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Conserved domains on  [gi|386781686|ref|NP_001248169|]
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mimecan precursor [Macaca mulatta]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
123-249 2.73e-07

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781686 123 YLYARFNKIKKLTAkDFADIPNLRRLDFTGNLIEDIEDGtfsklslleelslaenqLLKLPvlppKLTLFNAKYNKIKSr 202
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-----------------LGNLT----NLKELDLSNNQITD- 196

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386781686 203 giKANAFKKLNNLTFLYLDHNALESVPLNLPE--SLRVIHLQFNNIASI 249
Cdd:COG4886  197 --LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL 243
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-249 2.73e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781686 123 YLYARFNKIKKLTAkDFADIPNLRRLDFTGNLIEDIEDGtfsklslleelslaenqLLKLPvlppKLTLFNAKYNKIKSr 202
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-----------------LGNLT----NLKELDLSNNQITD- 196

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386781686 203 giKANAFKKLNNLTFLYLDHNALESVPLNLPE--SLRVIHLQFNNIASI 249
Cdd:COG4886  197 --LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL 243
LRR_8 pfam13855
Leucine rich repeat;
143-225 4.44e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781686  143 PNLRRLDFTGNLIEDIEDGTFSKlslleelslaenqllklpvlPPKLTLFNAKYNKIKSrgIKANAFKKLNNLTFLYLDH 222
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------LSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 386781686  223 NAL 225
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
176-251 4.83e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 4.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386781686 176 ENQLLKLPV-LPPKLTLFNAKYNKIKsrgIKANAFKKlnNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITD 251
Cdd:PRK15370 334 ENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPE 405
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-249 2.73e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 51.47  E-value: 2.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781686 123 YLYARFNKIKKLTAkDFADIPNLRRLDFTGNLIEDIEDGtfsklslleelslaenqLLKLPvlppKLTLFNAKYNKIKSr 202
Cdd:COG4886  140 ELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEE-----------------LGNLT----NLKELDLSNNQITD- 196

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 386781686 203 giKANAFKKLNNLTFLYLDHNALESVPLNLPE--SLRVIHLQFNNIASI 249
Cdd:COG4886  197 --LPEPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL 243
LRR_8 pfam13855
Leucine rich repeat;
143-225 4.44e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.36  E-value: 4.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781686  143 PNLRRLDFTGNLIEDIEDGTFSKlslleelslaenqllklpvlPPKLTLFNAKYNKIKSrgIKANAFKKLNNLTFLYLDH 222
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKG--------------------LSNLKVLDLSNNLLTT--LSPGAFSGLPSLRYLDLSG 58


                  ...
gi 386781686  223 NAL 225
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
176-251 4.83e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.77  E-value: 4.83e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 386781686 176 ENQLLKLPV-LPPKLTLFNAKYNKIKsrgIKANAFKKlnNLTFLYLDHNALESVPLNLPESLRVIHLQFNNIASITD 251
Cdd:PRK15370 334 ENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPAALQIMQASRNNLVRLPE 405
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-275 3.16e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 41.84  E-value: 3.16e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781686 123 YLYARFNKIKKLTaKDFADIPNLRRLDFTGNLIEDIEDgTFSKLSLLEELSLAENQLLKLPVLP--PKLTLFNAKYNKIK 200
Cdd:COG4886  186 ELDLSNNQITDLP-EPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQLT 263

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386781686 201 SrgikANAFKKLNNLTFLYLDHNALESVPL-NLPESLRVIHLQFNNIASITDDTFCKANDTSYIRDRIEEIRLEGN 275
Cdd:COG4886  264 D----LPPLANLTNLKTLDLSNNQLTDLKLkELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
LRR_8 pfam13855
Leucine rich repeat;
187-246 1.19e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 1.19e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 386781686  187 PKLTLFNAKYNKIKSrgIKANAFKKLNNLTFLYLDHNALESVPLN----LPeSLRVIHLQFNNI 246
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLP-SLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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