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Conserved domains on  [gi|386781755|ref|NP_001247667|]
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nucleoporin Nup37 [Macaca mulatta]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 1.51e-15

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  16 EDYVHVVEFNPfengdSGNLIAYGG-NNYVVIGtctfqeeeaDVEGiqYKTLRTF-HHGVRVDGIAWSPETRLdslppvi 93
Cdd:COG2319  204 TGAVRSVAFSP-----DGKLLASGSaDGTVRLW---------DLAT--GKLLRTLtGHSGSVRSVAFSPDGRL------- 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  94 kFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHS-PGMSV 171
Cdd:COG2319  261 -LASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTgAVRSV 336

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 386781755 172 CWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216
Cdd:COG2319  337 AFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 1.51e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  16 EDYVHVVEFNPfengdSGNLIAYGG-NNYVVIGtctfqeeeaDVEGiqYKTLRTF-HHGVRVDGIAWSPETRLdslppvi 93
Cdd:COG2319  204 TGAVRSVAFSP-----DGKLLASGSaDGTVRLW---------DLAT--GKLLRTLtGHSGSVRSVAFSPDGRL------- 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  94 kFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHS-PGMSV 171
Cdd:COG2319  261 -LASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTgAVRSV 336

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 386781755 172 CWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216
Cdd:COG2319  337 AFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-194 2.90e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 2.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  64 KTLRTFH-HGVRVDGIAWSPETRldslppviKFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIAS 142
Cdd:cd00200  168 KCVATLTgHTGEVNSVAFSPDGE--------KLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPD-GYLLAS 236

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 386781755 143 VSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYD 194
Cdd:cd00200  237 GSEDGTIRVWDLRtGECVQTLSGHTNSvTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-153 5.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 386781755   113 DKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
118-153 2.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 386781755  118 KVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 153
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
16-216 1.51e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 1.51e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  16 EDYVHVVEFNPfengdSGNLIAYGG-NNYVVIGtctfqeeeaDVEGiqYKTLRTF-HHGVRVDGIAWSPETRLdslppvi 93
Cdd:COG2319  204 TGAVRSVAFSP-----DGKLLASGSaDGTVRLW---------DLAT--GKLLRTLtGHSGSVRSVAFSPDGRL------- 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  94 kFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLE-GVQTAHFVLHS-PGMSV 171
Cdd:COG2319  261 -LASGSADGTVRLW--DLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLAtGKLLRTLTGHTgAVRSV 336

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 386781755 172 CWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216
Cdd:COG2319  337 AFSPDGKT-LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAF 380
WD40 COG2319
WD40 repeat [General function prediction only];
64-216 2.13e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.10  E-value: 2.13e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  64 KTLRTF-HHGVRVDGIAWSPETRLdslppVIkfcTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIAS 142
Cdd:COG2319  153 KLLRTLtGHSGAVTSVAFSPDGKL-----LA---SGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSP-DGKLLAS 221

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 386781755 143 VSDDHTCRIWNLEGVQTAHFVLHSPGM--SVCWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHW 216
Cdd:COG2319  222 GSADGTVRLWDLATGKLLRTLTGHSGSvrSVAFSPDGRL-LASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAF 296
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 64-194 2.90e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 74.68  E-value: 2.90e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  64 KTLRTFH-HGVRVDGIAWSPETRldslppviKFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIAS 142
Cdd:cd00200  168 KCVATLTgHTGEVNSVAFSPDGE--------KLLSSSSDGTIKLW--DLSTGKCLGTLRGHENGVNSVAFSPD-GYLLAS 236

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 386781755 143 VSDDHTCRIWNLE-GVQTAHFVLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYD 194
Cdd:cd00200  237 GSEDGTIRVWDLRtGECVQTLSGHTNSvTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
64-195 2.31e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.02  E-value: 2.31e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  64 KTLRTF-HHGVRVDGIAWSPETRLdslppvikFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIAS 142
Cdd:COG2319  279 ELLRTLtGHSGGVNSVAFSPDGKL--------LASGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSPD-GKTLAS 347

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 386781755 143 VSDDHTCRIWNLEGVQTAH-FVLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYDL 195
Cdd:COG2319  348 GSDDGTVRLWDLATGELLRtLTGHTGAvTSVAFSPDGRT-LASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-216 1.87e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.87e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  59 EGIQYKTLRTFH-HGVRVDGIAWSPETRLDSlppvikfcTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeG 137
Cdd:cd00200  121 DVETGKCLTTLRgHTDWVNSVAFSPDGTFVA--------SSSQDGTIKLW--DLRTGKCVATLTGHTGEVNSVAFSPD-G 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755 138 QEIASVSDDHTCRIWNL-EGVQTAHFVLHSPG-MSVCWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAH 215
Cdd:cd00200  190 EKLLSSSSDGTIKLWDLsTGKCLGTLRGHENGvNSVAFSPDGYL-LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLA 268


                 .
gi 386781755 216 W 216
Cdd:cd00200  269 W 269
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 71-271 1.89e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 69.67  E-value: 1.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  71 HGVRVDGIAWSPETRLdslppvikFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPKeGQEIASVSDDHTCR 150
Cdd:cd00200    8 HTGGVTCVAFSPDGKL--------LATGSGDGTIKVW--DLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755 151 IWNLEGVQTAH-FVLH-SPGMSVCWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVA 228
Cdd:cd00200   77 LWDLETGECVRtLTGHtSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQ 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 386781755 229 GNDWLIWDItRSSYPQNKRPVHMDRACLFRWSTISENLFATTG 271
Cdd:cd00200  156 DGTIKLWDL-RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
WD40 COG2319
WD40 repeat [General function prediction only];
71-238 2.94e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 2.94e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  71 HGVRVDGIAWSPETRLDSlppvikfcTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCR 150
Cdd:COG2319   77 HTAAVLSVAFSPDGRLLA--------SASADGTVRLW--DLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVR 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755 151 IWNLE-GVQTAHFVLHSPGM-SVCWHPEETFkLMVAEKNGTIRFYDLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVA 228
Cdd:COG2319  146 LWDLAtGKLLRTLTGHSGAVtSVAFSPDGKL-LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSA 224

                        170
                 ....*....|
gi 386781755 229 GNDWLIWDIT 238
Cdd:COG2319  225 DGTVRLWDLA 234
WD40 COG2319
WD40 repeat [General function prediction only];
64-156 3.55e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 3.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  64 KTLRTF-HHGVRVDGIAWSPETRLdslppvikFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQEIAS 142
Cdd:COG2319  321 KLLRTLtGHTGAVRSVAFSPDGKT--------LASGSDDGTVRLW--DLATGELLRTLTGHTGAVTSVAFSP-DGRTLAS 389

                         90
                 ....*....|....
gi 386781755 143 VSDDHTCRIWNLEG 156
Cdd:COG2319  390 GSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 59-153 1.89e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 54.65  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755  59 EGIQYKTLRTfhHGVRVDGIAWSPETRLdslppvikFCTSAADMKIRLFtsDLQDKNEYKVLEGHTDFINGLVFDPkEGQ 138
Cdd:cd00200  208 TGKCLGTLRG--HENGVNSVAFSPDGYL--------LASGSEDGTIRVW--DLRTGECVQTLSGHTNSVTSLAWSP-DGK 274

                         90
                 ....*....|....*
gi 386781755 139 EIASVSDDHTCRIWN 153
Cdd:cd00200  275 RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 116-238 1.90e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 1.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386781755 116 EYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWNLEGVQTAH-FVLHSPGMSVC-WHPEETFkLMVAEKNGTIRFY 193
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRtLKGHTGPVRDVaASADGTY-LASGSSDKTIRLW 78

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 386781755 194 DLLAQQAILSLESEQVPLMSAHWCLKNTFKVGAVAGNDWLIWDIT 238
Cdd:cd00200   79 DLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVE 123
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 113-153 5.12e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.68  E-value: 5.12e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 386781755   113 DKNEYKVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 153
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
118-153 2.10e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.10e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 386781755  118 KVLEGHTDFINGLVFDPkEGQEIASVSDDHTCRIWN 153
Cdd:pfam00400   5 KTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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