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Conserved domains on  [gi|386766402|ref|NP_001247284|]
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crumbs, isoform C [Drosophila melanogaster]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1155-1290 1.33e-36

Laminin G domain;


:

Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.33e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1155 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1234
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 386766402  1235 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1290
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1388-1550 2.78e-25

Laminin G domain;


:

Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.78e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1388 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1467
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1468 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1543
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 386766402  1544 VSNGSLN 1550
Cdd:pfam00054  125 VNGKPLD 131
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1692-1828 1.96e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1692 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1769
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 386766402  1770 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1828
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 792-828 1.45e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.45e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402  792 DVDECLSF-PCLNGATCHNKINAYECVCQPGYEGENCE 828
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.14e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


:

Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386766402  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1009-1045 1.23e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 1009 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 1045
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1901-1937 3.30e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.30e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 1901 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1937
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2057-2094 3.43e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402 2057 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2094
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 830-865 1.35e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.35e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  830 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 865
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 907-943 2.37e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402  907 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 943
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1939-1974 2.91e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402 1939 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1974
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 868-905 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402  868 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 905
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1593-1622 6.13e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.13e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 386766402 1593 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1622
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 6.63e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 753-789 5.01e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  753 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 789
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1047-1082 1.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402 1047 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1082
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 716-750 2.06e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 386766402  716 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 750
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 7.94e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.94e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 386766402   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2096-2133 9.00e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 9.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 2096 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2133
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 605-633 1.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.24e-03
                           10        20
                   ....*....|....*....|....*....
gi 386766402   605 CPQENCLNGGTCLGYSGNYSCICASGYTG 633
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1316-1346 1.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.63e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402  1316 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1346
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2137-2175 4.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402 2137 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2175
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.99e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.99e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 6.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.14e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 386766402  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1155-1290 1.33e-36

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.33e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1155 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1234
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 386766402  1235 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1290
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1388-1550 2.78e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.78e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1388 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1467
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1468 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1543
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 386766402  1544 VSNGSLN 1550
Cdd:pfam00054  125 VNGKPLD 131
LamG smart00282
Laminin G domain;
1150-1287 4.98e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 4.98e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   1150 DINLQFRTTLPNGVLAFGTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVFIGS-KLNDSNWHKVFVAINTSHLVLSAN 1228
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLA--LELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386766402   1229 DE--QAIFPVGSYETANnsqpSFPRTYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVNGK 1287
Cdd:smart00282   79 GGnrVSGESPGGLTILN----LDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1136-1285 8.05e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 88.24  E-value: 8.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402 1136 TSLISVTTEREEG--YDINLQFRTTLPNGVLAFGTTGEKNEpvSYILELINGRLNLHSSLLnkWEGVFIGSK--LNDSNW 1211
Cdd:cd00110     7 SSYVRLPTLPAPRtrLSISFSFRTTSPNGLLLYAGSQNGGD--FLALELEDGRLVLRYDLG--SGSLVLSSKtpLNDGQW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386766402 1212 HKVFVAINTSHLVLSANDEQAI-FPVGSYETANNSQPSFprtYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVN 1285
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPL---YLGGLPEDLKSPGLPVSP---GFVGCIRDLKVN 151
LamG smart00282
Laminin G domain;
1383-1546 8.24e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.14  E-value: 8.24e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   1383 DISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTL 1462
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG--------GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRS 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   1463 VQVKLNGTE--YFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPgiipvpgagipiedttvpkeaddsrdyFKGIIQ 1540
Cdd:smart00282   73 VTLSVDGGNrvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPG---------------------------FRGCIR 125


                    ....*.
gi 386766402   1541 DVKVSN 1546
Cdd:smart00282  126 NLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1376-1544 1.18e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402 1376 RAIRSILDISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGEllVKMQFSGTPEAYTVG-GQKLDNGYNHLI 1454
Cdd:cd00110    16 PAPRTRLSISFSFRTTSPNGLLLYAGSQN--------GGDFLALELEDGR--LVLRYDLGSGSLVLSsKTPLNDGQWHSV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402 1455 EVVRNQTLVQVKLNGTEYFRKTLSTTG--LLDAQVLYLGGPAPTRESLLGATtepgiipvpgagipiedttvpkeaddsR 1532
Cdd:cd00110    86 SVERNGRSVTLSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV---------------------------S 138

                         170
                  ....*....|..
gi 386766402 1533 DYFKGIIQDVKV 1544
Cdd:cd00110   139 PGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1692-1828 1.96e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1692 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1769
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 386766402  1770 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1828
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 792-828 1.45e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.45e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402  792 DVDECLSF-PCLNGATCHNKINAYECVCQPGYEGENCE 828
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.14e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386766402  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1009-1045 1.23e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 1009 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 1045
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
792-828 1.97e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 1.97e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    792 DVDECLSF-PCLNGATCHNKINAYECVCQPGYE-GENCE 828
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1901-1937 3.30e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.30e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 1901 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1937
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2057-2094 3.43e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402 2057 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2094
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG smart00282
Laminin G domain;
1688-1826 3.79e-07

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 51.19  E-value: 3.79e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   1688 IDIAFRTRAG-GTLLYIDNVDG--FFEIGVNGGRVTITWKLSALHFGESARFEKENtDGEWSRIYLRAHNSKLeggwkgw 1764
Cdd:smart00282    2 ISFSFRTTSPnGLLLYAGSKGGgdYLALELRDGRLVLRYDLGSGPARLTSDPTPLN-DGQWHRVAVERNGRSV------- 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386766402   1765 eSM-VDPTPAFSTDIDQAAfqSLIATSTQVYLGGMPESRQARGSTLSaqqgSQFKGCVGEARV 1826
Cdd:smart00282   74 -TLsVDGGNRVSGESPGGL--TILNLDGPLYLGGLPEDLKLPPLPVT----PGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1688-1826 1.18e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 50.11  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402 1688 IDIAFRTR-AGGTLLYIDN--VDGFFEIGVNGGRVTITWKLSAlhfgESARFEKENT--DGEWSRIYLRAHNSKLeggwk 1762
Cdd:cd00110    24 ISFSFRTTsPNGLLLYAGSqnGGDFLALELEDGRLVLRYDLGS----GSLVLSSKTPlnDGQWHSVSVERNGRSV----- 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386766402 1763 gweSM-VDPTPAFstDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAqqgsQFKGCVGEARV 1826
Cdd:cd00110    95 ---TLsVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP----GFVGCIRDLKV 150
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 830-865 1.35e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.35e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  830 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 865
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 907-943 2.37e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402  907 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 943
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1939-1974 2.91e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402 1939 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1974
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 868-905 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402  868 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 905
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2057-2094 4.00e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.00e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   2057 DINECES-NPCQNGGQCKDLVGRYECDCQGTGFEGIRCE 2094
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1009-1045 4.08e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.08e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   1009 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFE-GTHCE 1045
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1593-1622 6.13e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.13e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 386766402 1593 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1622
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 6.63e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1590-1620 1.01e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 1.01e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402  1590 CRKNPCLHNAECRNTWNDYTCKCPNGYKGKN 1620
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1901-1937 1.15e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.15e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   1901 DIDECL-NTECLNNGTCINQVAAFFCQCQPGFE-GQHCE 1937
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
830-866 2.00e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 2.00e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    830 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMT-GRICD 866
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
868-905 3.30e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.30e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    868 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSGTGYEGENCE 905
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1939-1975 3.57e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.57e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   1939 NIDECA-DQPCHNGGNCTDLIASYVCDCPEDYM-GPQCD 1975
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 753-789 5.01e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  753 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 789
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
907-943 6.31e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 6.31e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    907 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYK-GKNCE 943
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-455 6.96e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 6.96e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 386766402    425 NVDEC-DKNPCLNGGRCFDTYGWYTCQCLDGW 455
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1047-1082 1.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402 1047 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1082
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
386-423 1.72e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.72e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    386 DTDECAS-QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQ 423
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 716-750 2.06e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 386766402  716 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 750
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 429-458 5.46e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.46e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 386766402   429 CDKNPCLNGGRCFDTYGWYTCQCLDGWGGE 458
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1013-1041 7.12e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.12e-04
                           10        20
                   ....*....|....*....|....*....
gi 386766402  1013 CDSNPCSKHGNCNDGIGTYTCECEPGFEG 1041
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 911-941 7.94e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.94e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402   911 CLSNPCTNGAKCLDRVKDYFCDCHNGYKGKN 941
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 7.94e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.94e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 386766402   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2096-2133 9.00e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 9.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 2096 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2133
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 605-633 1.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.24e-03
                           10        20
                   ....*....|....*....|....*....
gi 386766402   605 CPQENCLNGGTCLGYSGNYSCICASGYTG 633
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 796-826 1.27e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.27e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402   796 CLSFPCLNGATCHNKINAYECVCQPGYEGEN 826
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
2096-2133 1.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   2096 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPY-CGAYC 2133
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1592-1622 1.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.34e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 386766402   1592 KNPCLHNAECRNTWNDYTCKCPNGYK-GKNCQ 1622
Cdd:smart00179    8 GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1316-1346 1.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.63e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402  1316 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1346
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-498 2.32e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|....*...
gi 386766402  471 CLNGGTCLDKPIGFQCLCPPEYTGELCQ 498
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
753-790 2.87e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.87e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 386766402    753 DVDECTLHPkICGNG-ICKNEKGSYKCYCTPGFT-GVHCD 790
Cdd:smart00179    1 DIDECASGN-PCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 718-749 3.33e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.33e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 386766402   718 CATQPCQNGGECVDLPnGDYECKCTRGWTGRT 749
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA pfam07645
Calcium-binding EGF domain;
753-783 4.67e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 4.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 386766402   753 DVDECTLHPKIC-GNGICKNEKGSYKCYCTPG 783
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1047-1082 4.73e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.73e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 386766402   1047 NIDECDRYNPCQRG-TCYDQIDDYDCDCDANY-GGKNC 1082
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2137-2175 4.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402 2137 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2175
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.99e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.99e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 610-637 5.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.14e-03
                          10        20
                  ....*....|....*....|....*...
gi 386766402  610 CLNGGTCLGYSGNYSCICASGYTGYNCQ 637
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2061-2092 5.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 5.40e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 386766402  2061 CESNPCQNGGQCKDLVGRYECDCQgTGFEGIR 2092
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 6.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.14e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 386766402  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1318-1348 8.58e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 8.58e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 386766402 1318 PNPCHSNGECTDLWHTFACHCPRPFFGHTCQ 1348
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
1155-1290 1.33e-36

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 135.52  E-value: 1.33e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1155 FRTTLPNGVLAFGttGEKNEPVSYILELINGRLNLHSSLLNKWEGVFIGSKLNDSNWHKVFVAINTSHLVLSANDEQaiF 1234
Cdd:pfam00054    1 FRTTEPSGLLLYN--GTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEA--R 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 386766402  1235 PVGSYETANNSQPSFPRTYLGGTIPNLKSYLRHLTHQPSaFVGCMQDIMVNGKWIF 1290
Cdd:pfam00054   77 PTGESPLGATTDLDVDGPLYVGGLPSLGVKKRRLAISPS-FDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
1388-1550 2.78e-25

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 103.17  E-value: 2.78e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1388 IRTREPTGQVFYLGTDPRKAptknigdsYVAAKLHGGELLVKMQFSGTPeAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1467
Cdd:pfam00054    1 FRTTEPSGLLLYNGTQTERD--------FLALELRDGRLEVSYDLGSGA-AVVRSGDKLNDGKWHSVELERNGRSGTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1468 NGTEyfrktlsttglldaqvlylggpAPTRESLLGATTepgIIPVPGA----GIPIEdtTVPKEADDSRDYFKGIIQDVK 1543
Cdd:pfam00054   72 DGEA----------------------RPTGESPLGATT---DLDVDGPlyvgGLPSL--GVKKRRLAISPSFDGCIRDVI 124


                   ....*..
gi 386766402  1544 VSNGSLN 1550
Cdd:pfam00054  125 VNGKPLD 131
LamG smart00282
Laminin G domain;
1150-1287 4.98e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 93.94  E-value: 4.98e-22
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   1150 DINLQFRTTLPNGVLAFGTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVFIGS-KLNDSNWHKVFVAINTSHLVLSAN 1228
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKGGGDYLA--LELRDGRLVLRYDLGSGPARLTSDPtPLNDGQWHRVAVERNGRSVTLSVD 78

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 386766402   1229 DE--QAIFPVGSYETANnsqpSFPRTYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVNGK 1287
Cdd:smart00282   79 GGnrVSGESPGGLTILN----LDGPLYLGGLPEDLKLPPLPVTP---GFRGCIRNLKVNGK 132
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1136-1285 8.05e-20

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 88.24  E-value: 8.05e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402 1136 TSLISVTTEREEG--YDINLQFRTTLPNGVLAFGTTGEKNEpvSYILELINGRLNLHSSLLnkWEGVFIGSK--LNDSNW 1211
Cdd:cd00110     7 SSYVRLPTLPAPRtrLSISFSFRTTSPNGLLLYAGSQNGGD--FLALELEDGRLVLRYDLG--SGSLVLSSKtpLNDGQW 82

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386766402 1212 HKVFVAINTSHLVLSANDEQAI-FPVGSYETANNSQPSFprtYLGGTIPNLKSYLRHLTHqpsAFVGCMQDIMVN 1285
Cdd:cd00110    83 HSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPL---YLGGLPEDLKSPGLPVSP---GFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1155-1287 3.65e-16

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 76.69  E-value: 3.65e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1155 FRTTLPNGVLAFgTTGEKNEPVSyiLELINGRLNLHSSLLNKWEGVF-IGSKLNDSNWHKVFVAINTSHLVLSANDEQAI 1233
Cdd:pfam02210    1 FRTRQPNGLLLY-AGGGGSDFLA--LELVNGRLVLRYDLGSGPESLLsSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVV 77

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 386766402  1234 FPVGSYETANNSQPSfpRTYLGGTIPNLksyLRHLTHQPSAFVGCMQDIMVNGK 1287
Cdd:pfam02210   78 SSLPPGESLLLNLNG--PLYLGGLPPLL---LLPALPVRAGFVGCIRDVRVNGE 126
LamG smart00282
Laminin G domain;
1383-1546 8.24e-15

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 73.14  E-value: 8.24e-15
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   1383 DISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTL 1462
Cdd:smart00282    1 SISFSFRTTSPNGLLLYAGSKG--------GGDYLALELRDGRLVLRYDLGSGPARLTSDPTPLNDGQWHRVAVERNGRS 72

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   1463 VQVKLNGTE--YFRKTLSTTGLLDAQVLYLGGPAPTRESLLGATTEPgiipvpgagipiedttvpkeaddsrdyFKGIIQ 1540
Cdd:smart00282   73 VTLSVDGGNrvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPVTPG---------------------------FRGCIR 125


                    ....*.
gi 386766402   1541 DVKVSN 1546
Cdd:smart00282  126 NLKVNG 131
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1376-1544 1.18e-13

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 70.52  E-value: 1.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402 1376 RAIRSILDISMFIRTREPTGQVFYLGTDPrkaptkniGDSYVAAKLHGGEllVKMQFSGTPEAYTVG-GQKLDNGYNHLI 1454
Cdd:cd00110    16 PAPRTRLSISFSFRTTSPNGLLLYAGSQN--------GGDFLALELEDGR--LVLRYDLGSGSLVLSsKTPLNDGQWHSV 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402 1455 EVVRNQTLVQVKLNGTEYFRKTLSTTG--LLDAQVLYLGGPAPTRESLLGATtepgiipvpgagipiedttvpkeaddsR 1532
Cdd:cd00110    86 SVERNGRSVTLSVDGERVVESGSPGGSalLNLDGPLYLGGLPEDLKSPGLPV---------------------------S 138

                         170
                  ....*....|..
gi 386766402 1533 DYFKGIIQDVKV 1544
Cdd:cd00110   139 PGFVGCIRDLKV 150
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1692-1828 1.96e-09

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 57.43  E-value: 1.96e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1692 FRTRAG-GTLLYIDNVDG-FFEIGVNGGRVTITWKLSALHFGESARfEKENTDGEWSRIYLRAHNSKLeggwkgwESMVD 1769
Cdd:pfam02210    1 FRTRQPnGLLLYAGGGGSdFLALELVNGRLVLRYDLGSGPESLLSS-GKNLNDGQWHSVRVERNGNTL-------TLSVD 72

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 386766402  1770 PTPAFSTDIDQaaFQSLIATSTQVYLGGMPESRqaRGSTLSAQQGsqFKGCVGEARVGD 1828
Cdd:pfam02210   73 GQTVVSSLPPG--ESLLLNLNGPLYLGGLPPLL--LLPALPVRAG--FVGCIRDVRVNG 125
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 792-828 1.45e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 1.45e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402  792 DVDECLSF-PCLNGATCHNKINAYECVCQPGYEGENCE 828
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 91-228 1.14e-07

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 53.19  E-value: 1.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   91 AYFNGSTYLRLTTPMPIWDHSAISF----RSCRGgeIL---AQQYNKNSIVISVLNDFLQISlagpaVHGPNNRLDVKLP 163
Cdd:cd00110     2 VSFSGSSYVRLPTLPAPRTRLSISFsfrtTSPNG--LLlyaGSQNGGDFLALELEDGRLVLR-----YDLGSGSLVLSSK 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386766402  164 YQLLDNRWHTLQFKYEYGNLYLHVDRAASI-FANSTYNSQFLTNQDI-------GYKDAILILGNSFSGCLLD 228
Cdd:cd00110    75 TPLNDGQWHSVSVERNGRSVTLSVDGERVVeSGSPGGSALLNLDGPLylgglpeDLKSPGLPVSPGFVGCIRD 147
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1009-1045 1.23e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.23e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 1009 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFEGTHCE 1045
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 1388-1546 1.26e-07

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 52.42  E-value: 1.26e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1388 IRTREPTGQVFYLGtdprkaptkNIGDSYVAAKLHGGELLVKMQFSGTPEAYTVGGQKLDNGYNHLIEVVRNQTLVQVKL 1467
Cdd:pfam02210    1 FRTRQPNGLLLYAG---------GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSV 71

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402  1468 NG--TEYFRKTLSTTGLLDAQVLYLGGPAPTResllgattepgiipvpgagipiedttvPKEADDSRDYFKGIIQDVKVS 1545
Cdd:pfam02210   72 DGqtVVSSLPPGESLLLNLNGPLYLGGLPPLL---------------------------LLPALPVRAGFVGCIRDVRVN 124


                   .
gi 386766402  1546 N 1546
Cdd:pfam02210  125 G 125
EGF_CA smart00179
Calcium-binding EGF-like domain;
792-828 1.97e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 49.17  E-value: 1.97e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    792 DVDECLSF-PCLNGATCHNKINAYECVCQPGYE-GENCE 828
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1901-1937 3.30e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.30e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 1901 DIDECLNTE-CLNNGTCINQVAAFFCQCQPGFEGQHCE 1937
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2057-2094 3.43e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.40  E-value: 3.43e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402 2057 DINECES-NPCQNGGQCKDLVGRYECDCQgTGFEGIRCE 2094
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
LamG smart00282
Laminin G domain;
1688-1826 3.79e-07

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 51.19  E-value: 3.79e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402   1688 IDIAFRTRAG-GTLLYIDNVDG--FFEIGVNGGRVTITWKLSALHFGESARFEKENtDGEWSRIYLRAHNSKLeggwkgw 1764
Cdd:smart00282    2 ISFSFRTTSPnGLLLYAGSKGGgdYLALELRDGRLVLRYDLGSGPARLTSDPTPLN-DGQWHRVAVERNGRSV------- 73

                            90       100       110       120       130       140
                    ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 386766402   1765 eSM-VDPTPAFSTDIDQAAfqSLIATSTQVYLGGMPESRQARGSTLSaqqgSQFKGCVGEARV 1826
Cdd:smart00282   74 -TLsVDGGNRVSGESPGGL--TILNLDGPLYLGGLPEDLKLPPLPVT----PGFRGCIRNLKV 129
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 1688-1826 1.18e-06

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 50.11  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766402 1688 IDIAFRTR-AGGTLLYIDN--VDGFFEIGVNGGRVTITWKLSAlhfgESARFEKENT--DGEWSRIYLRAHNSKLeggwk 1762
Cdd:cd00110    24 ISFSFRTTsPNGLLLYAGSqnGGDFLALELEDGRLVLRYDLGS----GSLVLSSKTPlnDGQWHSVSVERNGRSV----- 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 386766402 1763 gweSM-VDPTPAFstDIDQAAFQSLIATSTQVYLGGMPESRQARGSTLSAqqgsQFKGCVGEARV 1826
Cdd:cd00110    95 ---TLsVDGERVV--ESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPVSP----GFVGCIRDLKV 150
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 830-865 1.35e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.35e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  830 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMTGRIC 865
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 907-943 2.37e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.09  E-value: 2.37e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402  907 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYKGKNCE 943
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1939-1974 2.91e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.71  E-value: 2.91e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402 1939 NIDECADQ-PCHNGGNCTDLIASYVCDCPEDYMGPQC 1974
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 868-905 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402  868 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSgTGYEGENCE 905
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 425-460 3.61e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.61e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  425 NVDECD-KNPCLNGGRCFDTYGWYTCQCLDGWGGEIC 460
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2057-2094 4.00e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.00e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   2057 DINECES-NPCQNGGQCKDLVGRYECDCQGTGFEGIRCE 2094
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1009-1045 4.08e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 4.08e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   1009 NINECDS-NPCSKHGNCNDGIGTYTCECEPGFE-GTHCE 1045
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1593-1622 6.13e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 6.13e-06
                          10        20        30
                  ....*....|....*....|....*....|
gi 386766402 1593 NPCLHNAECRNTWNDYTCKCPNGYKGKNCQ 1622
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 386-423 6.63e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 6.63e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402  386 DTDECASQ-PCQNNGSCIDRINGFSCDCSgTGYTGAFCQ 423
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCP-PGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1590-1620 1.01e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 43.91  E-value: 1.01e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402  1590 CRKNPCLHNAECRNTWNDYTCKCPNGYKGKN 1620
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1901-1937 1.15e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 1.15e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   1901 DIDECL-NTECLNNGTCINQVAAFFCQCQPGFE-GQHCE 1937
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
830-866 2.00e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.39  E-value: 2.00e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    830 DIDECGS-NPCSNGSTCIDRINNFTCNCIPGMT-GRICD 866
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
868-905 3.30e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.30e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    868 DIDDCV-GDPCLNGGQCIDQLGGFRCDCSGTGYEGENCE 905
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1939-1975 3.57e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.57e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   1939 NIDECA-DQPCHNGGNCTDLIASYVCDCPEDYM-GPQCD 1975
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 753-789 5.01e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.01e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402  753 DVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHC 789
Cdd:cd00054     1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
907-943 6.31e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 6.31e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    907 NIDECLS-NPCTNGAKCLDRVKDYFCDCHNGYK-GKNCE 943
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
425-455 6.96e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.85  E-value: 6.96e-05
                            10        20        30
                    ....*....|....*....|....*....|..
gi 386766402    425 NVDEC-DKNPCLNGGRCFDTYGWYTCQCLDGW 455
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1047-1082 1.68e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.68e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 386766402 1047 NIDECDRYNPCQR-GTCYDQIDDYDCDCDANYGGKNC 1082
Cdd:cd00054     1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
386-423 1.72e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 1.72e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402    386 DTDECAS-QPCQNNGSCIDRINGFSCDCSGTGYTGAFCQ 423
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 716-750 2.06e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.06e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 386766402  716 NQCATQ-PCQNGGECVDLPNGdYECKCTRGWTGRTC 750
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGS-YRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 429-458 5.46e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.46e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 386766402   429 CDKNPCLNGGRCFDTYGWYTCQCLDGWGGE 458
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1013-1041 7.12e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.12e-04
                           10        20
                   ....*....|....*....|....*....
gi 386766402  1013 CDSNPCSKHGNCNDGIGTYTCECEPGFEG 1041
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 911-941 7.94e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.94e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402   911 CLSNPCTNGAKCLDRVKDYFCDCHNGYKGKN 941
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 466-495 7.94e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.90  E-value: 7.94e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 386766402   466 CQTQQCLNGGTCLDKPIGFQCLCPPEYTGE 495
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGK 30
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2096-2133 9.00e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 9.00e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 386766402 2096 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPYCGAYC 2133
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 605-633 1.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.24e-03
                           10        20
                   ....*....|....*....|....*....
gi 386766402   605 CPQENCLNGGTCLGYSGNYSCICASGYTG 633
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 796-826 1.27e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.27e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402   796 CLSFPCLNGATCHNKINAYECVCQPGYEGEN 826
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
2096-2133 1.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.34e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 386766402   2096 DIDECNmEGDYCGGLGRCFNKPGSFQCICQKPY-CGAYC 2133
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1592-1622 1.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.34e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 386766402   1592 KNPCLHNAECRNTWNDYTCKCPNGYK-GKNCQ 1622
Cdd:smart00179    8 GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 1316-1346 1.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.63e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402  1316 CKPNPCHSNGECTDLWHTFACHCPRPFFGHT 1346
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-498 2.32e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.32e-03
                          10        20
                  ....*....|....*....|....*...
gi 386766402  471 CLNGGTCLDKPIGFQCLCPPEYTGELCQ 498
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
753-790 2.87e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.87e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 386766402    753 DVDECTLHPkICGNG-ICKNEKGSYKCYCTPGFT-GVHCD 790
Cdd:smart00179    1 DIDECASGN-PCQNGgTCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1593-1622 2.92e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.07  E-value: 2.92e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 386766402 1593 NPCLHNAECRNTWNDYTCKCPNGYKG-KNCQ 1622
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 718-749 3.33e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.33e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 386766402   718 CATQPCQNGGECVDLPnGDYECKCTRGWTGRT 749
Cdd:pfam00008    1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA pfam07645
Calcium-binding EGF domain;
753-783 4.67e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 4.67e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 386766402   753 DVDECTLHPKIC-GNGICKNEKGSYKCYCTPG 783
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1047-1082 4.73e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.73e-03
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 386766402   1047 NIDECDRYNPCQRG-TCYDQIDDYDCDCDANY-GGKNC 1082
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYtDGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2137-2175 4.75e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 4.75e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 386766402 2137 DPCNATDLCSNGGRCVESCGakpDYYCECPEGFAGKNCT 2175
Cdd:cd00054     3 DECASGNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 269-299 4.99e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.59  E-value: 4.99e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 386766402   269 CLNDPCMGHGTCSSSPEGYECRCTARYSGKN 299
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 610-637 5.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 5.14e-03
                          10        20
                  ....*....|....*....|....*...
gi 386766402  610 CLNGGTCLGYSGNYSCICASGYTGYNCQ 637
Cdd:cd00054    11 CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 2061-2092 5.40e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 5.40e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 386766402  2061 CESNPCQNGGQCKDLVGRYECDCQgTGFEGIR 2092
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-341 6.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.14e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 386766402  311 NPCENGGSClENSRGDYQCFCDPNHSGQHCE 341
Cdd:cd00054     9 NPCQNGGTC-VNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 795-828 7.09e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 7.09e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 386766402  795 ECLSF-PCLNGATCHNKINAYECVCQPGYEGE-NCE 828
Cdd:cd00053     1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGDrSCE 36
EGF_CA pfam07645
Calcium-binding EGF domain;
792-821 7.48e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 7.48e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 386766402   792 DVDECLSFP--CLNGATCHNKINAYECVCQPG 821
Cdd:pfam07645    1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1318-1348 8.58e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.08  E-value: 8.58e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 386766402 1318 PNPCHSNGECTDLWHTFACHCPRPFFGHTCQ 1348
Cdd:cd00054     8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 1012-1045 8.72e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 8.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 386766402 1012 ECD-SNPCSKHGNCNDGIGTYTCECEPGFEG-THCE 1045
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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