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Conserved domains on  [gi|386766166|ref|NP_001247214|]
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Na/Ca-exchange protein, isoform F [Drosophila melanogaster]

Protein Classification

CaCA family sodium/calcium exchanger( domain architecture ID 11489785)

CaCA family sodium/calcium exchanger mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4-960 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


:

Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1463.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166    4 LLKSIFTCALFVIFVYATAQSLLKVQETEARQayLNVTSSSSSNLSQDDGHFLsrrlrqvshgeegdegapsqmddeleq 83
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYY--------------------------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   84 mtkvhgeapdaeelreCSEGLVLPLWMPQrNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
Cdd:TIGR00845  52 ----------------CKEGVILPIWEPQ-NPSVGDKIARATVYFVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKK 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRR 243
Cdd:TIGR00845 115 PNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRK 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  244 IRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVVA 322
Cdd:TIGR00845 195 IKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKYVYKRYRAGKqRGMIIE 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  323 GEHDQVEMDAEKGPKQPMVTSARGN--------DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSR 394
Cdd:TIGR00845 275 TEGDRPKSKTEIEMDGKMVNSHVDNfldgalvlEVKEFDEARREMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSR 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  395 AFYRIQATRKMVGSGNLMRKIQERAHSDLTEVkaQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG-DISTY 473
Cdd:TIGR00845 355 AFYRIQATRLMTGAGNILKKHAADAARKAVSM--HEVATDDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGgDLTNT 432

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  474 ASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVK--------------LA 539
Cdd:TIGR00845 433 VYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgileanhvsavaqLA 512

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  540 VPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATES-KDYEGARGELVFENNES 618
Cdd:TIGR00845 513 SPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGgKDFEDTCGELEFENDET 592

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  619 EKFIDLFILEESSYEKDVSFKVHIGEPRLAPEkhehsgepthDELAAKIKEV-----EKKPVQDLTELDRILLLSKPRNG 693
Cdd:TIGR00845 593 EKTIRVKIVDDEEYEKNDTFFIELGEPRWAKR----------GIKAALLLNEtitddDQKLTSKEEEERRIAEMGKPRLG 662

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  694 ELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPAdESEFDNDDEEEEVPSCFSYVSHFVCLFWK 773
Cdd:TIGR00845 663 EHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAG-DDDDDDEDGEEKLPSCFDYVMHFLTVFWK 741

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  774 VLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNC 853
Cdd:TIGR00845 742 VLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADAS 821

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  854 IGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRwHKGIGAELGGPKVSKY 933
Cdd:TIGR00845 822 IGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRR-RPEIGGELGGPRTAKL 900

                         970       980
                  ....*....|....*....|....*..
gi 386766166  934 ISAAILVFLWVFYVVICILEAYDVIRV 960
Cdd:TIGR00845 901 LTSALFVLLWLLYILFSSLEAYCHIKG 927
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4-960 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1463.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166    4 LLKSIFTCALFVIFVYATAQSLLKVQETEARQayLNVTSSSSSNLSQDDGHFLsrrlrqvshgeegdegapsqmddeleq 83
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYY--------------------------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   84 mtkvhgeapdaeelreCSEGLVLPLWMPQrNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
Cdd:TIGR00845  52 ----------------CKEGVILPIWEPQ-NPSVGDKIARATVYFVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKK 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRR 243
Cdd:TIGR00845 115 PNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRK 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  244 IRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVVA 322
Cdd:TIGR00845 195 IKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKYVYKRYRAGKqRGMIIE 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  323 GEHDQVEMDAEKGPKQPMVTSARGN--------DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSR 394
Cdd:TIGR00845 275 TEGDRPKSKTEIEMDGKMVNSHVDNfldgalvlEVKEFDEARREMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSR 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  395 AFYRIQATRKMVGSGNLMRKIQERAHSDLTEVkaQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG-DISTY 473
Cdd:TIGR00845 355 AFYRIQATRLMTGAGNILKKHAADAARKAVSM--HEVATDDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGgDLTNT 432

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  474 ASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVK--------------LA 539
Cdd:TIGR00845 433 VYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgileanhvsavaqLA 512

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  540 VPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATES-KDYEGARGELVFENNES 618
Cdd:TIGR00845 513 SPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGgKDFEDTCGELEFENDET 592

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  619 EKFIDLFILEESSYEKDVSFKVHIGEPRLAPEkhehsgepthDELAAKIKEV-----EKKPVQDLTELDRILLLSKPRNG 693
Cdd:TIGR00845 593 EKTIRVKIVDDEEYEKNDTFFIELGEPRWAKR----------GIKAALLLNEtitddDQKLTSKEEEERRIAEMGKPRLG 662

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  694 ELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPAdESEFDNDDEEEEVPSCFSYVSHFVCLFWK 773
Cdd:TIGR00845 663 EHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAG-DDDDDDEDGEEKLPSCFDYVMHFLTVFWK 741

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  774 VLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNC 853
Cdd:TIGR00845 742 VLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADAS 821

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  854 IGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRwHKGIGAELGGPKVSKY 933
Cdd:TIGR00845 822 IGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRR-RPEIGGELGGPRTAKL 900

                         970       980
                  ....*....|....*....|....*..
gi 386766166  934 ISAAILVFLWVFYVVICILEAYDVIRV 960
Cdd:TIGR00845 901 LTSALFVLLWLLYILFSSLEAYCHIKG 927
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 300-417 1.40e-45

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 160.16  E-value: 1.40e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  300 RRLLVYKYMDKNYRVNK-RGTVVAGEHD-------QVEMDAEKGPKQPMVTSARGN----DAEAFDEARREYITLLTELR 367
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKrRGIIVETEGElgpkegiEMLMDGKLVGSHVMEGGAEGPvddpEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 386766166  368 QKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQE 417
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAA 130
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 441-529 1.26e-35

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 130.07  E-value: 1.26e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   441 PIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFE 520
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80


                   ....*....
gi 386766166   521 EDECFYIRL 529
Cdd:smart00237  81 KDETFYVRL 89
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
795-949 1.61e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.09  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 795 IFVIGVITAIIG-----DAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAA--KHDEGAdncIGNVTGSNAVNVFL 867
Cdd:COG0530  156 LLVLGLALLVVGarllvDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAArkGEDDLA---VGNIIGSNIFNILL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 868 GIGLAWTIAavyhsshgmtfnvePGTIGFAVALF--CGEALIAIMLIMFRRWHKGIGAelggpkvskyISAAILVFLWVF 945
Cdd:COG0530  233 VLGIGALIT--------------PIPVDPAVLSFdlPVMLAATLLLLGLLRTGGRIGR----------WEGLLLLALYLA 288


                 ....
gi 386766166 946 YVVI 949
Cdd:COG0530  289 YLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 791-872 2.47e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.25  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 791 FVVSIFVIGVITAIIGD-----AASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEgADNCIGNVTGSNAVNV 865
Cdd:PRK10734   3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNI 81


                 ....*..
gi 386766166 866 FLGIGLA 872
Cdd:PRK10734  82 LLILGLA 88
 
Name Accession Description Interval E-value
caca TIGR00845
sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of ...
 4-960 0e+00

sodium/calcium exchanger 1; The Ca2+:Cation Antiporter (CaCA) Family (TC 2.A.19)Proteins of the CaCA family are found ubiquitously, having been identified in animals, plants, yeast, archaea and widely divergent bacteria.All of the characterized animal proteins catalyze Ca2+:Na+ exchange although some also transport K+. The NCX1 plasma membrane protein exchanges 3 Na+ for 1 Ca2+. The E. coli ChaA protein catalyzes Ca2+:H+ antiport but may also catalyze Na+:H+ antiport. All remaining well-characterized members of the family catalyze Ca2+:H+ exchange.This model is specific for the eukaryotic sodium ion/calcium ion exchangers of the Caca family [Transport and binding proteins, Other]


Pssm-ID: 273296 [Multi-domain]  Cd Length: 928  Bit Score: 1463.86  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166    4 LLKSIFTCALFVIFVYATAQSLLKVQETEARQayLNVTSSSSSNLSQDDGHFLsrrlrqvshgeegdegapsqmddeleq 83
Cdd:TIGR00845   1 MLRLSLSPLFSVGFHLLTAVSLLFLHVDHARA--LTEASSSGSNTGECTGSYY--------------------------- 51

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   84 mtkvhgeapdaeelreCSEGLVLPLWMPQrNISVGDRLVRGFVYFVLLIYLFVGVSIIADRFMAAIEAITSIERAVVVKG 163
Cdd:TIGR00845  52 ----------------CKEGVILPIWEPQ-NPSVGDKIARATVYFVAMVYMFLGVSIIADRFMASIEVITSQEKEITIKK 114

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  164 PNNTKQVMHVRIWNETVANLTLMALGSSAPEILLSVIEIYAKDFESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAGEVRR 243
Cdd:TIGR00845 115 PNGETTVTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFEAGDLGPSTIVGSAAFNMFIIIAICVYVIPDGETRK 194

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  244 IRHLRVFFVTALFSVFAYVWLWLILSVFTPGVILVWEAIVTLLFFPLTVLWAYIAERRLLVYKYMDKNYRVNK-RGTVVA 322
Cdd:TIGR00845 195 IKHLRVFFVTAAWSVFAYVWLYLILAVFSPGVVEVWEGLLTFFFFPLCVVFAWVADRRLLFYKYVYKRYRAGKqRGMIIE 274

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  323 GEHDQVEMDAEKGPKQPMVTSARGN--------DAEAFDEARREYITLLTELRQKYPDADLEQLEMMAQEQVLARSSKSR 394
Cdd:TIGR00845 275 TEGDRPKSKTEIEMDGKMVNSHVDNfldgalvlEVKEFDEARREMIRILKELKQKHPDKDLEQLEEMANYQVLSRQQKSR 354

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  395 AFYRIQATRKMVGSGNLMRKIQERAHSDLTEVkaQLHAGDDEEADDPIRMYFEPGHYTVMENCGEFEVRVVRRG-DISTY 473
Cdd:TIGR00845 355 AFYRIQATRLMTGAGNILKKHAADAARKAVSM--HEVATDDEENDPVSKIFFEPGHYTCLENCGTVALTVVRRGgDLTNT 432

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  474 ASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFEEDECFYIRLFNPSEGVK--------------LA 539
Cdd:TIGR00845 433 VYVDYRTEDGTANAGSDYEFTEGTLVFKPGETQKEFRIGIIDDDIFEEDEHFYVRLSNLRVGSEdgileanhvsavaqLA 512

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  540 VPMIATVMILDDDHAGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATES-KDYEGARGELVFENNES 618
Cdd:TIGR00845 513 SPNTATVTILDDDHAGIFTFEEDVFHVSESIGIMEVKVLRTSGARGTVIVPYRTVEGTARGGgKDFEDTCGELEFENDET 592

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  619 EKFIDLFILEESSYEKDVSFKVHIGEPRLAPEkhehsgepthDELAAKIKEV-----EKKPVQDLTELDRILLLSKPRNG 693
Cdd:TIGR00845 593 EKTIRVKIVDDEEYEKNDTFFIELGEPRWAKR----------GIKAALLLNEtitddDQKLTSKEEEERRIAEMGKPRLG 662

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  694 ELTTAYVRIRESQEFKATVDKLVAKANVSAVLGTSSWKEQFKDALTVIPAdESEFDNDDEEEEVPSCFSYVSHFVCLFWK 773
Cdd:TIGR00845 663 EHTKLEVIIEESYEFKSTVDKLIKKTNLALVVGTHSWREQFIEAITVSAG-DDDDDDEDGEEKLPSCFDYVMHFLTVFWK 741

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  774 VLFAFVPPTDICGGYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGADNC 853
Cdd:TIGR00845 742 VLFAFVPPTEYWGGWACFVVSILMIGVLTAFIGDLASHFGCTIGLKDSVTAVVFVALGTSVPDTFASKVAATQDQYADAS 821

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  854 IGNVTGSNAVNVFLGIGLAWTIAAVYHSSHGMTFNVEPGTIGFAVALFCGEALIAIMLIMFRRwHKGIGAELGGPKVSKY 933
Cdd:TIGR00845 822 IGNVTGSNAVNVFLGIGVAWSIAAIYHAANGTQFKVSPGTLAFSVTLFTIFAFICIGVLLYRR-RPEIGGELGGPRTAKL 900

                         970       980
                  ....*....|....*....|....*..
gi 386766166  934 ISAAILVFLWVFYVVICILEAYDVIRV 960
Cdd:TIGR00845 901 LTSALFVLLWLLYILFSSLEAYCHIKG 927
Na_Ca_ex_C pfam16494
C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher ...
 300-417 1.40e-45

C-terminal extension of sodium/calcium exchanger domain; Na_Ca_ex_C is a region of the higher eukaryote sodium/calcium exchanger domain that extends toward the C-terminal, and is cytoplasmic.


Pssm-ID: 465141  Cd Length: 136  Bit Score: 160.16  E-value: 1.40e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  300 RRLLVYKYMDKNYRVNK-RGTVVAGEHD-------QVEMDAEKGPKQPMVTSARGN----DAEAFDEARREYITLLTELR 367
Cdd:pfam16494   1 RRLLFYKYLYKRYRADKrRGIIVETEGElgpkegiEMLMDGKLVGSHVMEGGAEGPvddpEAKELDEARREVIRILKELK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 386766166  368 QKYPDADLEQLEMMAQEQVLARSSKSRAFYRIQATRKMVGSGNLMRKIQE 417
Cdd:pfam16494  81 QKHPDKDLEQLEEMANYEALSHQPKSRAFYRIQATRKMTGAGNILKKHAA 130
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 441-529 1.26e-35

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 130.07  E-value: 1.26e-35
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   441 PIRMYFEPGHYTVMENCGEFEVRVVRRGDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVFE 520
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80


                   ....*....
gi 386766166   521 EDECFYIRL 529
Cdd:smart00237  81 KDETFYVRL 89
Calx-beta pfam03160
Calx-beta domain;
441-529 1.77e-33

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 123.90  E-value: 1.77e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  441 PIRMYFEPGHYTVMENCGEFEVRVVRR-GDISTYASVEYETQDGTASAGTDFVGRKGLLSFPPGVDEQRFRIEVIDDDVF 519
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMsGTLRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|
gi 386766166  520 EEDECFYIRL 529
Cdd:pfam03160  81 EGDENFFVLL 90
Calx_beta smart00237
Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin ...
 554-643 2.65e-30

Domains in Na-Ca exchangers and integrin-beta4; Domain in Na-Ca exchangers and integrin subunit beta4 (and some cyanobacterial proteins)


Pssm-ID: 197594 [Multi-domain]  Cd Length: 90  Bit Score: 114.66  E-value: 2.65e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   554 AGIFAFTDSVFEITESVGRFELKVMRYSGARGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSYE 633
Cdd:smart00237   1 AGSVGFEQPVYTVSESDGEVEVCVVRTGGARGPVVVPYSTEDGTATAGSDYEPVPGELTFPPGETEKEIRIKIIDDDIYE 80

                           90
                   ....*....|
gi 386766166   634 KDVSFKVHIG 643
Cdd:smart00237  81 KDETFYVRLS 90
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 787-952 1.35e-26

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 106.15  E-value: 1.35e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  787 GYVTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEgADNCIGNVTGSNAVNVF 866
Cdd:pfam01699   2 SLLLFILGLLLISVAADLLVDSAEVLARVLGISGTVLGLTILALGTSLPELVSSIIAALRGE-PDLALGNVIGSNIFNIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  867 LGIGLAWTIAAVYHSSHGMTFNVEpgtIGFAVALFCGEALIAIMLIMFRRWHKGIGaelggpkvskyisaAILVFLWVFY 946
Cdd:pfam01699  81 LVLGLSALIGPVKVDSLLLKLDLG---VLLLVALLLLLLLLLLLLPLFGRLSRFEG--------------LVLLLLYIVY 143


                  ....*.
gi 386766166  947 VVICIL 952
Cdd:pfam01699 144 LVFQIV 149
Calx-beta pfam03160
Calx-beta domain;
554-643 2.72e-26

Calx-beta domain;


Pssm-ID: 397326 [Multi-domain]  Cd Length: 91  Bit Score: 103.48  E-value: 2.72e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  554 AGIFAFTDSVFEITESVGRFELKVMRYSGA-RGTVIVPYWTENDTATESKDYEGARGELVFENNESEKFIDLFILEESSY 632
Cdd:pfam03160   1 AGVIGFEPPTYQVSENDGVAEVCVVRMSGTlRRTVVVPYRTEDGTATAGDDYEPVEGELVFGPGETEKCINVTIIDDDVY 80

                          90
                  ....*....|.
gi 386766166  633 EKDVSFKVHIG 643
Cdd:pfam03160  81 EGDENFFVLLS 91
Na_Ca_ex pfam01699
Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral ...
 126-296 2.41e-18

Sodium/calcium exchanger protein; This is a family of sodium/calcium exchanger integral membrane proteins. This family covers the integral membrane regions of the proteins. Sodium/calcium exchangers regulate intracellular Ca2+ concentrations in many cells; cardiac myocytes, epithelial cells, neurons retinal rod photoreceptors and smooth muscle cells. Ca2+ is moved into or out of the cytosol depending on Na+ concentration. In humans and rats there are 3 isoforms; NCX1 NCX2 and NCX3.


Pssm-ID: 426387 [Multi-domain]  Cd Length: 149  Bit Score: 82.65  E-value: 2.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  126 VYFVLLIYLFVGVSIIADRFMAAIEAITSIeravvvkgpnntkqvmhvRIWNETVANLTLMALGSSAPEILLSVIEIYAK 205
Cdd:pfam01699   1 LSLLLFILGLLLISVAADLLVDSAEVLARV------------------LGISGTVLGLTILALGTSLPELVSSIIAALRG 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  206 dfeSGDLGPGTIVGSAAYNLFMIIAVCMI--WIPAGEVRRIRHLRVFFVTALFSVFAYVWLWLILsvftPGVILVWEAIV 283
Cdd:pfam01699  63 ---EPDLALGNVIGSNIFNILLVLGLSALigPVKVDSLLLKLDLGVLLLVALLLLLLLLLLLLPL----FGRLSRFEGLV 135

                         170
                  ....*....|...
gi 386766166  284 TLLFFPLTVLWAY 296
Cdd:pfam01699 136 LLLLYIVYLVFQI 148
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
795-949 1.61e-13

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 72.09  E-value: 1.61e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 795 IFVIGVITAIIG-----DAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAA--KHDEGAdncIGNVTGSNAVNVFL 867
Cdd:COG0530  156 LLVLGLALLVVGarllvDGAVEIARALGVSELVIGLTIVAIGTSLPELATSIVAArkGEDDLA---VGNIIGSNIFNILL 232

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 868 GIGLAWTIAavyhsshgmtfnvePGTIGFAVALF--CGEALIAIMLIMFRRWHKGIGAelggpkvskyISAAILVFLWVF 945
Cdd:COG0530  233 VLGIGALIT--------------PIPVDPAVLSFdlPVMLAATLLLLGLLRTGGRIGR----------WEGLLLLALYLA 288


                 ....
gi 386766166 946 YVVI 949
Cdd:COG0530  289 YLAL 292
2A1904 TIGR00927
K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying ...
 111-358 8.92e-11

K+-dependent Na+/Ca+ exchanger; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273344 [Multi-domain]  Cd Length: 1096  Bit Score: 66.17  E-value: 8.92e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   111 PQRNISVGDRLvRGFVYFVL--LIYLFVGVSIIADR-FMAAIEAITsieravvvkgpnNTKQVmhvriwNETVANLTLMA 187
Cdd:TIGR00927  443 PPDLFSVEERR-QGWVVLHIfgMMYVFVALAIVCDEyFVPALGVIT------------DKLQI------SEDVAGATFMA 503

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   188 LGSSAPEILLSVIEIYakdFESGDLGPGTIVGSAAYNLFMIIAVCMIWipageVRRIRHLRVFFVTALFSVFAYVWLWLI 267
Cdd:TIGR00927  504 AGGSAPELFTSLIGVF---ISHSNVGIGTIVGSAVFNILFVIGTCALF-----SREILNLTWWPLFRDVSFYILDLMMLI 575

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166   268 LsVFTPGVILVWEAIVTLL---FFPLTVLWAYIAErrLLVYKYMDKN--YRVNKRGTVVAGEHDQVEMDAEKGP---KQP 339
Cdd:TIGR00927  576 L-FFLDSLIAWWESLLLLLayaLYVFTMKWNKQIE--LWVKEQLSRRpvAKVMALGDLSKGDVAEAEHTGERTGeegERP 652

                          250
                   ....*....|....*....
gi 386766166   340 MVTSARgNDAEAFDEARRE 358
Cdd:TIGR00927  653 TEAEGE-NGEESGGEAEQE 670
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 789-917 8.22e-10

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 61.19  E-value: 8.22e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  789 VTFVVSIFVIGVITAIIGDAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEGaDNCIGNVTGSNAVNVFLG 868
Cdd:TIGR00367 173 VLLIIGLIGLVVGSRLLVDGAVKIAEILGISEKIIGLTLLAIGTSLPELVVSLAAARKGLG-DIAVGNVIGSNIFNILVG 251

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 386766166  869 IGLAWTIAAVYHSSHGMTFNvepGTIGFAVALFCgeALIAIMLIMFRRW 917
Cdd:TIGR00367 252 LGVPSLFMPIPVEPLAYNLD---APVMVIVTLLL--MLFFKTSMKLGRW 295
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
807-954 8.65e-10

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 60.92  E-value: 8.65e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 807 DAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEgADNCIGNVTGSNAVNVFLGIGLAWTIAavyhsshgmT 886
Cdd:COG0530    6 RGADALARRLGISPLVIGLTIVAFGTSLPELAVSVTAALDGS-PDIAVGNVVGSNIANILLILGLAALIR---------P 75

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 386766166 887 FNVEPGTIGFAVALFCGEALIAIMLIMFRRWhkgigaelggpkvsKYISAAILVFLWVFYVVICILEA 954
Cdd:COG0530   76 LAVDRRVLRRDLPFLLLASLLLLALLLDGTL--------------SRIDGVILLLLYVLYLYYLIRRA 129
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
178-301 8.81e-10

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 60.92  E-value: 8.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 178 ETVANLTLMALGSSAPEILLSVIEIYakdFESGDLGPGTIVGSAAYNLFMIIAVCMIwipageVRRIR-HLRVFFVTALF 256
Cdd:COG0530   19 PLVIGLTIVAFGTSLPELAVSVTAAL---DGSPDIAVGNVVGSNIANILLILGLAAL------IRPLAvDRRVLRRDLPF 89

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 386766166 257 SVFAYVWLWLilsVFTPGVILVWEAIVTLLFFPLTVLWAYIAERR 301
Cdd:COG0530   90 LLLASLLLLA---LLLDGTLSRIDGVILLLLYVLYLYYLIRRARK 131
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 792-878 3.44e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 50.02  E-value: 3.44e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  792 VVSIFVIGVITAIIG-----DAASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHdEGADNCIGNVTGSNAVNVF 866
Cdd:TIGR00367   3 LIGYLILGLILLIYGadlfvKSSVRIARHLGISPLIIGVTVVAIGTSLPELFTSLIASLM-GQPDIGVGNVIGSNIFNIL 81

                          90
                  ....*....|..
gi 386766166  867 LGIGLAWTIAAV 878
Cdd:TIGR00367  82 LILGLSAIFSPI 93
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 180-288 4.15e-06

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 49.63  E-value: 4.15e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  180 VANLTLMALGSSAPEILLSVIEIYAkdfESGDLGPGTIVGSAAYNLFMIIAVCMIWIPAgEVRRIRHLRVFFVTALFSVF 259
Cdd:TIGR00367  38 IIGVTVVAIGTSLPELFTSLIASLM---GQPDIGVGNVIGSNIFNILLILGLSAIFSPI-IVDKDWLRRDILFYLLVSIL 113

                          90       100
                  ....*....|....*....|....*....
gi 386766166  260 AYVWLWLILSVFTPGVILVWEAIVTLLFF 288
Cdd:TIGR00367 114 LLFFGLDGQISRIDGVVLLILYIVYLLFL 142
ECM27 COG0530
Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];
176-294 5.38e-06

Ca2+/Na+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 440296 [Multi-domain]  Cd Length: 293  Bit Score: 49.36  E-value: 5.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 176 WNETVANLTLMALGSSAPEILLSVIEIYAKDfesGDLGPGTIVGSAAYNLFMIIAVCMIWIPaGEVRRIRHLRVFFVTAL 255
Cdd:COG0530  184 VSELVIGLTIVAIGTSLPELATSIVAARKGE---DDLAVGNIIGSNIFNILLVLGIGALITP-IPVDPAVLSFDLPVMLA 259

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 386766166 256 FSVFayvwlwLILSVFTPGVILVWEAIVTLLFFPLTVLW 294
Cdd:COG0530  260 ATLL------LLGLLRTGGRIGRWEGLLLLALYLAYLAL 292
PRK10734 PRK10734
putative calcium/sodium:proton antiporter; Provisional
 791-872 2.47e-04

putative calcium/sodium:proton antiporter; Provisional


Pssm-ID: 182684 [Multi-domain]  Cd Length: 325  Bit Score: 44.25  E-value: 2.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166 791 FVVSIFVIGVITAIIGD-----AASYFGCALNIKDSVTAILFVALGTSIPDTFASMIAAKHDEgADNCIGNVTGSNAVNV 865
Cdd:PRK10734   3 LATALLIIGLLLLVYGAdrlvfAASILCRTFGIPPLIIGMTVVGIGTSLPEIIVSVAASLHGQ-RDLAVGTALGSNITNI 81


                 ....*..
gi 386766166 866 FLGIGLA 872
Cdd:PRK10734  82 LLILGLA 88
TIGR00367 TIGR00367
K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and ...
 178-288 1.99e-03

K+-dependent Na+/Ca+ exchanger related-protein; This model models a family of bacterial and archaeal proteins that is homologous, except for lacking a central region of ~ 250 amino acids and an N-terminal region of > 100 residues, to a functionally proven potassium-dependent sodium-calcium exchanger of the rat. [Unknown function, General]


Pssm-ID: 273039 [Multi-domain]  Cd Length: 307  Bit Score: 41.54  E-value: 1.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 386766166  178 ETVANLTLMALGSSAPEILLSVIEIYAKDfesGDLGPGTIVGSAAYNLFMIIAVCMIwipagevrrIRHLRVFFVTALF- 256
Cdd:TIGR00367 204 EKIIGLTLLAIGTSLPELVVSLAAARKGL---GDIAVGNVIGSNIFNILVGLGVPSL---------FMPIPVEPLAYNLd 271

                          90       100       110
                  ....*....|....*....|....*....|...
gi 386766166  257 -SVFAYVWLWLILSVFTPGVILVWEAIVTLLFF 288
Cdd:TIGR00367 272 aPVMVIVTLLLMLFFKTSMKLGRWEGILLLALY 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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