NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|392886203|ref|NP_001250545|]
View 

DDB1- and CUL4-associated factor 11 homolog [Caenorhabditis elegans]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
175-506 1.04e-32

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 175 NGTKIVVASQDEKIRFYQRNPDKSKYrskymksdELRVDQcgWSILDTAISLNGDLIAYGTWKDAVFV-----GKLDFTe 249
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLR--------TLTGHS--GAVTSVAFSPDGKLLASGSDDGTVRLwdlatGKLLRT- 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 250 rqnitwfpidLNGEPGRdhcaVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIvNAHEDDVNSVCFADLGSnLIYS 329
Cdd:COG2319  200 ----------LTGHTGA----VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGR-LLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 330 AGDDGLVKVWDkraWSDGdvEPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDlrkfsnmsgvsqhwdyrwqpap 409
Cdd:COG2319  264 GSADGTVRLWD---LATG--ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD---------------------- 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 410 pglcqpVAGDTSVMTLRGHSVLHTLVRanFSPEStgrRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTEN 489
Cdd:COG2319  317 ------LATGKLLRTLTGHTGAVRSVA--FSPDG---KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385

                        330
                 ....*....|....*..
gi 392886203 490 EIVSSAWDGvtTVWTWD 506
Cdd:COG2319  386 TLASGSADG--TVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
175-506 1.04e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 175 NGTKIVVASQDEKIRFYQRNPDKSKYrskymksdELRVDQcgWSILDTAISLNGDLIAYGTWKDAVFV-----GKLDFTe 249
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLR--------TLTGHS--GAVTSVAFSPDGKLLASGSDDGTVRLwdlatGKLLRT- 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 250 rqnitwfpidLNGEPGRdhcaVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIvNAHEDDVNSVCFADLGSnLIYS 329
Cdd:COG2319  200 ----------LTGHTGA----VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGR-LLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 330 AGDDGLVKVWDkraWSDGdvEPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDlrkfsnmsgvsqhwdyrwqpap 409
Cdd:COG2319  264 GSADGTVRLWD---LATG--ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD---------------------- 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 410 pglcqpVAGDTSVMTLRGHSVLHTLVRanFSPEStgrRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTEN 489
Cdd:COG2319  317 ------LATGKLLRTLTGHTGAVRSVA--FSPDG---KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385

                        330
                 ....*....|....*..
gi 392886203 490 EIVSSAWDGvtTVWTWD 506
Cdd:COG2319  386 TLASGSADG--TVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 168-506 1.28e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 1.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 168 FCTQYIQNGTKIVVASQDEKIRFYQRNPDKSKYRSKYMKSdelrvdqcgwSILDTAISLNGDLIAYGTWKDAVFVGKLDf 247
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG----------PVRDVAASADGTYLASGSSDKTIRLWDLE- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 248 TERQNITWfpidlngepgRDHC-AVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIvNAHEDDVNSVCFaDLGSNL 326
Cdd:cd00200   82 TGECVRTL----------TGHTsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAF-SPDGTF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 327 IYSAGDDGLVKVWDKRAWSdgdvePVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLRKFSnmsgvsqhwdyrwq 406
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGK-----CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-------------- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 407 pappglcqpvagdtSVMTLRGHSvlHTLVRANFSPestGRRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHP 486
Cdd:cd00200  211 --------------CLGTLRGHE--NGVNSVAFSP---DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271

                        330       340
                 ....*....|....*....|
gi 392886203 487 TENEIVSSAWDGvtTVWTWD 506
Cdd:cd00200  272 DGKRLASGSADG--TIRIWD 289
WD40 pfam00400
WD domain, G-beta repeat;
350-387 2.95e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.95e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392886203  350 EPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWD 387
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 350-387 3.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 392886203   350 EPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWD 387
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
175-506 1.04e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 129.65  E-value: 1.04e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 175 NGTKIVVASQDEKIRFYQRNPDKSKYrskymksdELRVDQcgWSILDTAISLNGDLIAYGTWKDAVFV-----GKLDFTe 249
Cdd:COG2319  131 DGKTLASGSADGTVRLWDLATGKLLR--------TLTGHS--GAVTSVAFSPDGKLLASGSDDGTVRLwdlatGKLLRT- 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 250 rqnitwfpidLNGEPGRdhcaVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIvNAHEDDVNSVCFADLGSnLIYS 329
Cdd:COG2319  200 ----------LTGHTGA----VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTL-TGHSGSVRSVAFSPDGR-LLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 330 AGDDGLVKVWDkraWSDGdvEPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDlrkfsnmsgvsqhwdyrwqpap 409
Cdd:COG2319  264 GSADGTVRLWD---LATG--ELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD---------------------- 316

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 410 pglcqpVAGDTSVMTLRGHSVLHTLVRanFSPEStgrRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTEN 489
Cdd:COG2319  317 ------LATGKLLRTLTGHTGAVRSVA--FSPDG---KTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR 385

                        330
                 ....*....|....*..
gi 392886203 490 EIVSSAWDGvtTVWTWD 506
Cdd:COG2319  386 TLASGSADG--TVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 168-506 1.28e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 123.98  E-value: 1.28e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 168 FCTQYIQNGTKIVVASQDEKIRFYQRNPDKSKYRSKYMKSdelrvdqcgwSILDTAISLNGDLIAYGTWKDAVFVGKLDf 247
Cdd:cd00200   13 TCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG----------PVRDVAASADGTYLASGSSDKTIRLWDLE- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 248 TERQNITWfpidlngepgRDHC-AVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIvNAHEDDVNSVCFaDLGSNL 326
Cdd:cd00200   82 TGECVRTL----------TGHTsYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTL-RGHTDWVNSVAF-SPDGTF 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 327 IYSAGDDGLVKVWDKRAWSdgdvePVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLRKFSnmsgvsqhwdyrwq 406
Cdd:cd00200  150 VASSSQDGTIKLWDLRTGK-----CVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGK-------------- 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 407 pappglcqpvagdtSVMTLRGHSvlHTLVRANFSPestGRRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHP 486
Cdd:cd00200  211 --------------CLGTLRGHE--NGVNSVAFSP---DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSP 271

                        330       340
                 ....*....|....*....|
gi 392886203 487 TENEIVSSAWDGvtTVWTWD 506
Cdd:cd00200  272 DGKRLASGSADG--TIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 271-503 3.84e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 119.75  E-value: 3.84e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 271 VFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIVNaHEDDVNSV-CFADlgSNLIYSAGDDGLVKVWDkraWSDGdv 349
Cdd:cd00200   12 VTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG-HTGPVRDVaASAD--GTYLASGSSDKTIRLWD---LETG-- 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 350 EPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLRKFsnmsgvsqhwdyrwqpappglcqpvagdTSVMTLRGHS 429
Cdd:cd00200   84 ECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETG----------------------------KCLTTLRGHT 135

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 392886203 430 --VLHtlVRanFSPESTgrrYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTENEIVSSAWDGVTTVW 503
Cdd:cd00200  136 dwVNS--VA--FSPDGT---FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLW 204
WD40 COG2319
WD40 repeat [General function prediction only];
175-510 2.73e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 2.73e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 175 NGTKIVVASQDEKIRFYQRNPDKSKYRSKYMKSdelrvdqcgwSILDTAISLNGDLIAYGTWKDAVFVgkLDFTERQNIT 254
Cdd:COG2319   89 DGRLLASASADGTVRLWDLATGLLLRTLTGHTG----------AVRSVAFSPDGKTLASGSADGTVRL--WDLATGKLLR 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 255 WfpidLNGEPGrdhcAVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIvNAHEDDVNSVCFA-DlgSNLIYSAGDD 333
Cdd:COG2319  157 T----LTGHSG----AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSpD--GKLLASGSAD 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 334 GLVKVWDkraWSDGdvEPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDlrkfsnmsgvsqhwdyrwqpappglc 413
Cdd:COG2319  226 GTVRLWD---LATG--KLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWD-------------------------- 274

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 414 qpVAGDTSVMTLRGHSvlHTLVRANFSPEStgrRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTENEIVS 493
Cdd:COG2319  275 --LATGELLRTLTGHS--GGVNSVAFSPDG---KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLAS 347

                        330
                 ....*....|....*..
gi 392886203 494 SAWDGVTTVWTWDERQE 510
Cdd:COG2319  348 GSDDGTVRLWDLATGEL 364
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 270-510 5.02e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 113.58  E-value: 5.02e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 270 AVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIVnAHEDDVNSVCFADLGSnLIYSAGDDGLVKVWDkraWSDGdv 349
Cdd:cd00200   53 PVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLT-GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWD---VETG-- 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 350 EPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLRKFSnmsgvsqhwdyrwqpappglcqpvagdtSVMTLRGHS 429
Cdd:cd00200  126 KCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK----------------------------CVATLTGHT 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 430 vlHTLVRANFSPesTGRRYIyTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTENEIVSSAWDGVTTVWTWDERQ 509
Cdd:cd00200  178 --GEVNSVAFSP--DGEKLL-SSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGE 252


                 .
gi 392886203 510 E 510
Cdd:cd00200  253 C 253
WD40 COG2319
WD40 repeat [General function prediction only];
175-389 3.05e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.99  E-value: 3.05e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 175 NGTKIVVASQDEKIRFYQRNPDKSKYRskymksdeLRVDqcGWSILDTAISLNGDLIAYGTWKDAVFVgkLDFTERQNIT 254
Cdd:COG2319  215 DGKLLASGSADGTVRLWDLATGKLLRT--------LTGH--SGSVRSVAFSPDGRLLASGSADGTVRL--WDLATGELLR 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 255 WFPidlnGEPGRdhcaVFCVKFSDSSEQIVCGTSQYSIHVFDVEQRRRIRTIvNAHEDDVNSVCFADLGsNLIYSAGDDG 334
Cdd:COG2319  283 TLT----GHSGG----VNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTL-TGHTGAVRSVAFSPDG-KTLASGSDDG 352

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 392886203 335 LVKVWDKRawsdgDVEPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLR 389
Cdd:COG2319  353 TVRLWDLA-----TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
298-510 1.73e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 90.74  E-value: 1.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 298 EQRRRIRTIVNAHEDDVNSVCFADLGSnLIYSAGDDGLVKVWDKRAWsdgdvEPVGVFAGHRDGVTHVDSRQDERYLLSN 377
Cdd:COG2319   65 AAAGALLATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLATG-----LLLRTLTGHTGAVRSVAFSPDGKTLASG 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 378 SKDQTIKVWDLrkfsnmsgvsqhwdyrwqpappglcqpvAGDTSVMTLRGHSvlHTLVRANFSPEStgrRYIYTGCARGE 457
Cdd:COG2319  139 SADGTVRLWDL----------------------------ATGKLLRTLTGHS--GAVTSVAFSPDG---KLLASGSDDGT 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 392886203 458 VVVYDIMSGTVSRRLKGHTAVVRECDWHPTENEIVSSAWDGVTTVWTWDERQE 510
Cdd:COG2319  186 VRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 351-509 3.69e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 76.22  E-value: 3.69e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 351 PVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLrkfsnmsgvsqhwdyrwqpappglcqpvAGDTSVMTLRGHSv 430
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDL----------------------------ETGELLRTLKGHT- 51

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 392886203 431 lHTLVRANFSPESTgrrYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHPTENEIVSSAWDGVTTVWTWDERQ 509
Cdd:cd00200   52 -GPVRDVAASADGT---YLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGK 126
WD40 COG2319
WD40 repeat [General function prediction only];
339-510 2.73e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 59.15  E-value: 2.73e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 339 WDKRAWSDGDVEPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWDLRKFSNMSGVSQHWDYRWQPAPPGLCQPVA- 417
Cdd:COG2319   16 LALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAs 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 392886203 418 ----GDTSVMTLRGHSVLHTL------VRA-NFSPEStgrRYIYTGCARGEVVVYDIMSGTVSRRLKGHTAVVRECDWHP 486
Cdd:COG2319   96 asadGTVRLWDLATGLLLRTLtghtgaVRSvAFSPDG---KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP 172

                        170       180
                 ....*....|....*....|....
gi 392886203 487 TENEIVSSAWDGVTTVWTWDERQE 510
Cdd:COG2319  173 DGKLLASGSDDGTVRLWDLATGKL 196
WD40 pfam00400
WD domain, G-beta repeat;
350-387 2.95e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.95e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392886203  350 EPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWD 387
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 350-387 3.69e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.84  E-value: 3.69e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 392886203   350 EPVGVFAGHRDGVTHVDSRQDERYLLSNSKDQTIKVWD 387
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 299-340 9.61e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 9.61e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 392886203   299 QRRRIRTIvNAHEDDVNSVCFADLGsNLIYSAGDDGLVKVWD 340
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 465-503 1.72e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.22  E-value: 1.72e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 392886203   465 SGTVSRRLKGHTAVVRECDWHPTENEIVSSAWDGVTTVW 503
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
305-340 5.84e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.71  E-value: 5.84e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 392886203  305 TIVNAHEDDVNSVCFADLGsNLIYSAGDDGLVKVWD 340
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
466-503 1.67e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.67e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 392886203  466 GTVSRRLKGHTAVVRECDWHPTENEIVSSAWDGVTTVW 503
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH