Cdd:COG2319   91 RLLASASADGTVRLWDL-------ATGLLLRTLTGHT----GAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLT 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 589 GHKLPVICMDISYDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHI 668
Cdd:COG2319  160 GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLL 239

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 388454184 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE-RTREPL 709
Cdd:COG2319  240 RTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDlATGELL 281
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 102-618 1.16e-38

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 145.94  E-value: 1.16e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQ 181
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 182 HCFKTMVGHRTEVWGLVLVSEEKRLITGASDSELRVWDIaylqeiedleepdpkkikgsspgvqdtleaedgtfemdeap 261
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV----------------------------------------- 122

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 262 edrilscrkagsimregrdrvvnlavektgrilachgtdsvlelfcilskeeikkkmdkkmkkarkkaklhsckgeeedp 341
Cdd:cd00200      --------------------------------------------------------------------------------

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 342 evnvemslqdeiqrvtniktsakiksfdlihsPQGELKavfllqnnlvelyslnpslptpqpvrtsrITIGGHRSDVRTL 421
Cdd:cd00200  123 --------------------------------ETGKCL-----------------------------TTLRGHTDWVNSV 141

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 422 SFSSDNIAVLSAAAD-SIKIWnrstlqcirtmtceyalcsffvpgdrqvvigtktgklqlyDLASGNLLETIDAHDGALW 500
Cdd:cd00200  142 AFSPDGTFVASSSQDgTIKLW----------------------------------------DLRTGKCVATLTGHTGEVN 181

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 501 SMSLSPDQRGFVTGGADKSVKFWDFelvkdenstqkrLSVKQTRTLQLDED-VLCVSYSPNQKLLAVSLLDCTVKIFYVD 579
Cdd:cd00200  182 SVAFSPDGEKLLSSSSDGTIKLWDL------------STGKCLGTLRGHENgVNSVAFSPDGYLLASGSEDGTIRVWDLR 249

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 388454184 580 TLKFFLSLYGHKLPVICMDISYDGALIATGSADRNVKIW 618
Cdd:cd00200  250 TGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
47-230 3.35e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 147.75  E-value: 3.35e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGS 126
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGS 265

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 127 KDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLVSEEKRL 206
Cdd:COG2319  266 ADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTL 345

                        170       180
                 ....*....|....*....|....
gi 388454184 207 ITGASDSELRVWDIAYLQEIEDLE 230
Cdd:COG2319  346 ASGSDDGTVRLWDLATGELLRTLT 369
WD40 COG2319
WD40 repeat [General function prediction only];
36-230 1.80e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 142.74  E-value: 1.80e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  36 GRYVAVPACEH-VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLK 114
Cdd:COG2319  132 GKTLASGSADGtVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVA 211

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 115 YDQLGGRLASGSKDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEV 194
Cdd:COG2319  212 FSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGV 291

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 388454184 195 WGLVLVSEEKRLITGASDSELRVWDIAYLQEIEDLE 230
Cdd:COG2319  292 NSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLT 327
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-230 3.09e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 138.62  E-value: 3.09e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGS 126
Cdd:cd00200   33 IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSS 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 127 KDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLVSEEKRL 206
Cdd:cd00200  113 RDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKL 192

                        170       180
                 ....*....|....*....|....
gi 388454184 207 ITGASDSELRVWDIAYLQEIEDLE 230
Cdd:cd00200  193 LSSSSDGTIKLWDLSTGKCLGTLR 216
WD40 COG2319
WD40 repeat [General function prediction only];
36-221 4.16e-36

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 141.59  E-value: 4.16e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  36 GRYVAVPACEH-VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLK 114
Cdd:COG2319  216 GKLLASGSADGtVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVA 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 115 YDQLGGRLASGSKDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEV 194
Cdd:COG2319  296 FSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAV 375

                        170       180
                 ....*....|....*....|....*..
gi 388454184 195 WGLVLVSEEKRLITGASDSELRVWDIA 221
Cdd:COG2319  376 TSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-233 9.73e-36

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 137.47  E-value: 9.73e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGS 126
Cdd:cd00200   75 IRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSS 154

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 127 KDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGlVLVSEEKRL 206
Cdd:cd00200  155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNS-VAFSPDGYL 233

                        170       180
                 ....*....|....*....|....*...
gi 388454184 207 ITGAS-DSELRVWDIAYLQEIEDLEEPD 233
Cdd:cd00200  234 LASGSeDGTIRVWDLRTGECVQTLSGHT 261
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-524 3.31e-35

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 135.93  E-value: 3.31e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  61 LQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDVIVWDVINES 140
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 141 GLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGlVLVSEEKRLITGAS-DSELRVWD 219
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNS-VAFSPDGTFVASSSqDGTIKLWD 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 220 IaylqeiedleepdpkkikgsspgvqdtleaedgtfemdeapedRILSCRKagsimregrdrvvnlavektgrilachgt 299
Cdd:cd00200  164 L-------------------------------------------RTGKCVA----------------------------- 171

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 300 dsvlelfcilskeeikkkmdkkmkkarkkaklhsckgeeedpevnvemslqdeiqrvtniktsakiksfdlihspqgelk 379
Cdd:cd00200      --------------------------------------------------------------------------------

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 380 avfllqnnlvelyslnpslptpqpvrtsriTIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMT-CEYA 457
Cdd:cd00200  172 ------------------------------TLTGHTGEVNSVAFSPDGEKLLSSSSDgTIKLWDLSTGKCLGTLRgHENG 221

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 388454184 458 LCSFFVPGDRQVVI-GTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Cdd:cd00200  222 VNSVAFSPDGYLLAsGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 47-219 1.74e-33

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 130.92  E-value: 1.74e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGS 126
Cdd:cd00200  117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSS 196

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 127 KDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLVSEEKRL 206
Cdd:cd00200  197 SDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRL 276

                        170
                 ....*....|...
gi 388454184 207 ITGASDSELRVWD 219
Cdd:cd00200  277 ASGSADGTIRIWD 289
Utp12 pfam04003
Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. ...
 804-907 6.47e-29

Dip2/Utp12 Family; This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2.


Pssm-ID: 461125  Cd Length: 106  Bit Score: 111.49  E-value: 6.47e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  804 PSAYVLE-IFKGIRSSELEESLLVLPFSYVPDILKLFNEFIQLGSD-VELICRCLFFLLRIHFGQITSNQMLVPVIEKLR 881
Cdd:pfam04003   1 NDEYLLEsVLEKIPPSDIELTLLRLPFSYVLRLLKFLAERLAERSPhLELLLRWLKFLLRTHGGYLVSNPDLRPVLRSLQ 80

                          90       100
                  ....*....|....*....|....*.
gi 388454184  882 ETTISKVSQVRDVIGFNMAGLDYLKR 907
Cdd:pfam04003  81 KLLRRRLKELKDLLGLNLGALDYLLS 106
WD40 COG2319
WD40 repeat [General function prediction only];
36-180 2.23e-27

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 115.78  E-value: 2.23e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  36 GRYVAVpACEH--VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTL 113
Cdd:COG2319  258 GRLLAS-GSADgtVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 388454184 114 KYDQLGGRLASGSKDTDVIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT 180
Cdd:COG2319  337 AFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
537-710 2.02e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 112.70  E-value: 2.02e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 537 RLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIATGSADRNVK 616
Cdd:COG2319   24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVR 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 617 IWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHD 696
Cdd:COG2319  104 LWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                        170
                 ....*....|....
gi 388454184 697 KSLRLWERTREPLI 710
Cdd:COG2319  184 GTVRLWDLATGKLL 197
WD40 COG2319
WD40 repeat [General function prediction only];
558-710 1.63e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 82.65  E-value: 1.63e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 558 SPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISYDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVM 637
Cdd:COG2319    3 SADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 388454184 638 YLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLI 710
Cdd:COG2319   83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 46-135 2.92e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 2.92e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  46 HVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASG 125
Cdd:cd00200  200 TIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279

                         90
                 ....*....|
gi 388454184 126 SKDTDVIVWD 135
Cdd:cd00200  280 SADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 664-703 5.92e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 5.92e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454184   664 KFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
665-703 7.97e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 51.96  E-value: 7.97e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 388454184  665 FEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 482-703 4.49e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.94  E-value: 4.49e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 482 DLASGNLLETidahDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEdvLCV-SYSPN 560
Cdd:PLN00181 473 DLKQGDLLNS----SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGRDIHYPVVELASRSKLSG--ICWnSYIKS 546

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 561 QklLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISY-DGALIATGSADRNVKIWGLDFGDCHKSLfAHDDSVMYL 639
Cdd:PLN00181 547 Q--VASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI-KTKANICCV 623

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 388454184 640 QFVPKSHLFFTAGK-DHKIKQWDADKFE-HIQTLEGHHQEIWCLAVSPSGDyVVSSSHDKSLRLWE 703
Cdd:PLN00181 624 QFPSESGRSLAFGSaDHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSST-LVSSSTDNTLKLWD 688
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 485-524 4.72e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 4.72e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454184   485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 54-113 7.52e-07

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 48.04  E-value: 7.52e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 388454184   54 KGEKI--LILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTL 113
Cdd:pfam12894  25 NWQRVwtLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCL 86
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 47-222 9.51e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 9.51e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184  47 VFIWDLRKGEKILILQGLKQEVTCL-CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGhKAAITTLKYDQLGGR-LAS 124
Cdd:PLN00181 557 VQVWDVARSQLVTEMKEHEKRVWSIdYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT-KANICCVQFPSESGRsLAF 635

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 125 GSKDTDVIVWDVINES-GLYRLKGHKDAITQALFLrEKNLLVTSGKDTMVKWWDLD------TQHCFKTMVGHrTEVWGL 197
Cdd:PLN00181 636 GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDLSmsisgiNETPLHSFMGH-TNVKNF 713

                        170       180
                 ....*....|....*....|....*.
gi 388454184 198 VLVS-EEKRLITGASDSELRVWDIAY 222
Cdd:PLN00181 714 VGLSvSDGYIATGSETNEVFVYHKAF 739
WD40 pfam00400
WD domain, G-beta repeat;
586-618 1.38e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 1.38e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 388454184  586 SLYGHKLPVICMDISYDGALIATGSADRNVKIW 618
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
486-524 1.85e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.41  E-value: 1.85e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 388454184  486 GNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 580-618 2.55e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 2.55e-06
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 388454184   580 TLKFFLSLYGHKLPVICMDISYDGALIATGSADRNVKIW 618
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 54-93 2.21e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 2.21e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454184    54 KGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFS 93
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 102-135 2.77e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.77e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 388454184   102 TFNGHKAAITTLKYDQLGGRLASGSKDTDVIVWD 135
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 623-661 2.91e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.91  E-value: 2.91e-05
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 388454184   623 GDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWD 661
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 468-620 6.56e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 47.00  E-value: 6.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 468 QVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSL-SPDQRGFVTGGADKSVKFWdfelvkdenSTQKRLSVKqtrTL 546
Cdd:PLN00181 547 QVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLW---------SINQGVSIG---TI 614

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 388454184 547 QLDEDVLCVSYsPNQKLLAVSLLDCTVKIFYVDtlkfflsLYGHKLPVICM-----DISY----DGALIATGSADRNVKI 617
Cdd:PLN00181 615 KTKANICCVQF-PSESGRSLAFGSADHKVYYYD-------LRNPKLPLCTMighskTVSYvrfvDSSTLVSSSTDNTLKL 686


                 ...
gi 388454184 618 WGL 620
Cdd:PLN00181 687 WDL 689
WD40 pfam00400
WD domain, G-beta repeat;
102-135 1.27e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.27e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 388454184  102 TFNGHKAAITTLKYDQLGGRLASGSKDTDVIVWD 135
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
623-661 1.61e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.61e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 388454184  623 GDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWD 661
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
55-93 1.71e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.71e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 388454184   55 GEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFS 93
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 142-177 3.67e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.67e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 388454184   142 LYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWD 177
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
142-177 1.22e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 388454184  142 LYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWD 177
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 180-219 1.27e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.27e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 388454184   180 TQHCFKTMVGHRTEVWGLVLVSEEKRLITGASDSELRVWD 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
183-219 2.88e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 2.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 388454184  183 CFKTMVGHRTEVWGLVLVSEEKRLITGASDSELRVWD 219
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
410-442 3.31e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 3.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 388454184  410 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWN 442
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDgTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 410-442 8.17e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 8.17e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 388454184   410 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWN 442
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDgTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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